Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade.

scientific article published on 14 September 2003

Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM931
P698PubMed publication ID14502279
P5875ResearchGate publication ID9087246

P50authorElizabeth SimpsonQ15968540
Steven H SacksQ60712059
P2093author name stringJulian Dyson
Stipo Jurcevic
Conrad A Farrar
Maggie Millrain
James E Marsh
Roseanna E G Hargreaves
Nicola J Monk
P2860cites workCD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Phenotypic analysis of antigen-specific T lymphocytesQ28290058
Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunityQ33703237
Current trends in transplant immunologyQ33716996
Transplantation tolerance-where do we stand?Q33764678
The role of T cell apoptosis in transplantation tolerance.Q34046810
Novel, non-antigen-specific therapeutic approaches to autoimmune/inflammatory diseasesQ34096275
The role of peripheral T-cell deletion in transplantation toleranceQ34262660
An H-YDb epitope is encoded by a novel mouse Y chromosome geneQ34409498
The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloningQ34425408
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primatesQ34433847
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosisQ36028683
In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactionsQ36362569
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memoryQ36363299
Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.Q37387592
T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive stateQ38173933
Predominant role for C5b-9 in renal ischemia/reperfusion injury.Q40437461
Examination of HY response: T cell expansion, immunodominance, and cross-priming revealed by HY tetramer analysisQ40779426
Interleukin-2 receptor-directed therapies: antibody-or cytokine-based targeting moleculesQ40897983
The role of CD40 ligand in costimulation and T-cell activationQ41332099
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.Q54073234
Failure of combined costimulatory blockade in animal transplant modelQ56906306
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent mannerQ56906395
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathwaysQ56908985
CD40 ligand-independent B cell activation revealed by CD40 ligand-deficient T cell clones: evidence for distinct activation requirements for antibody formation and B cell proliferationQ61268446
Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation ToleranceQ61651670
T cells are just dying to accept graftsQ63408399
A cell culture model for T lymphocyte clonal anergyQ67299314
Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic miceQ68074352
Mice deficient for the CD40 ligandQ72610555
Thromboembolic complications after treatment with monoclonal antibody against CD40 ligandQ73401367
Reply to failure of combined costimulatory blockade in animal transplant modelQ73401375
Monoclonal antibody therapies-a 'constant' threat to cancerQ73606520
Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioningQ73910639
Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance inductionQ74191513
The allogeneic T and B cell response is strongly dependent on complement components C3 and C4Q74623666
Graft tolerance: a duel of two signalsQ77890098
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primatesQ77890140
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)1275-1280
P577publication date2003-09-14
P1433published inNature MedicineQ1633234
P1476titleFc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
P478volume9

Reverse relations

cites work (P2860)
Q93368314Ablation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade
Q34870978An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig.
Q39265882Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation
Q34166913Antibody-mediated depletion of lymphocyte-activation gene-3 (LAG-3(+) )-activated T lymphocytes prevents delayed-type hypersensitivity in non-human primates.
Q51797602Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model.
Q90154642CD11b is a novel alternate receptor for CD154 during alloimmunity
Q35318823CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes
Q36339318CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules
Q42876261CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase
Q37801909Co-stimulation blockade as a new strategy in kidney transplantation: benefits and limits.
Q42820665Combined Application of Blocking Antibodies and MicroRNA Interference in Inhibiting CD44 Expression
Q34361871Costimulation blockade inhibits allergic sensitization but does not affect established allergy in a murine model of grass pollen allergy
Q34187594Costimulatory pathways in transplantation
Q59387560Critical role of the calpain/calpastatin balance in acute allograft rejection
Q37316082Depleting T-cell subpopulations in organ transplantation
Q35223846Differential outcomes in prediabetic vs. overtly diabetic NOD mice nonmyeloablatively conditioned with costimulatory blockade
Q38515353Differential sensitivity of regulatory and effector T cells to cell death: a prerequisite for transplant tolerance.
Q56900682Enhancement of T cell activation by immobilized hu5C8 (anti-CD40L) monoclonal antibody
Q37019142Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure
Q50948280Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection.
Q38751293First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 6: patient selection for pilot clinical trials of islet xenotra
Q36689232From current immunosuppressive strategies to clinical tolerance of allografts
Q83940098From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis
Q37755305Functional dichotomy of NK cells in organ transplantation
Q45732570Gene transfer of human CD40Ig does not prevent rejection in a non-human primate kidney allotransplantation model
Q34015403Germinal center B cell depletion diminishes CD4+ follicular T helper cells in autoimmune mice
Q36838049Glucocorticoid-induced TNFR-related protein stimulation reverses cardiac allograft acceptance induced by CD40-CD40L blockade
Q36540470IL-10 from marginal zone precursor B cells controls the differentiation of Th17, Tfh and Tfr cells in transplantation tolerance
Q34873028IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice
Q46009385Indefinite mouse heart allograft survival in recipient treated with CD4(+)CD25(+) regulatory T cells with indirect allospecificity and short term immunosuppression.
Q57983040Inducing Tolerance to a Soluble Foreign Antigen by Encapsulated Cell Transplants
Q54297363Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing.
Q45884021Induction of donor-specific tolerance in sublethally irradiated recipients by gene therapy
Q37075945Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo
Q36001633Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance
Q34309101Intermittent antibody-based combination therapy removes alloantibodies and achieves indefinite heart transplant survival in presensitized recipients.
Q30577194Laminins affect T cell trafficking and allograft fate
Q38742520Modulation of cytotoxic responses by targeting CD160 prolongs skin graft survival across major histocompatibility class I barrier
Q38316361Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade.
Q35675449Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates
Q38445344Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance
Q37259532OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade
Q54283965Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade.
Q37691776Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?
Q26769878Report from IPITA-TTS Opinion Leaders Meeting on the Future of β-Cell Replacement
Q33947967Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
Q37610449Role of IDO in organ transplantation: promises and difficulties
Q80015991Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection
Q37043717Special regulatory T-cell review: Regulation of immune responses--examining the role of T cells
Q37400003Strategic nonmyeloablative conditioning: CD154:CD40 costimulatory blockade at primary bone marrow transplantation promotes engraftment for secondary bone marrow transplantation after engraftment failure
Q38837473T Cell Cosignaling Molecules in Transplantation
Q36251293T cell tolerance induced by therapeutic antibodies
Q33920121T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway
Q36568502TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance
Q37562436TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts
Q38150101Targeting co-stimulatory pathways: transplantation and autoimmunity
Q35596631The CD40/CD40L costimulatory pathway in inflammatory bowel disease
Q36984472The classical complement pathway in transplantation: unanticipated protective effects of C1q and role in inductive antibody therapy
Q36530319The last 5 years of basic science investigation in transplant immunology
Q61651660The new immunosuppression: just kill the T cell
Q38013049The role of complement in the early immune response to transplantation.
Q37474964Translating costimulation blockade to the clinic: lessons learned from three pathways
Q37359067Transplant acceptance following anti-CD4 versus anti-CD40L therapy: evidence for differential maintenance of graft-reactive T cells
Q36406567Transplant tolerance: models, concepts and facts
Q35887823Transplantation of hematopoietic stem cells for induction of unresponsiveness to organ allografts
Q55221876Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity.

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