Stem cells in human neurodegenerative disorders--time for clinical translation?

scientific article

Stem cells in human neurodegenerative disorders--time for clinical translation? is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1172/JCI40543
P3181OpenCitations bibliographic resource ID183823
P932PMC publication ID2798697
P698PubMed publication ID20051634

P2093author name stringZaal Kokaia
Olle Lindvall
P2860cites workHuman neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice.Q24534130
Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemiaQ24569823
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS modelQ24631645
Disease-specific induced pluripotent stem cellsQ24641981
Evidence for stroke-induced neurogenesis in the human brainQ24678200
Spinal cord injury reveals multilineage differentiation of ependymal cellsQ27333067
Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcomeQ28235047
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injuryQ28250167
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's diseaseQ28275257
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat modelQ28344741
Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recoveryQ28475604
Neuronal subtype-specific genes that control corticospinal motor neuron development in vivoQ28507231
Fezl is required for the birth and specification of corticospinal motor neuronsQ28586952
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factorsQ28749672
Mechanisms and functional implications of adult neurogenesisQ29547295
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagationQ29615640
Neuronal replacement from endogenous precursors in the adult brain after strokeQ29615772
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neuronsQ29616199
Directed differentiation of embryonic stem cells into motor neuronsQ29616200
Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseQ29617304
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's diseaseQ29619506
Stimulation of endogenous neurogenesis by anti-EFRH immunization in a transgenic mouse model of Alzheimer's diseaseQ30478932
Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian miceQ30480781
Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic miceQ30491245
Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult ratsQ30581117
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.Q30833707
Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke modelQ30841172
Cell therapy in Parkinson's diseaseQ33212017
Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke modelQ33269334
Extensive neuronal differentiation of human neural stem cell grafts in adult rat spinal cordQ33273600
GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.Q33292690
Survival, migration and neuronal differentiation of human fetal striatal and cortical neural stem cells grafted in stroke-damaged rat striatumQ33293607
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degenerationQ33387798
Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injuryQ33421738
Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model.Q33565361
Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.Q33713837
Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantationQ40544827
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron diseaseQ42188656
Stroke-induced neurogenesis in aged brainQ42480928
Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trialQ42483132
Transplantation of cultured human neuronal cells for patients with strokeQ42492334
In vitro generation and transplantation of precursor-derived human dopamine neuronsQ43700682
Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.Q44037381
Rat forebrain neurogenesis and striatal neuron replacement after focal strokeQ44226820
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseQ44571920
Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanismsQ44736716
Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.Q44816539
Specification of motoneurons from human embryonic stem cells.Q45246951
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer diseaseQ45883058
Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS miceQ45887127
Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemiaQ46253405
Directed evolution of motor neurons from genetically engineered neural precursorsQ46477359
Functional integration of newly generated neurons into striatum after cerebral ischemia in the adult rat brain.Q46477375
Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cellsQ46730802
Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's diseaseQ46803369
Identification of intrinsic determinants of midbrain dopamine neuronsQ46913434
Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult ratsQ47847785
Endogenous neurogenesis in the human brain following cerebral infarctionQ48185382
Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model.Q48199408
Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian ratsQ48242730
Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental strokeQ48262046
Generation of functional dopamine neurons from neural precursor cells isolated from the subventricular zone and white matter of the adult rat brain using Nurr1 overexpressionQ48305268
Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia.Q48326932
Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain.Q48338775
IGF-I specifically enhances axon outgrowth of corticospinal motor neuronsQ48389957
Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats.Q48396299
Abeta immunotherapy protects morphology and survival of adult-born neurons in doubly transgenic APP/PS1 mice.Q48410700
Growth factor-stimulated generation of new cortical tissue and functional recovery after stroke damage to the motor cortex of ratsQ48417804
Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus.Q48482142
Dyskinesias following neural transplantation in Parkinson's diseaseQ48590785
Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke.Q48600819
