Transplantation tolerance: lessons from experimental rodent models

scientific article published on 17 August 2007

Transplantation tolerance: lessons from experimental rodent models is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1111/J.1432-2277.2007.00533.X
P932PMC publication ID2156188
P698PubMed publication ID17711408
P5875ResearchGate publication ID6129380

P2093author name stringSatish N Nadig
Kathryn J Wood
Cherry I Kingsley
P2860cites workCytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
CTLA-4 can function as a negative regulator of T cell activationQ28235866
Human mesenchymal stem cells modulate allogeneic immune cell responsesQ28288692
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cellsQ29618766
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.Q33853487
CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10Q73509865
Deletion of alloantigen-reactive thymocytes as a mechanism of adult tolerance induction following intrathymic antigen administrationQ73565569
Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligandQ73585351
CD4(+), CD25(+) T cells as regulators of alloimmune responsesQ73667423
Blockade of the CD40 pathway fails to prevent CD8 T cell-mediated intestinal allograft rejectionQ73667838
Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioningQ73910639
CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejectionQ73948820
Regulation of TGF-beta response during T cell activation is modulated by IL-10Q74147852
Rapid achievement of complete donor chimerism and low regimen-related toxicity after reduced conditioning with fludarabine, carmustine, melphalan and allogeneic transplantationQ74249616
T cells primed by Leishmania major infection cross-react with alloantigens and alter the course of allograft rejectionQ74817270
The induction of transplantation tolerance by intrathymic (i.t.) delivery of alloantigen: a critical relationship between i.t. deletion, thymic export of new T cells and the timing of transplantationQ77658966
Mechanism of acquired thymic tolerance induced by a single major histocompatibility complex class I peptide with the dominant epitope: differential analysis of regulatory cytokines in the lymphoid and intragraft compartmentsQ78164664
Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerismQ78237930
Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapyQ78488897
Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complexQ78833880
In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation toleranceQ79143624
Unmanipulated HLA 2-3 antigen-mismatched (haploidentical) stem cell transplantation using nonmyeloablative conditioningQ79329006
Non-myeloablative mixed chimerism approaches and tolerance, a split decisionQ80052362
Combined costimulation blockade prevents rejection of allogeneic islets in miceQ80256661
Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant modelQ83978985
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathwayQ70897771
Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimenQ72051514
CD40 ligand blockade induces CD4+ T cell tolerance and linked suppressionQ73098784
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Actively acquired tolerance of foreign cellsQ34233179
CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenaseQ34356219
Late hepatic allograft dysfunctionQ34426400
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primatesQ34433847
Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-toleranceQ34503328
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.Q34504134
Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunityQ34505678
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.Q34529123
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulationQ34591923
"Infectious" transplantation tolerance.Q34726892
Regulatory T cells in transplantation toleranceQ35092535
Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapyQ35237202
Control of immune pathology by regulatory T cellsQ35580406
Regulatory cells in transplantation.Q35580423
Heterologous immunity: an overlooked barrier to toleranceQ35583521
Induction of toleranceQ35712092
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejectionQ35939463
Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantationQ36104468
Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance.Q36350355
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimenQ36355970
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulationQ36367099
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockadeQ36369151
Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survivalQ36370261
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responsesQ36376333
Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell toleranceQ36401145
Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cellsQ36401309
A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppressionQ36447586
Costimulation blockade and its possible future use in clinical transplantation.Q36570561
Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal modelQ37174844
A critical role for transforming growth factor-beta in donor transfusion-induced allograft toleranceQ37388089
Mixed allogeneic chimerism as an approach to transplantation toleranceQ39580661
Mesenchymal stem cells and organ transplantation: current status and promising futureQ40321342
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.Q40459668
Costimulation blockade, busulfan, and bone marrow promote titratable macrochimerism, induce transplantation tolerance, and correct genetic hemoglobinopathies with minimal myelosuppression.Q40794187
Preliminary results of intrathymic injection of donor cells to prevent acute rejection in human heart transplantationQ40970026
Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8.Q41326954
Total lymphoid irradiation in kidney and liver transplantation in the baboon: prolonged graft survival and alterations in T cell subsets with low cumulative dose regimensQ41546952
Tolerance to class I-disparate renal allografts in miniature swine. Maintenance of tolerance despite induction of specific antidonor CTL responses.Q42691510
Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejectionQ43655794
Target dose adjustment of busulfan in pediatric patients undergoing bone marrow transplantationQ43848079
In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantationQ44097232
Anti-CD40 therapy extends renal allograft survival in rhesus macaquesQ44190483
New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.Q44200460
Reliable engraftment, low toxicity, and durable remissions following allogeneic blood stem cell transplantation with minimal conditioningQ44210726
Programmed death-1 targeting can promote allograft survivalQ44223920
Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal diseaseQ44228610
Long-term survival of intestinal allografts induced by costimulation blockade, busulfan and donor bone marrow infusion.Q44549969
The natural history of chronic allograft nephropathyQ44688416
CTLA4Ig: bridging the basic immunology with clinical applicationQ45234481
Preimplantation-stage stem cells induce long-term allogeneic graft acceptance without supplementary host conditioningQ45883050
HLA-haploidentical nonmyeloablative stem cell transplantation: induction to tolerance without passing through mixed chimaerismQ46397702
Costimulation blockade with belatacept in renal transplantationQ46569880
Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathwaysQ46963324
Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimenQ47784478
Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.Q51541351
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.Q54139898
Infectious tolerance.Q55068093
Recipient memory-like lymphocytes remain unresponsive to graft antigens after CAMPATH-1H induction with reduced maintenance immunosuppressionQ56786693
Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation toleranceQ56904417
Role for thymic and splenic regulatory CD4+ T cells induced by donor dendritic cells in allograft tolerance by LF15-0195 treatmentQ56904437
CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponsesQ56904642
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatmentQ56906119
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent mannerQ56906395
Transplantation of anergic histoincompatible bone marrow allograftsQ56906962
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatmentQ56907083
The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survivalQ56907194
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivoQ56907415
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathwaysQ56908985
Stimulating PD-1???negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1Q57202266
Cutting Edge: Persistent Viral Infection Prevents Tolerance Induction and Escapes Immune Control Following CD28/CD40 Blockade-Based RegimenQ58194512
CD40 ligand-transduced co-stimulation of T cells in the development of helper functionQ58882277
Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenograftsQ59068399
IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In VivoQ60700622
MECHANISMS OF TOLERANCE INDUCTION AFTER INTRATHYMIC ISLET INJECTIONQ60700627
Dominant transplantation tolerance impairs CD8+ T cell function but not expansionQ61651663
Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation ToleranceQ61651670
CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTSQ61651679
Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in miceQ61791934
CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanismQ63354517
CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathwaysQ64038816
Treatment of renal-cell cancer by transplantation of allogeneic stem cells.Q64981713
Induction of donor-specific unresponsiveness by intrathymic islet transplantationQ68354945
P433issue10
P921main subjectimmune toleranceQ1356761
organ transplantationQ69253852
P304page(s)828-841
P577publication date2007-08-17
2007-10-01
P1433published inTransplant InternationalQ15762140
P1476titleTransplantation tolerance: lessons from experimental rodent models
P478volume20

