Matrix-embedded cells control osteoclast formation

scientific article (publication date: 11 September 2011)

Matrix-embedded cells control osteoclast formation is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1033717400
P356DOI10.1038/NM.2448
P3181OpenCitations bibliographic resource ID728343
P932PMC publication ID3192296
P698PubMed publication ID21909103
P5875ResearchGate publication ID51640510

P2093author name stringStavros C Manolagas
Jinhu Xiong
Charles A O'Brien
Robert L Jilka
Robert S Weinstein
Melda Onal
P2860cites workBirth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1Q22306225
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
RANK is essential for osteoclast and lymph node developmentQ24598872
Control of RANKL gene expressionQ24619669
The amazing osteocyteQ24635849
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
VEGFA is necessary for chondrocyte survival during bone developmentQ28590528
Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature CommitteeQ29616160
Genetic regulation of osteoclast development and functionQ29617421
Developmental regulation of the growth plateQ29618969
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopyQ30653079
Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoterQ33578103
Activation of bone remodeling after fatigue: differential response to linear microcracks and diffuse damageQ34126530
Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progressionQ34495205
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitorsQ34546901
Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoidsQ34790932
“Whither flows the fluid in bone?” An osteocyte's perspectiveQ35538190
Dissociation between bone resorption and bone formation in osteopenic transgenic miceQ36800774
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.Q36860987
Dicer-dependent pathways regulate chondrocyte proliferation and differentiationQ36882995
Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2Q37085639
Commitment to the osteoblast lineage is not required for RANKL gene expressionQ37176364
Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorptionQ37249047
Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on boneQ37383855
Action of RANKL and OPG for osteoclastogenesis.Q37384996
Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblastsQ39076759
DMP1-targeted Cre expression in odontoblasts and osteocytesQ40154569
MLO-Y4 osteocyte-like cells support osteoclast formation and activationQ40692837
STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroiQ40945774
Role of osteoblasts in hormonal control of bone resorption—A hypothesisQ41551873
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strengthQ46186977
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.Q46459616
Osteoprotegerin deficiency and juvenile Paget's diseaseQ48292818
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.Q50335960
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.Q50722204
Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.Q53628612
IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.Q53670887
Osteoblastic cells are involved in osteoclast formation.Q54374668
Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancerQ64965676
Receptor activator of NF-kappa B and osteoprotegerin expression by human microvascular endothelial cells, regulation by inflammatory cytokines, and role in human osteoclastogenesisQ73684776
Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationQ74742272
Targeted ablation of osteocytes induces osteoporosis with defective mechanotransductionQ80432871
Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiationQ81152482
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)1235-41
P577publication date2011-09-11
P1433published inNature MedicineQ1633234
P1476titleMatrix-embedded cells control osteoclast formation
P478volume17

Reverse relations

cites work (P2860)
Q37589815A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse
Q41017658A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro
Q90190614A Review of the Potential Application of Osteocyte-Related Biomarkers, Fibroblast Growth Factor-23, Sclerostin, and Dickkopf-1 in Predicting Osteoporosis and Fractures
Q34802787A method for isolating high quality RNA from mouse cortical and cancellous bone
Q34658332A new method to investigate how mechanical loading of osteocytes controls osteoblasts
Q49925395A vitronectin-derived peptide reverses ovariectomy-induced bone loss via regulation of osteoblast and osteoclast differentiation.
Q40012509AAV8-mediated expression of N-acetylglucosamine-1-phosphate transferase attenuates bone loss in a mouse model of mucolipidosis II.
Q39448176Absence of the Vitamin D Receptor Inhibits Atherosclerotic Plaque Calcification in Female Hypercholesterolemic Mice
Q92282155Actin and Actin-Associated Proteins in Extracellular Vesicles Shed by Osteoclasts
Q35586060Activation of HIFa pathway in mature osteoblasts disrupts the integrity of the osteocyte/canalicular network
Q53190419Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β-Catenin and RANKL/OPG.
Q36005508Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations
Q27342550Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures
Q36733053Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts
Q38047183Advances in osteoimmunology: pathophysiologic concepts and treatment opportunities
Q64889366Ageing characteristics of bone indicated by transcriptomic and exosomal proteomic analysis of cortical bone cells.
Q41917846Aging, Osteocytes, and Mechanotransduction.
Q93208366Alterations in osteocyte mediated osteoclastogenesis during estrogen deficiency and under ROCK-II inhibition: An in vitro study using a novel postmenopausal multicellular niche model
Q36144039Alterations in the osteocyte lacunar-canalicular microenvironment due to estrogen deficiency
Q37609485Altered gene dosage confirms the genetic interaction between FIAT and αNAC.
