A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

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A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. is …
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review articleQ7318358
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P6179Dimensions Publication ID1020329526
P356DOI10.1038/NI1179
P698PubMed publication ID15785758
P5875ResearchGate publication ID7949360

P50authorAlexander RudenskyQ21012878
P2093author name stringJason D Fontenot
P2860cites workDisruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activationQ24291515
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cellsQ24306205
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndromeQ24626901
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cellsQ24645614
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
The amount of scurfin protein determines peripheral T cell number and responsivenessQ28504592
Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genesQ28509666
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Q28591451
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyQ29619109
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfQ29619194
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Selecting and maintaining a diverse T-cell repertoireQ33783983
The third function of the thymus.Q33826591
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationQ33876035
Regulatory T cells in autoimmmunity*.Q33904108
Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotypeQ34065191
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Interleukin 2 signaling is required for CD4(+) regulatory T cell functionQ34527240
Interleukin-2 is essential for CD4+CD25+ regulatory T cell functionQ34550108
Human T regulatory cells can use the perforin pathway to cause autologous target cell deathQ34551876
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.Q34554035
Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in MiceQ34705919
CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasisQ35159540
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitroQ35171080
Development and function of CD25+CD4+ regulatory T cellsQ35692191
Tolerance, not immunity, crucially depends on IL-2.Q35877199
Self-representation in the thymus: an extended viewQ35877206
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetesQ35978587
Mechanisms of suppression by suppressor T cellsQ36078047
The role of TCR specificity in naturally arising CD25+ CD4+ regulatory T cell biologyQ36176101
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulationQ36367099
Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cellsQ36369536
T cell regulation as a side effect of homeostasis and competitionQ36370619
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsivenessQ36370807
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivoQ36371283
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.Q36371658
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.Q36399562
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitisQ36401257
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune diseaseQ36672085
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activationQ37358144
Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic educationQ37537286
Regulatory potential and control of Foxp3 expression in newborn CD4+ T cellsQ37569057
Do suppressor T cells exist?Q39485474
Suppressor Cells and ImmunoregulationQ40119140
Lck activity controls CD4/CD8 T cell lineage commitment.Q41729181
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive stateQ42466421
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell functionQ46468450
Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cellsQ47240613
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor functionQ47579310
Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.Q47726082
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependencyQ47992795
Peptide specificity of thymic selection of CD4+CD25+ T cells.Q51058071
Mature T cells depend on signaling through the IKK complex.Q52005562
CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations.Q52165458
Allergy and ImmunologyQ56019729
Cutting Edge: TGF- Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T CellsQ58131166
TGF regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivoQ58131190
Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epitheliumQ59652622
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic miceQ71641038
CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10Q73509865
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideQ73688337
Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cellsQ74137391
Origin of regulatory T cells with known specificity for antigenQ74381747
T cell regulation: a special job or everyone's responsibility?Q74433979
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivoQ77342616
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expressionQ77995835
Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activityQ78701749
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptorsQ80444910
CD25- T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansionQ81111400
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)331-337
P577publication date2005-04-01
P1433published inNature ImmunologyQ1071725
P1476titleA well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.
P478volume6