Directed differentiation of human-induced pluripotent stem cells generates active motor neurons

scientific article published on April 2009

Directed differentiation of human-induced pluripotent stem cells generates active motor neurons is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/STEM.31
P932PMC publication ID2895909
P698PubMed publication ID19350680
P5875ResearchGate publication ID24261650

P50authorKathrin PlathQ30347917
Bennett G. NovitchQ42321183
Harley I KornblumQ114444398
P2093author name stringJoy A Umbach
Martina Wiedau-Pazos
Saravanan Karumbayaram
Michaela Patterson
Amander T Clark
Anne E Conway
Anne Lindgren
Laura Richter
William E Lowry
Steve A Goldman
P2860cites workInduced pluripotent stem cell lines derived from human somatic cellsQ27860597
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Vertebrate neurogenesis is counteracted by Sox1-3 activityQ28205692
Reprogramming of human somatic cells to pluripotency with defined factorsQ28262710
Induced pluripotent stem cells from a spinal muscular atrophy patientQ29614340
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neuronsQ29616199
Directed differentiation of embryonic stem cells into motor neuronsQ29616200
Generation of human induced pluripotent stem cells from dermal fibroblastsQ34588555
Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small moleculesQ37254921
Marked differences in differentiation propensity among human embryonic stem cell linesQ40012772
Functional properties of motoneurons derived from mouse embryonic stem cells.Q40517622
Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activityQ43089641
Specification of motoneurons from human embryonic stem cells.Q45246951
Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cellsQ46730802
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.Q51066733
Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.Q51986995
A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity.Q52034963
Motor neuron columnar fate imposed by sequential phases of Hox-c activity.Q52098449
Development of ionic currents underlying changes in action potential waveforms in rat spinal motoneurons.Q52181242
Functional motor unit failure precedes neuromuscular degeneration in canine motor neuron diseaseQ73775072
Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosisQ79733723
P433issue4
P921main subjectHuman Induced Pluripotent Stem CellsQ88981775
P304page(s)806-811
P577publication date2009-04-01
P1433published inStem CellsQ15724411
P1476titleDirected differentiation of human-induced pluripotent stem cells generates active motor neurons
P478volume27

