Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation

scientific article

Resolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1210/ER.2008-0006
P932PMC publication ID2819735
P698PubMed publication ID18664617
P5875ResearchGate publication ID23135203

P50authorDaniel J. MooreQ38325799
Craig S. NunemakerQ57438288
P2093author name stringAnthony L McCall
Boris Kovatchev
Kenneth L Brayman
Xiaolun Huang
Robert J Ketchum
P2860cites workDisruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
The autoimmune regulator (AIRE) is a DNA-binding proteinQ24291636
ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4+ T cellsQ24296273
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-betaQ24311833
A family of cytokine-inducible inhibitors of signallingQ24313168
The unique cytoarchitecture of human pancreatic islets has implications for islet cell functionQ24541464
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradationQ24654107
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeQ24677071
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Positional cloning of the APECED geneQ28116470
The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding proteinQ28140689
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimenQ28141785
Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agentsQ28196845
Serum levels of interleukin 6, C-reactive protein, vascular cell adhesion molecule 1, and monocyte chemotactic protein 1 in relation to insulin resistance and glucose intolerance--the Chennai Urban Rural Epidemiology Study (CURES)Q28200186
Toll-like receptors and acquired immunityQ35642955
Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupusQ35741943
Hepatocyte growth factor gene therapy for islet transplantationQ35753520
Use of Sertoli cell transplants to provide local immunoprotection for tissue graftsQ35790833
Achievement of insulin independence via pancreatic islet transplantation using a remote isolation center: a first-year review.Q35803455
Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivoQ35847438
Islet transplantation in patients with diabetes mellitus: choice of immunosuppressionQ35891569
Death effectors of beta-cell apoptosis in type 1 diabetesQ35908961
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hostsQ35928910
Beta-cells in type 2 diabetes: a loss of function and massQ35946606
Regulatory functions of CD8+CD28– T cells in an autoimmune disease modelQ36001202
Methods of human islet culture for transplantationQ36008369
The role of the innate immunity in islet transplantationQ36084955
Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibodyQ36263421
How do CD4+CD25+ regulatory T cells control autoimmunity?Q36279165
Advances in pancreatic islet transplantation in humansQ36347873
Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells. Transfer of diabetes and insulitis to nondiabetic (NOD X B10) F1 mice with bone marrow cells from NOD miceQ36357636
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic processQ36363681
Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screeningQ36364959
Continuous glucose monitoring and closed-loop systemsQ36367034
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.Q36370525
Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes ModelQ36371477
Systemic exposure to irradiated apoptotic cells induces autoantibody productionQ36401434
Prospective and challenges of islet transplantation for the therapy of autoimmune diabetesQ36455218
Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.Q36458495
Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory stateQ36459935
Current status of pancreatic islet transplantation.Q36475429
Developments in clinical islet, liver thoracic, kidney and pancreas transplantation in the last 5 yearsQ36505718
Interventional strategies to prevent beta-cell apoptosis in islet transplantation.Q36521066
Type 1 diabetes: pathogenesis and preventionQ36538943
Chemokines and their receptors in islet allograft rejection and as targets for tolerance inductionQ36560836
Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.Q36603252
Complexity of anti-immunosenescence strategies in humansQ36616598
Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantationQ28201202
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2Q28201656
Aire deficient mice develop multiple features of APECED phenotype and show altered immune responseQ28202432
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Pharmacological approaches to studying platelet function: an overviewQ28210863
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damageQ28214799
Adenosine A2A receptor agonists as anti-inflammatory agentsQ28242079
Islet transplantation as a treatment for diabetes - a work in progressQ28244953
The influence of age on T cell generation and TCR diversityQ28251818
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAXQ28265206
Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonistsQ28354178
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cellsQ28513895
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant ratQ28571409
Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cellsQ28574877
Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitusQ28581226
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsQ28586863
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signalingQ28646137
