Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis

scientific article published on 02 February 2011

Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3109/08923973.2010.513391
P698PubMed publication ID21284556
P5875ResearchGate publication ID49801493

P2093author name stringAbbas Mirshafiey
Farhad Jadidi-Niaragh
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Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosisQ48003302
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Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients.Q48271985
Polyclonal expansion of regulatory T cells interferes with effector cell migration in a model of multiple sclerosis.Q48442373
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Differentiation of regulatory T cells 1 is induced by CD2 costimulationQ24291651
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Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cellsQ24538658
The T-cell pool is anergized in patients with multiple sclerosis in remissionQ24643433
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Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotypeQ24652223
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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
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The inhibitory cytokine IL-35 contributes to regulatory T-cell functionQ28258462
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IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine productionQ28289204
NKT cells derive from double-positive thymocytes that are positively selected by CD1dQ28508188
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T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiationQ28511506
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cellsQ28512367
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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
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A biased Valpha24+ T-cell repertoire leads to circulating NKT-cell defects in a multiple sclerosis patient at the onset of his disease.Q52958014
Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.Q53271841
Rapamycin enriches for CD4(+) CD25(+) CD27(+) Foxp3(+) regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple sclerosis.Q53557761
Paralysis of CD4(+)CD25(+) regulatory T cell response in chronic autoimmune encephalomyelitis.Q53570832
B7H1-Ig fusion protein activates the CD4+ IFN-gamma receptor+ type 1 T regulatory subset through IFN-gamma-secreting Th1 cells.Q53601507
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis.Q53654834
Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.Q53671871
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
IL-2, IFN-gamma, and IL-12 gene polymorphisms and susceptibility to multiple sclerosis.Q54476654
How many mechanisms do regulatory T cells need?Q54568607
An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.Q54608720
Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function.Q54641462
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Q54645452
Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.Q54697381
Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytesQ56903667
EVI5 is a risk gene for multiple sclerosisQ57309121
Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable regionQ58133075
Transient expression of FOXP3 in human activated nonregulatory CD4+ T cellsQ58234949
Interleukin-10 and tumor necrosis factor-alpha: model of immunomodulation in multiple sclerosisQ58832274
Early events in the thymus affect the balance of effector and regulatory T cellsQ59077338
Foxp3-dependent programme of regulatory T-cell differentiationQ59084714
Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+regulatory T-cell function and FOXP3 expressionQ59149671
Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cellsQ36370232
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.Q36370315
Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer stainingQ36370359
Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivoQ36371283
Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cellsQ36371345
Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-GalactosylceramideQ36371546
The Src family tyrosine kinase Fyn regulates natural killer T cell developmentQ36375458
Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the diseaseQ36380402
Tr1 cells: from discovery to their clinical application.Q36390028
The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cellsQ36400520
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitisQ36401257
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal periodQ36402733
Developmental regulation of Foxp3 expression during ontogeny.Q36403564
In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramersQ36404648
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Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.Q36457107
CD4+CD25+ Tregs and NKT cells: regulators regulating regulatorsQ36492658
Th17: an effector CD4 T cell lineage with regulatory T cell tiesQ36510274
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune diseaseQ36672085
An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locusQ36693352
T(H)-17 cells in the circle of immunity and autoimmunityQ36765453
NKT cells: T lymphocytes with innate effector functionsQ36788766
Control points in NKT-cell developmentQ36858868
Multiple sclerosis: a complicated picture of autoimmunity.Q36915907
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populationsQ36930892
Understanding the behavior of invariant NKT cells in autoimmune diseasesQ36955593
Regulatory T cells and infection: a dangerous necessityQ36975739
Foxp3+ regulatory T cells in the control of experimental CNS autoimmune diseaseQ37031066
NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut floraQ37061082
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving targetQ37111968
Is FOXP3 a bona fide marker for human regulatory T cells?Q37131913
The suppression of hypersensitivity by ocular-induced CD8(+) T cells requires compatibility in the Qa-1 haplotypeQ37135668
Emerging concepts in CD8(+) T regulatory cellsQ37136267
Invariant NKT cells inhibit development of the Th17 lineageQ37159061
Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppressionQ33246674
Association between protective and deleterious HLA alleles with multiple sclerosis in Central East SardiniaQ33490625
TGF-beta and regulatory T cell in immunity and autoimmunityQ33722462
Immune regulatory CNS-reactive CD8+T cells in experimental autoimmune encephalomyelitisQ33886414
Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansionQ33932451
Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.Q34032006
NKT cells: facts, functions and fallacies.Q34091324
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-toleranceQ34111451
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptorQ34116317
Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosisQ34116965
Sea-level fingerprinting as a direct test for the source of global meltwater pulse IA.Q34118671
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Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosisQ34311395
IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cellsQ34318928
Role of LAG-3 in regulatory T cells.Q34358935
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanismQ34392100
Control of T-cell activation by CD4+ CD25+ suppressor T cellsQ34448423
Type 1 T regulatory cells.Q34448429
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strengthQ34520749
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.Q34529123
Development and selection of NKT cellsQ34547258
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.Q34569888
CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancerQ34585720
Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashionQ34590084
