CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer

scientific article published on February 2006

CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.176.3.1582
P698PubMed publication ID16424187
P5875ResearchGate publication ID7348940

P50authorMark J. SmythQ38544864
Dale I GodfreyQ56957983
P2093author name stringYoshihiro Hayakawa
Michele W L Teng
Jeremy Swann
Konstantinos Kyparissoudis
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectimmunotherapyQ1427096
P304page(s)1582-1587
P577publication date2006-02-01
P1433published inJournal of ImmunologyQ3521441
P1476titleCD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer
P478volume176

Reverse relations

cites work (P2860)
Q35512402A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas.
Q38227889A new hope in immunotherapy for malignant gliomas: adoptive T cell transfer therapy
Q37769443A new role for T cells in dampening innate inflammatory responses
Q38730855A novel method for assaying human regulatory T cell direct suppression of B cell effector function.
Q40117289A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.
Q36449146Activated mouse CD4+Foxp3− T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity
Q41085383Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
Q28744029Activation of Cytotoxic and Regulatory Functions of NK Cells by Sindbis Viral Vectors
Q64998492Adaptive NK Cells Resist Regulatory T-cell Suppression Driven by IL37.
Q33912853Adaptive control of innate immunity
Q35269067Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression
Q39969906Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10.
Q84086506Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency
Q50320917An attempt to induce an immunomodulatory effect in rowers with spirulina extract.
Q36916476Anti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cells
Q45857655Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1.
Q27000514Antibody-based immunotherapy for ovarian cancer: where are we at?
Q42185296Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation?
Q85895064Associations Between Infiltrating Lymphocyte Subsets and Hepatocellular Carcinoma
Q38151057At the Bench: Preclinical rationale for exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias
Q48834589Augmented anti-tumor activity of NK-92 cells expressing chimeric receptors of TGF-βR II and NKG2D.
Q36546883Autologous stem cell transplant recipients tolerate haploidentical related‐donor natural killer cell–enriched infusions
Q43418649B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion
Q39134212Blocking transforming growth factor-β signaling pathway augments antitumor effect of adoptive NK-92 cell therapy
Q37234615Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells
Q37346143Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells.
Q34091467CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice
Q34624101CD4 +CD25 + regulatory T cells decreased the antitumor activity of cytokine-induced killer (CIK) cells of lung cancer patients
Q37317928CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus
Q41677003CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-β and OX40.
Q36915014CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer
Q36600237CD4+CD25+ regulatory T cell therapy for the induction of donor-specific clinical transplantation tolerance
Q37754524CD4+CD25+ regulatory T-cell therapy
Q64976727CD4+CD25+Foxp3+ regulatory T cells suppress NKG2D-mediated NK cell cytotoxicity in peripheral blood.
Q30445860CD86 is an activation receptor for NK cell cytotoxicity against tumor cells
Q35674757CTLA-4⁺ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis
Q37315667Can NK cells be a therapeutic target in human cancer?
Q38114594Cellular therapy of cancer with natural killer cells—where do we stand?
Q38102783Clinical application of regulatory T cells in type 1 diabetes.
Q36696647Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunotherapy
Q37327064Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responses
Q26781260Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress
Q37268005Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation
Q37771915Cytokine regulation of natural killer cell effector functions
Q61903522Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity
Q36764903Dendritic cell-based active specific immunotherapy for malignant glioma
Q40176032Depletion of CD4+CD25+ regulatory T cells enhances interleukin-2-induced antitumor immunity in a mouse model of colon adenocarcinoma
Q33688225Differential effects of IL-2 and IL-21 on expansion of the CD4+ CD25+ Foxp3+ T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic lymphocytic leukemia
Q40832649Disturbed Th17/Treg Balance in Patients with Non-small Cell Lung Cancer
Q82849384Do adaptive immune cells suppress or activate innate immunity?
Q35632112Early detection of breast cancer using total biochemical analysis of peripheral blood components: a preliminary study
Q36422943Effective modulation of CD4+CD25+high regulatory T and NK cells in malignant patients by combination of interferon-α and interleukin-2
Q37038163Effects of first-line chemotherapy on natural killer cells in adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma.