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyQ29619109
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protectionQ30307082
The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic miceQ30309929
Inhibition of STAT4 activation by lisofylline is associated with the protection of autoimmune diabetesQ30312012
Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine inductionQ30312207
The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantationQ30312209
Lisofylline, a novel anti-inflammatory agent, enhances glucose-stimulated insulin secretion in vivo and in vitro: studies in prediabetic and normal ratsQ30312217
A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsisQ30433444
Inflammation blockade improves pancreatic islet functionQ30435500
A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cellsQ30435569
Inflammatory blockade improves human pancreatic islet function and viabilityQ30435910
Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetesQ30440311
Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitisQ30441350
Cloned receptors and cardiovascular responses to adenosineQ30467649
CD4+ CD25+ regulatory T-cells inhibit the islet innate immune response and promote islet engraftmentQ82984549
Insulin sensitivity, glucose effectiveness, and free fatty acid dynamics after human islet transplantation for type 1 diabetesQ82995443
Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivoQ83059341
Islets transplanted intraportally into the liver are stimulated to insulin and glucagon release exclusively through the hepatic arteryQ83149361
A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunityQ83288981
Ameliorating injury during preservation and isolation of human islets using the two-layer method with perfluorocarbon and UW solutionQ83829195
Assessment of glycemic control after islet transplantation using the continuous glucose monitor in insulin-independent versus insulin-requiring type 1 diabetes subjectsQ83874715
Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2.Q44255124
Survival and metabolic function of syngeneic rat islet grafts transplanted in the omental pouchQ44339715
Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cellsQ44517194
Thymic transplantation in miniature swine: III. Induction of tolerance by transplantation of composite thymokidneys across fully major histocompatibility complex-mismatched barriersQ44552329
Importance of hyperglycemia on the primary function of allogeneic islet transplantsQ44584364
Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse.Q44631808
Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantationQ44662213
Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: local immunosuppression or islet toxicity?Q44711155
Intraportally transplanted pancreatic islets revascularized from hepatic arterial systemQ44763396
Elevated vascular endothelial growth factor production in islets improves islet graft vascularization.Q44816724
Increased NF-kappa B activity in B cells and bone marrow-derived dendritic cells from NOD miceQ44870681
Resistance to anti-CD45RB-induced tolerance in NOD mice: mechanisms involvedQ44892804
Closing the loop: the adicol experienceQ44937934
CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independentQ44988229
NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance inductionQ45043581
Transplantation for type I diabetes: comparison of vascularized whole-organ pancreas with isolated pancreatic isletsQ45071409
Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic isletsQ45172296
Pharmacologically regulated regeneration of functional human pancreatic islets.Q45178243
{beta}-Cell function following human islet transplantation for type 1 diabetesQ45199133
The portal immunosuppressive storm: relevance to islet transplantation?Q45234964
Evaluation of intrathymic islet transplantation in the prediabetic periodQ45349099
TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR ratsQ45532280
The effect of cyclosporin-A, low-temperature culture, and anti-Ia antibodies on prevention of rejection of rat islet allograftsQ45794005
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destructionQ45858530
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitroQ45862217
Hepatocyte Growth Factor Gene Therapy for Pancreatic Islets in Diabetes: Reducing the Minimal Islet Transplant Mass Required in a Glucocorticoid-Free Rat Model of Allogeneic Portal Vein Islet TransplantationQ45869446
Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I.Q45874299
Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoyQ45876325
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic miceQ45883411
Lisofylline, an inhibitor of unsaturated phosphatidic acid generation, ameliorates interleukin-1 beta-induced dysfunction in cultured rat isletsQ46215526
Purified murine islet allografts: islet engraftment as influenced by implantation site and glucotoxicity.Q46297668
Destruction of islet isografts by severe nonspecific inflammationQ46377623
Angiotensin II type 1 receptor inhibition markedly improves the blood perfusion, oxygen tension and first phase of glucose-stimulated insulin secretion in revascularised syngeneic mouse islet graftsQ46475231
Differences in suppressor of cytokine signaling-1 (SOCS-1) expressing islet allograft destruction in normal BALB/c and spontaneously-diabetic NOD recipient mice.Q46478181
Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell massQ46570550
Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes.Q46608639
Regulation of pancreatic beta-cell mass and proliferation by SOCS-3.Q46745814
Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetesQ46774731
Intra-ductal glutamine administration reduces oxidative injury during human pancreatic islet isolation.Q46816085
Natural killer T-cells participate in rejection of islet allografts in the liver of miceQ46870163
Long-term acceptance of fully allogeneic cardiac grafts by cotransplantation of vascularized thymus in miniature swineQ46900304
NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cellsQ47241689
Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivityQ47265853
Distinct maturation of, but not migration between, human monocyte-derived dendritic cells upon ingestion of apoptotic cells of early or late phasesQ47310051
Size-dependent revascularization of transplanted pancreatic isletsQ47336429
Intraislet endothelial cells contribute to revascularization of transplanted pancreatic isletsQ47690560
Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction.Q47725489
B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice.Q47757360
Putative environmental factors in Type 1 diabetes.Q48030340
Activation of Macrophage-Associated Molecules after Brain Death in IsletsQ48336546
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopyQ30853783
Activation of SOCS-3 by resistinQ30856129
Low revascularization of experimentally transplanted human pancreatic isletsQ30872883
Androgen receptors in thymic epithelium modulate thymus size and thymocyte developmentQ31957984
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejectionQ33187036
Five-year follow-up after clinical islet transplantationQ33218078
Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cellsQ33624770
Limited effect of CpG ODN in preventing type 1 diabetes in NOD miceQ33628140
HLA-mismatched renal transplantation without maintenance immunosuppressionQ33640791
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?Q33806397
A(2A) adenosine receptors in human peripheral blood cellsQ33849871
Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligandQ33853062
Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infectionQ33868162
Natural adjuvants: endogenous activators of dendritic cellsQ33878894
Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetesQ33894591
Further studies on the transplantation of isolated pancreatic isletsQ34044682
Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetesQ34091887
Inhibition of ICAM-1/LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation toleranceQ34107796
Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicityQ34109834
Tolerance to islet autoantigens in type 1 diabetesQ34178116
Revascularization and microcirculation of freely grafted islets of LangerhansQ34245839
Innate immunity and inflammation: a transcriptional paradigmQ34303215
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis.Q34360402
A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1Q34388164
Pancreatic islet transplantation for diabetes: successes, limitations, and challenges for the futureQ34396192
Adenosine receptors: G protein-mediated signalling and the role of accessory proteins.Q34487172
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosisQ34495385
Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusionsQ34527799
Toll-like receptors in systemic autoimmune diseaseQ34576448
Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents.Q34596884
Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosisQ34646812
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitisQ34719541
"Infectious" transplantation tolerance.Q34726892
Regulation of regulatory T cells: role of dendritic cells and toll-like receptorsQ36638378
Role of autoantibodies in type 1 diabetesQ36664712
Cooperation of Toll-like receptor signals in innate immune defenceQ36743540
Islet vasculature as a regulator of endocrine pancreas functionQ36755457
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.Q36766872
CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospectsQ36826059
Glucolipotoxicity: fuel excess and beta-cell dysfunction.Q36861036
The impact of insulin resistance on endothelial function, progenitor cells and repairQ36892494
Progress toward antibody-induced transplantation toleranceQ36921578
Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cellsQ36937316
Type 1 diabetes as a relapsing-remitting disease?Q36992950
Cytokines and beta-cell biology: from concept to clinical translationQ37019667
Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure: results from the DCCT. Diabetes Control and Complications TrialQ37055003
The role of sex steroids and gonadectomy in the control of thymic involution.Q37092435
Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transductionQ37332163
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patientsQ37356987
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetesQ37358159
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation toleranceQ37494764
TLR agonists abrogate costimulation blockade-induced prolongation of skin allograftsQ37562436
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese miceQ38295719
IFN-gamma/TNF-alpha synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic beta cell deathQ38303234
Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protectionQ38310308
Tolerogenic dendritic cells transferring hyporesponsiveness and synergizing T regulatory cells in transplant toleranceQ40135934
Functional MR microimaging of pancreatic beta-cell activationQ40276558
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradationQ40328896
Exposure to chronic high glucose induces beta-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic beta-cellsQ40381260
Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritisQ40419753
Baculovirus p35 increases pancreatic beta-cell resistance to apoptosisQ40421895
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.Q40452210
The role of innate immunity in autoimmunity.Q40459661
Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}.Q40477727
The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockadeQ40624980
Insulin dependent diabetes mellitus in the non-obese diabetic mouse: a disease mediated by T cell anergy?Q40636843
Non-genetic risk determinants of type 1 diabetesQ40655935
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.Q40673661
Target cell defense prevents the development of diabetes after viral infection.Q40741831
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.Q40816941
Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma -mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cellsQ40857756
Glucose toxicity: the implications of hyperglycemia in the pathophysiology of diabetes mellitus.Q40939499
Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cellsQ40991239
Prevention of diabetes in BB/Wor rats by intrathymic islet injectionQ41018994
Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell functionQ41020720
Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice.Q41151273
Hematopoietic cell transplantation for the induction of allo- and xenotolerance.Q41180145
Allotransplantation of culture-isolated neonatal rat islet tissue. Absence of MHC class II positive antigen-presenting cells in nonimmunogenic isletsQ41259986
A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitusQ41291146
In Vivo Imaging of Immune Rejection in Transplanted Pancreatic IsletsQ60192350
A defect in bone marrow derived dendritic cell maturation in the nonobesediabetic mouseQ60739111
Evidence from Transgenic Mice That Interferon-β May Be Involved in the Onset of Diabetes MellitusQ60937528
Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation ToleranceQ61651670
Cytokine profile and insulin antibody IgG subclasses in patients with recent onset Type 1 diabetes treated with oral insulinQ63348373
Changes in Inflammatory Cytokines Are Related to Impaired Glucose Tolerance in Offspring of Type 2 Diabetic SubjectsQ64355576
Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt miceQ67589807
Intrathymic Islet Transplantation in the Spontaneously Diabetic BB RatQ67904500
Pretransplantation blood transfusion revisitedQ68016806
Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birthQ68143697
Induction of donor-specific unresponsiveness by intrathymic islet transplantationQ68354945
Transplantation of intact pancreatic islets in ratsQ68495876
Transplantation of isolated pancreatic islets across strong and weak histocompatibility barriersQ68506774
Glucose toxicityQ68519957
Immunostimulation circumvents diabetes in NOD/Lt miceQ69313715
Effect of cyclosporine and low-temperature culture on prevention of rejection of islet xenografts (rat-to-mouse)Q70286871
Gamma interferon induces novel expression of Ia antigens by rat pancreatic islet endocrine cellsQ70356955
NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 miceQ70395198
A new site for islet transplantation--a peritoneal-omental pouchQ70443079
Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graftQ70464374
Pancreatic islet transplantation: immuno-alteration with ultraviolet irradiationQ70482507
Effect of hypoxia on insulin secretion by isolated rat and canine islets of LangerhansQ70530953
Bone marrow abnormalities in the non-obese diabetic mouseQ70608733
Adenosine enhances IL-10 secretion by human monocytesQ71151729
New perspectives on the microvasculature of the islets of Langerhans in the ratQ71470083
Spontaneous diabetes in rats: destruction of islets is prevented by immunological toleranceQ71565180
Prolongation of islet xenograft survival by in vitro culture of rat megaislets in 95% O2Q71612293
Interferon expression in the pancreases of patients with type I diabetesQ71698025
Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytesQ71699810
Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltratesQ71811771
Prevention of spontaneous autoimmune diabetes in diabetes-prone BB rats by prophylactic treatment with antirat interferon-gamma antibodyQ71930600
Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic miceQ71968128
Survival of heart allografts in nonimmunosuppressed murine recipients by pretreatment of the donor tissue with anti-Ia antibodiesQ72063085
Deletion of donor-reactive T lymphocytes in adult mice after intrathymic inoculation with lymphoid cellsQ72216469
Protective effect of preservation of canine pancreas by the two-layer (University of Wisconsin solution/perfluorochemical) method against rewarming ischemic injury during implantationQ72322224
The failure of intrathymic transplantation of nonimmunogenic islet allografts to promote induction of donor-specific unresponsivenessQ72354324
Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD miceQ72495233
Tolerance induction in a fully allogeneic combination using anti-T cell receptor-alpha beta monoclonal antibody, low dose irradiation, and donor bone marrow transfusionQ72580976
Prolongation of rat islet allografts with the use of ultraviolet irradiation, without immunosuppressionQ72816659
Protection against autoimmune diabetes in mixed bone marrow chimeras: mechanisms involvedQ73026029
Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environmentQ73034296
Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cellsQ73048880
Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naïve phenotypesQ73066946
Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunityQ73209258
Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic miceQ73289663
Islet isolation and transplantation outcomes of pancreas preserved with University of Wisconsin solution versus two-layer method using preoxygenated perfluorocarbonQ48356065
Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin.Q50691879
The metabolic syndrome sensitizes leukocytes for glucose-induced immune gene expression.Q51483620
Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes.Q51500191
Heightened interferon-alpha/beta response causes myeloid cell dysfunction and promotes T1D pathogenesis in NOD mice.Q51775394
[Significance of the size of islands of Langerhans for successful vascularization after free transplantation]Q51833263
Stimulation by glucose of the blood flow to the pancreatic islets of the ratQ51853114
Toll-dependent control mechanisms of CD4 T cell activation.Q51996404
A role for TGFbeta and B cells in immunologic tolerance after intravenous injection of soluble antigen.Q52017514
Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection.Q52022038
Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes.Q52172385
Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.Q52226171
Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation?Q52536571
SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.Q52574322
Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.Q52575906
Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK.Q53579615
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.Q53591473
Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects.Q53604416
Improved human islet isolation using nicotinamide.Q53612771
Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility.Q53626789
Thymocyte/splenocyte-derived CD4+CD25+Treg stimulated by anti-CD200R2 derived dendritic cells suppress mixed leukocyte cultures and skin graft rejection.Q53627738
Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.Q53650288
Composite islet-endothelial cell grafts: a novel approach to counteract innate immunity in islet transplantation.Q53654471
NOD B-cells are insufficient to incite T-cell-mediated anti-islet autoimmunity.Q53668853
Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-2.Q53729453
CD4+CD25+ regulatory T cells control the progression from periinsulitis to destructive insulitis in murine autoimmune diabetes.Q53846131
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.Q53859655
Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis.Q53875137
IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.Q53879223
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.Q53883439
Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.Q53904936
NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.Q53941826
International trial of the Edmonton protocol for islet transplantation.Q54032399
NOD mice have a generalized defect in their response to transplantation tolerance induction.Q54095945
Both CD4(+)and CD8(+)T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats.Q54104308
Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice.Q54154251
Priming with donor spleen cells and activated B cells can induce prolonged survival of class I-disparate skin allografts in cyclophosphamide-treated miceQ54162391
Intrathymic transplantation of islet antigen affects CD8+ diabetogenic T-cells resulting in tolerance to autoimmune IDDM.Q54166748
Drug-induced tolerance to allografts in mice. X. Augmentation of split tolerance in murine combinations disparate at both H-2 and non-H-2 antigens by the use of spleen cells from donors preimmunized with recipient antigens.Q54407631
Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: implications for the management of diabetes.Q54453992
Association between microchimerism and multiple sclerosis in Canadian twins.Q54592056
Characteristics of rat CD4(+)CD25(+) T cells and their ability to prevent not only diabetes but also insulitis in an adoptive transfer model in BB ratsQ56902065
Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashionQ56904126
Immunomodulation of pancreatic islet allografts in mice with CTLA4Ig secreting muscle cellsQ56909439
Role of Blood Glucose in Cytokine Gene Expression in Early Syngeneic Islet TransplantationQ57160908
The Type 1 Diabetes Locus Idd6 Controls TLR1 ExpressionQ57632620
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptorsQ57731080
Angiotensin II Type 1 Receptor Blockade Improves Hyperglycemia-Induced Endothelial Dysfunction and Reduces Proinflammatory Cytokine Release From LeukocytesQ57790233