Stem cells in the treatment of chronic spinal cord injury: evaluation of somatosensitive evoked potentials in 39 patientsQ48681632
Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacinQ48699328
Persistent production of neurons from adult brain stem cells during recovery after stroke.Q48739755
Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in ratsQ48752451
Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemiaQ48852632
Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.Q50610700
Transplanted mouse embryonic stem-cell-derived motoneurons form functional motor units and reduce muscle atrophy.Q50612517
Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord.Q50707969
Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.Q50735935
Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.Q51986995
Case report on the clinical results of a combined cellular therapy for chronic spinal cord injured patients.Q52592016
Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic strokeQ80399919
Stem cell treatment in Amyotrophic Lateral SclerosisQ80507987
Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosisQ81541349
Autologous mesenchymal stem cell transplantation in stroke patientsQ81803888
Stem cell clinics online: the direct-to-consumer portrayal of stem cell medicineQ82764821
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's diseaseQ33726762
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.Q33925878
Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson diseaseQ34118080
Increased hippocampal neurogenesis in Alzheimer's disease.Q34281877
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.Q34416128
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.Q34433743
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum.Q34538268
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after strokeQ34949959
Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells.Q35094909
Failure of neuronal maturation in Alzheimer disease dentate gyrusQ35327913
Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enoughQ35751844
Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantationQ35789004
Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer's disease-like transgenic (pPDGF-APPSw,Ind) miceQ36334459
Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells.Q36491400
Regenerating the brainQ36687833
Neural stem/precursor cells for the treatment of ischemic stroke.Q36870255
Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult ratQ37019997
I.V. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult ratQ37020088
Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemiaQ37020101
Stem and progenitor cell therapies: recent progress for spinal cord injury repairQ37127835
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cellsQ37164421
Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALSQ37183861
Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke modelQ37184529
Stem cells for spinal cord repairQ37204415
Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's diseaseQ37221341
Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small moleculesQ37254921
Is it too soon for mesenchymal stem cell trials in people with ALS?Q37279972
Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's diseaseQ37300209
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinicQ37307355
Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: differentiation and structural integration into the segmental motor circuitryQ37307371
Stem cell therapy in stroke.Q37319445
Generation of spinal motor neurons from human fetal brain-derived neural stem cells: role of basic fibroblast growth factorQ37335277
Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating strokeQ37354712
Why have we failed to achieve neuroprotection in Parkinson's disease?Q37363916
Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex.Q37416265
Stem cell-based cell therapy in neurological diseases: a reviewQ37419268
Cell therapy for CNS traumaQ37426384
Therapeutic cloning in individual parkinsonian miceQ37449986
Microglia in ALS: the good, the bad, and the restingQ37592030
Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up.Q39311874
Factors affecting the clinical outcome after neural transplantation in Parkinson's diseaseQ39360071
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patientQ39434658
VEGF enhance cortical newborn neurons and their neurite development in adult rat brain after cerebral ischemia.Q39835764
Directed differentiation of human-induced pluripotent stem cells generates active motor neuronsQ39863440
Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cellsQ39910905
Effects of human neural stem cell transplantation in canine spinal cord hemisectionQ40010874
Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosisQ40035096
Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harmQ40139859
L3/Lhx8 is a pivotal factor for cholinergic differentiation of murine embryonic stem cells.Q40167536
Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.Q40216832
Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic ratsQ40220494
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult ratsQ40250561
Recovery from paralysis in adult rats using embryonic stem cells.Q40262579
A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic strokeQ40319588
Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primatesQ40339968
GDNF delivery using human neural progenitor cells in a rat model of ALS.Q40425197
The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.Q40462051
Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantationQ40493282
Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factorQ40504543
Functional properties of motoneurons derived from mouse embryonic stem cells.Q40517622
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
P304page(s)29-40
P577publication date2010-01-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleStem cells in human neurodegenerative disorders--time for clinical translation?
