Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

scientific article

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/INTIMM/10.12.1969
P698PubMed publication ID9885918
P5875ResearchGate publication ID13402996

P2093author name stringItoh M
Sakaguchi S
Takahashi T
Shimizu J
Sakaguchi N
Toda M
Iwata M
Kuniyasu Y
P433issue12
P921main subjectautoimmune diseaseQ8084905
P304page(s)1969-1980
P577publication date1998-12-01
P1433published inInternational ImmunologyQ15710043
P1476titleImmunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state
P478volume10

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Q34374572Immunologic self tolerance maintained by T-cell-mediated control of self-reactive T cells: implications for autoimmunity and tumor immunity
Q34509694Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
Q34839054Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT)
Q34609440Immunological principles of T-cell-mediated adverse drug reactions in skin
Q90050590Immunometabolic Checkpoints of Treg Dynamics: Adaptation to Microenvironmental Opportunities and Challenges
Q42590646Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease
Q35683325Immunoregulatory T cells in autoimmunity
Q35040824Immunoregulatory T cells in cancer immunotherapy.
Q26798402Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites
Q54125905Impact of alemtuzumab treatment on the survival and function of human regulatory T cells in vitro.
Q36886212Impact of methimazole treatment on magnesium concentration and lymphocytes activation in adolescents with Graves' disease.
Q53232463Impaired immune regulation after radioiodine therapy for Graves' disease and the protective effect of Methimazole.
Q80516143Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells
Q42951816Improved generation of anti-tumor immunity by antigen dose limitation
Q34593804In vitro Treg suppression assays
Q41774667In vitro induction of regulatory T cells by anti-CD3 antibody in humans
Q84978571In vitro lipopolysaccharide treatment alters regulatory T cell properties in chickens
Q51987584In vivo depletion of CD4+CD25+ regulatory T cells enhances the antigen-specific primary and memory CTL response elicited by mature mRNA-electroporated dendritic cells.
Q35171080In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
Q40511233In vivo elimination of CD25+ regulatory T cells leads to tumor rejection of B16F10 melanoma, when combined with interleukin-12 gene transfer
Q39559727In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy
Q42726353Increase of CD4(+)CD25(+) T cells in Smad3(-/-) mice
Q48021387Increased Susceptibility to Plasmodium falciparum in Infants is associated with Low, not High, Placental Malaria Parasitemia
Q44466939Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis
Q33770196Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage
Q33814943Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation
Q42804882Induction of Donor-Specific Tolerance Using Superagonistic CD28 Antibody in Rat Renal Allografts: Regulatory T-Cell Expansion Before Engraftment May Be Important
Q36957222Induction of Th17 cells in the tumor microenvironment improves survival in a murine model of pancreatic cancer
Q47240621Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells
Q30907499Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway
Q34983446Induction of immune tolerance by dendritic cells: implications for preventative and therapeutic immunotherapy of autoimmune disease
Q37120570Induction of mucosal tolerance in SLE: a sniff or a sip away from ameliorating lupus?
Q37096361Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment
Q39188242Influence of CD4+CD25+ T cells on Plasmodium berghei NK65 infection in BALB/c mice
Q43282513Influence of enamel matrix derivative on primary CD4+ T-helper lymphocyte migration, CD25 activation, and apoptosis.
Q42112406Influence of serum and soluble CD25 (sCD25) on regulatory and effector T-cell function in hepatocellular carcinoma
Q34656577Inhibiting cardiac allograft rejection with interleukin-35 therapy combined with decitabine treatment in mice
Q28221643Inhibition of NF-kappa B during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches
Q40311949Inhibition of T-cell responses by CD4 on an antigen-presenting cell
Q37455696Innate immunity and asthma
Q35662882Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation.
Q55337327Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes.