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune diseaseQ34693075
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cellsQ34709777
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases.Q34710256
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitisQ34719541
NKT cells: potential targets for autoimmune disease therapy?Q34764715
Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosisQ34789216
B cells and multiple sclerosisQ34808657
Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosisQ35127765
Foxp3 and natural regulatory T cells: key to a cell lineage?Q35204514
Association of the APOE epsilon4 allele with disease activity in multiple sclerosisQ35452445
The regulatory T cell family: distinct subsets and their interrelationsQ35603236
Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.Q35808883
Activated CD4+CD25+ T cells selectively kill B lymphocytesQ35848308
T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cellsQ35848548
Regulatory T cells: friend or foe in immunity to infection?Q35934156
Regulatory functions of CD8+CD28– T cells in an autoimmune disease modelQ36001202
Neuroprotection from complement-mediated inflammatory damageQ36024930
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotypeQ36059631
Developmental program of mouse Valpha14i NKT cellsQ36070685
Toward an understanding of NKT cell biology: progress and paradoxesQ36072480
Signaling for NKT cell development: the SAP-FynT connectionQ36076597
The B7/CD28 costimulatory family in autoimmunityQ36079881
Immunotherapeutic potential for ceramide-based activators of iNKT cellsQ36110182
Regulation of immunity by self-reactive T cellsQ36148406
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.Q36189566
IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis.Q36259695
The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damageQ36299396
Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of miceQ36363483
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesionsQ36365596
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reactionQ36368672
Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis.Q36369797
Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitisQ36369830
A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stageQ36370202
Suppressor T cells in human diseasesQ42971257
Functionally distinct NKT cell subsets and subtypesQ42972264
The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to diseaseQ43279096
Glucocorticoid treatment restores the impaired suppressive function of regulatory T cells in patients with relapsing-remitting multiple sclerosisQ43279655
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cellsQ43756252
Expansion of regulatory CD8+ T-lymphocytes and fall of activated CD8+ T-lymphocytes after i.v. methyl-prednisolone for multiple sclerosis relapse.Q43925131
CD4+CD25+FoxP3+PD1- regulatory T cells in acute and stable relapsing-remitting multiple sclerosis and their modulation by therapy.Q43945959
NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturationQ44113021
Recognition of bacterial glycosphingolipids by natural killer T cellsQ44582192
Modulation of tryptophan catabolism by regulatory T cells.Q44632333
Effect of glatiramer acetate (Copaxone) on CD4+CD25high T regulatory cells and their IL-10 production in multiple sclerosisQ44641644
Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation.Q44991530
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.Q45299244
A unifying multiple sclerosis etiology linking virus infection, sunlight, and vitamin D, through viral interleukin-10.Q45396039
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokinesQ45889051
Glatiramer acetate improves regulatory T-cell function by expansion of naive CD4(+)CD25(+)FOXP3(+)CD31(+) T-cells in patients with multiple sclerosis.Q45914495
Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosisQ46065971
Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells.Q46078718
HIV-specific IL-10-positive CD8+ T cells suppress cytolysis and IL-2 production by CD8+ T cellsQ46342730
The SH2D2A gene and susceptibility to multiple sclerosisQ46539653
Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulationQ46760280
CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditisQ47283198
Astrocyte-induced regulatory T cells mitigate CNS autoimmunity.Q47374946
Immune regulation by invariant NKT cells in autoimmunityQ37175394
Revival of CD8+ Treg-mediated suppressionQ37178215
The genetics of multiple sclerosis: SNPs to pathways to pathogenesisQ37187340
The role of regulatory T cells in multiple sclerosisQ37199648
Gender and sex hormones in multiple sclerosis pathology and therapy.Q37209917
Multiple sclerosis and regulatory T cellsQ37258383
Antioxidant therapy in multiple sclerosis.Q37258404
The development and function of regulatory T cellsQ37274250
CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?Q37279450
Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activationQ37285947
Human CD4 and CD8 regulatory T cells in infectious diseases and vaccinationQ37286650
Novel therapeutic strategies for multiple sclerosis--a multifaceted adversaryQ37313911
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patientsQ37356987
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitisQ37408819
TGF-beta as a promising option in the treatment of multiple sclerosis.Q37414480
Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosisQ37426985
Development of Valpha4+ NK T cells in the early stages of embryogenesisQ37527374
Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitisQ37593413
Regulatory T cells and inhibitory cytokines in autoimmunityQ37621070
Recent advances in processing and presentation of CD1 bound lipid antigensQ37676539
Immunopharmacological role of the leukotriene receptor antagonists and inhibitors of leukotrienes generating enzymes in multiple sclerosis.Q37713745
Invariant NKT cells regulate experimental autoimmune encephalomyelitis and infiltrate the central nervous system in a CD1d-independent mannerQ38476162
Immunoglobulin-containing cells in multiple-sclerosis plaquesQ39450637
Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosisQ39808633
Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearanceQ40071336
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.Q40110921
Novel immunosuppressive therapy by M2000 in experimental multiple sclerosisQ40382676
Decreased FOXP3 levels in multiple sclerosis patientsQ40414528
Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.Q40565739
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patientsQ40656580
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.Q40811244
Regulation of experimental autoimmune encephalomyelitis in the C57BL/6J mouse by NK1.1+, DX5+, alpha beta+ T cellsQ40822117
Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity.Q40833931
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosisQ41738233
Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells [corrected].Q41907086
Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cellsQ41908906
Importance of intrathecal synthesis of IgD in multiple sclerosis. A combined clinical, immunologic, and magnetic resonance imaging studyQ41982746
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ TregsQ42181372
MicroRNA--managing the TH-17 inflammatory responseQ42732940
Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the targetQ42942508
Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cellsQ42944333
Abnormal Tr1 differentiation in multiple sclerosisQ42953557
Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cellsQ42966143
P433issue3
P921main subjectmultiple sclerosisQ8277
immunosuppressionQ1455316
P304page(s)545-567
P577publication date2011-02-02
P1433published inImmunopharmacology and ImmunotoxicologyQ4200316
P1476titleRegulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis
P478volume33

Reverse relations

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