Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice

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Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1036715545
P356DOI10.1038/GT.2009.80
P698PubMed publication ID19626053
P5875ResearchGate publication ID26689451

P2093author name stringH J Lee
B G Kim
I H Park
S U Kim
D H Hwang
J I Seok
I S Joo
P2860cites workTreatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.Q45879717
Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinase.Q46817719
Vascular endothelial growth factor prevents paralysis and motoneuron death in a rat model of excitotoxic spinal cord neurodegenerationQ46965352
Low levels of the vascular endothelial growth factor in CSF from early ALS patients.Q47376496
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS modelQ47427098
Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model.Q48199408
Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhageQ48244314
Effect of new O-superfamily conotoxin SO3 on sodium and potassium currents of cultured hippocampal neurons.Q48385868
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.Q51659718
Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis.Q54622823
Stem cell therapy in human ALSQ56929793
Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosisQ57244943
Intrathecal morphine in mice: a new techniqueQ71852099
Stem cells for Parkinson disease and ALS: replacement or protection?Q76390308
Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expressionQ80673128
Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patientsQ80729597
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activationQ22004269
VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotectionQ24302846
Stem cells for the treatment of neurological disordersQ28249501
Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cellsQ28570673
Vascular endothelial growth factor is a secreted angiogenic mitogenQ28646475
Neurotrophins and their receptors: a convergence point for many signalling pathwaysQ29616108
Directed differentiation of embryonic stem cells into motor neuronsQ29616200
Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionatorQ29619043
Amyotrophic lateral sclerosisQ29619516
Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult ratsQ30581117
Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis miceQ33698123
Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerationsQ34458377
Molecular and cellular pathways of neurodegeneration in motor neurone diseaseQ35489359
Stem-cell therapy for amyotrophic lateral sclerosis.Q35832769
Targets for vascular protection after acute ischemic strokeQ35850986
Human neural stem cells genetically modified for brain repair in neurological disordersQ35918287
Randomized control trials in ALS: lessons learnedQ35932089
Gene-based treatment of motor neuron diseasesQ36288219
Stem cell-based cell therapy for spinal cord injuryQ36893915
Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke modelQ40184078
Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson diseaseQ40278367
GDNF delivery using human neural progenitor cells in a rat model of ALS.Q40425197
Fate of immortalized human neuronal progenitor cells transplanted in rat spinal cord.Q40458312
Functional properties of motoneurons derived from mouse embryonic stem cells.Q40517622
Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington diseaseQ40543499
Arteriogenesis Induced by Intramyocardial Vascular Endothelial Growth Factor 165 Gene Transfer in Chronically Ischemic PigsQ44592507
Growth factors and nonparenchymal cell conditioned media induce mitogenic responses in stable long-term adult rat hepatocyte culturesQ44732718
Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury.Q44816539
Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS.Q45076564
Entrance in mitosis of adult cardiomyocytes in ischemic pig hearts after plasmid-mediated rhVEGF165 gene transferQ45856834
Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheepQ45857099
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic deathQ45863485
Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouseQ45869109
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.Q45877621
P433issue10
P921main subjectamyotrophic lateral sclerosisQ206901
neural stem cellQ2944097
overexpressionQ61643320
P304page(s)1234-1244
P577publication date2009-07-23
P1433published inGene TherapyQ15763095
P1476titleIntrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice
P478volume16

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