Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide

scientific article

Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20031192
P932PMC publication ID2194137
P698PubMed publication ID14657217
P5875ResearchGate publication ID8975180

P50authorMoriya TsujiQ37842009
P2093author name stringGuangli Yang
Richard W Franck
John Schmieg
P2860cites workConvergent C-glycolipid synthesis via the Ramberg-Bäcklund reaction: active antiproliferative glycolipidsQ73846224
Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumorsQ73889862
Synthesis and growth inhibitory properties of glucosamine-derived glycerolipidsQ74110089
A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune systemQ77929123
Human peripheral blood Valpha24+ Vbeta11+ NKT cells expand following administration of alpha-galactosylceramide-pulsed dendritic cellsQ78336930
A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumorsQ78632792
CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramidesQ28254991
NKT cells: facts, functions and fallacies.Q34091324
Immunotherapy with ligands of natural killer T cellsQ34688305
Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivoQ35168204
The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansionQ35978664
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducersQ36361001
Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramersQ36368804
CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolutionQ36404242
alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malariaQ37229005
Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biologyQ41039639
Mouse CD1-specific NK1 T cells: development, specificity, and functionQ41464349
The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cellsQ41815553
A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cellsQ43756252
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR.Q44146651
Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neuronsQ45713713
Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation.Q52023804
Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice.Q52525223
Prolonged IFN-gamma-producing NKT response induced with alpha-galactosylceramide-loaded DCs.Q53963043
Selective induction of NK cell proliferation and cytotoxicity by activated NKT cellsQ59387569
Sequential production of interferon-gamma by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of alpha -galactosylceramideQ60489559
Structure-activity relationship of alpha-galactosylceramides against B16-bearing miceQ72317791
Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cellsQ73098737
Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cellsQ73250789
Costimulation-dependent modulation of experimental autoimmune encephalomyelitis by ligand stimulation of V alpha 14 NK T cellsQ73311971
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
(1R)-1,5-anhydro-1-[(3S,4S,5R)-3-(hexacosanoylamino)-4,5-dihydroxynonadecyl]-D-galactitolQ27225773
P304page(s)1631-1641
P577publication date2003-12-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleSuperior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide
P478volume198