Q80984051Interactions between immune cells and their microenvironment
Q34527240Interleukin 2 signaling is required for CD4(+) regulatory T cell function
Q36796532Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity
Q47291768Interleukin-2 blocks the antitumour activity caused by depletion of CD25 cells in a murine renal adenocarcinoma model
Q45387848Interleukin-6 small interfering RNA improved the herpes simplex virus-induced systemic inflammation in vivo Behcet's disease-like mouse model
Q35849633Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
Q37864700Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family
Q33888375Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice
Q92358696Knockdown of serine/threonine-protein kinase 24 promotes tumorigenesis and myeloid-derived suppressor cell expansion in an orthotopic immunocompetent gastric cancer animal model
Q36227859LAT-mediated signaling in CD4+CD25+ regulatory T cell development
Q83921292Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells
Q80097552Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation
Q37408819Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis
Q36073220Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity
Q35101466Levels of interleukin-35 and its relationship with regulatory T-cells in chronic hepatitis B patients
Q39127345Loss of Tolerance and Autoimmunity Affecting Multiple Organs inSTAT5A/5B-Deficient Mice
Q53319780Lymphopenia in occupational pulmonary silicosis with or without autoimmune disease.
Q36278295MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis
Q36369536Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells
Q35624707Mechanisms of peripheral immune tolerance: conversion of the immune to the unresponsive phenotype
Q37111968Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
Q38059338Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?
Q42210265Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo
Q38097311Modulating T regulatory cells in cancer: how close are we?
Q41895496Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cells
Q44632333Modulation of tryptophan catabolism by regulatory T cells.
Q50671091Molecular Mechanisms of Regulatory T Cell Development and Suppressive Function
Q38008361Molecular mechanisms of treg-mediated T cell suppression
Q42138753Monoclonal regulatory T cells provide insights into T cell suppression
Q35792672Multi-peptide coupled-cell tolerance ameliorates ongoing relapsing EAE associated with multiple pathogenic autoreactivities
Q38023409Multiple treg suppressive modules and their adaptability.
Q81862487Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells
Q53990042Murine metal-induced systemic autoimmunity: baseline and stimulated cytokine mRNA expression in genetically susceptible and resistant strains.
Q35740112Murine regulatory T cells contain hyperproliferative and death-prone subsets with differential ICOS expression
Q53523527Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression.
Q34374592Natural regulatory CD4 T cells expressing CD25.
Q34676250Natural regulatory T cells in autoimmunity
Q29619194Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Q35146722Negative T cell costimulation and islet tolerance.
Q36278051Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
Q90197782Next-generation regulatory T cell therapy
Q34299829Non-Th2 regulatory T-cell control of Th1 autoimmunity
Q33638166Normal human pregnancy results in maternal immune activation in the periphery and at the uteroplacental interface
Q34506140Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo
Q36938411Novel exosome-targeted CD4+ T cell vaccine counteracting CD4+25+ regulatory T cell-mediated immune suppression and stimulating efficient central memory CD8+ CTL responses
Q36399562Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.
Q36537926OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
Q37761492OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.
Q41927855Obstructive jaundice expands intrahepatic regulatory T cells, which impair liver T lymphocyte function but modulate liver cholestasis and fibrosis.
Q38161566Optimizing the use of regulatory T cells in allotransplantation: recent advances and future perspectives
Q36097025Oral Squamous Carcinoma Cells Express B7-H1 and B7-DC Receptors in Vivo
Q34305347Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro.
Q64265316PD-1 regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
Q42017650PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.
Q34997285PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs
Q77704341Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals
Q87245704Participation of T regulatory cells in equine recurrent airway obstruction
Q41446869Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs.
Q36652177Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity
Q34774087Plasticity and overlap of in vitro-induced regulatory T-cell markers in healthy humans
Q73688321Policing the regulators
Q33927418Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance
Q37669512Preoperative lymphocyte-to-monocyte ratio predicts survival in primary hepatitis B virus-positive hepatocellular carcinoma after curative resection
Q48751155Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28.
