Viewpoint: therapeutic implications of CTLA-4 compartmentalization

scientific article

Viewpoint: therapeutic implications of CTLA-4 compartmentalization is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1034/J.1600-6143.2003.00182.X
P698PubMed publication ID12859525
P5875ResearchGate publication ID10661971

P2093author name stringJoaquín Madrenas
Miren L Baroja
P2860cites workStructural basis for co-stimulation by the human CTLA-4/B7-2 complexQ24291065
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responsesQ24291066
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptorsQ24535662
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor proteinQ24648500
CTLA-4 ligation blocks CD28-dependent T cell activationQ24678229
Structure of murine CTLA-4 and its role in modulating T cell responsivenessQ27627704
Functional rafts in cell membranesQ27860768
The immunological synapse: a molecular machine controlling T cell activationQ28139151
T cell receptor signaling precedes immunological synapse formationQ28203073
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
CD28 function: a balance of costimulatory and regulatory signalsQ28215020
Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2AQ28216798
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activationQ28281516
Molecular basis of T cell inactivation by CTLA-4Q28291723
Structural analysis of CTLA-4 function in vivoQ28610379
CTLA-4 up-regulation plays a role in tolerance mediated by CD45.Q31793582
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylationQ32058522
Regulation of protein kinase cascades by protein phosphatase 2A.Q33632946
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantationQ34178136
The immunological synapse.Q34178149
The amplification of TCR signaling by dynamic membrane microdomainsQ34264026
Floating the raft hypothesis: lipid rafts play a role in immune cell activationQ34289960
The T cell receptor for antigen: signaling and ligand discriminationQ34297955
Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tailQ34505121
Activation and inhibition of lymphocytes by costimulationQ34517906
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strengthQ34520749
The CD28 signaling pathway regulates glucose metabolismQ34525357
The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responsesQ34542227
Negative co-receptors on lymphocytesQ34612576
Structural mechanisms of costimulationQ34614732
CTLA-4: new insights into its biological function and use in tumor immunotherapyQ34711491
Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 moleculesQ34719707
Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.Q34895271
Neural and immunological synaptic relationsQ34979919
Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activationQ35559258
Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergyQ36041455
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockadeQ36369151
Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationQ36370285
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.Q36370461
Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.Q36851780
B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.Q39907809
Lipid rafts unite signaling cascades with clathrin to regulate BCR internalizationQ40696448
In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.Q40696454
CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.Q40761126
The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.Q40850973
Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).Q40884227
Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.Q40932906
Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.Q41909802
Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell functionQ42108511
CTLA-4-Ig regulates tryptophan catabolism in vivo.Q44170968
Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.Q45888780
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitmentQ46457840
Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone sizeQ47177328
The interaction properties of costimulatory molecules revisited.Q52942338
CD28-independent costimulation of T cells in alloimmune responses.Q53935539
Membrane compartmentation is required for efficient T cell activation.Q54132378
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.Q54308518
Immunology. The immunological synapse--a multitasking systemQ56904592
CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expressionQ56905906
Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulationQ56906094
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent mannerQ56906395
The inhibitory function of CTLA-4 does not require its tyrosine phosphorylationQ56906426
Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4Q56906434
Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activationQ56907139
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2Q56908447
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagementQ56908957
CD28 Signaling via VAV/SLP-76 AdaptorsQ57289668
The immunological synapse: required for T cell receptor signalling or directing T cell effector function?Q73918678
CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosisQ74844499
A receptor/cytoskeletal movement triggered by costimulation during T cell activationQ77696385
T lymphocyte costimulation mediated by reorganization of membrane microdomainsQ77923394
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)919-926
P577publication date2003-08-01
P1433published inAmerican Journal of TransplantationQ4744273
P1476titleViewpoint: therapeutic implications of CTLA-4 compartmentalization
P478volume3

Reverse relations

cites work (P2860)
Q33808334CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells
Q37114482Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation
Q35772868The roles of the new negative T cell costimulatory pathways in regulating autoimmunity

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