Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals

scientific article published on 01 February 2002

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1074-7613(02)00279-0
P698PubMed publication ID11869680

P2093author name stringRichard A Flavell
Yongwon Choi
E Allison Green
P2860cites workCD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.Q52165458
A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic miceQ71682317
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell developmentQ73311881
The temporal importance of TNFalpha expression in the development of diabetesQ73867591
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigensQ77658430
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potentialQ24680634
Dendritic cells and the control of immunityQ27860918
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Functions of newly identified members of the tumor necrosis factor receptor/ligand superfamilies in lymphocytesQ33721729
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
Regulatory T cells in autoimmmunity*.Q33904108
Evidence for a new Graves disease susceptibility locus at chromosome 18q21.Q34390493
The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.Q34452348
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functionsQ36366592
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationQ36368029
Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.Q36375728
TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorQ36380989
Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathologyQ36400410
Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigensQ36400803
Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destructionQ36401408
The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1).Q36401438
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecificQ40910998
Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.Q41700461
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive stateQ42466421
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune responseQ43986613
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic miceQ45854348
Transmission of haplotypes of microsatellite markers rather than single marker alleles in the mapping of a putative type 1 diabetes susceptibility gene (IDDM6)Q47765109
P433issue2
P304page(s)183-191
P577publication date2002-02-01
P1433published inImmunityQ6005457
P1476titlePancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals
P478volume16

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