Q38806901Prognostic value of preoperative lymphocyte-to-monocyte ratio in pancreatic adenocarcinoma
Q40217993Prognostic value of preoperative peripheral blood monocyte count in patients with colorectal liver metastasis after liver resection
Q43856158Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4⁺ Foxp3⁺ regulatory T cells.
Q91638895Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
Q46401511Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk
Q42392644Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development
Q30437887Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: antigen-dependent expansion and TCR analysis
Q83194142Re-establishing immunological self-tolerance in autoimmune disease
Q30573918Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance
Q45148312Recent thymic origin, differentiation, and turnover of regulatory T cells
Q33629928Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia
Q41146735Recovered changes in the spleen by agmatine treatment after transient cerebral ischemia
Q28595009Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
Q37583435Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection
Q36631649Regulating regulatory T cells
Q37474900Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells
Q26823216Regulation generation: the suppressive functions of human regulatory T cells
Q36097043Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango
Q37400302Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells
Q33860019Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6
Q34842135Regulation of tumour immunity by CD25+ T cells
Q37051205Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect
Q64949232Regulatory Role of CD4+ T Cells in Myocarditis.
Q92129582Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Q52715799Regulatory T Cells As Potential Targets for HIV Cure Research.
Q90220063Regulatory T Cells in Tumor Microenvironment and Approach for Anticancer Immunotherapy
Q48668293Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation
Q37233985Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
Q21131435Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection
Q36388773Regulatory T cell-mediated transplantation tolerance
Q36986732Regulatory T cells - a brief history and perspective
Q35582278Regulatory T cells accumulate in the lung allergic inflammation and efficiently suppress T-cell proliferation but not Th2 cytokine production
Q37900645Regulatory T cells and IL-17-producing cells in graft-versus-host disease
Q36079905Regulatory T cells and autoimmune disease
Q36079900Regulatory T cells and intestinal homeostasis
Q41834768Regulatory T cells and the control of the allergic response.
Q37338455Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development
Q36969926Regulatory T cells and toll-like receptors: regulating the regulators
Q35029947Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism
Q28267935Regulatory T cells exert checks and balances on self tolerance and autoimmunity
Q82609485Regulatory T cells exhibit enhanced migratory characteristics, a feature impaired in patients with multiple sclerosis
Q54332931Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model.
Q35621984Regulatory T cells for tolerance therapy: revisiting the concept
Q35553553Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
Q84073243Regulatory T cells in cancer
Q91297827Regulatory T cells in cancer immunosuppression - implications for anticancer therapy
Q39044365Regulatory T cells in cancer immunotherapy
Q36534833Regulatory T cells in graft-versus-host disease.
Q36562855Regulatory T cells in human autoimmune diseases
Q82076756Regulatory T cells in rheumatoid arthritis
Q36203572Regulatory T cells in the control of autoimmune diabetes: the case of the NOD mouse
Q34348983Regulatory T cells in the control of immune pathology.
Q36563523Regulatory T cells in the periphery
Q35092535Regulatory T cells in transplantation tolerance
Q34786943Regulatory T cells in transplantation.
Q37691776Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?
Q34633260Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10
Q41891844Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae
Q37412624Regulatory T cells overturned: the effectors fight back
Q90518726Regulatory T cells promote corneal endothelial cell survival following transplantation via interleukin-10
Q35472407Regulatory T cells require TCR signaling for their suppressive function
Q34531452Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
Q35092531Regulatory T cells under scrutiny
Q26827787Regulatory T cells: Mechanisms of suppression and impairment in autoimmune liver disease
Q37967097Regulatory T cells: banned cells for decades
Q37593768Regulatory T cells: how do they suppress immune responses?
Q35912319Regulatory T cells: peace keepers in the gut.