Q38271156Alternative pathways of osteoclastogenesis in inflammatory arthritis
Q34647373An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations
Q42038120Anabolic steroids reduce spinal cord injury-related bone loss in rats associated with increased Wnt signaling
Q50090300Autophagy as a target for glucocorticoid-induced osteoporosis therapy
Q53162347Autophagy: a new player in skeletal maintenance?
Q37133071Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner
Q37189212Basic biology of skeletal aging: role of stress response pathways
Q28265584Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab
Q50101275Biology and Mechanisms of Action of the Vitamin D Hormone
Q26801599Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Q34366449Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond
Q34646678Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.
Q35878832Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis.
Q38835028Bone Loss in HIV Infection
Q99561826Bone Marrow Microvasculature
Q40067457Bone Remodeling and the Microbiome.
Q47859307Bone Resorption Is Regulated by Circadian Clock in Osteoblasts
Q38185586Bone and the innate immune system
Q27023494Bone cell communication factors and Semaphorins
Q38185298Bone cell senescence: mechanisms and perspectives
Q42266513Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6.
Q35964838Bone loss following spinal cord injury in a rat model.
Q39093915Bone marrow micro-environment is a crucial player for myelomagenesis and disease progression.
Q48361504Bone mechanobiology in mice: toward single-cell in vivo mechanomics
Q37415673Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis
Q64066842Bone morphogenetic proteins: Their role in regulating osteoclast differentiation
Q48003981Bone remodeling as a spatial evolutionary game
Q26797366Bone remodeling in the context of cellular and systemic regulation: the role of osteocytes and the nervous system
Q37976305Bone, sweet bone--osteoporotic fractures in diabetes mellitus.
Q85075751Bone: Osteocyte RANKL in bone homeostasis: a paradigm shift?
Q98771616Bovine Milk Extracellular Vesicles Are Osteoprotective by Increasing Osteocyte Numbers and Targeting RANKL/OPG System in Experimental Models of Bone Loss
Q97527734CSF-1 in Osteocytes Inhibits Nox4-mediated Oxidative Stress and Promotes Normal Bone Homeostasis
Q30538292Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development
Q26775406Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function
Q28072561Cancer Cell Colonisation in the Bone Microenvironment
Q36480304Canonical Notch activation in osteocytes causes osteopetrosis
Q45942621Carbonic anhydrase III protects osteocytes from oxidative stress.
Q33831453Carboxyl terminus of Hsp70-interacting protein regulation of osteoclast formation in mice through promotion of tumor necrosis factor receptor-associated factor 6 protein degradation
Q26865580Cartilage to bone transitions in health and disease
Q92185702Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
Q28067045Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
Q38934459Cell-to-cell communication in guided bone regeneration: molecular and cellular mechanisms
Q38960505Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk
Q26748812Characterisation of matrix vesicles in skeletal and soft tissue mineralisation
Q41972888Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine model
Q51216875Circulating Dickkopf-1 and sclerostin in patients with Paget's disease of bone.
Q26743435Clinical applications of vibration therapy in orthopaedic practice
Q92370299Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity
Q92221417Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis
Q41261207Conditioned medium from fresh and demineralized bone enhances osteoclastogenesis in murine bone marrow cultures
Q35096932Connexin 43 channels are essential for normal bone structure and osteocyte viability
Q35781909Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling
Q42500075Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor
Q37445916Control of bone remodeling by the peripheral sympathetic nervous system
Q35991486Control of bone resorption in mice by Schnurri-3.
Q36822669Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages
Q60312831Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice
Q42053319Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice
Q90263630Coupling factors involved in preserving bone balance
Q59051790Coupling of bone resorption and formation by RANKL reverse signalling
Q37506724Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit
Q47131626Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation
Q40988880DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.
Q53208210Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.
Q87327139Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population
Q37557163Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.
Q47135954Degeneration of the osteocyte network in the C57BL/6 mouse model of aging
Q47105930Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes
Q38832148Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice.
Q34228323Deletion of a single β-catenin allele in osteocytes abolishes the bone anabolic response to loading
Q36808470Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice
Q37970800Denosumab for the management of bone disease in patients with solid tumors
Q35452966Denosumab for treatment of immobilization-related hypercalcaemia in a patient with advanced renal failure
Q54265115Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours.
