Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects.

scientific article published on 10 April 2018

Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.PNEUROBIO.2018.04.005
P932PMC publication ID6077089
P698PubMed publication ID29653250

P50authorSek Won KongQ58041273
P2093author name stringBob S Carter
Kwang-Soo Kim
Jeffrey Schweitzer
Bin Song
Nayeon Lee
Kai-C Sonntag
Young Cha
Pierre Leblanc
Jin Hyuk Jung
Carolyn Neff
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Donor-Specific Anti-HLA Antibodies in Huntington's Disease Recipients of Human Fetal Striatal GraftsQ45296825
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiencyQ45857796
Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis.Q45952942
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Nuclear transfer embryonic stem cells provide an in vitro culture model for Parkinson's disease.Q46132065
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On the origin of the term "stem cell".Q46520877
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Primate adult brain cell autotransplantation produces behavioral and biological recovery in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian St. Kitts monkeysQ46921956
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Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells.Q47666594
Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantationQ47734532
Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's diseaseQ47794452
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Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapyQ47888502
The Parkinson Pandemic-A Call to ActionQ47972031
Potential Pitfall of Pluripotent Stem CellsQ48000303
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.Q48132718
Maturation of human iPS cell-derived dopamine neuron precursors in alginate-Ca(2+) hydrogelQ48189107
Generation of germline-competent induced pluripotent stem cellsQ28131699
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
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Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's diseaseQ28275257
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Human induced pluripotent stem cells free of vector and transgene sequencesQ29547624
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Epidemiology of Parkinson's diseaseQ29614901
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingQ29615601
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagationQ29615640
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's diseaseQ29615682
A more efficient method to generate integration-free human iPS cellsQ29615748
Direct generation of functional dopaminergic neurons from mouse and human fibroblastsQ29616184
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Somatic coding mutations in human induced pluripotent stem cellsQ29616798
Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseQ29617304
Genome sequencing of mouse induced pluripotent stem cells reveals retroelement stability and infrequent DNA rearrangement during reprogrammingQ30413933
Human embryonic stem cells derived by somatic cell nuclear transfer.Q30544785
Efficient generation of human iPSCs by a synthetic self-replicative RNA.Q30558268
Adrenal medullary transplant to the striatum of patients with advanced Parkinson's disease: 1-year motor and psychomotor dataQ30570278
Remote control of induced dopaminergic neurons in parkinsonian rats.Q30581671
Increased genomic integrity of an improved protein-based mouse induced pluripotent stem cell method compared with current viral-induced strategiesQ33551989
Genetic background drives transcriptional variation in human induced pluripotent stem cellsQ33716774
Preclinical Analysis of Fetal Human Mesencephalic Neural Progenitor Cell Lines: Characterization and Safety In Vitro and In VivoQ33722449
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potencyQ33732735
The Immunogenicity and Immune Tolerance of Pluripotent Stem Cell DerivativesQ33753295
Metabolic requirements for the maintenance of self-renewing stem cellsQ33893346
Induced neuronal reprogrammingQ33904255
Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.Q33925878
Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cellsQ34019032
Reprogramming of mouse and human cells to pluripotency using mature microRNAs.Q34027071
Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's diseaseQ39519102
Management of tardive dyskinesiaQ39556122
Copy number variation and selection during reprogramming to pluripotencyQ39582693
Memory in Induced Pluripotent Stem Cells: Reprogrammed Human Retinal-Pigmented Epithelial Cells Show Tendency for Spontaneous RedifferentiationQ39649746
Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's diseaseQ39693665
Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensityQ39717297
Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescenceQ39739455
Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned ratsQ39788084
Reversal of dopaminergic degeneration in a parkinsonian rat following micrografting of human bone marrow-derived neural progenitorsQ39792829
Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: potential for restorative treatment in Parkinson's diseaseQ39898054
Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's diseaseQ39903811
Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cellsQ39993972
Marked differences in differentiation propensity among human embryonic stem cell linesQ40012772
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Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.Q40216832
Differential X Chromosome Inactivation Patterns during the Propagation of Human Induced Pluripotent Stem CellsQ40369134
Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells.Q40381244
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Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF.Q40519699
Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer.Q40809607
Cell Therapy for Parkinson's Disease: A Translational Approach to Assess the Role of Local and Systemic Immunosuppression.Q40839095
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Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.Q40942115
Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo.Q41018807
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X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation.Q41463591
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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.Q41964090
Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a non-human primateQ42072961
Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral ReprogrammingQ42180819
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?Q35966394
Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod PhotoreceptorsQ35990735
Immune problems in central nervous system cell therapy.Q36045396
Stem cells may reshape the prospect of Parkinson's disease therapy.Q36080015
Specification of midbrain dopamine neurons from primate pluripotent stem cellsQ36117009
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cellsQ36140488
Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's DiseaseQ36250893
Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expressionQ34030950
An integrative analysis of reprogramming in human isogenic system identified a clone selection criterion.Q34046292
Effect of human donor cell source on differentiation and function of cardiac induced pluripotent stem cellsQ34053605
