Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond

scientific article

Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2014.00511
P932PMC publication ID4202272
P698PubMed publication ID25368616
P5875ResearchGate publication ID267814148

P2093author name stringYongwon Choi
Matthew C Walsh
P2860cites workEmerging Functions of RANKL in Lymphoid TissuesQ21131222
The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesisQ24297505
Distinct molecular mechanism for initiating TRAF6 signallingQ24302174
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiationQ24315189
Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesisQ24324701
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6Q24537518
RANK is essential for osteoclast and lymph node developmentQ24598872
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerQ24605866
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Targeting RANKL in metastasisQ26849690
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motifQ28138697
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γQ59064307
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
Pathogenesis of osteoporosisQ73280016
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokinesQ74269794
Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysisQ77435071
Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF)Q77630526
Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cellsQ77630549
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Self-assembled RANK induces osteoclastogenesis ligand-independently.Q40360377
MLO-Y4 osteocyte-like cells support osteoclast formation and activationQ40692837
Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cellsQ40927574
OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40.Q40991620
Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokinesQ41000781
TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorptionQ41027241
Osteoprotection by semaphorin 3A.Q41791623
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".Q42321791
Multimerization of the receptor activator of nuclear factor-kappaB ligand (RANKL) isoforms and regulation of osteoclastogenesisQ42795870
A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive functionQ42811314
Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signalingQ43648531
Bifurcation of osteoclasts and dendritic cells from common progenitorsQ43757343
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast functionQ44072080
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritisQ44688981
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.Q46711436
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitisQ47884508
Osteoprotegerin deficiency and juvenile Paget's diseaseQ48292818
TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.Q50335956
Progesterone/RANKL is a major regulatory axis in the human breast.Q51042996
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Q51949099
Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.Q51997176
Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues.Q52172979
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Osteoclastogenesis inhibitory factor (OCIF) directly inhibits bone-resorbing activity of isolated mature osteoclasts.Q52532345
LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin.Q53955124
TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cellsQ56975249
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsQ57184743
NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1Q57675122
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-βQ57675150
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiationQ57675158
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanismsQ58326878
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient miceQ28140546
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysisQ28141482
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-SrcQ28142620
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
Matrix-embedded cells control osteoclast formationQ28247746
Evidence for osteocyte regulation of bone homeostasis through RANKL expressionQ28247757
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumabQ28265584
Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinaseQ28278061
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptorQ28285539
The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamilyQ28291317
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing MaspinQ28294196
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisQ28294501
Osteoimmunology: interplay between the immune system and bone metabolismQ28303107
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentQ28508430
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
RANKL Is Necessary and Sufficient to Initiate Development of Antigen-Sampling M Cells in the Intestinal EpitheliumQ29397534
Osteoclast differentiation and activationQ29547556
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Metastasis to bone: causes, consequences and therapeutic opportunitiesQ29614310
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubismQ30168144
Dynamic visualization of RANKL and Th17-mediated osteoclast function.Q30533914
Enhancement of an anti-tumor immune response by transient blockade of central T cell toleranceQ33569842
Cell biology of the osteoclastQ33700885
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.Q33823576
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interactionQ33886695
A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.Q33951432
FHL2 inhibits the activated osteoclast in a TRAF6-dependent mannerQ34014506
Strength of TRAF6 signalling determines osteoclastogenesisQ34166675
Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2Q34302372
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.Q34469691
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unitQ34750367
Role of RANK ligand in mediating increased bone resorption in early postmenopausal womenQ34912769
Ubiquitination in signaling to and activation of IKK.Q37995681
New developments in osteoimmunologyQ38052462
Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivoQ38114066
Osteoprotegerin: multiple partners for multiple functionsQ38119335
Regulations of gene expression in medullary thymic epithelial cells required for preventing the onset of autoimmune diseasesQ38132390
Management of bone disease in multiple myelomaQ38179039
RANKL/RANK - from bone physiology to breast cancerQ38184201
Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance: role in the interactions with receptor activator of nuclear factor kappaB ligand (RANKL) and RANK.Q38311660
Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulatorQ38363724
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitusQ39197051
Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the boneQ39946634
Regulation of cancer cell migration and bone metastasis by RANKL.Q40298349
Biology of the TRANCE axisQ35145622
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signallingQ35194008
Requirement for NF-kappaB in osteoclast and B-cell developmentQ35199657
Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine.Q35235833
Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signalingQ35598825
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
RANK-dependent autosomal recessive osteopetrosis: characterization of five new cases with novel mutationsQ35837418
RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulationQ35893658
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epitheliumQ36011240
Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epitheliumQ36028169
Mechanistic insight into osteoclast differentiation in osteoimmunologyQ36073894
Receptor activator of nuclear factor κB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone lossQ36216058
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formationQ36217430
Osteocyte RANKL: new insights into the control of bone remodelingQ36253514
Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCEQ36368551
Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptorsQ36375584
TRANCE, a tumor necrosis factor family member, enhances the longevity and adjuvant properties of dendritic cells in vivoQ36375923
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorQ36380989
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in miceQ36512214
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte developmentQ36750060
Tumor necrosis factor family receptors regulating bone turnover: new observations in osteoblastic and osteoclastic cell linesQ36889722
Microfold (M) cells: important immunosurveillance posts in the intestinal epitheliumQ36940409
DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk.Q36977266
The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cellsQ36991688
Osteoporosis and inflammationQ37073877
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivoQ37114842
Advances in the regulation of osteoclasts and osteoclast functionsQ37177840
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasisQ37302910
NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanismQ37363042
Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradationQ37410560
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial developmentQ37421214
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinaseQ37647341
Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signalsQ37825125
Rank/Rankl/opg: literature reviewQ37960379
P407language of work or nameEnglishQ1860
P304page(s)511
P577publication date2014-10-20
P1433published inFrontiers in ImmunologyQ27723748
P1476titleBiology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond
P478volume5

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