Q36629738Development of the endochondral skeleton
Q92277418Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF-κB-NFATc1 signal pathway
Q47114199Diet and Exercise: a Match Made in Bone
Q48204635Direct cell-cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo
Q39010800Direct crosstalk between cancer and osteoblast lineage cells fuels metastatic growth in bone via auto-amplification of IL-6 and RANKL signaling pathways.
Q36699646Disruption of claudin-18 diminishes ovariectomy-induced bone loss in mice
Q41853542Diverse osteoclastogenesis of bone marrow from mandible versus long bone
Q37631418Dmp1 Promoter-Driven Diphtheria Toxin Receptor Transgene Expression Directs Unforeseen Effects in Multiple Tissues
Q36055881Do epigenetic marks govern bone mass and homeostasis?
Q30557138Dysapoptosis of osteoblasts and osteocytes increases cancellous bone formation but exaggerates cortical porosity with age.
Q27345068Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice
Q38814167E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models
Q35805977ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation
Q48138766Early bone tissue aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocyte death and micropetrosis
Q92158664Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement
Q33896735Effect of age on regulation of human osteoclast differentiation
Q36849984Effect of zoledronate on the responses of osteocytes to acute parathyroid hormone.
Q91386375Effective CRISPR interference of an endogenous gene via a single transgene in mice
Q35864023Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice
Q24631082Effects of PTH on osteocyte function
Q47963128Effects of Sex and Notch Signaling on the Osteocyte Cell Pool
Q37624806Effects of bioactive lipids and lipoproteins on bone.
Q45875296Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice
Q91404818Elevated glucose acts directly on osteocytes to increase sclerostin expression in diabetes
Q33723186Elevated suppressor of cytokine signaling-1 (SOCS-1): a mechanism for dysregulated osteoclastogenesis in HIV transgenic rats
Q91659143Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice
Q21131222Emerging Functions of RANKL in Lymphoid Tissues
Q35755106Endogenous Glucocorticoids and Bone.
Q90718787Endoplasmic reticulum stress is induced in growth plate hypertrophic chondrocytes in G610C mouse model of osteogenesis imperfecta
Q92767392Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation
Q57265483EphrinB2 Signalling in Osteoblast Differentiation, Bone Formation and Endochondral Ossification
Q37289187Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through β-catenin-dependent and -independent pathways
Q53645929Establishment of optimized in vitro assay methods for evaluating osteocyte functions.
Q38661460Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
Q36179747Estrogen and the skeleton
Q37621495Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice
Q36497298Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual
Q34543980Estrogens and Androgens in Skeletal Physiology and Pathophysiology
Q35287635Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association
Q30009390Etanercept administration to neonatal SH3BP2 knock-in cherubism mice prevents TNF-α-induced inflammation and bone loss
Q55247652Evidence for Ongoing Modeling-Based Bone Formation in Human Femoral Head Trabeculae via Forming Minimodeling Structures: A Study in Patients with Fractures and Arthritis.
Q35143361Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis
Q38307446Evolutionary physiology of bone: bone metabolism in changing environments.
Q33585182Excessive dietary intake of vitamin A reduces skull bone thickness in mice
Q38726181Experimental studies of bone mechanoadaptation: bridging in vitro and in vivo studies with multiscale systems
Q61446362Extracellular vesicles in bone: "dogrobbers" in the "eternal battle field"
Q46943837FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2.
Q35253119FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation
Q36280893FOXO1 inhibits osteoclastogenesis partially by antagnozing MYC.
Q37052939FOXOs attenuate bone formation by suppressing Wnt signaling.
Q38365059Fate of growth plate hypertrophic chondrocytes: death or lineage extension?
Q35779219Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.
Q92426976Flrt2 is involved in fine-tuning of osteoclast multinucleation
Q92621353Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
Q36617127For whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases
Q90451142Friend or Foe? Essential Roles of Osteoclast in Maintaining Skeletal Health
Q47668279From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone.
Q54289536From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.
Q41907618Functional heterogeneity of osteocytes in FGF23 production: the possible involvement of DMP1 as a direct negative regulator.
Q27002647Functions of the osteocyte network in the regulation of bone mass
Q38027020Genetics of osteoporosis from genome-wide association studies: advances and challenges
Q37714895Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
Q51093091Glucocorticoid-Induced Osteoporosis.
Q36157622Glucocorticoid-induced osteoporosis and osteonecrosis
Q38195432Glucocorticoid-induced osteoporosis: mechanisms, management, and future perspectives.