Q37697589Regulatory T cells: roles of T cell receptor for their development and function
Q37498880Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms
Q36563537Regulatory T-cell physiology and application to treat autoimmunity
Q36212618Regulatory T-cells in chronic lymphocytic leukemia and autoimmune diseases
Q37914338Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis
Q46934849Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy
Q37205678Regulatory T cell subsets in filarial infection and their function
Q48020021Resistance of regulatory T cells to glucocorticoid-induced [corrected] TNFR family-related protein (GITR) during Plasmodium yoelii infection.
Q33373073Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy
Q36224502Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells
Q41132577Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12.
Q35705245Revival of the regulatory T cell: new targets for drug development
Q35981635Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis
Q36563507Role of TCR specificity in CD4+ CD25+ regulatory T-cell selection
Q37090518Role of regulatory T cells in gastrointestinal inflammatory disease
Q38830072Roles of regulatory T cells in cancer immunity
Q35671669Routes to transplant tolerance versus rejection; the role of cytokines.
Q40771683SHARPIN controls the development of regulatory T cells
Q37701348Self-tolerance and autoimmunity in a regulatory T cell model
Q44418597Sequential Involvement of Two Distinct CD4+ Regulatory T Cells during the Course of Transplantable Tumor Growth and Protection from 3–Methylcholanthrene‐induced Tumorigenesis by CD25–depletion
Q61806576Sex Differences in Mouse Popliteal Lymph Nodes
Q37055402Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
Q44788673Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation
Q37702272Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice
Q27002575Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?
Q34032006Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.
Q34190602Specificity, restriction and effector mechanisms of immunoregulatory CD8 T cells
Q39402895Spectrum of T-lymphocyte activities regulating allergic lung inflammation
Q40360050Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Function
Q34111451Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
Q42906446Stimulation of α7 Nicotinic Acetylcholine Receptor by Nicotine Increases Suppressive Capacity of Naturally Occurring CD4+CD25+Regulatory T Cells in Mice In Vitro
Q36203554Stress proteins as inducers and targets of regulatory T cells in arthritis
Q80405125Studies on naïve CD4+CD25+T cells inhibition of naïve CD4+CD25- T cells in mixed lymphocyte cultures
Q37224027Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo
Q44628780Subpopulations of equine blood lymphocytes expressing regulatory T cell markers.
Q56903922Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4+CD25+ Regulatory T Cells In Vivo
Q35762936Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis
Q37967572Suppression assays with human T regulatory cells: a technical guide.
Q33359540Suppression of HIV-specific and allogeneic T cell activation by human regulatory T cells is dependent on the strength of signals
Q30388030Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells
Q45106594Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression
Q37290190Suppressor T cells regulate the nonanergic cell population that remains after peripheral tolerance is induced to the Mls-1 antigen in T cell receptor Vbeta 8.1 transgenic mice
Q35849305Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44
Q36376333Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
Q37000546Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice
Q30252330T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells
Q36370619T cell regulation as a side effect of homeostasis and competition
Q73703389T cells at the turn of the twenty-first century
Q92715292T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression
Q39017604T regulatory cell mediated immunotherapy for solid organ transplantation: A clinical perspective
Q36425917T regulatory cells as an immunotherapy for transplantation
Q35459820T regulatory cells: aid or hindrance in the clearance of disease?
Q37993692T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man.
Q34552317T-cell tolerance and autoimmune diabetes
Q36079878T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens
Q24805370T-cell-mediated control of autoimmunity
Q35589560T-helper cell tolerance to ubiquitous nuclear antigens
Q50567211T-lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover.
Q34987498T-regulatory cells: are we re-discovering T suppressors?
Q37358159TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes
Q47667692TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
Q38647664TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis
Q34556464TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
Q38632049TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner
Q53644347TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.
Q38224804TREG-cell therapies for autoimmune rheumatic diseases.