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian ratsQ34115609
Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid.Q34156273
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.Q34175757
Passage number is a major contributor to genomic structural variations in mouse iPSCsQ34195138
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cellsQ34197304
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cellsQ34236195
Inhibition of pluripotent stem cell-derived teratoma formation by small moleculesQ34362039
Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditionsQ34373911
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.Q34416128
RIKEN suspends first clinical trial involving induced pluripotent stem cellsQ34493074
Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's diseaseQ34515645
Induced Pluripotent Stem Cells Meet Genome EditingQ34525438
Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reportsQ34530719
Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration.Q34553328
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in cultureQ34596358
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell linesQ34714112
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 yearsQ34768147
Local control of the host immune response performed with mesenchymal stem cells: perspectives for functional intracerebral xenotransplantationQ34885388
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitorsQ35002960
Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson diseaseQ35015732
ES cell-derived renewable and functional midbrain dopaminergic progenitors.Q35034938
A comparison of non-integrating reprogramming methodsQ35087542
Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectorsQ35180600
Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's diseaseQ35575249
Effects of Integrating and Non-Integrating Reprogramming Methods on Copy Number Variation and Genomic Stability of Human Induced Pluripotent Stem CellsQ35679665
Cell-based therapies for Parkinson disease—past insights and future potentialQ35736662
Human induced pluripotent stem cells in Parkinson's disease: A novel cell source of cell therapy and disease modelingQ35789181
Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation PotentialQ35896332
Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCsQ35905022
Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.Q35947502
Sequential bilateral transplantation in Parkinson's disease: effects of the second graftQ48194358
Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamenQ48200600
Nigral grafts in animal models of Parkinson's disease. Is recovery beyond motor function possible?Q48274245
Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains.Q48294409
Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's diseaseQ48405897
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditionsQ48435042
Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain.Q48543745
Co-administration of adenovirus vector expressing CTLA4-Ig prolongs transgene expression in the brain of mice sensitized with adenovirusQ48913603
Converting human skin cells to neurons: a new tool to study and treat brain disorders?Q48922209
Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era.Q50183713
Neurotrophic factor expression in expandable cell populations from brain samples in living patients with Parkinson's disease.Q50859562
An efficient method for the derivation of mouse embryonic stem cells.Q51306983
Polar Extremes in the Clinical Use of Stem Cells.Q52781958
Human embryonic stem cell-derived neural precursors as a continuous, stable, and on-demand source for human dopamine neurons.Q53562546
Parkinson's diseaseQ54072241
Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.Q54397059
Trials of embryonic stem cells to launch in ChinaQ59080264
Lewy body pathology in long-term fetal nigral transplants: is Parkinson's disease transmitted from one neural system to another?Q64876440
Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studiesQ67243403
Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formationQ82927480
Etiology and pathogenesis of Parkinson's diseaseQ84231134
Directed differentiation of dopamine neurons from human pluripotent stem cellsQ84712134
Deep-brain stimulation for Parkinson's diseaseQ85211794
Developing dopaminergic cell therapy for Parkinson's disease--give up or move forward?Q86096962
Concise review: Genomic instability in human stem cells: current status and future challenges.Q38235527
Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense?Q38253146
Direct lineage reprogramming: strategies, mechanisms, and applicationsQ38346530
The prion hypothesis of Parkinson's diseaseQ38418624
How to make a midbrain dopaminergic neuronQ38503992
In vitro and in vivo analyses of human embryonic stem cell-derived dopamine neuronsQ38515054
Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cellsQ38536402
Cell therapy for Parkinson's disease: Functional role of the host immune response on survival and differentiation of dopaminergic neuroblastsQ38560345
Clinical translation of stem cell transplantation in Parkinson's diseaseQ38579206
Direct somatic lineage conversionQ38594907
MHC matching improves engraftment of iPSC-derived neurons in non-human primatesQ38635387
Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD).Q38677985
Variability of human pluripotent stem cell lines.Q38694107
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutationsQ38705984
A decade of transcription factor-mediated reprogramming to pluripotencyQ38736148
Pluripotent stem cells progressing to the clinicQ38747535
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.Q38771932
A New, Dynamic Era for Somatic Cell Nuclear Transfer?Q38818717
Brain repair and reprogramming: the route to clinical translation.Q38829948
Looking to the future following 10 years of induced pluripotent stem cell technologiesQ38834610
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscienceQ38838046
Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural ProgenitorsQ38883920
Molecular Obstacles to Clinical Translation of iPSCsQ38906911
Genomic Instability of iPSCs: Challenges Towards Their Clinical ApplicationsQ38945910
iPSCs and fibroblast subclones from the same fibroblast population contain comparable levels of sequence variations.Q38975316
Neural Subtype Specification from Human Pluripotent Stem CellsQ38998787
Human induced pluripotent stem cell-derived neurons improve motor asymmetry in a 6-hydroxydopamine-induced rat model of Parkinson's diseaseQ39031960
Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's diseaseQ39116027
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's diseaseQ39235649
Neural grafting for Parkinson's disease: challenges and prospects.Q39282063
Factors affecting the clinical outcome after neural transplantation in Parkinson's diseaseQ39360071
Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's diseaseQ39397495
Assessing the Safety of Human Pluripotent Stem Cells and Their Derivatives for Clinical Applications.Q39430919
Dopamine release from nigral transplants visualized in vivo in a Parkinson's patientQ39434658
P921main subjectpluripotencyQ1894941
Parkinson's diseaseQ11085
P304page(s)1-20
P577publication date2018-04-11
P1433published inProgress in NeurobiologyQ15716615
P1476titlePluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects
P478volume168