Q38266799Glucocorticoid-induced osteoporosis: who to treat with what agent?
Q35126180HDAC5 controls MEF2C-driven sclerostin expression in osteocytes
Q50020268HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice
Q36489227Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption
Q38848655Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations
Q48303279Hallmarks of Bone Metastasis
Q37234928Haploinsufficiency of osterix in chondrocytes impairs skeletal growth in mice
Q100752651Hindlimb unloading causes regional loading-dependent changes in osteocyte inflammatory cytokines that are modulated by exogenous irisin treatment
Q50469317Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats.
Q36442972Histone deacetylase 3 is required for maintenance of bone mass during aging
Q36742145Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion
Q52715750Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts.
Q27027402Historically significant events in the discovery of RANK/RANKL/OPG
Q49912580Host defense against oral microbiota by bone-damaging T cells.
Q90397024How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review
Q38968738How rare bone diseases have informed our knowledge of complex diseases
Q38794651Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation
Q35633235Hypothesis: Coupling between Resorption and Formation in Cancellous bone Remodeling is a Mechanically Controlled Event
Q54293545IL-1β and compressive forces lead to a significant induction of RANKL-expression in primary human cementoblasts.
Q89761248IL-33/IL-31 Axis in Osteoporosis
Q39027493IL-6 alters osteocyte signaling toward osteoblasts but not osteoclasts
Q92686848IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis
Q37621816Identification of Senescent Cells in the Bone Microenvironment
Q89668133IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95
Q40958715Immediate effects of retinoic acid on gene expression in primary murine osteoblasts
Q88540268Impact of the Autonomic Nervous System on the Skeleton
Q35221512Impaired bone homeostasis in amyotrophic lateral sclerosis mice with muscle atrophy.
Q26858876In vitro and in vivo approaches to study osteocyte biology
Q37087683Increased bone mass in mice lacking the adipokine apelin
Q36696225Increased mandibular condylar growth in mice with estrogen receptor beta deficiency
Q37018548Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton
Q42134971Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints
Q87400126Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts
Q36216958Inflammatory focal bone destruction in femoral heads with end-stage haemophilic arthropathy: a study on clinic samples with micro-CT and histological analyses
Q39324315Inhibition of mechanical stress-induced NF-κB promotes bone formation
Q35905296Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading
Q42248557Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone
Q27316867Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL
Q37994636Intercellular cross-talk among bone cells: new factors and pathways.
Q88220668Interleukin-1-induced acute bone resorption facilitates the secretion of fibroblast growth factor 23 into the circulation
Q58784782Involvement of Osteocytes in the Action of Toxin
Q38004958Is psoriatic arthritis a result of abnormalities in acquired or innate immunity?
Q31128487Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling
Q37981265Leukemia inhibitory factor: a paracrine mediator of bone metabolism.
Q38716121Lipoxin A4 suppresses osteoclastogenesis in RAW264.7 cells and prevents ovariectomy-induced bone loss
Q36255236Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis
Q36785422Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage
Q52699543MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.
Q33835628Maintenance of Bone Homeostasis by DLL1-Mediated Notch Signaling
Q104466224Making and Shaping Endochondral and Intramembranous Bones
Q48187280Mammalian target of rapamycin as a therapeutic target in osteoporosis
Q38033444Management of glucocorticoid-induced osteoporosis.
Q58582775Maternal RANKL Reduces the Osteopetrotic Phenotype of Null Mutant Mouse Pups
Q36019769Mechanical regulation of signaling pathways in bone
Q36109949Mechanical vibration inhibits osteoclast formation by reducing DC-STAMP receptor expression in osteoclast precursor cells
Q90401265Mechanically-Loaded Breast Cancer Cells Modify Osteocyte Mechanosensitivity by Secreting Factors That Increase Osteocyte Dendrite Formation and Downstream Resorption
Q26798296Mechanism and Treatment Strategy of Osteoporosis after Transplantation
Q52805840Mechanisms of bone response to injury.
Q36994689Membrane trafficking in osteoblasts and osteoclasts: new avenues for understanding and treating skeletal diseases
Q64960178Mesenchymal Stromal Cell-Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl-Deficient Osteopetrosis.
Q34246045Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism.
Q35259448Microgravity control of autophagy modulates osteoclastogenesis.
Q35054970Minireview: nuclear receptor regulation of osteoclast and bone remodeling
Q37034768Mitogen-inducible gene-6 partly mediates the inhibitory effects of prenatal dexamethasone exposure on endochondral ossification in long bones of fetal rats
Q26851553Modulation of osteoclast differentiation and bone resorption by Rho GTPases
Q38721980Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy.