Thymic transplantation in miniature swine. I. Development and function of the "thymokidney"Q73299809
Primary nonfunction of islet xenografts in rat recipients results from non-T-cell-mediated immune responsesQ73321620
Thymic transplantation in miniature swine. II. Induction of tolerance by transplantation of composite thymokidneys to thymectomized recipientsQ73520553
Magnetic resonance-defined periportal steatosis following intraportal islet transplantation: a functional footprint of islet graft survival?Q73581826
Exocrine contamination of isolated islets of Langerhans deteriorates the process of revascularization after free transplantationQ73648733
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideQ73688337
Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigensQ73929105
Survival and function of syngeneic rat islet grafts placed within the thymus versus under the kidney capsuleQ74083380
Role of macrophages and natural killer cells in the rejection of pig islet xenografts in miceQ74147280
Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factorQ74181605
Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinaseQ74244221
Contribution of ecto-5'-nucleotidase to the inhibition of platelet aggregation by human endothelial cellsQ74296189
Intrathymic kidney cells delay the onset of lupus nephritis in MRL-lpr/lpr miceQ74535813
Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic miceQ74601824
Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivoQ75224515
gamma-Interferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1Q77292209
Adoptively transferable tolerance induced by CD45RB monoclonal antibodyQ77361906
Bystander apoptosis triggers dendritic cell maturation and antigen-presenting functionQ77483789
Linked suppression of skin graft rejection can operate through indirect recognitionQ77620004
Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genesQ77658697
The potential contribution of rejection to survival of transplanted human isletsQ77683727
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Non-hematopoietic allograft cells directly activate CD8+ T cells and trigger acute rejection: an alternative mechanism of allorecognitionQ77719695
Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitisQ77751091
Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucoseQ77795060
Vascularized thymic lobe transplantation in miniature swine: I. Vascularized thymic lobe allografts support thymopoiesisQ77801806
Cellular and molecular changes accompanying the progression from insulitis to diabetesQ77952302
I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic miceQ77967366
Decreased vascular density in mouse pancreatic islets after transplantationQ78014687
Regulatory T cells maintain peripheral tolerance to islet allografts induced by intrathymic injection of MHC class I allopeptidesQ78229544
CD25+ immunoregulatory CD4 T cells mediate acquired central transplantation toleranceQ78701766
Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantationQ78724482
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cellsQ78806915
Examination of gene expression profile of functional human pancreatic islets after 2-week cultureQ79439038
Glycemic thresholds for activation of counterregulatory hormone and symptom responses in islet transplant recipientsQ79455744
Postprandial hyperglycemia alters inflammatory and hemostatic parametersQ79999725
Prevention of diabetes in nonobese diabetic mice by nonmyeloablative allogeneic bone marrow transplantationQ80172749
TLR engagement prevents transplantation toleranceQ80256970
Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytesQ80257287
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosisQ80353010
Procurement of the human pancreas for pancreatic islet transplantationQ80465083
Cutting edge: primary B lymphocytes preferentially expand allogeneic FoxP3+ CD4 T cellsQ80736006
Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetesQ80813712
MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivoQ81008990
CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific reactivation in vivo is critical for bystander regulationQ81406391
Would blockage of cytokines improve the outcome of pancreatic islet transplantation?Q81459802
Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cellsQ82097325
Graft vascular function after transplantation of pancreatic isletsQ34728192
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic isletsQ34796756
Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivoQ35059150
Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connectionQ35073626
Severe pancreatitis with exocrine destruction and increased islet neogenesis in mice with suppressor of cytokine signaling-1 deficiency.Q35103140
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases.Q35132147
Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes.Q35165534
Regulatory CD4+CD25+T cells in prevention of allograft rejectionQ35212916
Reduction of inflammation by decreasing production of interleukin-1 or by specific receptor antagonismQ35382135
Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinantsQ35467756
Involvement of growth factors in thymic involutionQ35591810
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?Q35609267
NF-kappa B prevents beta cell death and autoimmune diabetes in NOD miceQ35629489
Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expressionQ35632241
