Approaches for immunological tolerance induction to stem cell-derived cell replacement therapies

scientific article published on May 2010

Approaches for immunological tolerance induction to stem cell-derived cell replacement therapies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1586/ECI.10.20
P698PubMed publication ID20441429

P2093author name stringPaul J Fairchild
Ashleigh S Boyd
P2860cites workActivation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotypeQ24293121
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1Q24300625
Prevention of allogeneic fetal rejection by tryptophan catabolismQ24336018
Disease-specific induced pluripotent stem cellsQ24641981
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.Q24655516
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
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Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Multilineage potential of adult human mesenchymal stem cellsQ27860737
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Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Expression of programmed death 1 ligands by murine T cells and APCQ28214264
Sheep cloned by nuclear transfer from a cultured cell lineQ28275874
1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activationQ28370605
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Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivoQ39823115
Characterization of dendritic cells and macrophages generated by directed differentiation from mouse induced pluripotent stem cellsQ39856765
Directed differentiation of human-induced pluripotent stem cells generates active motor neuronsQ39863440
The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injuryQ40025597
Embryonic stem cells and their differentiated derivatives have a fragile immune privilege but still represent novel targets of immune attackQ40083810
Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory functionQ40095781
Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cellsQ40229749
Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells.Q40395995
Embryonic stem cells: a novel source of dendritic cells for clinical applications.Q40482532
Human embryonic stem cells possess immune-privileged propertiesQ40531152
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Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivoQ40662801
Embryoid-body cells derived from a mouse embryonic stem cell line show differentiation into functional hepatocytesQ40722072
NKT cell-derived RANTES recruits APCs and CD8+ T cells to the spleen during the generation of regulatory T cells in toleranceQ40723327
Surface antigens of human embryonic stem cells: changes upon differentiation in cultureQ40729324
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapyQ40738121
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Central tolerance of T cellsQ41098056
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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive stateQ42466421
Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cellsQ42793227
Expression of immunoglobulin superfamily cell adhesion molecules on murine embryonic stem cellsQ42984504
Human embryonic stem cell (hES) derived dendritic cells are functionally normal and are susceptible to HIV-1 infectionQ43052736
Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cellsQ43224014
Dendritic cell maturation is required for the cross-tolerization of CD8+ T cellsQ44485559
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradationQ44786842
Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cellsQ45345520
Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 inductionQ45880435
Infusion of mesenchymal stem cells and rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance.Q45948061
GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.Q46490849
Co-infusion of donor bone marrow with host mesenchymal stem cells treats GVHD and promotes vascularized skin allograft survival in ratsQ47795541
Neural progenitor cells lack immunogenicity and resist destruction as allografts.Q47795672
Fluids from immune privileged sites endow macrophages with the capacity to induce antigen-specific immune deviation via a mechanism involving transforming growth factor-betaQ48498169
The immune system and the nervous systemQ48852534
The blood-brain barrier protects foreign antigens in the brain from immune attackQ49013222
Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats.Q50616625
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy.Q50767537
Differentiation of human embryonic stem cells into immunostimulatory dendritic cells under feeder-free culture conditions.Q51948437
Immunosuppression by embryonic stem cells.Q51970329
Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.Q51981243
Involution and cystic transformation of the thymus in the bottlenose dolphin, Tursiops truncatus.Q53154840
Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart.Q53478474
Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells.Q53503551
Undifferentiated murine embryonic stem cells cannot induce portal tolerance but may possess immune privilege secondary to reduced major histocompatibility complex antigen expression.Q53588370
Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.Q53722655
Transgenic bovine chimeric offspring produced from somatic cell-derived stem-like cells.Q53949587
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Q54645452
A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cellsQ56765649