Q38249864Molecular and cellular basis of bone resorption
Q90047097Molecular determinants for the polarization of macrophage and osteoclast
Q98465934Molecular mechanisms and clinical management of cancer bone metastasis
Q55261693Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture.
Q38113518Molecular mechanisms of osteoblast/osteocyte regulation by connexin43.
Q38074961Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts
Q37110385Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone.
Q89208054Mouse Cre Models for the Study of Bone Diseases
Q37673482Mouse models for the evaluation of osteocyte functions
Q38155200Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis
Q38070410Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond
Q39014215Murine Rankl-/- Mesenchymal Stromal Cells Display an Osteogenic Differentiation Defect Improved by a RANKL-Expressing Lentiviral Vector
Q38557126Muscle-Bone Crosstalk in Amyotrophic Lateral Sclerosis
Q42906705Mutual enhancement of differentiation of osteoblasts and osteocytes occurs through direct cell-cell contact
Q36595304Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
Q38705141Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication
Q27007096NSAID therapy effects on healing of bone, tendon, and the enthesis
Q38052462New developments in osteoimmunology
Q37987556New regulation mechanisms of osteoclast differentiation
Q38169910Nitric oxide signaling in mechanical adaptation of bone
Q28590415Notch signaling in osteocytes differentially regulates cancellous and cortical bone remodeling
Q27324936Novel approaches for two and three dimensional multiplexed imaging of osteocytes
Q26853017Nuclear receptors in bone physiology and diseases
Q35899482Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation.
Q50701558OA10 is a novel p38alpha mitogen-activated protein kinase inhibitor that suppresses osteoclast differentiation and bone resorption.
Q36246080OsteoRheumatology: a new discipline?
Q36542861Osteoblast lineage-specific effects of notch activation in the skeleton
Q36040583Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass
Q38289071Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling.
Q39162234Osteoblasts subjected to mechanical strain inhibit osteoclastic differentiation and bone resorption in a co-culture system
Q36568536Osteoclast fusion and regulation by RANKL-dependent and independent factors
Q36580426Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
Q36949734Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems
Q64236844Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis
Q35755039Osteoclasts: New Insights
Q33846076Osteocyte Apoptosis Caused by Hindlimb Unloading is Required to Trigger Osteocyte RANKL Production and Subsequent Resorption of Cortical and Trabecular Bone in Mice Femurs
Q38671237Osteocyte Mechanobiology
Q36253514Osteocyte RANKL: new insights into the control of bone remodeling
Q64971630Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice.
Q36759428Osteocyte apoptosis
Q33803842Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo.
Q38230277Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption-formation cycles?
Q36514172Osteocyte control of osteoclastogenesis
Q41085034Osteocyte isolation and culture methods
Q45898154Osteocyte lacunar density and area in newly formed bone of the augmented sinus.
Q34328711Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading
Q49847220Osteocyte regulation of bone and blood
Q37981072Osteocyte regulation of bone mineral: a little give and take.
Q41459925Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression.
Q36005495Osteocyte signaling in bone
Q35700825Osteocyte specific responses to soluble and mechanical stimuli in a stem cell derived culture model.
Q34017216Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
Q35032099Osteocyte-derived insulin-like growth factor I is not essential for the bone repletion response in mice
Q37626024Osteocyte-driven bone remodeling
Q36357606Osteocytes and Skeletal Pathophysiology
Q87264632Osteocytes and chondrocytes embedded in bone matrix control bone remodelling
Q48153017Osteocytes play an important role in experimental periodontitis in healthy and diabetic mice through expression of RANKL.
Q39998421Osteocytes produce interferon-β as a negative regulator of osteoclastogenesis
Q36759496Osteocytes remove and replace perilacunar mineral during reproductive cycles
Q85040085Osteocytes, RANKL and bone loss
Q28267634Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone
Q37958204Osteocytes: central conductors of bone biology in normal and pathological conditions
Q27022407Osteocytes: master orchestrators of bone
Q37404925Osteocytic osteolysis: time for a second look?
Q55517542Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin.
