Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner

scientific article published on 01 January 2000

Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.164.1.512
P698PubMed publication ID10605049

P2093author name stringN E Phillips
A A Rossini
D L Greiner
J P Mordes
T G Markees
N N Iwakoshi
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)512-521
P577publication date2000-01-01
P1433published inJournal of ImmunologyQ3521441
P1476titleTreatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner
P478volume164

Reverse relations

cites work (P2860)
Q79312305Allogeneic parenchymal and hematopoietic tissues differ in their ability to induce deletion of donor-reactive T cells
Q79125739Alloimmune Injury and Rejection of Human Skin Grafts on Human Peripheral Blood Lymphocyte–Reconstituted Non-Obese Diabetic Severe Combined Immunodeficient β2-Microglobulin-Null Mice
Q46755803Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death
Q34382303Allospecific CD154+ T cells associate with rejection risk after pediatric liver transplantation
Q28349898An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection
Q48004570Anti-CD45RB and donor-specific spleen cells transfusion inhibition allograft skin rejection mediated by memory T cells
Q35650992Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade
Q73668003Blockade of CD154 at the time of donor-specific blood transfusion does not improve kidney graft survival in rhesus monkeys
Q42907214CD154 blockade abrogates allospecific responses and enhances CD4(+) regulatory T-cells in mouse orthotopic lung transplant
Q37308134CD154 deficiency uncouples allograft CD8+ T-cell effector function from proliferation and inhibits murine airway obliteration
Q37781118CD47 in xenograft rejection and tolerance induction
Q36897526CD47 is required for suppression of allograft rejection by donor-specific transfusion
Q37190095CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein.
Q37157989CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
Q56904684CTLA-41g in combination with anti-CD40L prolongs xenograft survival and inhibits anti-gal ab production in GT-Ko mice
Q30573064Central memory CD8+ T lymphocytes mediate lung allograft acceptance.
Q33241067Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning
Q36491890Costimulatory blockade of CD154-CD40 in combination with T-cell lymphodepletion results in prevention of allogeneic sensitization
Q36468274Cytotoxic effector function of CD4-independent, CD8(+) T cells is mediated by TNF-α/TNFR.
Q38515353Differential sensitivity of regulatory and effector T cells to cell death: a prerequisite for transplant tolerance.
Q58726665Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance
Q36262113Donor bone marrow cells are essential for iNKT cell-mediated Foxp3+ Treg cell expansion in a murine model of transplantation tolerance
Q56902663Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation
Q46898362Effect of immunosuppressants on the expansion and function of naturally occurring regulatory T cells
Q36328926Facilitating physiologic self-regeneration: a step beyond islet cell replacement
Q44591644Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade.
Q35539009Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice
Q35679173Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
Q37023032Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice
Q33608752Immunization with host-type CD8{alpha}+ dendritic cells reduces experimental acute GVHD in an IL-10-dependent manner
Q47122472Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin
Q35583502In remembrance of things past: memory T cells and transplant rejection
Q46054318Inability to induce tolerance through direct antigen presentation
Q35179356Induction of tolerance for islet transplantation for type 1 diabetes
Q38491611Induction of transplantation tolerance converts potential effector T cells into graft-protective regulatory T cells.
Q35038079Induction of transplantation tolerance in non-human primate preclinical models
Q34364120LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
Q44482849Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L.
Q30577194Laminins affect T cell trafficking and allograft fate
Q33525541Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells
Q74415772Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells
Q34786946Mechanisms of transplant tolerance induction using costimulatory blockade
Q36095846Memory T cells and their exhaustive differentiation in allograft tolerance and rejection
Q44200460New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.
Q35901211Peripheral deletion of mature alloreactive B cells induced by costimulation blockade
Q73668242Primate skin allotransplantation with anti-CD154 monotherapy
Q52011668Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice.
Q44033349Prolongation of fully allogeneic skin graft survival in the rat by combined administration of costimulatory blockade and sirolimus.
Q37170972Protein kinase C signaling during T cell activation induces the endoplasmic reticulum stress response
Q37068128Rapid dendritic cell activation and resistance to allotolerance induction in anti-CD154-treated mice receiving CD47-deficient donor-specific transfusion
Q37721479Recent progress and new perspectives in studying T cell responses to allografts
Q33947967Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
Q39178547Role of Memory T Cells in Allograft Rejection and Tolerance
Q37494823Skin allograft maintenance in a new synchimeric model system of tolerance
Q36251293T cell tolerance induced by therapeutic antibodies
Q35583511T-cell costimulatory pathways in allograft rejection and tolerance
Q26865338T-cell exhaustion in allograft rejection and tolerance
Q36568502TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance
Q37562436TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts
Q37290406TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Q37266849TNF superfamily: costimulation and clinical applications
Q26851647Tempering allorecognition to induce transplant tolerance with chemically modified apoptotic donor cells
Q35583506The balance of deletion and regulation in allograft tolerance.
Q74464420The immunobiology of inductive anti-CD40L therapy in transplantation: allograft acceptance is not dependent upon the deletion of graft-reactive T cells
Q78339275The nature and mechanisms of DN regulatory T-cell mediated suppression
Q61651660The new immunosuppression: just kill the T cell
Q35128263The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
Q34269503Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.
Q83460631Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells
Q34786072Tolerance through bone marrow transplantation with costimulation blockade
Q36004707Tolerance-inducing strategies in islet transplantation
Q39289936Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice
Q86018709Transitional-2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival
Q42091259Transplantation survival is maintained by granzyme B+ regulatory cells and adaptive regulatory T cells
Q36915471Transplantation tolerance: lessons from experimental rodent models
Q100457761Triazolopyrimidine derivative NK026680 and donor-specific transfusion induces CD4+CD25+Foxp3+ T cells and ameliorates allograft rejection in an antigen-specific manner
Q37494764Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance
Q26798362Update on CD40 and CD154 blockade in transplant models
Q35177419Viewpoint: therapeutic implications of CTLA-4 compartmentalization
Q36876313Viral infection: a potent barrier to transplantation tolerance
Q83599621[Organ transplantation and blood transfusion]

Search more.