Recent advances in osteoclast biology.

scientific article published in February 2018

Recent advances in osteoclast biology. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00418-018-1636-2
P698PubMed publication ID29392395

P50authorTakehito OnoQ62752490
P2093author name stringTomoki Nakashima
P2860cites workThe molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesisQ24297505
Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1Q24300916
Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in boneQ24309351
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiationQ24315189
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesisQ24324701
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6Q24537518
RANK is essential for osteoclast and lymph node developmentQ24598872
Carbonic anhydrase II deficiency identified as the primary defect in the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcificationQ24600356
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesQ24628843
HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and functionQ24644323
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Fracture healing: mechanisms and interventionsQ26851958
Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificityQ27635130
Structural and functional insights of RANKL-RANK interaction and signalingQ27661741
RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy ReceptorQ27674275
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Osteopetrosis and its relevance for the discovery of new functions associated with the skeletonQ28085259
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survivalQ28142897
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and manQ28201425
Osteoimmunology in Bone Fracture Healing.Q39396818
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiationQ40119268
Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota.Q40230484
Murine dendritic cell transdifferentiation into osteoclasts is differentially regulated by innate and adaptive cytokinesQ40241909
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient miceQ28207641
Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel geneQ28210464
Matrix-embedded cells control osteoclast formationQ28247746
Evidence for osteocyte regulation of bone homeostasis through RANKL expressionQ28247757
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling BoneQ28267634
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiationQ28280363
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiencyQ28284581
Ventastega curonica and the origin of tetrapod morphologyQ28285249
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesisQ28293009
Heritable disorders of the RANKL/OPG/RANK signaling pathwayQ28299674
RANKL-induced DC-STAMP is essential for osteoclastogenesisQ28504881
Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defectsQ28505493
Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone massQ28506158
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cellsQ28506839
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretionQ28512093
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal functionQ28512374
Immune complexes regulate bone metabolism through FcRγ signallingQ28512966
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and humanQ28590831
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionQ28592760
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasisQ28593488
Hematopoietic stem cell: self-renewal versus differentiationQ29396498
Missing pieces in the NF-kappaB puzzleQ29547864
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeletonQ30010102
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubismQ30157499
Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone lossQ30415395
Microgravity promotes osteoclast activity in medaka fish reared at the international space stationQ30665836
Blimp1-mediated repression of negative regulators is required for osteoclast differentiationQ33733731
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.Q33794960
FHL2 inhibits the activated osteoclast in a TRAF6-dependent mannerQ34014506
Activating transcription factor 4 regulates osteoclast differentiation in mice.Q34028709
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritisQ34102750
LOX Fails to Substitute for RANKL in OsteoclastogenesisQ40547452
The calcineurin/nuclear factor of activated T cells signaling pathway regulates osteoclastogenesis in RAW264.7 cellsQ40599606
Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiationQ40808939
Phospholipids in animal eukaryotic membranes: transverse asymmetry and movementQ40841743
Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression.Q41459925
Role of osteoblasts in hormonal control of bone resorption—A hypothesisQ41551873
Osteoprotection by semaphorin 3A.Q41791623
Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesisQ41995909
Phosphatidylethanolamine dynamics are required for osteoclast fusionQ42290733
Autoamplification of NFATc1 expression determines its essential role in bone homeostasisQ42972503
Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR.Q43580089
Vav3 regulates osteoclast function and bone massQ45265424
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.Q46711436
Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/Akt and Erk pathways in association with signaling Adaptor DAP12.Q46840295
The axial skeleton of the Devonian tetrapod IchthyostegaQ47253242
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
Alteration of RANKL-induced osteoclastogenesis in primary cultured osteoclasts from SERCA2+/- miceQ47871560
Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.Q47944184
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.Q48083226
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.Q48222451
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.Q50335578
Real-time intravital imaging of pH variation associated with osteoclast activity.Q51301045
Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.Q51547582
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.Q52537176
Osteoblastic cells are involved in osteoclast formation.Q54374668
Immune Interactions with CD4+ T Cells Promote the Development of Functional Osteoclasts from Murine CD11c+ Dendritic CellsQ57184758
NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1Q57675122
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanismsQ58326878
The -Isoform of p38 MAPK Specifically Regulates Arthritic Bone LossQ61900817
Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligandQ64378984
The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cellsQ69541163
The gene encoding the mouse homologue of the human osteoclast-specific 116-kDa V-ATPase subunit bears a deletion in osteosclerotic (oc/oc) mutantsQ73531419
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokinesQ74269794
Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligandQ79181865
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formationQ79383955
MafB negatively regulates RANKL-mediated osteoclast differentiationQ79421924
Phenotypic characteristics of bone in carbonic anhydrase II-deficient miceQ80444950
Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiationQ81152482
Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cellsQ83454126
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivoQ84136412
Human mesenchymal stromal cells express CD14 cross-reactive epitopesQ84514622
Eighth Bone Quality Seminar Proceedings 2013Q88012211
RANKL-Independent Osteoclastogenesis: A Long-Standing ControversyQ89229670
Macrophages and osteoclasts stem from a bipotent progenitor downstream of a macrophage/osteoclast/dendritic cell progenitorQ89777426
Biology of the RANKL-RANK-OPG System in Immunity, Bone, and BeyondQ34366449
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivoQ34420830
A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone lossQ34567407
Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoidsQ34790932
Requirement for NF-kappaB in osteoclast and B-cell developmentQ35199657
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.Q35760837
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast developmentQ35787174
Mechanobiology of the skeleton.Q36141041
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisQ36368706
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptorsQ36375584
Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axisQ36402845
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone lossQ36402985
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.Q36404187
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosisQ36560045
Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formationQ36580426
Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.Q36760597
Role of Thyroid Hormones in Skeletal Development and Bone MaintenanceQ36773018
Dissociation between bone resorption and bone formation in osteopenic transgenic miceQ36800774
Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cellsQ37049540
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.Q37126990
RANK, RANKL and osteoprotegerin in bone biology and disease.Q37199218
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP).Q37302319
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesisQ37370702
Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C>T mutation in CLCN7.Q37449518
Acute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish immediately after exposure to microgravityQ37525966
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent mannerQ37739585
Advances in osteoclast biology: old findings and new insights from mouse modelsQ37850997
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorptionQ38015040
Emerging role of primary cilia as mechanosensors in osteocytesQ38064200
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosQ38342636
Imaging of Paget's disease of boneQ38985801
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerinQ39116155
P433issue4
P304page(s)325-341
P577publication date2018-02-01
P1433published inHistochemistry and Cell BiologyQ1524012
P1476titleRecent advances in osteoclast biology
P478volume149