P478volume120

Reverse relations

cites work (P2860)
Q889239913D bioprinter applied picosecond pulsed electric fields for targeted manipulation of proliferation and lineage specific gene expression in neural stem cells
Q100314972A Trimodal Ultrasound, Photoacoustic and Magnetic Resonance Imaging Approach for Longitudinal Post-operative Monitoring of Stem Cells in the Spinal Cord
Q55396812A model of hematopoietic bone marrow apoptosis during growth factor deprivation in combination with a cytokine.
Q38781123A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs).
Q35214817A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs).
Q35169918Acupuncture: a potent therapeutic tool for inducing adult neurogenesis
Q38873789Adapting Preclinical Benchmarks for First-in-Human Trials of Human Embryonic Stem Cell-Based Therapies
Q39342788Adeno-associated virus type 2 vector-mediated glial cell line-derived neurotrophic factor gene transfer induces neuroprotection and neuroregeneration in a ubiquitin-proteasome system impairment animal model of Parkinson's disease.
Q38332493Adult human neural stem cell therapeutics: Current developmental status and prospect
Q36861593Adult human olfactory epithelial-derived progenitors: a potential autologous source for cell-based treatment for Parkinson's disease
Q38168862Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function
Q91792094Adult neurogenesis: Is it showtime for clinical translation?
Q41877527Aging and neurogenesis, a lesion from Alzheimer's disease.
Q34033021Allopregnanolone and neurogenesis in the nigrostriatal tract
Q27334826Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease
Q37361564Amyloid-β oligomers regulate the properties of human neural stem cells through GSK-3β signaling
Q38160459Amyotrophic lateral sclerosis: applications of stem cells - an update.
Q35224557ApoE is required for maintenance of the dentate gyrus neural progenitor pool
Q37432078Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury
Q28076197Applications of CRISPR/Cas9 for Gene Editing in Hereditary Movement Disorders
Q35673895Aptamer technology for tracking cells' status & function
Q41226076Astrocyte reactivity after brain injury-: The role of galectins 1 and 3.
Q41452682Bcl-2 enhances the formation of newborn striatal long-projection neurons in adult rat brain after a transient ischemic stroke
Q51546444Biogrid--a microfluidic device for large-scale enzyme-free dissociation of stem cell aggregates.
Q45871821Bone marrow-derived mesenchymal stem cells expressing the bFGF transgene promote axon regeneration and functional recovery after spinal cord injury in rats
Q59137766Brain Plasticity in Mammals: An Example for the Role of Comparative Medicine in the Neurosciences
Q52315021Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds.
Q36554467Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells
Q36587910Breast and abdominal adipose multipotent mesenchymal stromal cells and stage-specific embryonic antigen 4 expression.
Q47793278Caspase-3 modulates regenerative response after stroke
Q51762402Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities.
Q37921767Cell replacement therapy for Parkinson's disease: how close are we to the clinic?
Q38079793Cell therapy for Parkinson's disease: what next?
Q44297524Cell transplantation and gene therapy in Parkinson's disease
Q28730429Cellular host responses to gliomas
Q42363724Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern
Q37972875Chemical and topographical patterning of hydrogels for neural cell guidance in vitro
Q36204514Clinical Trial of Human Fetal Brain-Derived Neural Stem/Progenitor Cell Transplantation in Patients with Traumatic Cervical Spinal Cord Injury
Q38697315Clinical translation of stem cells in neurodegenerative disorders.
Q28484677Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research
Q33882998Comparison of Nutech Functional Score with European Stroke Scale for Patients with Cerebrovascular Accident Treated with Human Embryonic Stem Cells: NFS for CVA Patients Treated with hESCs
Q38063851Concise review: self-renewal in the central nervous system: neural stem cells from embryo to adult.
Q34310248Constraint-induced movement therapy as a paradigm of translational research in neurorehabilitation: Reviews and prospects
Q91806326Constructing temporal regulatory cascades in the context of development and cell differentiation
Q38752501Control of obesity and glucose intolerance via building neural stem cells in the hypothalamus
Q38029969Cross-talk between neural stem cells and immune cells: the key to better brain repair?