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cites work (P2860)
Q27667168A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells
Q41165520A Solvent-free Approach to Glycosyl Amides: Towards the Synthesis of α-N-Galactosyl Ceramides
Q37644961A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity
Q33570532A multifactorial mechanism in the superior antimalarial activity of alpha-C-GalCer
Q33852300A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids
Q37491277A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens
Q34287659Activated iNKT cells promote memory CD8+ T cell differentiation during viral infection
Q55398868Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells.
Q37002932Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses
Q27318814Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis
Q53262191Activation of natural killer T cells by α-carba-GalCer (RCAI-56), a novel synthetic glycolipid ligand, suppresses murine collagen-induced arthritis.
Q38908501Activation strategies for invariant natural killer T cells
Q41639759Adjuvant effects of therapeutic glycolipids administered to a cohort of NKT cell-diverse pigs
Q30377447Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine.
Q41763024Alpha-S-GalCer: synthesis and evaluation for iNKT cell stimulation
Q34172161Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection
Q33877217Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation
Q42257577Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production
Q61986624Aminocyclitol-Substituted Phytoceramides and their Effects on iNKT Cell Stimulation
Q43634902An α-GalCer analogue with branched acyl chain enhances protective immune responses in a nasal influenza vaccine
Q26751343Antigen specificity of invariant natural killer T-cells
Q34338958Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency
Q39377809Beta-glucosylceramide administration (i.p.) activates natural killer T cells in vivo and prevents tumor metastasis in mice
Q35761273Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders
Q36474450Boosting the Immune Response: The Use of iNKT cell ligands as vaccine adjuvants
Q24625835C-galactosylceramide: Synthesis and immunology
Q37187358CD1d presentation of glycolipids
Q90259266CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond
Q36898124CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system
Q47927252Characterization and Functional Analysis of Mouse Semi-invariant Natural T Cells
Q53554033Characterizing host immune responses by monitoring fluorescently marked cells.
Q38115508Chemical tools for studying the biological function of glycolipids
Q37824065Clinical development of a novel CD1d-binding NKT cell ligand as a vaccine adjuvant
Q38564323Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses
Q34039891Cytokine dependent and independent iNKT cell activation
Q92093422Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents
Q39955940Design, synthesis, and functional activity of labeled CD1d glycolipid agonists
Q35850748Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo.
Q34103244Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells
Q34626935Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity
Q53077248Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.
Q40860044Editorial: CD1- and MR1-Restricted T Cells in Antimicrobial Immunity
Q40513167Eliciting Epitope-Specific CD8+ T Cell Response by Immunization with Microbial Protein Antigens Formulated with α-Galactosylceramide: Theory, Practice, and Protocols
Q36249071Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes
Q39633103Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses
Q33436168Establishment of mass spectrometric fingerprints of novel synthetic cholesteryl neoglycolipids: the presence of a unique C-glycoside species during electrospray ionization and during collision-induced dissociation tandem mass spectrometry
Q42972264Functionally distinct NKT cell subsets and subtypes
Q55318324Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control.
Q27667759Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
Q34479554Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
Q38885794Glycolipid activators of invariant NKT cells as vaccine adjuvants
Q34983932Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
Q37187603Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants
Q33762686Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion
Q36407438Glycolipid-activated NKT cells support the induction of persistent plasma cell responses and antibody titers
Q36517889Glycolipids as immunostimulating agents
Q27676395Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T Cells
Q35951531Going both ways: immune regulation via CD1d-dependent NKT cells
Q42668044Harnessing CD1d-restricted T cells toward antitumor immunity in humans
Q48343602Harnessing Invariant NKT Cells to Improve Influenza Vaccines: A Pig Perspective
Q37388427Harnessing human CD1d restricted T cells for tumor immunity: progress and challenges
Q37349692Harnessing invariant NKT cells in vaccination strategies
Q36584187How T lymphocytes recognize lipid antigens
Q24650966How do natural killer T cells help B cells?
Q39859712Human CD1 dimeric proteins as indispensable tools for research on CD1-binding lipids and CD1-restricted T cells
Q36637517Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells
Q37565143Human invariant natural killer T cells: implications for immunotherapy
Q39863367Human leukemic cells loaded with alpha-galactosylceramide (alpha-GalCer) activate murine NKT cells in situ
Q33267309Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions
Q39843991Identification of C-glycoside analogues that display a potent biological activity against murine and human invariant natural killer T cells
Q38079152Imaging natural killer T cells in action
Q38890717Immunotherapeutic strategies targeting natural killer T cell responses in cancer.
Q28543248Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells
Q38942602In vivo antimalarial activities of glycoalkaloids isolated from Solanaceae plants
Q37286356Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin
Q39735626Induction of Th1-biased cytokine production by alpha-carba-GalCer, a neoglycolipid ligand for NKT cells
Q34429040Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
Q36404025Innate NKT lymphocytes confer superior adaptive immunity via tumor-capturing dendritic cells
Q36990616Innate Valpha14(+) natural killer T cells mature dendritic cells, leading to strong adaptive immunity
Q48316500Innate immune cells for immunotherapy of autoimmune and cancer disorders.
Q36251325Intradermal NKT cell activation during DNA priming in heterologous prime-boost vaccination enhances T cell responses and protection against Leishmania
Q37822744Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens
Q36799695Invariant NKT cells and tolerance
Q21284987Invariant NKT cells as novel targets for immunotherapy in solid tumors
Q28083069Invariant natural killer T cells and their ligands: focus on multiple sclerosis
Q38120169Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease.
Q37686081Invariant natural killer T cells in rheumatic disease: a joint dilemma
Q34323476Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Q36739848Invariant natural killer T cells: bridging innate and adaptive immunity
Q36895646Invariant natural killer cells in the response to bacteria: the advent of specific antigens
