Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?

scientific article published on 11 February 2010

Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.TRRE.2010.01.002
P698PubMed publication ID20153159
P5875ResearchGate publication ID41427565

P50authorOlaf RötzschkeQ102526521
Paul Kwong Hang TamQ67251370
Francisco Salcido-OchoaQ78514348
P2093author name stringKirsten Falk
Julia Tsang
P2860cites workAnti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantationQ80512153
Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 geneQ80833054
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cellsQ81157115
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cellsQ81245689
Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-betaQ81245713
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cellsQ81357564
Inducing and expanding regulatory T cell populations by foreign antigenQ81392563
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activationQ24291515
FOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cellsQ24298812
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1Q24300625
Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive functionQ24305624
Identification and characterization of CD39/vascular ATP diphosphohydrolaseQ24336540
Foxp3 occupancy and regulation of key target genes during T-cell stimulationQ24623384
Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cellsQ24653129
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4Q28204758
Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptorsQ28268052
Ecto-enzyme and signaling functions of lymphocyte CD73Q28268472
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
A function for interleukin 2 in Foxp3-expressing regulatory T cellsQ28590646
High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptorsQ28592075
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of miceQ29622850
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protectionQ30307082
Identification of the Immunophilins Capable of Mediating Inhibition of Signal Transduction by Cyclosporin A and FK506: Roles of Calcineurin Binding and Cellular LocationQ36694583
CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospectsQ36826059
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cellsQ36842568
From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseasesQ36932946
The Foxp3+ regulatory T cell: a jack of all trades, master of regulationQ37088900
Blocking the immune response in ischemic acute kidney injury: the role of adenosine 2A agonistsQ30441415
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic miceQ30498716
Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responsesQ31838449
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivoQ33236315
Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemiaQ33629928
Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cellsQ33742099
In vitro and in vivo analysis of bone marrow-derived CD3+, CD4-, CD8-, NK1.1+ cell linesQ33854587
Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae.Q33886662
The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1.Q33932690
Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cellsQ33992696
Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferationQ33993967
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cellsQ34189120
The role of peripheral T-cell deletion in transplantation toleranceQ34262660
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosisQ34311395
Role of LAG-3 in regulatory T cells.Q34358935
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanismQ34392100
Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.Q34516841
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaQ34517421
Identification of regulatory T cells in tolerated allograftsQ34524237
Interleukin 2 signaling is required for CD4(+) regulatory T cell functionQ34527240
Human T regulatory cells can use the perforin pathway to cause autologous target cell deathQ34551876
Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(-)CD8- double-negative regulatory T cellsQ34552979
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.Q34553677
Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cellsQ34567368
Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cellsQ34577919
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosineQ34578972
Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppressionQ34579516
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytesQ34585878
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generationQ34657284
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cellsQ34709777
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticityQ37100901
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic toleranceQ37106789
Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expressionQ37245083
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivoQ37312884
Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cellsQ37317866
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetesQ37358159
Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells.Q38305613
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like diseaseQ38306073
Do suppressor T cells exist?Q39485474
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells.Q40034589
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.Q40110921
In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity.Q40197970
CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancerQ40327394
Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.Q40565739
In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR culturesQ40576782
Neuropilin-1: a surface marker of regulatory T cellsQ40584286
Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo.Q40643930
CD39 and control of cellular immune responsesQ40730152
Induction of TCR Vbeta-specific CD8+ CTLs by TCR Vbeta-derived peptides bound to HLA-E.Q40779421
Saying the 'S' word in public.Q40797288
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.Q40801370
P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharideQ40806805
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecificQ40910998
Immunology taught by virusesQ40933905
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasisQ41873492
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 productionQ41908710
Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cellsQ41908906
Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral bloodQ41988688
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-betaQ42096868
Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK.Q42159544
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive stateQ42466421
Molecular mechanisms underlying FOXP3 induction in human T cellsQ42491664
Modulation of dendritic cell function by naive and regulatory CD4+ T cellsQ42494637
Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice.Q42915120
Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapyQ42971266