Q38845640Osteocytic signalling pathways as therapeutic targets for bone fragility
Q88248494Osteoimmunology
Q38109578Osteoimmunology and bone homeostasis: relevance to spondyloarthritis
Q92405052Osteoimmunology of Oral and Maxillofacial Diseases: Translational Applications Based on Biological Mechanisms
Q47944184Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
Q92668034Osteoimmunology: evolving concepts in bone-immune interactions in health and disease
Q38216026Osteoimmunology: oncostatin M as a pleiotropic regulator of bone formation and resorption in health and disease
Q38116019Osteoimmunology: the expanding role of immunoreceptors in osteoclasts and bone remodeling
Q55056509Osteopetrosis rescue upon RANKL administration to Rankl(-/-) mice: a new therapy for human RANKL-dependent ARO.
Q41791623Osteoprotection by semaphorin 3A.
Q38659295Overcoming physical constraints in bone engineering: 'the importance of being vascularized'.
Q38183791Overview of skeletal development
Q34356431Oxytocin and bone
Q36012130P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes
Q90289155PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ
Q37221508PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption.
Q37096266Palmitic acid and DGAT1 deficiency enhance osteoclastogenesis, while oleic acid-induced triglyceride formation prevents it
Q27308118Parathyroid Hormone Induces Bone Cell Motility and Loss of Mature Osteocyte Phenotype through L-Calcium Channel Dependent and Independent Mechanisms
Q57151535Parathyroid Hormone Signaling in Osteocytes
Q92854752Parathyroid Hormone-Related Protein (PTHrP) Accelerates Soluble RANKL Signals for Downregulation of Osteogenesis of Bone Mesenchymal Stem Cells
Q58095951Parathyroid hormone (1-34) and its analogs differentially modulate osteoblastic RANKL expression via PKA/PP1/PP2A and SIK2/SIK3-CRTC3 signaling
Q37012357Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH.
Q42511931Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes
Q33901231Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes
Q33609126Parathyroid hormone: anabolic and catabolic actions on the skeleton
Q37305810Pathogenesis of age-related bone loss in humans
Q89860655Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
Q33814335Periosteal PTHrP regulates cortical bone modeling during linear growth in mice
Q35027916Periostin deficiency increases bone damage and impairs injury response to fatigue loading in adult mice
Q64241093Physical Activity and Bone Health: What Is the Role of Immune System? A Narrative Review of the Third Way
Q92718272Physicochemical Niche Conditions and Mechanosensing by Osteocytes and Myocytes
Q38867785Physiological and pathophysiological bone turnover - role of the immune system
Q34369482Physiological functions of osteoblast lineage and T cell-derived RANKL in bone homeostasis
Q35953079Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-κB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts
Q33559842Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration
Q39589743Profilin1 regulates sternum development and endochondral bone formation
Q55423545Propofol attenuates osteoclastogenesis by lowering RANKL/OPG ratio in mouse osteoblasts.
Q33744573Quiescent Bone Lining Cells Are a Major Source of Osteoblasts During Adulthood
Q48039377RANKL (Receptor Activator of NFκB Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice
Q89666841RANKL biology: bone metabolism, the immune system, and beyond
Q54228752RANKL blockade prevents and treats aggressive osteosarcomas.
Q36898545RANKL cytokine: from pioneer of the osteoimmunology era to cure for a rare disease
Q52684327RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement.
Q53487298RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation.
Q42409559RANKL expression in periodontal disease: where does RANKL come from?
Q59806646RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation
Q36246148RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis
Q38306944RANKL/OPG; Critical role in bone physiology.
Q89967663RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies
Q90999941Rapid bone loss occurs as early as 2 days after complete spinal cord transection in young adult rats
Q92460351Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization
Q50215136Recent advances in osteoclast biology.
Q26863480Recent progress in osteocyte research
Q36216058Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss
Q59095964Receptor becomes a ligand to control bone remodelling
Q38104374Recombinant hormones in osteoporosis
Q48528045Regulation of Bone Remodeling by Parathyroid Hormone
Q64069924Regulation of Osteoclast Differentiation and Skeletal Maintenance by Histone Deacetylases
Q64933738Regulation of Skeletal Homeostasis.
Q38681571Regulation of bone metabolism by Wnt signals
Q38183261Regulatory mechanisms of RANKL presentation to osteoclast precursors
Q35107089Repair of microdamage in osteonal cortical bone adjacent to bone screw
Q46470367Report of the CCFA pediatric bone, growth and muscle health workshop, New York City, November 11-12, 2011, with updates
Q36855971Retinoic acid-induced premature osteoblast-to-preosteocyte transitioning has multiple effects on calvarial development
Q27316361Rib fractures and death from deletion of osteoblast βcatenin in adult mice is rescued by corticosteroids
Q35916106Role of DNA methylation in the regulation of the RANKL-OPG system in human bone
Q37673466Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone.
