Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism

scientific article

Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.174.4.1783
P698PubMed publication ID15699103
P5875ResearchGate publication ID8033808

P50authorShimon SakaguchiQ17502433
Sergio A QuezadaQ60622517
P2093author name stringRandolph J Noelle
Li-Fan Lu
David C Gondek
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1783-1786
P577publication date2005-02-01
P1433published inJournal of ImmunologyQ3521441
P1476titleCutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
P478volume174

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cites work (P2860)
Q56889692A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity
Q28590646A function for interleukin 2 in Foxp3-expressing regulatory T cells
Q30826185A20 Haploinsufficiency Aggravates Transplant Arteriosclerosis in Mouse Vascular Allografts: Implications for Clinical Transplantation
Q33384634APC activation restores functional CD4(+)CD25(+) regulatory T cells in NOD mice that can prevent diabetes development
Q35848308Activated CD4+CD25+ T cells selectively kill B lymphocytes
Q84945701Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer
Q36288969Allograft rejection mediated by memory T cells is resistant to regulation
Q48480477Anti-GITR therapy promotes immunity against malignant glioma in a murine model.
Q37270469Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression
Q34979858Artemisinin analogue SM934 ameliorates murine experimental autoimmune encephalomyelitis through enhancing the expansion and functions of regulatory T cell
Q43418649B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion
Q53217292CCR4 dependent migration of Foxp3+ Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients
Q35228053CD134 Plus CD137 Dual Costimulation Induces Eomesodermin in CD4 T Cells To Program Cytotoxic Th1 Differentiation
Q37317928CD4(+)CD25 (+) regulatory T cells in human lupus erythematosus
Q33714522CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism
Q37082777CD4+ CD25+ regulatory T cells: a therapeutic target for liver diseases.
Q37794623CD4+ regulatory T cells in solid organ transplantation
Q36600237CD4+CD25+ regulatory T cell therapy for the induction of donor-specific clinical transplantation tolerance
Q37754524CD4+CD25+ regulatory T-cell therapy
Q44491431CD4+CD25+CD127dimFoxp3+ T cells are cytotoxic for human neurons
Q34709777CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
Q34423206CD4+CD25+Foxp3+IFNγ+CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cells
Q36291143CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesions
Q33796410CD46-induced human Treg enhance B-cell responses
Q45176452CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B.
Q35108103CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen
Q37520543CD8⁺ Treg cells associated with decreasing disease activity after intravenous methylprednisolone pulse therapy in lupus nephritis with heavy proteinuria
Q38170150Cellular and molecular mechanisms in cancer immune escape: a comprehensive review
Q36490768Checkpoint blockade in cancer immunotherapy
Q64974096Chimeric antigen receptor costimulation domains modulate human regulatory T cell function.
Q28069832Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives
Q54397365Clinical Significance of Regulatory T-Cell–Related Gene Expression in Peripheral Blood After Renal Transplantation
Q84794919Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma
Q28271806Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily
Q42934008Comment on "Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways".
Q55315496Common Features of Regulatory T Cell Specialization During Th1 Responses.
Q46733558Comparison of apoptosis and mortality measurements in peripheral blood mononuclear cells (PBMCs) using multiple methods
Q30438088Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node
Q40115071Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.
Q34133590Control of homeostatic proliferation by regulatory T cells
Q34054667Cutting Edge: Responder T cells regulate human DR+ effector regulatory T cell activity via granzyme B
Q37349582Cutting edge: regulatory T cells do not require stimulation through their TCR to suppress
Q38292676Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells.
Q33880763Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity.
Q37597931Cytotoxic CD4 T Cells-Friend or Foe during Viral Infection?
Q37530535DNA and protein co-administration induces tolerogenic dendritic cells through DC-SIGN mediated negative signals
Q39660421DX5(+)CD4(+) T cells modulate cytokine production by CD4(+) T cells towards IL-10 via the production of IL-4.
Q34588821Death by a thousand cuts: granzyme pathways of programmed cell death
Q38124437Deciphering and reversing tumor immune suppression.
