Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

scientific article published on 16 January 2013

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI64840
P932PMC publication ID3561821
P698PubMed publication ID23321671

P50authorRiku KivirantaQ114389913
Ilpo M O KoskivirtaQ114389914
Burkhard KleuserQ59916784
Eero I VuorioQ114389726
P2093author name stringJean Vacher
Roland Baron
Sutada Lotinun
Lynn Neff
William C Horne
Takuma Matsubara
Anja Lüth
Jorge A Alzate
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Intravenous bisphosphonate therapy for osteoporosis: where do we stand?Q36203266
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptorQ36347029
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Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.Q37015968
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formationQ37307155
Bone marrow-derived cathepsin K cleaves SPARC in bone metastasisQ37316559
c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomesQ37346002
Bisphosphonate associated osteonecrosis of the jaw.Q37415072
Femoral cortical stress lesions in long-term bisphosphonate therapy: a herald of impending fracture?Q37681262
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Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosisQ37889119
Human osteoblast-derived factors induce early osteogenic markers in human mesenchymal stem cells.Q39994432
Proteolytic processing and polarized secretion of tartrate-resistant acid phosphatase is altered in a subpopulation of metaphyseal osteoclasts in cathepsin K-deficient miceQ40086345
Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclastsQ42520796
An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materialsQ43563517
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosisQ44590934
Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatideQ44663247
Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrualQ45730145
Impaired gastric acidification negatively affects calcium homeostasis and bone mass.Q46008246
Human osteoblasts produce cathepsin K.Q46282719
A theoretical analysis of long-term bisphosphonate effects on trabecular bone volume and microdamageQ46329107
Complete genomic structure of the mouse cathepsin K gene (Ctsk) and its localization next to the Arnt gene on mouse chromosome 3.Q47955419
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Targeted expression of Cre recombinase in macrophages and osteoclasts in transgenic mice.Q50775674
Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys.Q51496187
Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.Q51801651
A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNFQ57184035
Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not DemineralizationQ57272396
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasisQ57675131
Pycnodysostosis: refined linkage and radiation hybrid analyses reduce the critical region to 2 cM at 1q21 and map two candidate genesQ71235368
Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydrideQ71597850
Characterization of osteoclast precursors in human bloodQ73309559
Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratioQ81304554
Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeysQ82663650
Osteoblast isolation from murine calvaria and long bonesQ82751283
The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular traffickingQ84479083
Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbitsQ84795050
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)666-681
P577publication date2013-01-16
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleOsteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
P478volume123

Reverse relations

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