Reverse relations

cites work (P2860)
Q89964126Anemonin Attenuates RANKL-Induced Osteoclastogenesis and Ameliorates LPS-Induced Inflammatory Bone Loss in Mice via Modulation of NFATc1
Q64983678Artesunate, an Anti-Malaria Agent, Attenuates Experimental Osteoarthritis by Inhibiting Bone Resorption and CD31hiEmcnhi Vessel Formation in Subchondral Bone.
Q92550919Cervus and cucumis peptides ameliorates bone erosion in experimental arthritis by inhibiting osteoclastogenesis
Q97066965Deciphering the underlying mechanism of Xianlinggubao capsule against osteoporosis by network pharmacology
Q92257336Fermented Sea Tangle (Laminaria japonica Aresch) Suppresses RANKL-Induced Osteoclastogenesis by Scavenging ROS in RAW 264.7 Cells
Q64073039Forceful mastication activates osteocytes and builds a stout jawbone
Q64264445Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice
Q50420732In focus in HCB: Hard Tissue Biology.
Q64085314Interleukin-27 prevents LPS-induced inflammatory osteolysis by inhibiting osteoclast formation and function
Q89977149METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export
Q90182318Nrf2 is required for suppressing osteoclast RANKL-induced differentiation in RAW 264.7 cells via inactivating cannabinoid receptor type 2 with AM630
Q98205366Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression
Q89820667Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System
Q96305136Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration
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Q58746996Peripheral blood monocytes show increased osteoclast differentiation potential compared to bone marrow monocytes
Q91941325Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts
Q64065836Protective Effects of Fermented Oyster Extract against RANKL-Induced Osteoclastogenesis through Scavenging ROS Generation in RAW 264.7 Cells
Q89666841RANKL biology: bone metabolism, the immune system, and beyond
Q93108751The Role of Exosomes in Bone Remodeling: Implications for Bone Physiology and Disease
Q91611014The Role of Macrophage in the Pathogenesis of Osteoporosis
Q92132065Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κB and P38 MAPK Signaling Pathways

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