Q35067630Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells
Q37383315Defining the mechanism(s) of protection by cytolytic CD8 T cells against a cryptic epitope derived from a retroviral alternative reading frame
Q37045247Dendritic cells and T cells in the regulation of cutaneous immunity
Q37203108Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft
Q37547414Development of virus-specific CD4+ and CD8+ regulatory T cells induced by human herpesvirus 6 infection
Q36844861Differential expression of interleukin-4 (IL-4) and IL-4 delta 2 mRNA, but not transforming growth factor beta (TGF-beta), TGF-beta RII, Foxp3, gamma interferon, T-bet, or GATA-3 mRNA, in patients with fast and slow responses to antituberculosis tre
Q26774590Disrupted regulatory T cell homeostasis in inflammatory bowel diseases
Q33772507Disruption of TGF-beta signaling prevents the generation of tumor-sensitized regulatory T cells and facilitates therapeutic antitumor immunity.
Q39928054Disturbances in some gene expression in T regulatory cells separated from children with metabolic syndrome.
Q35642843Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease
Q64982406Early expansion of donor-specific Tregs in tolerant kidney transplant recipients.
Q45403301Effects of CD4(+)CD25(+)Foxp3(+)regulatory T cells on early Plasmodium yoelii 17XL infection in BALB/c mice
Q36486882Emerging possibilities in the development and function of regulatory T cells
Q38107700Enhanced killing activity of regulatory T cells ameliorates inflammation and autoimmunity
Q56897895Epicutaneous immunization with DNP-BSA induces CD4+ CD25+ Treg cells that inhibit Tc1-mediated CS
Q51629955Estradiol-dependent perforin expression by human regulatory T-cells.
Q35530818Evaluation of immunosuppressive function of regulatory T cells using a novel in vitro cytotoxicity assay
Q56886145Ex Vivo Generation of Donor Antigen-Specific Immunomodulatory Cells: A Comparison Study of Anti-CD80/86 mAbs and CTLA4-lg Costimulatory Blockade
Q37294572Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy
Q37610691Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
Q26779184Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy
Q29307487FOXP3+ regulatory T cells in the human immune system
Q37937127FOXP3+ regulatory T cells: From suppression of rejection to induction of renal allograft tolerance
Q37828869FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
Q37804609FoxP3+ CD4+ T cells in systemic autoimmune diseases: the delicate balance between true regulatory T cells and effector Th-17 cells
Q33706998Foxp3 expression in p53-dependent DNA damage responses
Q36786930Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
Q45922599Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury.
Q35552966Foxp3+-Inducible Regulatory T Cells Suppress Endothelial Activation and Leukocyte Recruitment
Q33987128Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
Q36984057Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation
Q90588415Future prospects for CD8+ regulatory T cells in immune tolerance
Q34615533GITR/GITRL: more than an effector T cell co-stimulatory system.
Q36938160Generation and function of induced regulatory T cells
Q51004166Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice
Q34008970Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Q26765438Genetics and biology of pancreatic ductal adenocarcinoma
Q35551328Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Q36546727Good syndrome presenting with CD8⁺ T-Cell large granular lymphocyte leukemia
Q35619237Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease
Q35613097Granzyme B Regulates Antiviral CD8+ T Cell Responses
Q34308243Granzyme B in injury, inflammation, and repair
Q33706382Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Q30496008Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.
Q35912982Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells
Q34955529Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection
Q35010452Granzymes and perforin in solid organ transplant rejection
Q34097453Granzymes in age-related cardiovascular and pulmonary diseases
Q30435033HCV+ Hepatocytes Induce Human Regulatory CD4+ T Cells through the Production of TGF-β
Q42207253HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies.
Q34540245HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells
Q35624877Harnessing regulatory T cells for the treatment of inflammatory bowel disease.
Q37680540Harnessing regulatory T cells to suppress asthma: from potential to therapy
Q92018196High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies
Q43514433High levels of granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment
Q26853599Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs
Q54568607How many mechanisms do regulatory T cells need?
Q29614262How regulatory T cells work
Q84639319Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help
Q61711484Human CD4low CD25high regulatory T cells indiscriminately kill autologous activated T cells
Q52717949Human Cancer and Platelet Interaction, a Potential Therapeutic Target.
Q37040516Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis
Q42108248Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis
Q36488883Human peripheral blood T regulatory cells (Tregs), functionally primed CCR4+ Tregs and unprimed CCR4- Tregs, regulate effector T cells using FasL.
Q37598166Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody
Q47275057Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation
Q36227516IFNy+ and IFNy- Treg subsets with stable and unstable Foxp3 expression in kidney transplant recipients with good long-term graft function
Q36395621IFNγR signaling mediates alloreactive T-cell trafficking and GVHD
Q36509935IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy
Q43125547IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells
Q41825508IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation.
