Regulatory T cells in experimental autoimmune disease

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Regulatory T cells in experimental autoimmune disease is …
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scholarly articleQ13442814
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P6179Dimensions Publication ID1018755782
P356DOI10.1007/S00281-006-0021-8
P698PubMed publication ID16838180

P2093author name stringElisabeth Suri-Payer
Benedikt Fritzsching
P2860cites workToll-like receptor 8-mediated reversal of CD4+ regulatory T cell functionQ24317859
Essential role for CD103 in the T cell-mediated regulation of experimental colitisQ24646106
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanismsQ24673863
Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammationQ24676080
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
B cells and professional APCs recruit regulatory T cells via CCL4Q28204573
Where CD4+CD25+ T reg cells impinge on autoimmune diabetesQ28506933
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
A function for interleukin 2 in Foxp3-expressing regulatory T cellsQ28590646
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Q28591451
Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptorQ28595009
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survivalQ29547865
An essential role for Scurfin in CD4+CD25+ T regulatory cellsQ29618395
Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn diseaseQ30434096
Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitisQ30437306
Neonatal autoimmune disease: influence of CD4+ CD25+ regulatory T cellsQ30437481
Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph nodeQ30438088
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic miceQ30498716
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivoQ33723552
Regulatory T cells in autoimmmunity*.Q33904108
Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansionQ33932451
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporterQ33936032
Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.Q34032006
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune diseaseQ34132578
CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivityQ34161141
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cellsQ34189120
Toll-like receptor 2 controls expansion and function of regulatory T cellsQ34264024
Role of LAG-3 in regulatory T cells.Q34358935
Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cellsQ34374577
Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cellsQ34374601
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanismQ34392100
Regulatory T cells in spontaneous autoimmune encephalomyelitisQ34448458
Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-toleranceQ34503328
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant toleranceQ34530668
Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharideQ34531452
CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis.Q34533631
In vivo instruction of suppressor commitment in naive T cellsQ34548023
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsQ34556464
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signalingQ34561791
CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitroQ35171080
TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cellsQ35668744
CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient miceQ35748975
Activated CD4+CD25+ T cells selectively kill B lymphocytesQ35848308
Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cellsQ36064100
The role of self-peptides in the development of CD4+ CD25+ regulatory T cellsQ36070689
The NOD mouse: a model of immune dysregulationQ36072434
Regulatory T cells and intestinal homeostasisQ36079900
Control of type 1 autoimmune diabetes by naturally occurring CD4+CD25+ regulatory T lymphocytes in neonatal NOD mice.Q36242785
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulationQ36367099
Peripheral autoantigen induces regulatory T cells that prevent autoimmunityQ36367859
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsivenessQ36370807
Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph nodeQ36371218
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivoQ36371283
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state.Q36371658
Tr1 cells: from discovery to their clinical application.Q36390028
Peripheral expansion of thymus-derived regulatory cells in anti-myelin basic protein T cell receptor transgenic mice.Q51032566
Toll-dependent control mechanisms of CD4 T cell activation.Q51996404
CD40 ligation releases immature dendritic cells from the control of regulatory CD4+CD25+ T cells.Q52552727
Cutting edge: CD4+CD25+ regulatory T cells impaired for intestinal homing can prevent colitis.Q53671891
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.Q53883439
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.Q54139898
Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.Q54613578
CD4+CD25+ T cells prevent the development of organ-specific autoimmune disease by inhibiting the differentiation of autoreactive effector T cells.Q54630443
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation.Q54641474
Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells.Q54656483
Tolerogenic semimature dendritic cells suppress experimental autoimmune thyroiditis by activation of thyroglobulin-specific CD4+CD25+ T cellsQ56902811
Specific T regulatory cells display broad suppressive functions against experimental allergic encephalomyelitis upon activation with cognate antigenQ56902816
CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4Q56903729
B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitisQ56905051
Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory CellsQ57447880
Cutting Edge: TGF- Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T CellsQ58131166
Cooperation of Invariant NKT Cells and CD4+CD25+ T Regulatory Cells in the Prevention of Autoimmune MyastheniaQ63363300
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic miceQ71641038
CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10Q73509865
Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cellsQ73612987
Human CD4+ CD25+ regulatory T cells suppress NKT cell functionsQ73784466
Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cellsQ74244102
The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7Q74650540
Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitisQ75303091
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cellsQ75303125
Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetesQ77192908
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivoQ77342616
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitisQ78404404
T-cell compartments of prediabetic NOD miceQ78830234
Cutting edge: IL-12 induces CD4+CD25- T cell activation in the presence of T regulatory cellsQ80345062
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptorsQ80444910
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cellsQ81245689
CD4+ CD25+ regulatory T cells inhibit the maturation but not the initiation of an autoantibody responseQ81245701
Inducing and expanding regulatory T cell populations by foreign antigenQ81392563
MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosusQ81629357
A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infectionQ81675748
Vasoactive intestinal peptide induces regulatory T cells during experimental autoimmune encephalomyelitisQ82217105
CD4+CD25+ regulatory T cells inhibit the antigen-dependent expansion of self-reactive T cells in vivoQ82310867
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesionQ36399063
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.Q36399104
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cellsQ36399149
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal periodQ36402733
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cellsQ36402737
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralizationQ36402763
Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitisQ36403300
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetesQ36403481
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent mannerQ36403637
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetesQ37358159
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitisQ37593413
LF 15-0195 treatment protects against central nervous system autoimmunity by favoring the development of Foxp3-expressing regulatory CD4 T cells.Q38485693
Neuropilin-1: a surface marker of regulatory T cellsQ40584286
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecificQ40910998
Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cellsQ40969391
Modulation of monocyte/macrophage function by human CD4+CD25+ regulatory T cellsQ41895496
Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivoQ42210265
Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis.Q42844822
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashionQ45864833
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic miceQ45883411
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T CellsQ46025217
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic miceQ46081630
On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetesQ46818613
Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartmentQ47243986
CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditisQ47283198
Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the peripheryQ47368988
Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.Q47777664
Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitisQ47810532
Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cellsQ47810559
Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cellsQ47991866
Suppression of CD4+ T lymphocyte effector functions by CD4+CD25+ cells in vivo.Q47992041
Demonstration of strong enterobacterial reactivity of CD4+CD25- T cells from conventional and germ-free mice which is counter-regulated by CD4+CD25+ T cellsQ48020872
P433issue1
P921main subjectautoimmune diseaseQ8084905
P304page(s)3-16
P577publication date2006-07-13
P1433published inSeminars in ImmunopathologyQ15724576
P1476titleRegulatory T cells in experimental autoimmune disease
P478volume28