Q36486882Emerging possibilities in the development and function of regulatory T cells
Q28069422Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
Q40039638Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells
Q36471068Epigenetic regulation of immune escape genes in cancer
Q93081879Evaluation of quantitative changes in regulatory T cells in peripheral blood of kidney transplant recipients with skin cancer after conversion to mTOR inhibitors
Q56899556Foxp3-transduced polyclonal regulatory T cells suppress NK cell functions in a TGF-beta dependent manner
Q29614300Functions of natural killer cells
Q35208414Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
Q39476748Human tumor-induced and naturally occurring Treg cells differentially affect NK cells activated by either IL-2 or target cells
Q34651540IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells
Q82292256Identification of a unique double-negative regulatory T-cell population
Q26991724Immune cell promotion of metastasis
Q37993738Immune modulation of inflammatory conditions: regulatory T cells for treatment of GvHD
Q35050810Immune profiling and cancer post transplantation
Q35719883Immunosurveillance and therapy of multiple myeloma are CD226 dependent
Q35952087Impact of dietary components on NK and Treg cell function for cancer prevention
Q43263198Impairment in cytotoxicity and expression of NK cell- activating receptors on human NK cells following exposure to asbestos fibers
Q91708036Impairment of NKG2D-Mediated Tumor Immunity by TGF-β
Q34382955Induction of Immune Tolerance to a Therapeutic Protein by Intrathymic Gene Delivery
Q91759706Infectivity of GII.4 human norovirus does not differ between T-B-NK+ severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection
Q37000445Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs
Q46385904Inhibition of phosphoantigen-mediated gammadelta T-cell proliferation by CD4+ CD25+ FoxP3+ regulatory T cells
Q34550147Innate immune recognition and suppression of tumors
Q28068375Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells
Q93018628Integration analysis for novel lncRNA markers predicting tumor recurrence in human colon adenocarcinoma
Q27008625Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy
Q38240762Interactions between innate and adaptive lymphocytes.
Q41897122Interleukin-17D mediates tumor rejection through recruitment of natural killer cells
Q37930988Intestinal inflammation and colorectal cancer: a double-edged sword?
Q37996368Investigation of NK cell function and their modulation in different malignancies.
Q43865719Leveraging natural killer cells for cancer immunotherapy
Q35224136Liposome-encapsulated CpG enhances antitumor activity accompanying the changing of lymphocyte populations in tumor via intratumoral administration
Q52353493Local Immunotherapy of Cancer: Innovative Approaches to Harnessing Tumor-Specific Immune Responses.
Q36608731Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer
Q64259394Memory NK Cell Features Exploitable in Anticancer Immunotherapy
Q34847859Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells.
Q39281058MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver.
Q50671091Molecular Mechanisms of Regulatory T Cell Development and Suppressive Function
Q42200876Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells.
Q26823251Myeloid Suppressor Cells and Immune Modulation in Lung Cancer
Q83402971NK Cell Adoptive Transfer Combined with Ontak-Mediated Regulatory T Cell Elimination Induces Effective Adaptive Antitumor Immune Responses
Q40048056NK Cell Effector Functions Regulation by Modulating nTreg Cell Population During Progressive Growth of Dalton's Lymphoma in Mice
Q61811846NK Cell-Based Immunotherapy in Cancer Metastasis
Q37101325NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Q37315670NK cells and Treg cells: a fascinating dance cheek to cheek
Q39236283NK cells from malignant pleural effusions are not anergic but produce cytokines and display strong antitumor activity on short‐term IL‐2 activation
Q38036202NK cells: key to success of DC-based cancer vaccines?
Q35915642NK-dependent increases in CCL22 secretion selectively recruits regulatory T cells to the tumor microenvironment
Q39196323NKG2D ligand expression in pediatric brain tumors.
Q27014888NKG2D ligands as therapeutic targets
Q37287179NKG2D ligands in tumor immunity
Q38194944NKG2D signaling in cancer immunosurveillance
Q87354087Nanoparticle immunotherapy: Combo combat
Q37959322Natural Killer (NK) Cells in Antibacterial Innate Immunity: Angels or Devils?
Q33754724Natural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients
Q37996816Natural killer cell immune escape in acute myeloid leukemia.
Q38169654Natural killer cells and regulatory T cells: how to manipulate a graft for optimal GVL.
Q37866598Natural killer cells and solid tumors.
Q37524719Natural killer cells in allogeneic transplantation: effect on engraftment, graft- versus-tumor, and graft-versus-host responses
Q56898695Neem Leaf Glycoprotein Inhibits CD4 + CD25 + Foxp3 + Tregs to Restrict Murine Tumor Growth
Q27001081Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses
Q21560837Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth
Q36127288Nuclear receptors as modulators of the tumor microenvironment
Q48032304Overcoming immune tolerance against multiple myeloma with lentiviral calnexin-engineered dendritic cells
Q42149012Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells
Q36652177Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity
Q55401142Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice.
Q37287156Positive and negative influences of regulatory T cells on tumour immunity.
Q54278437Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand
Q37379967Potential role of NKG2D and its ligands in organ transplantation: new target for immunointervention
Q33769545Prediction of antiviral efficacy in patients with chronic hepatitis C by changes in forkhead box protein 3 levels
Q36057599Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
Q46113809Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation
Q33713903Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity
Q37256962Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells
Q43166710Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells.
Q26991447Regulatory T cell: a protection for tumour cells
Q45243164Regulatory T cells and NK cells in cancer patients
Q34651528Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.
Q38020963Regulatory T cells in the central nervous system
Q37691776Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?
Q38640091Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.
Q39418860Regulatory T cells inhibit Fas ligand-induced innate and adaptive tumour immunity.
Q28475223Regulatory T cells suppress natural killer cells during plasmid DNA vaccination in mice, blunting the CD8+ T cell immune response by the cytokine TGFbeta
Q35384216Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression
Q39210022Role of Distinct Natural Killer Cell Subsets in Anticancer Response
Q60489259Roles of the RANKL–RANK axis in antitumour immunity — implications for therapy
Q92317164STAT3 Modulation of Regulatory T Cells in Response to Radiation Therapy in Head and Neck Cancer
Q37281838Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
Q38067641Shaping of NK cell responses by the tumor microenvironment
Q59255570Some latest achievements in immunology research
Q26996034Subsets of human natural killer cells and their regulatory effects
Q34600272Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells
Q36907905T cell regulation of natural killer cells
Q28263622TGF-beta: a mobile purveyor of immune privilege
Q39155158TGF-β Family Signaling in Tumor Suppression and Cancer Progression.
Q34205905TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence
Q38005176Targeting NKG2D in tumor surveillance
Q30413623Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer
Q38829849Targeting natural killer cells in cancer immunotherapy
Q36975757The 'kiss of death' by dendritic cells to cancer cells
Q58700856The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10 Regulatory T Cells During Acute Retroviral Infection
Q57166654The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy
Q26774875The Role of Immune Cells in Chronic HBV Infection
Q36101238The Role of Regulatory T Cells in Mesothelioma.
Q57816901The Role of the Extracellular Matrix and Its Molecular and Cellular Regulators in Cancer Cell Plasticity
Q33608606The Treg/Th17 paradigm in lung cancer
Q34343645The Tumor Microenvironment in Colorectal Carcinogenesis
Q36694921The interaction between murine melanoma and the immune system reveals that prolonged responses predispose for autoimmunity
Q37638179The natural killer cell: a further innate mediator of gouty inflammation?
Q58211845The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2α but not HIF-1α
Q36652214The role of regulatory T cells in the control of natural killer cells: relevance during tumor progression
Q37452411The role of tregs in glioma-mediated immunosuppression: potential target for intervention.
Q28261890The roles of Galectin-3 in autoimmunity and tumor progression
Q84192939The variation of CD4+CD25+ regulatory T cells in the periphery blood and tumor microenvironment of non-small cell lung cancer patients and the downregulation effects induced by CpG ODN
Q39726876Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance
Q33712568Transforming growth factor beta (TGF-beta) and inflammation in cancer
Q39254820Transient Foxp3(+) regulatory T-cell depletion enhances therapeutic anticancer vaccination targeting the immune-stimulatory properties of NKT cells
Q52373701Treg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration
Q33330270Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials
Q40113311Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.
Q36997144Tumor stress, cell death and the ensuing immune response.
Q36516410Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer
Q89622537Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment
Q40047650Use of natural killer cells as immunotherapy for leukaemia.
Q37037667Virus-based immunotherapy of cancer: what do we know and where are we going?
Q41114263Visualization of Tumor-Immune Interaction - Target-Specific Imaging of S100A8/A9 Reveals Pre-Metastatic Niche Establishment

Search more.