Q89861814Technical Considerations in Ex Vivo Human Regulatory T Cell Migration and Suppression Assays
Q27312315Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis
Q21245397Th17/Treg ratio derived using DNA methylation analysis is associated with the late phase asthmatic response
Q47755372The Dual Role of Treg in Cancer
Q64241294The Effects of Immunosuppressive Factors on Primary Dendritic Cells from C57BL/6 and CBA Mice
Q37088900The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Q24633549The PD-1 pathway in tolerance and autoimmunity
Q36063908The Preoperative Peripheral Blood Monocyte Count Is Associated with Liver Metastasis and Overall Survival in Colorectal Cancer Patients
Q36222003The Role of Regulatory B Cell-Like Malignant Cells and Treg Cells in the Mouse Model of BCL1 Tumor Dormancy
Q37364109The T-cell receptor repertoire of regulatory T cells
Q64256609The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer
Q64235834The absolute counts of peripheral T lymphocyte subsets in patient with ankylosing spondylitis and the effect of low-dose interleukin-2
Q47955968The altered PD-1/PD-L1 pathway delivers the 'one-two punch' effects to promote the Treg/Th17 imbalance in pre-eclampsia
Q33953206The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis.
Q38008355The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells
Q83194650The cellular basis of cardiac allograft rejection. IX. Ratio of naïve CD4+CD25+ T cells/CD4+CD25- T cells determines rejection or tolerance
Q37274250The development and function of regulatory T cells
Q43061565The different effects of cyclosporin A and rapamycin on regulatory CD4+CD25+ T cells: potential relationship with transplant tolerance induction
Q46046855The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4⁺CD25⁺ regulatory T cells
Q37176386The effects of immunosuppression on regulatory CD4(+)CD25(+) T cells: impact on immunosuppression selection in transplantation
Q37727704The fate of regulatory T cells: survival or apoptosis
Q42656251The immune system in cancer metastasis: friend or foe?
Q57041494The immunoregulatory role of CD4+FoxP3+CD25−regulatory T cells in lungs of mice infected withBordetella pertussis
Q38350483The impact of biological therapy on regulatory T cells in rheumatoid arthritis
Q36882243The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells
Q35916845The influence of commensal bacteria on infection with enteric viruses
Q28258462The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Q42441813The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens
Q42758392The interplay between regulatory T cells and metabolism in immune regulation
Q35928046The molecular mechanisms of regulatory T cell immunosuppression
Q83834480The myocardium of fetuses with endocardial fibroelastosis contains fewer B and T lymphocytes than normal control myocardium
Q34238425The origin and regulation of autopathogenic T cells
Q54518671The paradox role of regulatory T cells in ischemic stroke.
Q28236898The pathogenesis of immune thrombocytopaenic purpura
Q35154721The peripheral generation of CD4+ CD25+ regulatory T cells
Q50987847The plasticity and stability of regulatory T cells.
Q34009654The power and the promise of restimulation-induced cell death in human immune diseases
Q34604823The puzzling world of murine T regulatory cells.
Q46774844The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma
Q35207494The role of CD4(+)CD25(+) regulatory T cells in Leishmania infection
Q54587598The role of CD4CD25 T cells in autoantibody production in murine lupus.
Q36141498The role of CD8+CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand
Q36747499The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
Q30441254The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function
Q35107549The role of regulatory T cells in controlling immunologic self-tolerance
Q38035240The role of regulatory T cells in neurodegenerative diseases
Q37738676The role of regulatory T cells in respiratory infections and allergy and asthma.
Q36652214The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression
Q27004368The role of regulatory T cells in the pathogenesis of sepsis and its clinical implication
Q49710338The role of salt for immune cell function and disease.
Q36822300The role of the LAT-PLC-gamma1 interaction in T regulatory cell function
Q34569892The role of the transcription factor Foxp3 in the development of regulatory T cells
Q36535760The role of virus-induced regulatory T cells in immunopathology
Q37803117The roles of c‐rel and interleukin‐2 in tolerance: a molecular explanation of self–nonself discrimination
Q34648178The soluble isoform of CTLA-4 as a regulator of T-cell responses
Q36715471The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice
Q39455086The suppressive effect of CD25+Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-β production
Q33826591The third function of the thymus.