Pretransplant Infusion of Mesenchymal Stem Cells Prolongs the Survival of a Semiallogeneic Heart Transplant through the Generation of Regulatory T CellsQ57702466
A role for CD95 ligand in preventing graft rejectionQ59066471
Foxp3-dependent programme of regulatory T-cell differentiationQ59084714
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytesQ29614341
Generation of mouse induced pluripotent stem cells without viral vectorsQ29614342
Induced pluripotent stem cells generated without viral integrationQ29614343
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblastsQ29614794
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAFQ29615685
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neuronsQ29616199
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cellsQ29618766
Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuliQ29618769
Generation of induced pluripotent stem cells using recombinant proteinsQ29619162
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skinQ29619238
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cellsQ29619409
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.Q30489278
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compoundsQ33382569
Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent mannerQ33438830
Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimenQ33499668
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disordersQ33560423
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cellsQ33591090
Reprogramming of pancreatic beta cells into induced pluripotent stem cellsQ33641629
The immunology of pregnancyQ33710909
Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?Q33740214
Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.Q33763653
Marrow stromal stem cellsQ33947769
Dendritic cells and prospects for transplantation toleranceQ34046816
Characterization of the expression of MHC proteins in human embryonic stem cellsQ34076010
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryoQ34131812
Adult frogs derived from the nuclei of single somatic cellsQ34252349
Designer dendritic cells for tolerance induction: guided not misguided missilesQ34319943
Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac graftsQ34387398
Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors.Q34550440
Generation and regulation of CD8(+) regulatory T cellsQ34602623
Thymic output in aged miceQ34694301
"Infectious" transplantation tolerance.Q34726892
Generation of pluripotent stem cells from adult mouse liver and stomach cellsQ34750323
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotencyQ34771507
Immature, but not inactive: the tolerogenic function of immature dendritic cellsQ34842360
Oct4-induced pluripotency in adult neural stem cells.Q34940495
Variation in the safety of induced pluripotent stem cell linesQ34991636
Hazardous crossing: immunosuppression and nosocomial infections in solid organ transplant recipientsQ35069193
Immunoregulation in the tissues by gammadelta T cellsQ35092547
Molecular complexities of stem cellsQ35104927
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi CellsQ35117509
The immune privilege of corneal graftsQ35186805
The Hair Follicle and Immune PrivilegeQ35569804
Mechanisms of and perspectives on the mesenchymal stem cell in immunotherapyQ35762417
The consequences of nuclear transfer for mammalian foetal development and offspring survival. A mitochondrial DNA perspective.Q35791048
Novel strategies for steroid-refractory acute graft-versus-host diseaseQ35987086
Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.Q36107275
Tissue expression of PD-L1 mediates peripheral T cell tolerance.Q36228541
Homeostatic T cell proliferation as a barrier to T cell toleranceQ36251301
Transplanting stem cells: potential targets for immune attack. Modulating the immune response against embryonic stem cell transplantationQ36313586
Immunogenicity of retransplanted rat kidney allografts. Effect of inducing chimerism in the first recipient and quantitative studies on immunosuppression of the second recipientQ36347161
Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cellsQ36370232
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.Q36370461
Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathwayQ36407194
Immune privilege induced by regulatory T cells in transplantation toleranceQ36593774
Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of toleranceQ36693370
Current concepts and perspectives of immunosuppression in organ transplantationQ36798362
Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenograftsQ36861712
Genetic modification of dendritic cells through the directed differentiation of embryonic stem cellsQ36944524
Emerging concepts in CD8(+) T regulatory cellsQ37136267
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerismQ37211290
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.Q37211408
Infectious tolerance via the consumption of essential amino acids and mTOR signalingQ37246191
Generation of pluripotent stem cells from patients with type 1 diabetesQ37327472
Functional cardiomyocytes derived from human induced pluripotent stem cellsQ37341034
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetesQ37358159
Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regenerationQ37537193
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cellsQ37704797
P433issue3
P921main subjectimmunologyQ101929
P304page(s)435-448
P577publication date2010-05-01
P1433published inExpert Review of Clinical ImmunologyQ15733763
P1476titleApproaches for immunological tolerance induction to stem cell-derived cell replacement therapies
P478volume6