Reverse relations

cites work (P2860)
Q38922184A Novel Model on DST-Induced Transplantation Tolerance by the Transfer of Self-Specific Donor tTregs to a Haplotype-Matched Organ Recipient
Q42234521BIOMARKERS OF OPERATIONAL TOLERANCE IN SOLID ORGAN TRANSPLANTATION.
Q38187177Biomarkers and possible mechanisms of operational tolerance in kidney transplant patients
Q43296293CCR5 blockade in combination with rapamycin prolongs cardiac allograft survival in mice
Q37794623CD4+ regulatory T cells in solid organ transplantation
Q46034786Clinical rejection and persistent immune regulation in kidney transplant patients.
Q37843801Clinical transplantation tolerance
Q46759811Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation.
Q26801029Deletional and regulatory mechanisms coalesce to drive transplantation tolerance through mixed chimerism
Q45134145Donor specific transplant tolerance is dependent on complement receptors.
Q33882845Identification of a B cell signature associated with renal transplant tolerance in humans.
Q47122472Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin
Q49962904Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation.
Q37384199Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection
Q35620293Neonatal desensitization for the study of regenerative medicine
Q28080994Reconsidering the detection of tolerance to individualize immunosuppression minimization and to improve long-term kidney graft outcomes
Q92511099Systemic silencing of PHD2 causes reversible immune regulatory dysfunction
Q37607455The immunological monitoring of kidney and liver transplants in adult and pediatric recipients
Q28478144The involvement of SMILE/TMTC3 in endoplasmic reticulum stress response
Q38039091Translating tolerogenic therapies to the clinic - where do we stand?
Q43139370Transplantation of tail skin to study allogeneic CD4 T cell responses in mice.

Search more.