Two functional subsets of FOXP3+ regulatory T cells in human thymus and peripheryQ43095588
The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockadeQ44217780
CD39 modulates IL-1 release from activated endothelial cellsQ44326497
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade.Q44591644
Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation toleranceQ44620458
Impaired T cell receptor signaling in Foxp3+ CD4 T cellsQ44927981
T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune responseQ45292627
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic miceQ46081630
What does the future hold for cell-based tolerogenic therapy?Q46228704
Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cellsQ46245992
Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigenQ46453779
Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety geneQ46491860
CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.Q46763767
Low circulating regulatory T-cell levels after acute rejection in liver transplantation.Q46919793
Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cellsQ46943431
Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era.Q47206753
Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activationQ47367538
"Infectious" transplantation tolerance.Q34726892
Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+CD28- T cellsQ34749747
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significanceQ34769236
The complementary roles of deletion and regulation in transplantation toleranceQ35058547
Alerting and tuning the immune response by extracellular nucleotidesQ35082626
Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantationQ35087194
Regulatory T cells in transplantation toleranceQ35092535
The balance of deletion and regulation in allograft tolerance.Q35583506
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.Q35698535
Regulatory T cells and organ transplantationQ35703532
Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravisQ35740840
Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivoQ35847438
Adenosine A2a receptors induce heterologous desensitization of chemokine receptorsQ35849780
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cellsQ35867877
Cellular distribution and functions of P2 receptor subtypes in different systemsQ35952737
Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft toleranceQ36024233
Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cellsQ36228688
Chronic renal allograft dysfunctionQ36240051
Role of regulatory T cells in human diseases.Q36308397
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulationQ36367099
Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cellsQ36369536
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cellsQ36371345
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.Q36399104
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cellsQ36399149
Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destructionQ36401408
Developmental regulation of Foxp3 expression during ontogeny.Q36403564
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitroQ36508920
Th17: the third member of the effector T cell trilogyQ36528977
Why hasn't eliminating acute rejection improved graft survival?Q36604328
Regulatory T cell-mediated suppression: potential role of ICER.Q36617641
Inflammasome adaptors and sensors: intracellular regulators of infection and inflammationQ36691082
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.Q36693820
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor functionQ47579310
Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cellsQ47810559
Regulatory CD25+ T cells in human kidney transplant recipientsQ47895876
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependencyQ47992795
Kidney and pancreas transplantation in the United States, 1995-2004.Q50112848
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.Q51103369
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.Q51541351
CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset.Q51995543
Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro.Q52042348
Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance.Q53674506
Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance.Q53775010
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.Q53883439
Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with Belatacept mediated CD28-CD80/86 blockadeQ56901372
ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cellsQ56901469
Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycinQ56901703
The generation of CD25+ CD4+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogenQ56902957
CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponsesQ56904642
CD4(+)CD25(+) T cells facilitate the induction of T cell anergyQ56904876
CD4+CD25high regulatory cells in human peripheral bloodQ56905059
Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftmentQ56907406
Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progressionQ57362835
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cellsQ57920567
Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epitheliumQ59652622
IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In VivoQ60700622
Critical Influence of Natural Regulatory CD25+ T Cells on the Fate of Allografts in the Absence of ImmunosuppressionQ61651649
Levels of peripheral T cell tolerance induced by different doses of tolerogenQ72761691
Rapamycin induces transforming growth factor-beta production by lymphocytesQ73111942
Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppressionQ73977252
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cellsQ74012969
Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance inductionQ74191513
The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cellsQ74286639
Anergic T cells act as suppressor cells in vitro and in vivoQ74578866
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
Control of neonatal tolerance to tissue antigens by peripheral T cell traffickingQ77544864
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethalityQ78033315
Dendritic cells prohibited by anergic T cells acquire tolerogenic propertiesQ78514350
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation toleranceQ79143624
Following anti-CD25 treatment, a functional CD4+CD25+ regulatory T-cell pool is present in renal transplant recipientsQ79364663
Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation toleranceQ79468642
CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressiveQ79629254
Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ TQ79834605
Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cellsQ80057973
Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipientsQ80154346
P433issue2
P921main subjectadenosine triphosphateQ80863
P304page(s)52-66
P577publication date2010-02-11
P1433published inTransplantation ReviewsQ15749559
P1476titleRegulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?
P478volume24

Reverse relations

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