The role of donor lymphoid cells in the transfer of allograft toleranceQ41370391
Immunogenetics and the cause of autoimmune diseaseQ41578264
The microbial product lipopolysaccharide confers diabetogenic potential on the T cell repertoire of BDC2.5/NOD mice: implications for the etiology of autoimmune diabetesQ41731978
Valpha14 NK T cell-triggered IFN-gamma production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets.Q41788479
Defects in the differentiation and function of bone marrow-derived dendritic cells in non-obese diabetic miceQ41852796
Interleukin 10 is a growth factor for a population of regulatory T cellsQ42224716
Macrophage-mediated cytotoxicity against cultured pancreatic islet cells.Q42455600
Pseudoislet vascularization. Induction of diaphragm-fenestrated endothelia from the hepatic sinusoidsQ42486707
Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulationQ42495919
Implantation site-dependent dysfunction of transplanted pancreatic isletsQ42510464
Feasibility of automating insulin delivery for the treatment of type 1 diabetesQ42604696
Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocolQ43456511
Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanismsQ43508044
Enhanced protection from renal ischemia-reperfusion [correction of ischemia:reperfusion] injury with A(2A)-adenosine receptor activation and PDE 4 inhibitionQ43623084
Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC functionQ43829924
Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantationQ43833546
Insulin gene transfer enhances the function of human islet grafts.Q43886282
Intrathymic islet transplantation in the canine: I. Histological and functional evidence of autologous intrathymic islet engraftment and survival in pancreatectomized recipientsQ43940363
Induction of angiogenesis by growth factors: relevance to pancreatic islet transplantationQ43983826
Effect of the two-layer (University of Wisconsin solution-perfluorochemical plus O2) method of pancreas preservation on human islet isolation, as assessed by the Edmonton Isolation ProtocolQ44228612
Control of B-cell responses by Toll-like receptorsQ59066168
P433issue5
P921main subjectinflammationQ101991
P304page(s)603-630
P577publication date2008-07-29
P1433published inEndocrine ReviewsQ3054007
P1476titleResolving the conundrum of islet transplantation by linking metabolic dysregulation, inflammation, and immune regulation
P478volume29

Reverse relations

cites work (P2860)
Q30432947A practical guide to rodent islet isolation and assessment
Q33604558Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death
Q34519401Creating transplant tolerance by taming adverse intragraft innate immunity
Q30430008Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation
Q42072077Delivery of a therapeutic protein by immune-privileged Sertoli cells
Q35568544Derivation of insulin producing cells from human endometrial stromal stem cells and use in the treatment of murine diabetes
Q42776160Effects of cyclooxygenase-2 inhibitor and adenosine triphosphate-sensitive potassium channel opener in syngeneic mouse islet transplantation
Q91455812Ethylene carbodiimide-fixed donor splenocytes combined with cordycepin induce long-term protection to mice cardiac allografts
Q48904983Ethylene carbodiimide-fixed donor splenocytes combined with α-1 antitrypsin induce indefinite donor-specific protection to mice cardiac allografts.
Q30430981Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling
Q30430239Evolution of β-Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation
Q30875559Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice
Q36258142Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice
Q37149186Human pancreatic islets and diabetes research
Q50856415Human α1-antitrypsin modifies B-lymphocyte responses during allograft transplantation.
Q28748969In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes
Q53393573Islet culture and counter-culture. Commentary on: Effect of short-term culture on functional and stress-related parameters in isolated human islets by Ihm et al.
Q48058086Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations
Q30415616Naturally occurring immunoglobulin M (nIgM) autoantibodies prevent autoimmune diabetes and mitigate inflammation after transplantation
Q36576134Regulatory properties of the intestinal microbiome effecting the development and treatment of diabetes
Q30743822Residual β-Cell Function Predicts Clinical Response After Autologous Hematopoietic Stem Cell Transplantation
Q44188868Selective depletion of alloreactive T cells leads to long-term islet allograft survival across a major histocompatibility complex mismatch in diabetic mice.
Q26823294Stem cell therapy to cure type 1 diabetes: from hype to hope
Q34152418TNF-α acutely upregulates amylin expression in murine pancreatic beta cells
Q57177826The Flaws and Future of Islet Volume Measurements
Q46360637The effects of digestion enzymes on islet viability and cellular composition
Q30409961The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation
Q46025705The synthetic liver X receptor agonist GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro.
Q27013927Use of glucagon-like peptide-1 agonists to improve islet graft performance
Q34977998β-Cell inflammation in human type 2 diabetes and the role of autophagy.

Search more.