Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells

scientific article published on 10 February 2011

Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.201040877
P698PubMed publication ID21341262

P50authorTim WorbsQ48309669
Reinhold ForsterQ63958748
P2093author name stringElisabeth Kremmer
Matthias Hoffmann
Xiaosun Liu
Pooja Mishra
Meike Wendland
Jan Beckmann
Jessica Kocks
Katharina Hoffmann
Sebastian Seth
Songfeng Yu
P2860cites workCCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organsQ28594485
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptorQ28595009
1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cellsQ33267228
The CD154-CD40 costimulatory pathway in transplantationQ34505360
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.Q34566731
Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytesQ34585878
Regulatory T cells interfere with the development of bronchus-associated lymphoid tissueQ34610191
Regulatory T cells in transplantation toleranceQ35092535
Chemokine receptor‐dependent alloresponsesQ35583497
Type I interferon dependence of plasmacytoid dendritic cell activation and migration.Q36403406
Plasmacytoid dendritic cells mediate oral toleranceQ36534744
Tolerogenic plasmacytoid DC.Q37683083
Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cellsQ38336314
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cellsQ42766901
Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligandQ42767299
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cellsQ42767496
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturationQ42861996
Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potentialQ44045898
Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells.Q46499903
CXCL9 antagonism further extends prolonged cardiac allograft survival in CCL19/CCL21-deficient miceQ46645969
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cellsQ46798648
Prolongation of allograft survival in ccr7-deficient miceQ47272614
Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation.Q47422815
Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venulesQ47438263
Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD.Q52595727
The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses.Q52946785
Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.Q53650288
An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.Q54736687
Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent mannerQ56906395
Mucosal CD8alpha+ DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory propertiesQ73196801
Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissueQ73844688
Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survivalQ74015557
Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cellsQ74321391
Improved skin allograft tolerance induced by treatment with donor splenocytes and an extended course of anti-CD154 monoclonal antibodyQ77177510
Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibodyQ79353930
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditionsQ80444912
Promotion of long-term heart allograft survival by combination of mobilized donor plasmacytoid dendritic cells and anti-CD154 monoclonal antibodyQ81065395
Transplantation 50 years later--progress, challenges, and promisesQ81191690
Plasmacytoid dendritic cell precursors induce allogeneic T-cell hyporesponsiveness and prolong heart graft survivalQ81923048
Primarily vascularized allografts of hearts in mice. The role of H-2D, H-2K, and non-H-2 antigens in rejectionQ93747372
P433issue3
P921main subjectdendritic cellQ506253
P304page(s)611-623
P577publication date2011-02-10
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleTolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7-deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells
P478volume41

Reverse relations

cites work (P2860)
Q40857525Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T-cell killing.
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Q83842405Fulfilling the dream: tolerogenic dendritic cells to treat multiple sclerosis
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Q37452783IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.
Q30577194Laminins affect T cell trafficking and allograft fate
Q37687786Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance?
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Q36660641Tolerogenic and activatory plasmacytoid dendritic cells in autoimmunity
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