Q52568314Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease.
Q26861926Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review
Q42738980Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1α/β-catenin pathway in middle cerebral artery occlusion rats
Q37756518Designing customized cell signalling circuits
Q37217325Development and application of neural stem cells for treating various human neurological diseases in animal models
Q38105080Devices for cell transplantation into the central nervous system: Design considerations and emerging technologies
Q34072824Differential pathotropism of non-immortalized and immortalized human neural stem cell lines in a focal demyelination model
Q37239718Differentiation and Molecular Properties of Mesenchymal Stem Cells Derived from Murine Induced Pluripotent Stem Cells Derived on Gelatin or Collagen.
Q39663866Differentiation of human neural progenitor cells regulated by Wnt-3a
Q47320169Differentiation of mesenchymal stem cells into neuron-like cells using composite 3D scaffold combined with valproic acid induction
Q51839740Direct GSK-3β inhibition enhances mesenchymal stromal cell migration by increasing expression of β-PIX and CXCR4.
Q42773447Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells
Q38195398Direct reprogrammed neuronal cells as a novel resource for cell transplantation therapy
Q39279039Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
Q37513881Distributed Features of Vimentin-Containing Neural Precursor Cells in Olfactory Bulb of SOD1G93A Transgenic Mice: a Study about Resource of Endogenous Neural Stem Cells.
Q35945343Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of Wharton Jelly mesenchymal stem cell secretome?
Q29615682Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease
Q36842220Dopamine receptors in human embryonic stem cell neurodifferentiation.
Q83199769Dopaminergic neurons for Parkinson's therapy
Q34376698Dynamic mass redistribution assay decodes differentiation of a neural progenitor stem cell
Q60046957Editorial: Adult Neurogenesis: Beyond Rats and Mice
Q48544863Effect of polyvinylidene fluoride electrospun fiber orientation on neural stem cell differentiation.
Q33781107Effects of combinatorial treatment with pituitary adenylate cyclase activating peptide and human mesenchymal stem cells on spinal cord tissue repair
Q37517917Effects of intravenous human umbilical cord blood CD34+ stem cell therapy versus levodopa in experimentally induced Parkinsonism in mice.
Q59101361Efficient reprogramming of mouse fibroblasts to neuronal cells including dopaminergic neurons
Q39282606Embryonic stem cell-derived neural stem cells fuse with microglia and mature neurons.
Q34687557Endogenous WNT signaling regulates hPSC-derived neural progenitor cell heterogeneity and specifies their regional identity
Q35178506Endogenously EGFP-Labeled Mouse Embryonic Stem Cells
Q34885564Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease
Q35697100Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury.
Q38172120Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives
Q26865616Epidermal growth factor, from gene organization to bedside
Q34627684Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke
Q41768916Evaluation of neural gene expression in serum treated embryonic stem cells in Alzheimer's patients
Q37858878Ex vivo gene transfer and correction for cell-based therapies
Q36482236Fantasies about stem cell therapy in chronic ischemic stroke patients
Q42084557Fate of transplanted bone marrow derived mesenchymal stem cells following spinal cord injury in rats by transplantation routes
Q34232844Fetal stem cell transplantation: Past, present, and future.
Q38889816Fluorescence-guided development of a tricistronic vector encoding bimodal optical and nuclear genetic reporters for in vivo cellular imaging
Q34916199Functionalized scaffold-mediated interleukin 10 gene delivery significantly improves survival rates of stem cells in vivo
Q34586090Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus
Q90788805Generation and post-injury integration of human spinal cord neural stem cells
Q26765258Generation of diverse neural cell types through direct conversion
Q92418503Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury
Q93173865Harnessing stem cells and biomaterials to promote neural repair
Q90354741High-Dose Neural Stem/Progenitor Cell Transplantation Increases Engraftment and Neuronal Distribution and Promotes Functional Recovery in Rats after Acutely Severe Spinal Cord Injury
Q27008225High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke
Q33732756High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Q26995364How do immune cells support and shape the brain in health, disease, and aging?