Q28080019The thymus and rheumatology: should we care?
Q92312875Theoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance
Q28066677Therapeutic efficacy of monthly subcutaneous injection of daclizumab in relapsing multiple sclerosis
Q82771162Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire
Q35867877Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells
Q36719265Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN.
Q73688337Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Q36959215Thymic versus induced regulatory T cells - who regulates the regulators?
Q27013062Thymus, innate immunity and autoimmune arthritis: interplay of gene and environment
Q74121842Tolerance and bystander suppression, with involvement of CD25-positive cells, is induced in rats receiving serum from ovalbumin-fed donors
Q61679981Tolerance and immunity in a mathematical model of T-cell mediated suppression
Q47948107Tolerance associated with cord blood transplantation may depend on the state of host dendritic cells
Q42157420Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells
Q36943091Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells
Q35877199Tolerance, not immunity, crucially depends on IL-2.
Q34264024Toll-like receptor 2 controls expansion and function of regulatory T cells
Q45252623Total colectomy improves altered distribution of regulatory T cells in patients with ulcerative colitis
Q34572232Transforming growth factor-beta in T-cell biology
Q24804340Transforming growth factor-beta-induced regulatory T cells referee inflammatory and autoimmune diseases
Q36736462Translational mini-review series on vaccines: Dendritic cell-based vaccines in renal cancer
Q42091259Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells
Q46602988Treatment of Uveitis by In Situ Administration of Ex Vivo-Activated Polyclonal Regulatory T Cells.
Q99726047Treg Enhancing Therapies to Treat Autoimmune Diseases
Q104068523Treg cell therapy: how cell heterogeneity can make the difference
Q36192911Treg cells, life history, and diversity
Q34273253Treg lymphocytes in autoimmune uveitis.
Q36497238Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs.
Q35951541Tregs and transplantation tolerance
Q37788679Tumor Infiltrating Regulatory T Cells: Tractable Targets for Immunotherapy
Q36403539Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation
Q37085357Tumor-induced impairment of TCR signaling results in compromised functionality of tumor-infiltrating regulatory T cells
Q64108546Turning the Tide Against Regulatory T Cells
Q41852651Type I diabetes-associated tolerogenic properties of interleukin-2.
Q34193045UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
Q53101377Unique roles of Schistosoma japonicum protein Sj16 to induce IFN-γ and IL-10 producing CD4(+)CD25(+) regulatory T cells in vitro and in vivo.
Q37190443Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
Q44476443Upregulation of GRAIL is associated with remission of ulcerative colitis.
Q37892594Vaccination therapy in renal cell carcinoma: current position and future options in metastatic and localized disease
Q33768325Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease
Q35845351Vγ1+ γδ T cells reduce IL-10-producing CD4+CD25+ T cells in the lung of ovalbumin-sensitized and challenged mice
Q42278097WITHDRAWN: The majority of T cells, including Treg cells, are developed from CD4(-)CD8(-)T progenitor cells without the involvement of the CD4(+)CD8(+) stage in the thymus
Q33745150What is the role of regulatory T cells in transplantation tolerance?
Q37227956What roles do regulatory T cells play in the control of the adaptive immune response?
Q35155949What's the difference between CD80 and CD86?
Q36762514When three is not a crowd: a Crossregulation model of the dynamics and repertoire selection of regulatory CD4+ T cells.
Q52689973When worlds collide: Th17 and Treg cells in cancer and autoimmunity.
Q37998914Working out mechanisms of controlled/physiologic inflammation in the GI tract
Q82893705[Immunological aspects of atherosclerosis]
Q61628000c-Rel but not NF-κB1 is important for T regulatory cell development
Q37137541mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function