Reverse relations

cites work (P2860)
Q26859884"Seq-ing" insights into the epigenetics of neuronal gene regulation
Q49168576A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.
Q36588788AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice
Q54964081Adherent vs. Free-Floating Neural Induction by Dual SMAD Inhibition for Neurosphere Cultures Derived from Human Induced Pluripotent Stem Cells.
Q38332493Adult human neural stem cell therapeutics: Current developmental status and prospect
Q90396913Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
Q44704967Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis
Q37000469An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.
Q39356795An orthogonal comparison of the proteome of human embryonic stem cells with that of human induced pluripotent stem cells of different genetic background
Q35071401Annual Research Review: The promise of stem cell research for neuropsychiatric disorders
Q92556132Application of chemical reaction engineering principles to 'body-on-a-chip' systems
Q37742101Approaches for immunological tolerance induction to stem cell-derived cell replacement therapies
Q21133511Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue
Q33684338Binary fate decisions in differentiating neurons
Q39259312Bone tissue engineering of induced pluripotent stem cells cultured with macrochanneled polymer scaffold
Q35648117Cell therapy for multiple sclerosis
Q42363724Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern
Q34329654Characterization of induced neural progenitors from skin fibroblasts by a novel combination of defined factors
Q39217787Clinical translation of bioartificial liver support systems with human pluripotent stem cell-derived hepatic cells
Q87175977Comparison of different protocols for neural differentiation of human induced pluripotent stem cells
Q38021973Concise review: human pluripotent stem cells in the treatment of spinal cord injury
Q37841398Concise review: stem cells for the treatment of cerebellar-related disorders
Q33924616Converted neural cells: induced to a cure?
Q26861926Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review
Q35958875Defining the nature of human pluripotent stem cell progeny
Q38906124Derivation of motor neuron-like cells from neonatal mouse testis in a simple culture condition.
Q50033636Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells
Q38752574Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.
Q48092727Differentiation Potential of Human Chorion-Derived Mesenchymal Stem Cells into Motor Neuron-Like Cells in Two- and Three-Dimensional Culture Systems.
Q28533809Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro
Q45043594Differentiation of mouse induced pluripotent stem cells into corneal epithelial-like cells
Q37460845Differentiation of spinal motor neurons from pluripotent human stem cells
Q53397967Differentiation potential of human bone marrow mesenchymal stem cells into motorneuron-like cells on electrospun gelatin membrane.
Q47970651Direct Reprogramming of Human Suspension Cells into Mesodermal Cell Lineages via Combined Magnetic Targeting and Photothermal Stimulation by Magnetic Graphene Oxide Complexes
Q37359163Direct conversion of adipocyte progenitors into functional neurons
Q58612523Direct conversion of mouse astrocytes into neural progenitor cells and specific lineages of neurons
Q64128448Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines
Q36780691Direct reprogramming of human fibroblasts into sweat gland-like cells
Q30585778Directing human induced pluripotent stem cells into a neurosensory lineage for auditory neuron replacement
Q24298254Dynamic distribution of linker histone H1.5 in cellular differentiation
Q39802426Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.
Q38034476Embryonic and induced pluripotent stem cell differentiation as a tool in neurobiology
Q36229098Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach
Q51831198Engineering personalized neural tissue by combining induced pluripotent stem cells with fibrin scaffolds.
Q34217805Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers
Q37998983Experimental therapies for repair of the central nervous system: stem cells and tissue engineering.
Q33989488Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells
Q34111572Female human iPSCs retain an inactive X chromosome
Q37293528FoxO3a contributes to the reprogramming process and the differentiation of induced pluripotent stem cells
Q37056282From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols
Q34264572Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons
Q36458914Generation of induced pluripotent stem cells from human Tenon's capsule fibroblasts
Q42159813Generation of transplantable Beta cells for patient-specific cell therapy
Q34234455Genetic basis of inherited macular dystrophies and implications for stem cell therapy.
Q34437293Genomic editing tools to model human diseases with isogenic pluripotent stem cells
Q38700229Glia-neuron interactions in neurological diseases: Testing non-cell autonomy in a dish
Q37684345Glial progenitor cell-based treatment of the childhood leukodystrophies
Q39166287Glioma gene therapy using induced pluripotent stem cell derived neural stem cells
Q36930602Healthy human CSF promotes glial differentiation of hESC-derived neural cells while retaining spontaneous activity in existing neuronal networks.
Q39037865High content analysis in amyotrophic lateral sclerosis
Q42125464Human induced pluripotent stem cells generated neural cells behaving like brain and spinal cord cells: An insight into the involvement of retinoic acid and sonic hedgehog proteins
Q37776428Human motor neuron generation from embryonic stem cells and induced pluripotent stem cells
Q30395748Human pluripotent stem cell-derived products: advances towards robust, scalable and cost-effective manufacturing strategies.
Q37950950Human pluripotent stem cells for disease modelling and drug screening
Q37931912Human pluripotent stem cells for genetic disease modeling and drug screening.
Q28652313Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes
Q33788845Human stem cells for craniomaxillofacial reconstruction.
Q48215211Hypergravity stimulation enhances PC12 neuron-like cell differentiation.
Q36253650Important precautions when deriving patient-specific neural elements from pluripotent cells
Q38753758In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
Q37745594In vitro regeneration of kidney from pluripotent stem cells
Q37592612Induced Pluripotent Stem Cells for Traumatic Spinal Cord Injury
Q34031081Induced Pluripotent Stem Cells-A New Foundation in Medicine
Q38014843Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine
Q38107885Induced pluripotency and direct reprogramming: a new window for treatment of neurodegenerative diseases
Q37800367Induced pluripotent stem (iPS) cells: an up-to-the-minute review
Q26823333Induced pluripotent stem cell technology and direct conversion: new possibilities to study and treat Parkinson's disease
Q37641699Induced pluripotent stem cell therapies for retinal disease
Q39830573Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures
Q38358569Induced pluripotent stem cells and their use in cardiac and neural regenerative medicine
Q38218254Induced pluripotent stem cells for regenerative medicine
Q38026488Induced pluripotent stem cells for spinal cord injury therapy: current status and perspective
Q35840653Induced pluripotent stem cells in the study of neurological diseases
Q37779822Induced pluripotent stem cells--alchemist's tale or clinical reality?
Q34923975Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders
