CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells.

scientific article published in November 2003

CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0896-8411(03)00114-8
P698PubMed publication ID14599847

P50authorBhagirath SinghQ57196187
P2093author name stringHui-Yu Qin
Pratibha Chaturvedi
Rinee Mukherjee
P2860cites workCD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanismsQ24673863
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppressionQ33338215
Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)Q33592891
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
IFN-gamma production by antigen-presenting cells: mechanisms emerge.Q34382913
Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation toleranceQ34448410
Control of T-cell activation by CD4+ CD25+ suppressor T cellsQ34448423
The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.Q34452348
Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor betaQ34517421
Transforming growth factor-beta in T-cell biologyQ34572232
Multiple roles for tumor necrosis factor-alpha and lymphotoxin alpha/beta in immunity and autoimmunityQ34731168
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulinQ36007054
T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD miceQ36356330
CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cellsQ36361889
Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic miceQ36361909
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulationQ36367099
Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cellsQ36367622
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiationQ36369726
Maturation stages of mouse dendritic cells in growth factor-dependent long-term culturesQ36376739
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patientsQ37356987
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.Q37683001
Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.Q37925551
Insulin-dependent diabetes mellitus as a beta-cell targeted disease of immunoregulationQ40377775
Tumour necrosis factor-alpha but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiationQ40678768
Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigenQ40701079
T regulatory cells 1 inhibit a Th2-specific response in vivoQ40846695
Origin, maturation and antigen presenting function of dendritic cells.Q40906220
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecificQ40910998
Induction of apoptosis in mature T cells by tumour necrosis factorQ41293478
The role of TNF alpha and related cytokines in the development and function of the autoreactive T-cell repertoireQ41628498
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive stateQ42466421
Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor poolQ42657755
Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic miceQ46570289
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependencyQ47992795
TGF-β1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expressionQ56987564
The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young malesQ68087911
Antigen based therapies to prevent diabetes in NOD miceQ71557201
Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in nonobese diabetic miceQ73258353
Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic miceQ73289663
Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell developmentQ73311881
A self MHC class II beta-chain peptide prevents diabetes in nonobese diabetic miceQ73869271
A dual role for TNF-alpha in type 1 diabetes: islet-specific expression abrogates the ongoing autoimmune process when induced late but not early during pathogenesisQ73966607
Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulationQ74080415
T cell memoryQ74578125
The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7Q74650540
Protection from insulin dependent diabetes mellitus afforded by insulin antigens in incomplete Freund's adjuvant depends on route of administrationQ74741683
Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cellsQ77291206
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitisQ78404404
P433issue3
P921main subjectpreproinsulinQ7240673
P304page(s)221-237
P577publication date2003-11-01
P1433published inJournal of AutoimmunityQ15716783
P1476titleCD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells
P478volume21

Reverse relations

cites work (P2860)
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