Q82292256Identification of a unique double-negative regulatory T-cell population
Q36691045Identification of early myeloid progenitors as immunosuppressive cells
Q94470282Immune Suppression in Pregnancy and Cancer: Parallels and Insights
Q38154343Immune mechanisms in hypertension and vascular injury
Q37864694Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells
Q37823689Immunomodulatory effects of eicosapentaenoic acid through induction of regulatory T cells
Q80236699Immunopathogenesis of psoriasis
Q84257326Immunosuppressive mechanisms of embryonic stem cells and mesenchymal stem cells in alloimmune response
Q33709232Immunotherapy for solid tumors--a review for surgeons
Q92412497Impaired tumor necrosis factor-α secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze
Q33855759Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis
Q96131145In situ conversion of defective Treg into SuperTreg cells to treat advanced IPEX-like disorders in mice
Q33997187In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.
Q38574966In vivo induction of regulatory T cells for immune tolerance in hemophilia
Q42076470In vivo sites and cellular mechanisms of T reg cell-mediated suppression
Q33770196Induced Regulatory T Cells Superimpose Their Suppressive Capacity with Effector T Cells in Lymph Nodes via Antigen-Specific S1p1-Dependent Egress Blockage
Q36948341Induced and Natural Regulatory T Cells in the Development of Inflammatory Bowel Disease
Q39785440Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation
Q47252494Induction of Immunosuppressive CD8+CD25+FOXP3+ Regulatory T Cells by Suboptimal Stimulation with Staphylococcal Enterotoxin C1.
Q30907499Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway
Q83120989Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells
Q37000445Inhibition of lung metastasis by chemokine CCL17-mediated in vivo silencing of genes in CCR4+ Tregs
Q84819752Inhibition of murine gammadelta lymphocyte expansion and effector function by regulatory alphabeta T cells is cell-contact-dependent and sensitive to GITR modulation
Q54983048Innate immunity and effector and regulatory mechanisms involved in allergic contact dermatitis.
Q37350929Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression
Q37440379Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance
Q44996678Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells
Q34655265Interleukin-2-dependent mechanisms of tolerance and immunity in vivo
Q37492932Interleukin-37 Enhances the Suppressive Activity of Naturally Occurring CD4+CD25+ Regulatory T Cells
Q46369670Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4 T cells by down-regulation of granzyme B.
Q34089124Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
Q80972826Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells
Q82551194Is liver‐targeted FOXp3 staining beneficial after living‐donor liver transplantation?
Q91973468JunB Controls Intestinal Effector Programs in Regulatory T Cells
Q41926775Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells.
Q36227859LAT-mediated signaling in CD4+CD25+ regulatory T cell development
Q83921292Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells
Q45952178Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.
Q87213112Loss of Immunization-Induced Epitope-Specific CD4 T-Cell Response following Anaplasma marginale Infection Requires Presence of the T-Cell Epitope on the Pathogen and Is Not Associated with an Increase in Lymphocytes Expressing Known Regulatory Cell
Q54317518MEK inhibition prevents tumour-shed transforming growth factor-β-induced T-regulatory cell augmentation in tumour milieu
Q51997055Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.
Q34559099Mast cells are essential intermediaries in regulatory T-cell tolerance
Q37317297Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models
Q36988144Mechanisms of granule-dependent killing
Q85945994Mesenchymal stem cells alleviate atherosclerosis by elevating number and function of CD4(+)CD25 (+)FOXP3 (+) regulatory T-cells and inhibiting macrophage foam cell formation
Q34847859Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells.
Q93247005Microbiome modulates intestinal homeostasis against inflammatory diseases
Q28393614Modification of the Tumor Microenvironment as a Novel Target of Renal Cell Carcinoma Therapeutics
Q50671091Molecular Mechanisms of Regulatory T Cell Development and Suppressive Function
Q38008361Molecular Mechanisms of Treg-Mediated T Cell Suppression
Q26765845NK Cell and CD4+FoxP3+ Regulatory T Cell Based Therapies for Hematopoietic Stem Cell Engraftment
Q37968236NKT cell self-reactivity: evolutionary master key of immune homeostasis?
Q53523527Natural Tregs, CD4+CD25+ inhibitory hybridomas, and their cell contact dependent suppression
Q34676250Natural regulatory T cells in autoimmunity
Q33869793Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression
Q27001081Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses
Q53471307New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells
Q34331993New roads open up for implementing immunotherapy in mesothelioma
Q35595880Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6.
