In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern.

scientific article published on October 2002

In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1074-7613(02)00421-1
P698PubMed publication ID12387734

P50authorVincenzo Di BartoloQ43204638
Claire HivrozQ55128271
Nicolas BlanchardQ56422460
P2093author name stringClaire Hivroz
Vincenzo Di Bartolo
Nicolas Blanchard
P2860cites workZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chainQ24294340
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activationQ24315021
Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulationQ24550768
The immunological synapse: a molecular machine controlling T cell activationQ28139151
T cell receptor signaling precedes immunological synapse formationQ28203073
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinaseQ28254719
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activationQ28281516
Three-dimensional segregation of supramolecular activation clusters in T cellsQ28282528
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contactsQ28282813
Selective modulation of protein kinase C-theta during T-cell activationQ28300613
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapseQ28507578
Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cellsQ28610639
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activationQ30167979
A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activationQ30491549
Microtubules and signal transductionQ33536499
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell lineQ33772316
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognitionQ33867251
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42Q34284892
Synaptic pattern formation during cellular recognitionQ36225863
Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanismQ36276679
Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cellsQ37384846
Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70.Q40769856
Differential roles of Lck and Itk in T cell response to antigen recognition revealed by calcium imaging and electron microscopy.Q40811238
Differential clustering of CD4 and CD3zeta during T cell recognitionQ40859028
Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathwaysQ41144539
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonistsQ41379043
Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cellsQ41398483
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.Q43566798
Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activationQ43619602
Receptor-directed focusing of lymphokine release by helper T cellsQ44044768
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transductionQ46517603
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activationQ47713209
Membrane compartmentation is required for efficient T cell activation.Q54132378
Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinaseQ55670931
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptorQ57185397
Role of ICAM-3 in the initial interaction of T lymphocytes and APCsQ57941405
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytesQ58617364
Differential requirement of ZAP-70 for CD2-mediated activation pathways of mature human T cellsQ73084670
Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytesQ73538023
Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cellsQ73630384
Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium responseQ74375728
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activationQ77307336
A receptor/cytoskeletal movement triggered by costimulation during T cell activationQ77696385
T lymphocyte costimulation mediated by reorganization of membrane microdomainsQ77923394
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)389-399
P577publication date2002-10-01
P1433published inImmunityQ6005457
P1476titleIn the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern
P478volume17

Reverse relations

cites work (P2860)
Q92290972A Ciliary View of the Immunological Synapse
Q47607418Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes.
Q30497888Adhesion shapes T cells for prompt and sustained T-cell receptor signalling.
Q35076666An evolutionary and structural perspective on T cell antigen receptor function
Q54570356Augmentation of T-cell immune responses and signal transduction proteins in oral cancer patients: potential for IL-2-mediated immunotherapy.
Q36934011CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain
Q35670765Casein kinase I delta controls centrosome positioning during T cell activation
Q34340660Cdc42-mediated MTOC polarization in dendritic cells controls targeted delivery of cytokines at the immune synapse.
Q34166030Centrosome docking at the immunological synapse is controlled by Lck signaling
Q30414445Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.
Q35856744Control of immune responses by trafficking cell surface proteins, vesicles and lipid rafts to and from the immunological synapse
Q37786677Cytoskeletal cross‐talk in the control of T cell antigen receptor signaling
Q37605931Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL
Q36102200Dynamic Association between HIV-1 Gag and Membrane Domains.
Q37470914Dynamics of membrane trafficking downstream of B and T cell receptor engagement: impact on immune synapses
Q30485468Fas death receptor enhances endocytic membrane traffic converging into the Golgi region
Q39796708Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes
Q40566969HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization
Q37247063HIV-1 at the immunological and T-lymphocytic virological synapse
Q55223802High-Affinity Ligands Can Trigger T Cell Receptor Signaling Without CD45 Segregation.
Q45957471Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity.
Q36483360IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo
Q53755056Imaging Vesicular Traffic at the Immune Synapse.
Q27003955Impaired T-Cell Function in B-Cell Lymphoma: A Direct Consequence of Events at the Immunological Synapse?
Q35091278Impairment of immunological synapse formation in adaptively tolerant T cells
Q36019340In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain
Q30485565In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells.
Q42592309Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells
Q41768892Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri
Q33811114Insufficient deactivation of the protein tyrosine kinase lck amplifies T-cell responsiveness in acute coronary syndrome
Q37347342LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse.
Q24672926LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation
Q39941887MTOC translocation modulates IS formation and controls sustained T cell signaling
Q41912555Murine Tim-1 is excluded from the immunological synapse
Q46793124Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.
Q38151848Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses.
Q44846647Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events
Q34413684Protein clusters on the T cell surface may suppress spurious early signaling events.
Q38943159Rab11-FIP3 Regulation of Lck Endosomal Traffic Controls TCR Signal Transduction
Q50026740Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
Q43243964Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.
Q30478093Recruitment of dynein to the Jurkat immunological synapse
Q39672265Recycling and LFA‐1‐dependent trafficking of ICAM‐1 to the immunological synapse
Q52668321Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.
Q35515678T cell activation by terminal complex of complement and immune complexes
Q37945207T cell polarization at the virological synapse
Q33361577T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury
Q33416441T-cell artificial focal triggering tools: linking surface interactions with cell response
Q93116339Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
Q40617614The Amide Class Herbicide 3,4-Dichloropropionanilide (DCPA) Alters the Mobility of Hydrocarbon Chains in T-Lymphocyte but not Macrophage Membranes
Q92763179The MTOC/Golgi Complex at the T-Cell Immunological Synapse
Q35145749The diversity of immunological synapses.
Q39710320The immune molecule CD3zeta and its downstream effectors ZAP-70/Syk mediate ephrin signaling in neurons to regulate early neuritogenesis
Q27002959The immunological synapse: the gateway to the HIV reservoir
Q33186337The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice
Q38151847The role of the cytoskeleton at the immunological synapse
Q34137493The scaffolding protein Dlg1 is a negative regulator of cell-free virus infectivity but not of cell-to-cell HIV-1 transmission in T cells
Q85183501The space and time frames of T cell activation at the immunological synapse
Q51000427VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites.
Q44052238Very low levels of surface CD45 reflect CLL cell fragility, are inversely correlated with trisomy 12 and are associated with increased treatment-free survival
Q35177419Viewpoint: therapeutic implications of CTLA-4 compartmentalization
Q42976627ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation.
Q41113593ZAP-70, CTLA-4 and proximal T cell receptor signaling in cows infected with Mycobacterium avium subsp. paratuberculosis
Q24298531ZAP70: a master regulator of adaptive immunity

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