CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment

scientific article published on 13 January 2003

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NI884
P8608Fatcat IDrelease_v67qupd7ajghbn6yt27zl5xk2i
P698PubMed publication ID12524538

P50authorJeffrey A BluestoneQ87186905
P2093author name stringJane L Grogan
Richard M Locksley
Qizhi Tang
Hélène Bour-Jordan
Julie A Auger
P2860cites workRole of IRS-2 in insulin and cytokine signallingQ24337494
Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcriptionQ24522496
An interleukin-4-induced transcription factor: IL-4 StatQ28248059
Essential role of Stat6 in IL-4 signallingQ28276199
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 geneQ28276209
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4Q28284177
Molecular basis of T cell inactivation by CTLA-4Q28291723
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokinesQ28509281
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cellsQ29614226
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Q29619280
Inhibition of IgG1 and IgE production by stimulation of the B cell CTLA-4 receptorQ34511796
The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic modelQ36365507
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.Q36376299
Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesisQ36551756
T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.Q36799306
Stat6 regulation of in vivo IL-4 responsesQ39529330
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine productionQ41065666
Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 geneQ41093086
IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cellsQ41527015
The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cellsQ42051849
The Src family kinase Fyn mediates signals induced by TCR antagonistsQ43968805
STAT6, NF-kappaB and C/EBP in CD23 expression and IgE productionQ45114540
NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cellsQ45304863
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.Q46001789
Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporterQ46062240
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cellsQ46091258
Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.Q51083007
Functional responses and costimulator dependence of memory CD4+ T cells.Q52030310
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.Q54113549
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
CTLA-4 engagement regulates NF-kappaB activation in vivoQ56904325
Polarization of naive CD4+ T cells toward the Th1 subset by CTLA-4 costimulationQ56906094
CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blastsQ56907031
CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cellsQ56907146
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetesQ56908828
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4Q56908993
Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivoQ73281771
A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammationQ73339834
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profileQ73520544
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATcQ74171908
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell fate commitmentQ14860192
P304page(s)182-188
P577publication date2003-01-13
P1433published inNature ImmunologyQ1071725
P1476titleCTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment
P478volume4

Reverse relations

cites work (P2860)
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