Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer

scientific article published on 01 October 2011

Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1034763253
P356DOI10.1007/S12026-011-8242-X
P698PubMed publication ID21918886

P50authorBor-Ching SheuQ57316614
P2093author name stringKing-Jen Chang
Su-Cheng Huang
Wen-Chun Chang
Chao-Hsu Li
Wen-Hong Kuo
P2860cites workQuantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late RelapseQ58211903
Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+T Lymphocytes in Human Cervical CarcinomaQ58377175
Predominant Th2/Tc2 Polarity of Tumor-Infiltrating Lymphocytes in Human Cervical CancerQ58377203
Bispecific antibody-mediated immunotherapy of the BCL1 lymphoma: increased efficacy with multiple injections and CD28-induced costimulationQ71099811
CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosisQ74844499
Depletion of CD4+CD25+ regulatory T cells promotes a tumor-specific immune response in pancreas cancer-bearing miceQ80211173
A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironmentQ80726091
Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinomaQ81676575
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cellsQ24306205
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanomaQ24548019
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesQ24676216
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancerQ29014531
How regulatory T cells workQ29614262
Breast cancer and the immune systemQ33753043
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumorsQ33944674
Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancerQ34210036
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanismQ34392100
A novel role of metalloproteinase in cancer-mediated immunosuppression.Q34513511
Human T regulatory cells can use the perforin pathway to cause autologous target cell deathQ34551876
Cell death mechanisms induced by cytotoxic lymphocytesQ34605017
Functional significance of the perforin/granzyme cell death pathwayQ34931863
Decreased tumor surveillance in perforin-deficient miceQ36367528
Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphomaQ36368808
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cellsQ36399149
Regulatory T cells and infection: a dangerous necessityQ36975739
Cytokine regulation networks in the cancer microenvironmentQ37175689
The significance of Treg cells in defective tumor immunityQ37177121
Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancerQ37239059
Positive and negative influences of regulatory T cells on tumour immunity.Q37287156
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearanceQ40071336
Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cellsQ40498116
Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral bloodQ41988688
Tumor-infiltrating Foxp3-CD4+CD25+ T cells predict poor survival in renal cell carcinoma.Q43782950
Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer.Q43937301
Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinoma.Q53332793
Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma.Q53342350
Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients?Q54539424
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinomaQ56904280
Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activationQ56905632
P433issue1
P1104number of pages9
P304page(s)71-79
P577publication date2011-10-01
P1433published inImmunologic ResearchQ15754981
P1476titleActivation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer
P478volume51

Reverse relations

cites work (P2860)
Q64886488Beyond PD-1/PD-L1 Inhibition: What the Future Holds for Breast Cancer Immunotherapy.
Q86169185Circulating autoantibody to CD25 may be a potential biomarker for early diagnosis of esophageal squamous cell carcinoma
Q40342447Expansion of CD14(+)CD16(+) monocytes is related to acute leukemia
Q36694379Further study of circulating IgG antibodies to CD25-derived peptide antigens in nonsmall cell lung cancer
Q33778945Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model.
Q45935803Study of circulating antibodies against CD25 and FOXP3 in breast cancer.

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