Q56888845Novel Effector Phenotype of Tim-3 Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients
Q38614686Novel therapeutic and diagnostic management of heart transplant patients
Q37180457OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.
Q38013107On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation
Q28081922Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells
Q37312476Outgrowth of CD4low/negCD25+ T cells with suppressor function in CD4+CD25+ T cell cultures upon polyclonal stimulation ex vivo
Q34733541Parasitic nematode-induced CD4+Foxp3+T cells can ameliorate allergic airway inflammation
Q34248293Perforin-dependent elimination of dendritic cells regulates the expansion of antigen-specific CD8+ T cells in vivo
Q36425407Peripheral Regulatory Cells Immunophenotyping in Kidney Transplant Recipients with Different Clinical Profiles: A Cross-Sectional Study
Q37620098Plasmacytoid dendritic cells: physiologic roles and pathologic states.
Q37287156Positive and negative influences of regulatory T cells on tumour immunity.
Q38235166Potential and limitations of regulatory T-cell therapy in solid organ transplantation.
Q92400296Preferential Homing of Tumor-specific and Functional CD8+ Stem Cell-like Memory T Cells to the Bone Marrow
Q33968779Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge.
Q37754132Prognostic significance of regulatory T cells in tumor
Q34215381Progress in understanding the immunopathogenesis of psoriasis
Q38097917Promoting transplantation tolerance; adoptive regulatory T cell therapy
Q84347834Pulling the Trigger on the Tumor‘s Bodyguards: What Puts Tregs Out of Action?
Q43708939RSV infection--an immune balancing act: commentary on the article by Bem et al. on page 650.
Q37002025Rapidly proliferating CD44hi peripheral T cells undergo apoptosis and delay posttransplantation T-cell reconstitution after allogeneic bone marrow transplantation
Q37184443Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2).
Q33648194Redox remodeling as an immunoregulatory strategy
Q26823216Regulation generation: the suppressive functions of human regulatory T cells
Q37128687Regulation of FoxP3 regulatory T cells and Th17 cells by retinoids
Q37835495Regulation of T cell activation by TLR ligands
Q36148406Regulation of immunity by self-reactive T cells
Q38497066Regulatory B cells in anti-tumor immunity
Q64949232Regulatory Role of CD4+ T Cells in Myocarditis.
Q36462109Regulatory T Cell Immunotherapy in Immune-Mediated Diseases
Q38057738Regulatory T Cell Induction, Migration, and Function in Transplantation
Q38948512Regulatory T Cells and Cancer: A Two-Sided Story
Q33715605Regulatory T Cells in Allergy and Asthma.
Q26746113Regulatory T Cells: Molecular Actions on Effector Cells in Immune Regulation
Q26784460Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation
Q37725749Regulatory T cell as a target for cancer therapy
Q44440268Regulatory T cell development in the absence of functional Foxp3.
Q39823591Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival
Q26991447Regulatory T cell: a protection for tumour cells
Q37776686Regulatory T cells (Treg) and Their Roles in Immune System with Respect to Immunopathological Disorders
Q42577777Regulatory T cells and Atherosclerosis
Q58775100Regulatory T cells and asthma
Q37599669Regulatory T cells and immune tolerance to tumors
Q37272005Regulatory T cells and natural killer T cells for modulation of GVHD following allogeneic hematopoietic cell transplantation
Q37695072Regulatory T cells and the risk of CMV end-organ disease in patients with AIDS.
Q34125717Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner
Q35765491Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Q30409790Regulatory T cells in AKI.
Q45066685Regulatory T cells in Acute and Chronic Kidney Diseases
Q35553553Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
Q38946820Regulatory T cells in allergic diseases.
Q84073243Regulatory T cells in cancer
Q38622693Regulatory T cells in cardiovascular diseases
Q34547120Regulatory T cells in experimental autoimmune disease
Q36863866Regulatory T cells in health and disease
Q36949181Regulatory T cells in the prevention of mucosal inflammatory diseases: patrolling the border
Q57471979Regulatory T cells in the treatment of disease
Q37691776Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?
Q39957163Regulatory T cells in transplantation: what we know and what we do not know
Q47154701Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells
Q90518726Regulatory T cells promote corneal endothelial cell survival following transplantation via interleukin-10
Q36430144Regulatory T cells, tumour immunity and immunotherapy
Q26827787Regulatory T cells: Mechanisms of suppression and impairment in autoimmune liver disease
Q37593768Regulatory T cells: how do they suppress immune responses?