Q33620143How neurogenesis finds its place in a hardwired sensory system
Q36319845Human Umbilical Tissue-Derived Cells Promote Synapse Formation and Neurite Outgrowth via Thrombospondin Family Proteins
Q30541296Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat.
Q39298289Human induced pluripotent stem cells improve stroke outcome and reduce secondary degeneration in the recipient brain
Q39299435Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L).
Q33638440Human motor neurons generated from neural stem cells delay clinical onset and prolong life in ALS mouse model
Q35176654Human neural stem cell transplantation in ALS: initial results from a phase I trial
Q36490240Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss
Q54625251Human umbilical cord blood-derived mesenchymal stem cells protect against neuronal cell death and ameliorate motor deficits in Niemann Pick type C1 mice.
Q47312408Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells.
Q87424282Icariin promotes self-renewal of neural stem cells: an involvement of extracellular regulated kinase signaling pathway
Q36129036Identification of embryonic stem cell-derived midbrain dopaminergic neurons for engraftment
Q30413268Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells
Q36374324Immunological regulation of neurogenic niches in the adult brain
Q45360064Impact of Theiler's virus infection on hippocampal neuronal progenitor cells: differential effects in two mouse strains
Q40612581In Vitro Conditioned Bone Marrow-Derived Mesenchymal Stem Cells Promote De Novo Functional Enteric Nerve Regeneration, but Not Through Direct-Transdifferentiation
Q46495043In Vivo Imaging of CNS Injury and Disease
Q36061125In Vivo Non-Invasive Tracking of Macrophage Recruitment to Experimental Stroke
Q37315468In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging Is Not Enhanced by Ferritin Expression
Q34359066In vitro expanded stem cells from the developing retina fail to generate photoreceptors but differentiate into myelinating oligodendrocytes
Q57158207In vitro studies on space-conforming self-assembling silk hydrogels as a mesenchymal stem cell-support matrix suitable for minimally invasive brain application
Q27022196In vivo imaging of endogenous neural stem cells in the adult brain
Q26753150Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging
Q64054563Inhibition of miRNA-27b enhances neurogenesis via AMPK activation in a mouse ischemic stroke model
Q38733954Initial graft size and not the innate immune response limit survival of engrafted neural stem cells
Q39189306Insights into cell-free therapeutic approach: Role of stem cell "soup-ernatant".
Q36411048Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.
Q31059372Interplay between cell migration and neurite outgrowth determines SH2B1β-enhanced neurite regeneration of differentiated PC12 cells
Q30459032Intracerebral neural stem cell transplantation improved the auditory of mice with presbycusis
Q48585796Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I).
Q58255075Intracranial Stem Cell-Based Transplantation: Reconsidering the Ethics of Phase 1 Clinical Trials in Light of Irreversible Interventions in the Brain
Q58124033Intraparenchymal Neural Stem/Progenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review
Q33897794Involvement of beta1-integrin up-regulation in basic fibroblast growth factor- and epidermal growth factor-induced proliferation of mouse neuroepithelial cells.
Q42291750In Vitro Generation of Vascular Wall-Resident Multipotent Stem Cells of Mesenchymal Nature from Murine Induced Pluripotent Stem Cells
Q58862267La transdifférenciation cellulaire au service de la sclérose latérale amyotrophique ?
Q50283926Labeling of Luciferase/eGFP-expressing bone marrow-derived stromal cells with fluorescent micron-sized iron oxide particles improves quantitative and qualitative multimodal imaging of cellular grafts in vivo.