Q37285947Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation
Q35837120Lipid and Carbohydrate Modifications of α-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation
Q33724575Lipid and glycolipid antigens of CD1d-restricted natural killer T cells
Q37219070Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer
Q27658388Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V 14i NKT Cells
Q39702161Methylene Homologues of Artemisone: An Unexpected Structure-Activity Relationship and a Possible Implication for the Design of C10-Substituted Artemisinins
Q33927443Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides
Q38050484Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells
Q36224039Molecular identification of GD3 as a suppressor of the innate immune response in ovarian cancer
Q34519826Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity
Q33653495Multiple innate signaling pathways cooperate with CD40 to induce potent, CD70-dependent cellular immunity
Q41138405NK and NKT Cell Depletion Alters the Outcome of Experimental Pneumococcal Pneumonia: Relationship with Regulation of Interferon-γ Production
Q27674653NKT TCR Recognition of CD1d- -C-Galactosylceramide
Q36568780NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma
Q26866223NKT cell networks in the regulation of tumor immunity
Q39128707Nanomapping of CD1d-glycolipid complexes on THP1 cells by using simultaneous topography and recognition imaging.
Q47221129Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective
Q35506478Natural killer T cell activation overcomes immunosuppression to enhance clearance of postsurgical breast cancer metastasis in mice
Q38148759Natural killer T cell based Immunotherapy
Q36521991Natural killer T cell-mediated antitumor immune responses and their clinical applications
Q37545341Natural killer T cells and the regulation of asthma
Q35798168Natural killer T cells as targets for immunotherapy of autoimmune diseases
Q36765720Natural killer T cells in health and disease
Q36799698Natural killer T cells regulate the development of asthma
Q42579685Natural killer T cells subsets in cancer, functional defects in prostate cancer and implications for immunotherapy
Q34605137Natural killer T cells: an unconventional T-cell subset with diverse effector and regulatory functions.
Q36969739Natural killer T-cell autoreactivity leads to a specialized activation state
Q42608724Non-glycosidic compounds can stimulate both human and mouse iNKT cells
Q50095531Non-specific CD8+ T cells and dendritic cells/macrophages participate in CD8+ T cell-mediated cluster formation against malaria liver-stage infection.
Q35925629Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma
Q38206819Optimizing NKT cell ligands as vaccine adjuvants
Q33318487Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules
Q63361216Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation
Q35973205Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids
Q42954809Potential role of NKT regulatory cell ligands for the treatment of immune mediated colitis
Q34761156Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model
Q95383075Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist
Q64076705Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy
Q38639439Protective role of NKT cells and macrophage M2-driven phenotype in bleomycin-induced pulmonary fibrosis
Q35684305Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production
Q37088000Recognition of CD1d-restricted antigens by natural killer T cells
Q34000070Regulation of anthrax toxin-specific antibody titers by natural killer T cell-derived IL-4 and IFNγ.
Q28256001Regulation of interferon-gamma during innate and adaptive immune responses
Q36139773Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.
Q37834024Regulatory T-cell as orchestra leader in immunosuppression process of multiple sclerosis
Q55365683Role of Natural Killer T Cells in the Development of Obesity and Insulin Resistance: Insights From Recent Progress.
Q40556221Selective Conditions Are Required for the Induction of Invariant NKT Cell Hyporesponsiveness by Antigenic Stimulation
Q38844616Small-Molecule Carbohydrate-Based Immunostimulants.
Q33599059Stimulation of natural killer T cells by glycolipids
Q47745185Strategies to Improve Vaccine Efficacy against Tuberculosis by Targeting Innate Immunity
Q38016483Strategy of lipid recognition by invariant natural killer T cells: 'one for all and all for one'.
Q27677017Structural and Functional Characterization of a Novel Nonglycosidic Type I NKT Agonist with Immunomodulatory Properties
Q84938053Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice
Q54643220Suppression of eosinophilic airway inflammation by treatment with alpha-galactosylceramide.
Q38862782Synthesis and biological activities of C-glycosides of KRN 7000 with novel ceramide residues
Q48213664Synthesis of C6''-modified α-C-GalCer analogues as mouse and human iNKT cell agonists
Q42160618Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids
Q26748456Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
Q39196835Tailored design of NKT-stimulatory glycolipids for polarization of immune responses
Q37995950Targeting natural killer cells and natural killer T cells in cancer
Q37874633Targeting the diverse immunological functions expressed by hepatic NKT cells
Q35860595The Alpha and Omega of Galactosylceramides in T Cell Immune Function
Q38883512The CD1 family: serving lipid antigens to T cells since the Mesozoic era.
Q26797344The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8(+) T Cell Generation
Q55094012The Role of Natural Killer T Cells in Cancer-A Phenotypical and Functional Approach.
Q37484801The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition
Q38611633The burgeoning family of unconventional T cells
Q34328138The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
Q42661990The crystal structure of human CD1d with and without alpha-galactosylceramide
Q34179888The effect of intracellular trafficking of CD1d on the formation of TCR repertoire of NKT cells
Q36799681The in vivo response of invariant natural killer T cells to glycolipid antigens
Q37762343The invariant NKT cell subset in anti-viral defenses: a dark horse in anti-influenza immunity?
Q27023425The regulatory role of invariant NKT cells in tumor immunity
Q24648939The role of NKT cells in tumor immunity
Q38090560The role of natural killer T cells in B cell malignancies
Q33843406The stimulating adventure of KRN 7000.
Q53050285The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.
Q36799691Therapeutic potential of CD1d-restricted invariant natural killer T cell-based treatment for autoimmune diseases
Q58777562Tissue-Specific Roles of NKT Cells in Tumor Immunity
Q37137098Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes
Q41841063Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues
Q35879532Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease
Q35998799alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles
Q33778356Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents
Q57598595α-GalCer ameliorates listeriosis by accelerating infiltration of Gr-1+ cells into the liver
Q93062542α-GalCer and iNKT Cell-Based Cancer Immunotherapy: Realizing the Therapeutic Potentials
Q59134498α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

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