CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta

scientific article published on 27 July 2009

CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0900191
P932PMC publication ID3057032
P698PubMed publication ID19635906
P5875ResearchGate publication ID26698928

P50authorGerald T NepomQ38546281
P2093author name stringThomas N Wight
Rebecca P Wu
Jane H Buckner
Paul L Bollyky
S Alice Long
Kathy R Braun
Stephen P Evanko
Anton Preisinger
Ben A Falk
P2860cites workFoxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cellsQ24298812
Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathwaysQ24323279
IL-10 inhibits apoptotic cell death in human T cells starved of IL-2Q24337335
CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent mannerQ24656647
ICOS co-stimulatory receptor is essential for T-cell activation and functionQ28187985
Resolution of lung inflammation by CD44Q28506254
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
Involvement of CD44 in cytoskeleton rearrangement and raft reorganization in T cells.Q32066969
Activation and interaction of CD44 and hyaluronan in immunological systems.Q33712311
Turnover of hyaluronan in synovial joints: elimination of labelled hyaluronan from the knee joint of the rabbitQ34098373
A crucial role for CD44 in inflammationQ34234182
Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complexQ34321775
Regulation of lung injury and repair by Toll-like receptors and hyaluronanQ34462186
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.Q34509694
The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neckQ46920694
Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cellsQ47280502
Inhibition of phagocytosis by high molecular weight hyaluronateQ47293204
Forms and functions of CD44.Q48004043
Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts.Q52537753
Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta.Q53576197
Angiogenesis induced by degradation products of hyaluronic acid.Q55057424
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune diseaseQ56902429
Engagement of CD44 up-regulates Fas Ligand expression on T cells leading to activation-induced cell deathQ57357307
Preparation and properties of fluorescein-labelled hyaluronateQ67353047
The selective suppression of immunogenicity by hyaluronic acidQ68970357
Implication of CD44 in adhesion-mediated overproduction of TGF-beta and IL-1 in monocytes from patients with bone marrow fibrosisQ71028521
Human CD4+ CD25+ regulatory T cells suppress NKT cell functionsQ73784466
Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ cultureQ73848985
A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory moleculesQ74442087
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
CD44 differentially activates mouse NK T cells and conventional T cellsQ79754988
Blockade of hyaluronan inhibits IL-2-induced vascular leak syndrome and maintains effectiveness of IL-2 treatment for metastatic melanomaQ81039615
Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell functionQ82037277
Hyaluronan and its catabolic products in tissue injury and repairQ34517570
TSG-6: a pluripotent inflammatory mediator?Q34527768
FOXP3 and NFAT: partners in toleranceQ34551714
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsQ34556464
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.Q34569888
Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravisQ35740840
Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44Q35849305
HyaluronanQ36001372
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.Q36078042
Mechanisms of suppression by suppressor T cellsQ36078047
Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signalQ36124510
Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4.Q36376473
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent mannerQ36403637
Hyaluronan fragments: an information-rich systemQ36528068
Hyaluronan in tissue injury and repairQ36824173
The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cellsQ36882243
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitisQ37408819
Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent mannerQ38327728
Early-response gene signalling is induced by angiogenic oligosaccharides of hyaluronan in endothelial cells. Inhibition by non-angiogenic, high-molecular-weight hyaluronan.Q38346862
Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shiftQ38975096
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.Q40013872
A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoformsQ40372564
Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression.Q40396971
Quantitative multi-gene transcriptional profiling using real-time PCR with a master templateQ40422373
IL-10 gene-deficient mice lack TGF-beta/Smad signaling and fail to inhibit proinflammatory gene expression in intestinal epithelial cells after the colonization with colitogenic Enterococcus faecalis.Q40455035
CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production.Q40463447
Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cellsQ40714989
CD44 (Pgp-1) inhibits CD3 and dexamethasone-induced apoptosisQ41292108
Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytesQ43870768
Crosslinking of CD44 on human osteoblastic cells upregulates ICAM-1 and VCAM-1.Q44371521
Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cellsQ44475100
Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblastsQ44756854
Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular leak syndrome by IL-2.Q44862536
Regulation of interleukin-2-induced vascular leak syndrome by targeting CD44 using hyaluronic acid and anti-CD44 antibodiesQ44890965
Mouse B cell activation is inhibited by CD44 cross-linkingQ44915237
CD44 contributes to T cell activationQ45237907
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cellsQ45304815
The TSC-mTOR signaling pathway regulates the innate inflammatory responseQ46321173
Hyaluronan cross-linking: a protective mechanism in inflammation?Q46743683
Hyaluronan synthesis is required for IL-2-mediated T cell proliferationQ46868588
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2232-2241
P577publication date2009-07-27
P1433published inJournal of ImmunologyQ3521441
P1476titleCD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
P478volume183

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