Q33618095Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration
Q27304388Learning-induced synaptic potentiation in implanted neural precursor cell-derived neurons
Q33684997Long distance directional growth of dopaminergic axons along pathways of netrin-1 and GDNF.
Q34530719Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports
Q39038123Long-term effects of magnetically targeted ferumoxide-labeled human neural stem cells in focal cerebral ischemia
Q42317100Magnetic Resonance Imaging of Ferumoxytol-Labeled Human Mesenchymal Stem Cells in the Mouse Brain
Q38222504Mechanotransduction: tuning stem cells fate
Q35849852Meeting the need for regenerative therapies I: target-based incidence and its relationship to U.S. spending, productivity, and innovation
Q26785623Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives
Q26799013Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities
Q38086083Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?
Q41878738Messenger RNA Expression Patterns of Neurotrophins during Transdifferentiation of Stem Cells from Human-Exfoliated Deciduous Teeth into Neural-like Cells
Q48690916MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins.
Q59136987MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis
Q38187574NK cells after transplantation: friend or foe.
Q39314365Nanoengineering neural stem cells on biomimetic substrates using magnetofection technology.
Q34352877Natural killer cell-activating receptor NKG2D mediates innate immune targeting of allogeneic neural progenitor cell grafts
Q36136023Neural differentiation of transplanted neural stem cells in a rat model of striatal lacunar infarction: light and electron microscopic observations
Q40884175Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis
Q35590505Neural stem cell gene therapy ameliorates pathology and function in a mouse model of globoid cell leukodystrophy.
Q37739742Neural stem cells and strategies for the regeneration of the central nervous system
Q38057868Neural stem cells and stroke
Q41884863Neural stem cells genetically modified to overexpress cu/zn-superoxide dismutase enhance amelioration of ischemic stroke in mice.
Q28264037Neural stem cells, adult neurogenesis, and galectin-1: from bench to bedside
Q38521764Neural stem cells: ready for therapeutic applications?
Q42065629Neurodegenerative Disease: A Perspective on Cell-Based Therapy in the New Era of Cell-Free Nano-Therapy
Q28307113Neurodegenerative disease and adult neurogenesis
Q38721612Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury
Q89036230Neuronal and Glial Differentiation of Human Neural Stem Cells Is Regulated by Amyloid Precursor Protein (APP) Levels
Q36950735Neuroplasticity in the context of motor rehabilitation after stroke.
Q35910744New considerations in the design of clinical trials for amyotrophic lateral sclerosis
Q36563408New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies
Q64957093Newly Generated and Non-Newly Generated "Immature" Neurons in the Mammalian Brain: A Possible Reservoir of Young Cells to Prevent Brain Aging and Disease?
Q92778200Non-invasive MRI quantification of cerebrospinal fluid dynamics in amyotrophic lateral sclerosis patients
Q48655751Novel bimodal iron oxide particles for efficient tracking of human neural stem cells in vivo
Q37945678Novel paths towards neural cellular products for neurological disorders
Q37835900Nuclear receptors and microRNAs: Who regulates the regulators in neural stem cells?
Q35882540Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5.
Q35559206Optimization of the magnetic labeling of human neural stem cells and MRI visualization in the hemiparkinsonian rat brain
Q58103551Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells
Q30829270Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson's disease model
Q98771582Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals
Q35611511Oxidative stress, redox regulation and diseases of cellular differentiation
Q33712879PACAP Promotes Matrix-Driven Adhesion of Cultured Adult Murine Neural Progenitors
Q38718614Paracrine Maturation and Migration of SH-SY5Y Cells by Dental Pulp Stem Cells
Q34282729Pathophysiologic cascades in ischemic stroke
Q37964983Perspectives of purinergic signaling in stem cell differentiation and tissue regeneration.
Q92518340Physiological and pathological effects of amyloid-β species in neural stem cell biology
Q52589683Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects.