Q26992195Role of osteocytes in multiple myeloma bone disease
Q89305255Role of pannexin 1 channels in load-induced skeletal response
Q36585836Role of paraoxonase-1 in bone anabolic effects of parathyroid hormone in hyperlipidemic mice
Q38056632Roles of Wnt signals in bone resorption during physiological and pathological states.
Q35949809Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation
Q34075583SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model
Q42371007SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes
Q37360148SIKs control osteocyte responses to parathyroid hormone
Q37660607SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
Q38986059SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.
Q33825376Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
Q53507211Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats.
Q48233828Sclerostin expression in bone tumours and tumour-like lesions.
Q31032805Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
Q43751384Selective glucocorticoid receptor modulation maintains bone mineral density in mice
Q91854213Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice
Q42590314Serotonin: a novel bone mass controller may have implications for alveolar bone
Q36201481Serum sclerostin increases in healthy adult men during bed rest.
Q34437537Sex steroid actions in male bone
Q36951811Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics
Q38192647Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load
Q37354085Skeletal metastasis: treatments, mouse models, and the Wnt signaling
Q40668097Smad1/5 and Smad4 expression are important for osteoclast differentiation
Q37310243Smad4 controls bone homeostasis through regulation of osteoblast/osteocyte viability
Q61135621Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
Q97643643Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone
Q47559021Solute Transport in the Bone Lacunar-Canalicular System (LCS).
Q34547308Spinal Cord Injury and Osteoporosis: Causes, Mechanisms, and Rehabilitation Strategies
Q34182834Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data
Q36793504Steroids and osteoporosis: the quest for mechanisms
Q36395303Stimulation of Osteogenesis in Bone Defects Implanted with Biodegradable Hydroxyapatite Composed of Rod-Shaped Particles under Mechanical Unloading
Q83228035Stimulation of Piezo1 by mechanical signals promotes bone anabolism
Q36636031Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity
Q38943616Strontium content and collagen-I coating of Magnesium-Zirconia-Strontium implants influence osteogenesis and bone resorption.
Q27300809Study of Osteoclast Adhesion to Cortical Bone Surfaces: A Correlative Microscopy Approach for Concomitant Imaging of Cellular Dynamics and Surface Modifications
Q90366914Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Q64891393Subchondral bone remodelling in osteoarthritis.
Q35286818Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone
Q36929011Suppression of autophagy in osteocytes mimics skeletal aging
Q51499839Supramolecular assemblies of histidinylated β-cyclodextrin for enhanced oligopeptide delivery into osteoclast precursors.
Q48047171Surface microtopography modulates sealing zone development in osteoclasts cultured on bone
Q92298046Systemic Bone Loss After Fracture
Q51515623Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression.
Q30422958Systems genetic analysis of osteoblast-lineage cells
Q27311542T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer
Q36984760T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics.
Q93053015TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis
Q38108518Talking among ourselves: paracrine control of bone formation within the osteoblast lineage
Q51046195Targeted Disruption of NF1 in Osteocytes Increases FGF23 and Osteoid With Osteomalacia-like Bone Phenotype.
Q38956445Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone
Q38861119Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells
Q47156108Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis
Q34983640Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes
Q27311269The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation
Q36649905The Dmp1-SOST Transgene Interacts With and Downregulates the Dmp1-Cre Transgene and the Rosa(Notch) Allele
Q90040615The Effects of Tocotrienol on Bone Peptides in a Rat Model of Osteoporosis Induced by Metabolic Syndrome: The Possible Communication between Bone Cells
Q64096227The Emerging Role of Osteocytes in Cancer in Bone
Q50069952The Expanding Life and Functions of Osteogenic Cells: From Simple Bone-Making Cells to Multifunctional Cells and Beyond
Q57790452The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases
Q41140478The Microdamage and Expression of Sclerostin in Peri-implant Bone under One-time Shock Force Generated by Impact
Q26773017The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis
Q92358408The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta
Q64106454The Osteocyte as a Novel Key Player in Understanding Periodontitis Through its Expression of RANKL and Sclerostin: a Review
Q98177574The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone Diseases
Q35744006The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice
Q64102143The RANKL-RANK Axis: A Bone to Thymus Round Trip
Q56453532The Role of Estrogen Receptor in Bone Cells
Q37287589The Role of Inflammatory Cytokines, the RANKL/OPG Axis, and the Immunoskeletal Interface in Physiological Bone Turnover and Osteoporosis
Q38747978The Role of Osteocytes in Age-Related Bone Loss
Q64268866The Role of Osteocytes in Inflammatory Bone Loss
Q39107516The Role of the Osteocyte in Bone and Nonbone Disease
Q35860523The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro
Q88296450The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation
Q33920055The best of both worlds - managing the cancer, saving the bone
Q36832631The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures
Q38200066The chondrocytic journey in endochondral bone growth and skeletal dysplasia
Q36275737The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption
Q58085028The conundrum of glucocorticoid-induced osteoporosis
Q33918020The effects of proteasome inhibitors on bone remodeling in multiple myeloma
Q38669228The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes.