Q29620731Regulatory T cells: mechanisms of differentiation and function
Q36484595Regulatory T cells: present facts and future hopes.
Q37697589Regulatory T cells: roles of T cell receptor for their development and function
Q37049217Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?
Q37309438Regulatory T-Cell Therapy for Graft-versus-host Disease
Q37834024Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis
Q36891917Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.
Q54329903Regulatory T-cells promote hepatitis B virus infection and hepatocellular carcinoma progression
Q33664082Regulatory function of cytomegalovirus-specific CD4+CD27-CD28- T cells
Q36539633Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis
Q26798141Research Progress on Regulatory T Cells in Acute Kidney Injury
Q99585601Restoring regulatory T-cell dysfunction in Alzheimer's disease through ex vivo expansion
Q93347701Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells
Q37854959Retinoic Acid, Immunity, and Inflammation
Q90288573Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation
Q41515965Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity
Q37729059Role of T cells in graft rejection and transplantation tolerance.
Q21132345Role of lymphocyte activation gene-3 (Lag-3) in conventional and regulatory T cell function in allogeneic transplantation
Q37107677Role of regulatory T cells during virus infection
Q37090518Role of regulatory T cells in gastrointestinal inflammatory disease
Q28742855SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism
Q40360057STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells
Q37097934Selective elimination of autoreactive T cells in vivo by the regulatory T cells
Q30574368Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Q37701348Self-tolerance and autoimmunity in a regulatory T cell model
Q37126477Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.
Q37112525Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells
Q38732326Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice
Q64084505Soluble CD83 Triggers Resolution of Arthritis and Sustained Inflammation Control in IDO Dependent Manner
Q89621603Stromal Vascular Fraction and its Role in the Management of Alopecia: A Review
Q36512526Strong-arming immune regulation: suppressing regulatory T-cell function to treat cancers
Q52681524Sublingual 'oral tolerance' induction with antigen conjugated to cholera toxin B subunit generates regulatory T cells that induce apoptosis and depletion of effector T cells
Q38006901T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis
Q36684909T-cell regulation: with complements from innate immunity
Q37902883T-helper cells in the etiopathogenesis of periodontal disease: A mini review
Q89209907TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice
Q36685552TH2 cells in the pathogenesis of airway remodeling: regulatory T cells a plausible panacea for asthma
Q90320536Targeting Antigen-Specific B Cells Using Antigen-Expressing Transduced Regulatory T Cells
Q37983467Targeting regulatory T cells
Q28078919The Biological Effects of IL-21 Signaling on B-Cell-Mediated Responses in Organ Transplantation
Q37088900The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Q97521477The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover
Q24633549The PD-1 pathway in tolerance and autoimmunity
Q37393703The T(reg)/Th17 cell balance: a new paradigm for autoimmunity
Q87628572The ThPOK transcription factor differentially affects the development and function of self-specific CD8(+) T cells and regulatory CD4(+) T cells
Q33769528The Type of Responder T-Cell Has a Significant Impact in a Human In Vitro Suppression Assay
Q39441289The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances.
Q37633282The battlefield of perforin/granzyme cell death pathways.
Q45370941The control of CD8+ T cell responses is preserved in perforin-deficient mice and released by depletion of CD4+CD25+ regulatory T cells
Q37728840The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease
Q37959968The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance
Q37274250The development and function of regulatory T cells
Q41462842The duration of T cell stimulation is a critical determinant of cell fate and plasticity.
Q37112199The effects of antibody treatment on regulatory CD4(+)CD25(+) T cells
Q37542878The enigmatic role of mast cells in dominant tolerance
Q36481704The hidden truth about gene expression in Tregs: is it what you don't see that counts?
Q28257250The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells
Q54518671The paradox role of regulatory T cells in ischemic stroke
Q37564741The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease
Q34009654The power and the promise of restimulation-induced cell death in human immune diseases
Q42208547The regulatory T cell effector molecule fibrinogen-like protein 2 is necessary for the development of rapamycin-induced tolerance to fully MHC-mismatched murine cardiac allografts
Q36814760The role of Granzyme B in atheromatous diseases
Q36752196The role of natural regulatory T cells in infection
Q30441254The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell function
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