Q33851241Predicting harms and benefits in translational trials: ethics, evidence, and uncertainty
Q41814387Preparation of N-Phenyl-lactam Derivatives Capable of Stimulating Neurogenesis and Their Use in the Treatment of Neurological Disorders
Q35983132Progenitor cell-based treatment of the pediatric myelin disorders
Q38107439Progress in stem cell therapy for major human neurological disorders.
Q48895003Prolonged membrane depolarization enhances midbrain dopamine neuron differentiation via epigenetic histone modifications
Q27010398Promoting remyelination in multiple sclerosis-recent advances
Q47591395Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range
Q90642363Prussian blue nanocubes as a multimodal contrast agent for image-guided stem cell therapy of the spinal cord
Q37606452Pulp cell tracking by radionuclide imaging for dental tissue engineering.
Q33683005Quality and freshness of human bone marrow-derived mesenchymal stem cells decrease over time after trypsinization and storage in phosphate-buffered saline
Q37086202Radially branched deployment for more efficient cell transplantation at the scale of the human brain.
Q36421297Rapid generation of sub-type, region-specific neurons and neural networks from human pluripotent stem cell-derived neurospheres
Q92478922Recent Progress in the Regeneration of Spinal Cord Injuries by Induced Pluripotent Stem Cells
Q30424375Recognition and control of the progression of age-related hearing loss
Q37811884Recognition of cellular implants by the brain's innate immune system.
Q33854353Recruiting adaptive cellular stress responses for successful brain ageing
Q37864499Regenerative medicine for stroke - are we there yet?
Q38261543Remyelinating strategies in multiple sclerosis
Q92140095Results from Phase I Clinical Trial with Intraspinal Injection of Neural Stem Cells in Amyotrophic Lateral Sclerosis: A Long-Term Outcome
Q36196143Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions.
Q47703114Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells
Q38001423Role of SDF1/CXCR4 interaction in experimental hemiplegic models with neural cell transplantation
Q37922875Roles for HIF-1α in neural stem cell function and the regenerative response to stroke.
Q57556336Rotary orbital suspension culture of embryonic stem cell-derived neural stem/progenitor cells: impact of hydrodynamic culture on aggregate yield, morphology and cell phenotype
Q92712916Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases
Q41220881Safflower Seed Oil, Containing Oleic Acid and Palmitic Acid, Enhances the Stemness of Cultured Embryonic Neural Stem Cells through Notch1 and Induces Neuronal Differentiation
Q48448566Secretome of mesenchymal progenitors from the umbilical cord acts as modulator of neural/glial proliferation and differentiation.
Q35902185Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion
Q27335199Sensitive Tumorigenic Potential Evaluation of Adult Human Multipotent Neural Cells Immortalized by hTERT Gene Transduction
Q38748983Simulation of developing human neuronal cell networks.
Q92556504Soluble Nogo receptor 1 fusion protein protects neural progenitor cells in rats with ischemic stroke
Q49122473Spatio-temporal dynamics, differentiation and viability of human neural stem cells after implantation into neonatal rat brain
Q38252939Stem Cells in Neurological Disorders: Emerging Therapy with Stunning Hopes.
Q35840661Stem cell applications in military medicine
Q37954422Stem cell challenges in the treatment of neurodegenerative disease.
Q38058140Stem cell models of Alzheimer's disease and related neurological disorders
Q38211724Stem cell therapy and cellular engineering for treatment of neuronal dysfunction in Huntington's disease
Q36301821Stem cell therapy for amyotrophic lateral sclerosis
Q26995278Stem cell transplantation for motor neuron disease: current approaches and future perspectives
Q37800936Stem cell-derived neurotrophic support for the neuromuscular junction in spinal muscular atrophy.
Q38580609Stem cells for therapy in TBI.
Q38630465Stem cells therapy for ALS.
Q37668947Stem cells: roadmap to the clinic
Q48409935Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative.