Q37801268Induced pluripotent stem cells: developmental biology to regenerative medicine
Q30420062Inducible pluripotent stem cells: not quite ready for prime time?
Q42483604Induction of putative stratified epithelial progenitor cells in vitro from mouse-induced pluripotent stem cells.
Q34314191Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy
Q39189306Insights into cell-free therapeutic approach: Role of stem cell "soup-ernatant".
Q37982705Intracerebral transplantation for neurological disorders. Lessons from developmental, experimental, and clinical studies.
Q35130996Investigation of hepatoprotective activity of induced pluripotent stem cells in the mouse model of liver injury.
Q27319853Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells
Q35540393Model systems of motor neuron diseases as a platform for studying pathogenic mechanisms and searching for therapeutic agents
Q93038643Modeling genetic epilepsies in a dish
Q34749749Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice
Q35473397Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons
Q26822886Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives
Q39148891Motor neuron differentiation from pluripotent stem cells and other intermediate proliferative precursors that can be discriminated by lineage specific reporters
Q34470920Moving stem cells to the clinic: potential and limitations for brain repair
Q47283219Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges
Q28551899Multiple Sclerosis Patient-Specific Primary Neurons Differentiated from Urinary Renal Epithelial Cells via Induced Pluripotent Stem Cells
Q34599726Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural precursors in vitro.
Q28648114Neural Commitment of Embryonic Stem Cells through the Formation of Embryoid Bodies (EBs)
Q33732735Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
Q40884175Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis
Q46524989Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs
Q36945734New frontier in regenerative medicine: site-specific gene correction in patient-specific induced pluripotent stem cells
Q38121637New therapy options for amyotrophic lateral sclerosis
Q39094722Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks
Q36607409Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo
Q34619318Nuclear reprogramming strategy modulates differentiation potential of induced pluripotent stem cells
Q58785850On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations
Q37893537PET molecular imaging in stem cell therapy for neurological diseases
Q37620711PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.
Q42205262Patch clamp apply in cardiomyocytes derived from patient's iPS cells for individual anticancer therapy.
Q41836711Patient-specific pluripotent stem cells in neurological diseases
Q47872679Polysaccharide nanofibers with variable compliance for directing cell fate
Q54403275Potential of Induced Pluripotent Stem Cells for the Regeneration of the Tracheal Wall
Q38010704Preclinical models to investigate retinal ischemia: advances and drawbacks
Q39684952Programmatic change: lung disease research in the era of induced pluripotency
Q37697617Progress and promise towards safe induced pluripotent stem cells for therapy
Q38795457Protein regulation of induced pluripotent stem cells by transplanting in a Huntington's animal model
Q33937536Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen
Q48018020Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage
Q27335011Purification of immature neuronal cells from neural stem cell progeny
Q38017202Recent developments in transposon-mediated gene therapy
Q37809803Research Advances in Amyotrophic Lateral Sclerosis, 2009 to 2010
Q93046793Restoring Motor Neurons in Spinal Cord Injury With Induced Pluripotent Stem Cells
Q89811163Small-molecule-mediated reprogramming: a silver lining for regenerative medicine
Q39309888Sourcing and using stem cell lines for radiation research: Potential, challenges and good stem cell culture practice
Q37976119Standardization of pluripotent stem cell cultures for toxicity testing
Q52619084Stem Cells Therapy for Spinal Cord Injury.
Q57345687Stem Cells, Bioengineering, and 3-D Scaffolds for Nervous System Repair and Regeneration
Q37643268Stem and Progenitor Cell-Based Therapy of the Central Nervous System: Hopes, Hype, and Wishful Thinking
Q36301821Stem cell therapy for amyotrophic lateral sclerosis
Q34129832Stem cell therapy for cerebral ischemia: from basic science to clinical applications
Q35087066Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease
Q37747349Stem cells in genetic myelin disorders
Q27687068Stem cells in human neurodegenerative disorders--time for clinical translation?
Q34845881Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells
Q39000555Substantial Differentiation of Human Neural Stem Cells Into Motor Neurons on a Biomimetic Polyurea
Q41634284Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain
Q38040207Systematic review of induced pluripotent stem cell technology as a potential clinical therapy for spinal cord injury.
Q58086434Systems-Wide Approaches in Induced Pluripotent Stem Cell Models
Q33788869Tbx1 modulates endodermal and mesodermal differentiation from mouse induced pluripotent stem cells
Q55437504The Efficacy of Graphene Foams for Culturing Mesenchymal Stem Cells and Their Differentiation into Dopaminergic Neurons.
Q58883595The Efficient Generation of Induced Pluripotent Stem (iPS) Cells from Adult Mouse Adipose Tissue-Derived and Neural Stem Cells
Q26860309The Potential for iPS-Derived Stem Cells as a Therapeutic Strategy for Spinal Cord Injury: Opportunities and Challenges
Q38559610The State of Play with iPSCs and Spinal Cord Injury Models.
Q37980016The emerging role of stem cells in ocular neurodegeneration: hype or hope?
Q35981667The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk
Q37856714The use of induced pluripotent stem cells in drug development
Q89166348Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons
Q35805656Transdifferentiation of Fibroblasts by Defined Factors
Q37772899Translational prospects for human induced pluripotent stem cells
Q37729046Transplantation of Embryonic Spinal Cord Derived Cells Helps to Prevent Muscle Atrophy after Peripheral Nerve Injury.
Q42408065Transplantation of Induced Pluripotent Stem Cell-Derived Neural Stem Cells Mediate Functional Recovery Following Thoracic Spinal Cord Injury Through Remyelination of Axons
Q84796896Transplantation of human glial-restricted neural precursors into injured spinal cord promotes functional and sensory recovery without causing allodynia
Q38065343Understanding ALS: new therapeutic approaches.
Q38399817Uniform-sized neurosphere-mediated motoneuron differentiation in microwell arrays.
Q38371445Use of stem cells for liver diseases-current scenario.
Q26796332Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies
Q34745357Vector-free and transgene-free human iPS cells differentiate into functional neurons and enhance functional recovery after ischemic stroke in mice
Q34714347What can pluripotent stem cells teach us about neurodegenerative diseases?
Q37131089Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?
Q89618057[Effect of the local application of stem cells on repairing facial nerve defects: a systematic review]
Q48598887iPSC Transplantation increases regeneration and functional recovery after ischemic stroke in neonatal rats
Q26765886iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System
Q34530170let-7 miRNAs can act through notch to regulate human gliogenesis

Search more.