Natural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients

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Natural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS18050856
P932PMC publication ID5454809
P698PubMed publication ID28513532

P50authorRodrigo F da SilvaQ50558813
Sophie F. DerchainQ50558827
Fernando GuimarãesQ60634851
Silke PaustQ77404691
Rodrigo Menezes JalesQ83732265
P2093author name stringDaniela Maira Cardozo
Adriana Yoshida
P2860cites workCancer statistics, 2015Q27860576
Targeted immune therapy of ovarian cancerQ28082828
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Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cellsQ28260343
Natural killer cells in human solid tumorsQ40110364
CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancerQ40327394
Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cellsQ40424164
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathwayQ40788629
Malignant ascitesQ41000476
Up-regulation of DNAM-1 and NKp30, associated with improvement of NK cells activation after long-term culture of mononuclear cells from patients with ovarian neoplasiaQ45865576
Clinical significance of ascites in epithelial ovarian cancer.Q45945444
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients.Q50769683
NK- and B-cell infiltration correlates with worse outcome in metastatic ovarian carcinoma.Q53257187
Isolation and characterization of human natural killer cell subsets.Q53481399
Social support, psychological distress, and natural killer cell activity in ovarian cancer.Q53655521
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinomaQ56904280
Identification of FOXP3-negative regulatory T-like (CD4+CD25+CD127low) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndromeQ56963542
DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer CellsQ57226771
Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFα in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapQ57904741
NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cellsQ61953868
Recombinant IL-2-activated NK cells mediate LAK activity against ovarian cancerQ68096412
Natural immunity against ovarian tumorsQ68810929
Natural killer cell activity in patients with ovarian tumors and uterine myomasQ72498723
Clinical impact of tumor-infiltrating lymphocytes for survival in curatively resected stage IV colon cancer with isolated liver or lung metastasisQ85639677
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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
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MUC16 (CA125): tumor biomarker to cancer therapy, a work in progressQ33713506
Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cellsQ33901387
„Natural” killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cellQ33906475
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Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumorsQ34442318
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.Q34515741
Human T regulatory cells can use the perforin pathway to cause autologous target cell deathQ34551876
Immune response in ovarian cancer: how is the immune system involved in prognosis and therapy: potential for treatment utilizationQ34557233
Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3.Q35195777
Unravelling natural killer cell function: triggering and inhibitory human NK receptorsQ35611389
B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escapeQ35798978
Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis.Q35818203
Activated CD4+CD25+ T cells selectively kill B lymphocytesQ35848308
Mechanisms of suppression by suppressor T cellsQ36078047
B7-H6 expression correlates with cancer progression and patient's survival in human ovarian cancerQ36095328
Ovarian cancer metastasis: integrating insights from disparate model organismsQ36111930
Regulatory T cells in ovarian cancer: biology and therapeutic potentialQ36321305
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent mannerQ36403637
Tumor and viral recognition by natural killer cells receptorsQ36558852
Anti-ovarian tumor response of donor peripheral blood mononuclear cells is due to infiltrating cytotoxic NK cellsQ36916476
Negative signaling by inhibitory receptors: the NK cell paradigmQ36983705
Tumor necrosis factor and cancer, buddies or foes?Q37073092
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic toleranceQ37106789
Functional analysis of human NK cells by flow cytometry.Q37143310
The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cellsQ37186494
Getting to know ovarian cancer ascites: opportunities for targeted therapy-based translational researchQ37196532
The immune system in the pathogenesis of ovarian cancerQ37613407
Ovarian cancer creates a suppressive microenvironment to escape immune eliminationQ37689997
B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumorsQ37923837
Targeting cancer-derived adenosine: new therapeutic approachesQ38230818
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.Q39531156
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
P577publication date2017-05-17
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleNatural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients
P478volume18

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cites work (P2860)
Q47121377Interleukin 6 Present in Inflammatory Ascites from Advanced Epithelial Ovarian Cancer Patients Promotes Tumor Necrosis Factor Receptor 2-Expressing Regulatory T Cells
Q92800249NK Cells in Ascites From Liver Disease Patients Display a Particular Phenotype and Take Part in Antibacterial Immune Response
Q58582595Peritoneal NK cells are responsive to IL-15 and percentages are correlated with outcome in advanced ovarian cancer patients
Q47773956Revisiting ovarian cancer microenvironment: a friend or a foe?
Q64256318Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer
Q90189356Three-Dimensional Cell Culture Based on Magnetic Fields to Assemble Low-Grade Ovarian Carcinoma Cell Aggregates Containing Lymphocytes

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