Q34324040Synergistic contribution of SMAD signaling blockade and high localized cell density in the differentiation of neuroectoderm from H9 cells
Q33599129Syringe needle skull penetration reduces brain injuries and secondary inflammation following intracerebral neural stem cell transplantation
Q92394719Targeting Purinergic Signaling and Cell Therapy in Cardiovascular and Neurodegenerative Diseases
Q38769589Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats
Q36554957Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats
Q38223428The (real) neurogenic/gliogenic potential of the postnatal and adult brain parenchyma
Q90009644The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer's Disease
Q38078024The challenges of translating stem cells for spinal cord injury and related disorders: what are the barriers and opportunities?
Q39740575The co-transduction of Nurr1 and Brn4 genes induces the differentiation of neural stem cells into dopaminergic neurons
Q37790600The impact of the Orphan Drug Act on the development and advancement of neurological products for rare diseases: a descriptive review
Q28568768The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms
Q36974665The pharmacology of regenerative medicine
Q38213991The potential of mesenchymal stem cell in prion research.
Q36776231The promise and perils of stem cell therapeutics
Q44623113Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord
Q38457643Therapeutic effect of BDNF-overexpressing human neural stem cells (HB1.F3.BDNF) in a rodent model of middle cerebral artery occlusion.
Q92738249Therapeutic effect of transplantation of human bone marrow‑derived mesenchymal stem cells on neuron regeneration in a rat model of middle cerebral artery occlusion
Q48639806Therapeutic effects of stem cells and substrate reduction in juvenile Sandhoff mice
Q50420577Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings.
Q41180607Therapeutic potential of human amniotic membrane-derived mesenchymal stem cells in APP transgenic mice
Q38457655Therapeutic potential of human induced pluripotent stem cells in experimental stroke
Q38921243Therapeutic potential of neural stem cells: greater in people's perception than in their brains?
Q27008479Therapeutics with SPION-labeled stem cells for the main diseases related to brain aging: a systematic review
Q48109614Three-dimensional culture of single embryonic stem-derived neural/stem progenitor cells in fibrin hydrogels: neuronal network formation and matrix remodelling
Q39615475Three-dimensional growth matrix for human embryonic stem cell-derived neuronal cells
Q39308308Toll-interacting protein deficiency promotes neurodegeneration via impeding autophagy completion in high-fat diet-fed ApoE-/- mouse model
Q33797532Towards translational therapies for multiple system atrophy
Q43213548Traceable microRNA-124 loaded nanoparticles as a new promising therapeutic tool for Parkinson's disease.
Q34279124Tracking stem cell differentiation in the setting of automated optogenetic stimulation
Q64764573Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease
Q38957847Transfection of the glial cell line-derived neurotrophic factor gene promotes neuronal differentiation
Q35549624Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil
Q33863539Transplantation of neural differentiated human mesenchymal stem cells into the cochlea of an auditory-neuropathy guinea pig model
Q26825854Transplantation of stem cell-derived astrocytes for the treatment of amyotrophic lateral sclerosis and spinal cord injury
Q42055739Transplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord.
Q36790753Treating non-motor symptoms of Parkinson's disease with transplantation of stem cells
Q48713811Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells
Q33825966Ultrasound-mediated piezoelectric differentiation of neuron-like PC12 cells on PVDF membranes
Q41332082Using magnetic nanoparticles for gene transfer to neural stem cells: stem cell propagation method influences outcomes
Q35077617Varicella-zoster virus infection of differentiated human neural stem cells
Q35036530Viability, differentiation capacity, and detectability of super-paramagnetic iron oxide-labeled muscle precursor cells for magnetic-resonance imaging
Q35470460Vision from next generation sequencing: multi-dimensional genome-wide analysis for producing gene regulatory networks underlying retinal development, aging and disease
Q34714347What can pluripotent stem cells teach us about neurodegenerative diseases?
Q34033246Why is it so difficult to derive pluripotent stem cells in domestic ungulates?
Q34155662cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

Search more.