Q37622533The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.
Q38654266The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior
Q64949054The lateral meningocele syndrome mutation causes marked osteopenia in mice.
Q35583735The mammalian lectin galectin-8 induces RANKL expression, osteoclastogenesis, and bone mass reduction in mice
Q50651156The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth.
Q36553435The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis
Q36593285The multifaceted actions of PTHrP in skeletal metastasis
Q27013693The multifaceted role of the vasculature in endochondral fracture repair
Q38050401The multiple facets of glucocorticoid action in rheumatoid arthritis
Q37203605The osteocyte: an endocrine cell ... and more
Q26777912The osteocyte: key player in regulating bone turnover
Q42002069The parathyroid hormone-regulated transcriptome in osteocytes: parallel actions with 1,25-dihydroxyvitamin D3 to oppose gene expression changes during differentiation and to promote mature cell function
Q38961342The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation.
Q35831159The regulation of osteoclast differentiation by Wnt signals
Q37189204The relevance of mouse models for investigating age-related bone loss in humans
Q33565236The role of DNA methylation in common skeletal disorders
Q45222224The role of bone marrow-derived cells during the bone healing process in the GFP mouse bone marrow transplantation model.
Q37337490The role of osteoblasts in bone metastasis
Q36941660The role of osteoclast differentiation and function in skeletal homeostasis
Q34744797The role of osteocytes in targeted bone remodeling: a mathematical model
Q39248512The role of stromal cells in inflammatory bone loss
Q38050402The skeleton as an endocrine organ
Q33675404Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions
Q36054527Toll-Like Receptor 2 Stimulation of Osteoblasts Mediates Staphylococcus Aureus Induced Bone Resorption and Osteoclastogenesis through Enhanced RANKL.
Q38012387Toward mechanical systems biology in bone
Q50104779Transforming growth factor-β in stem cells and tissue homeostasis
Q35453039Treatment of immobilization-related hypercalcaemia with denosumab
Q58752199Treatment options for osteogenesis imperfecta
Q89167528Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β-Catenin Cascade
Q57462447Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling
Q38775640Unfractionated Heparin Promotes Osteoclast Formation in Vitro by Inhibiting Osteoprotegerin Activity
Q36521118Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-Induced Expression of RANKL.
Q35744492Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives
Q50093296Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity
Q58609488Use it or lose it to age: A review of bone and muscle communication
Q35692597Vibration therapy: clinical applications in bone
Q37620408Vitamin D endocrine system and osteocytes
Q34621641Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
Q35067782Vitamin a is a negative regulator of osteoblast mineralization
Q36695575Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling
Q28285090WNT signaling in bone homeostasis and disease: from human mutations to treatments
Q91637803Wang-Bi Capsule Alleviates the Joint Inflammation and Bone Destruction in Mice with Collagen-Induced Arthritis
Q34732774Water extract of Spatholobus suberectus inhibits osteoclast differentiation and bone resorption
Q64075123What Are the Peripheral Blood Determinants for Increased Osteoclast Formation in the Various Inflammatory Diseases Associated With Bone Loss?
Q33784662Wnt signaling and osteoporosis
Q38128460Wnt signalling in osteoporosis: mechanisms and novel therapeutic approaches
Q54528928Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.
Q64062195Zoledronate Enhances Osteocyte-Mediated Osteoclast Differentiation by IL-6/RANKL Axis
Q55413820Zoledronic acid prevents disuse osteopenia and augments gene expression of osteoclastic differentiation markers in mice.
Q95510728[Research progress on the cellular and molecular mechanisms of tooth eruption]
Q39410557microRNA Expression in Rat Apical Periodontitis Bone Lesion
Q35860848p47phox-Nox2-dependent ROS Signaling Inhibits Early Bone Development in Mice but Protects against Skeletal Aging
Q37192084α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption
Q37381251β-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis