RANKL biology: bone metabolism, the immune system, and beyond

scientific article published on 07 February 2020

RANKL biology: bone metabolism, the immune system, and beyond is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1186/S41232-019-0111-3
P932PMC publication ID7006158
P698PubMed publication ID32047573

P2093author name stringTomoki Nakashima
Fumiyuki Sasaki
Mikihito Hayashi
Takehito Ono
P2860cites workCCR6 identifies lymphoid tissue inducer cells within cryptopatchesQ82866177
The Tumor Necrosis Factor Superfamily Member RANKL Suppresses Effector Cytokine Production in Group 3 Innate Lymphoid CellsQ88954027
Metastatic niche functions and therapeutic opportunitiesQ90526088
Role of the RANK/RANKL Pathway in Multiple MyelomaQ90858649
The RANK-RANKL axis: an opportunity for drug repurposing in cancer?Q91104635
Antigen presentation and adaptive immune responses in skinQ91160420
OsteoporosisQ91271255
Effects of the anti-RANKL antibody denosumab on joint structural damage in patients with rheumatoid arthritis treated with conventional synthetic disease-modifying antirheumatic drugs (DESIRABLE study): a randomised, double-blind, placebo-controlledQ91622660
Rethinking Thymic Tolerance: Lessons from MiceQ91900695
RANKL inhibition improves muscle strength and insulin sensitivity and restores bone massQ92237916
FDA approves first-in-class osteoporosis drugQ92503196
Osteoimmunology: evolving concepts in bone-immune interactions in health and diseaseQ92668034
Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage NicheQ92759524
Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast CancerQ93051641
Emerging Functions of RANKL in Lymphoid TissuesQ21131222
Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutationsQ24310432
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsQ24315251
Central control of fever and female body temperature by RANKL/RANKQ24321735
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesisQ24324701
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
RANK is essential for osteoclast and lymph node developmentQ24598872
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerQ24605866
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
RANK-RANKL signalling in cancerQ26747442
Immune regulation of bone metastasisQ27005871
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.Q27316833
RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy ReceptorQ27674275
Update on Inflammatory Biomarkers and Treatments in Ischemic StrokeQ28078744
Osteopetrosis and its relevance for the discovery of new functions associated with the skeletonQ28085259
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysisQ28141482
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
Matrix-embedded cells control osteoclast formationQ28247746
Evidence for osteocyte regulation of bone homeostasis through RANKL expressionQ28247757
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling BoneQ28267634
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesisQ28293009
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisQ28294501
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentQ28508430
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotypeQ28609693
RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal EpitheliumQ29397534
Innate lymphoid cells--a proposal for uniform nomenclatureQ29617431
Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in boneQ30619950
Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathwayQ31032805
Recent advances in the management of osteoporosisQ33672136
OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in miceQ33730470
Emerging therapeutic opportunities for skeletal restorationQ34161867
Juvenile Paget's disease with heterozygous duplication within TNFRSF11A encoding RANKQ34307564
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unitQ34750367
Prostaglandin E2-prostaglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppressionQ34835869
Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A geneQ35438270
Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation in the signal peptide of RANK.Q35568480
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epitheliumQ36011240
Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone lossQ36216058
RANKL-RANK interaction in immune regulatory systemsQ36412789
Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal musclesQ36810697
RANKL/RANK control Brca1 mutation-driven mammary tumorsQ37457304
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cellsQ37627734
New insights into osteoclastogenic signaling mechanismsQ38019255
Stromal infrastructure of the lymph node and coordination of immunityQ38286890
Idiopathic hyperphosphatasia and TNFRSF11B mutations: relationships between phenotype and genotype.Q38346910
Intestinal M cellsQ38658382
AIRE expands: new roles in immune tolerance and beyond.Q38773105
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitusQ39197051
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.Q39670403
LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagenQ39986041
Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota.Q40230484
Regulation of cancer cell migration and bone metastasis by RANKL.Q40298349
Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression.Q41459925
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destructionQ41927546
Juvenile Paget's disease: the second reported, oldest patient is homozygous for the TNFRSF11B "Balkan" mutation (966_969delTGACinsCTT), which elevates circulating immunoreactive osteoprotegerin levelsQ42163993
Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer.Q42234109
Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcificationQ42994159
Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injuryQ44579479
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritisQ44688981
RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathwayQ46072800
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiotaQ46167903
Langerhans Cells-Programmed by the Epidermis.Q47109271
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.Q47140509
The anti-tumor effect of RANKL inhibition in malignant solid tumors - A systematic review.Q47386961
Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesisQ47840579
Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.Q47944184
RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in MiceQ48039377
Osteoprotegerin deficiency and juvenile Paget's diseaseQ48292818
Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brainQ48502190
RANKL and RANK: From Mammalian Physiology to Cancer Treatment.Q48568949
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous SystemQ49133217
Host defense against oral microbiota by bone-damaging T cells.Q49912580
Recent advances in osteoclast biology.Q50215136
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.Q50335960
Intragenic SNP haplotypes associated with 84dup18 mutation in TNFRSF11A in four FEO pedigrees suggest three independent origins for this mutation.Q50457960
Phenotypic characterization of early onset Paget's disease of bone caused by a 27-bp duplication in the TNFRSF11A gene.Q50482693
Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis.Q50484870
Cross-talk of receptor activator of nuclear factor-κB ligand signaling with renin-angiotensin system in vascular calcification.Q50492455
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.Q53453365
RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.Q53487298
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsQ57184743
CNS infection and immune privilegeQ57476572
Lineage Relationship Analysis of RORγt+Innate Lymphoid CellsQ57520258
Coupling of bone resorption and formation by RANKL reverse signallingQ59051790
Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasisQ60921418
Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone lossQ61135621
Novel homozygous mutations in the osteoprotegerin gene TNFRSF11B in two unrelated patients with juvenile Paget's diseaseQ62129297
RANKL is a therapeutic target of bone destruction in rheumatoid arthritisQ64096832
One Disease, Many Genes: Implications for the Treatment of OsteopetrosesQ64228409
Innate Lymphoid Cells in Mucosal ImmunityQ64255314
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokinesQ74269794
Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysisQ77435071
P304page(s)2
P577publication date2020-02-07
P1433published inInflammation and RegenerationQ27723951
P1476titleRANKL biology: bone metabolism, the immune system, and beyond
P478volume40