Somatostatin receptors and autoimmune-mediated diabetes

scientific article

Somatostatin receptors and autoimmune-mediated diabetes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/DMRR.531
P698PubMed publication ID15624122

P2093author name stringF Charles Brunicardi
Michael A Norman
Xaio-Ping Wang
P2860cites workIn vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cellsQ22008658
C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrestQ22008681
Primary structure of the gene encoding rat preprosomatostatinQ24300788
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidneyQ24337883
Subtypes of the somatostatin receptor assemble as functional homo- and heterodimersQ28138304
Somatostatin and its receptor familyQ28141222
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimenQ28141785
Quantitative and functional expression of somatostatin receptor subtypes in human thymocytesQ28206900
Genetics of type 1 diabetes mellitusQ28215982
A genome-wide search for human type 1 diabetes susceptibility genesQ28247197
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor familyQ28285445
Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysisQ28294253
Classification and nomenclature of somatostatin receptorsQ28303973
Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopyQ28571964
Chemokines--chemotactic cytokines that mediate inflammationQ29616433
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisQ30080034
IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent).Q30585261
Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylationQ48707748
Coupling of rat somatostatin receptor subtypes to a G-protein gated inwardly rectifying potassium channel (GIRK1).Q48948032
Immunological abnormalities in islets at diagnosis paralleled further deterioration of glycaemic control in patients with recent-onset Type I (insulin-dependent) diabetes mellitus.Q51563425
Suppression and acceleration of autoimmune diabetes by neutralization of endogenous interleukin-12 in NOD mice.Q52022615
Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes.Q54045893
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene.Q54419614
The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice.Q55035859
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes RegistryQ55670898
A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetesQ56904317
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetesQ56908828
Somatostatin receptorsQ57042835
A key role for ICAM-1 in generating effector cells mediating inflammatory responsesQ57227924
TRANSGENIC MICE IN THE ANALYSIS OF METABOLIC REGULATIONQ62067333
Prevalence of adult-onset IDDM in the U.S. populationQ64112664
beta----alpha----delta pancreatic islet cellular perfusion in dogs.Q64965675
The combination of antibodies to GAD-65 and IA-2ic can replace the islet-cell antibody assay to identify subjects at risk of type 1 diabetes mellitus.Q64993164
The vascular order of islet cellular perfusion in the human pancreasQ67512788
Perfusion with anti-insulin gamma globulin indicates a B to A to D cellular perfusion sequence in the pancreas of the rhesus monkey, Macaca mulattaQ67533818
Immunohistochemical and histometrical studies of the human thymus with special emphasis on age-related changes in medullary epithelial and dendritic cellsQ68086991
Intra-islet regulationQ69047658
The anterograde and retrograde infusion of glucagon antibodies suggests that A cells are vascularly perfused before D cells within the rat isletQ69372132
Distribution of somatostatin receptors on murine spleen and Peyer's patch T and B lymphocytesQ69919531
Dynamic in vivo observation of rat islet microcirculationQ70528827
Somatostatin and macrophage function: modulation of hydrogen peroxide, nitric oxide and tumor necrosis factor releaseQ70923132
Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulationQ71395008
The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitusQ71420898
Differential Expression of Five Somatostatin Receptor Subtypes, SSTR1-5, in the CNS and Peripheral TissueQ72114597
Molecular cloning and functional expression of a brain-specific somatostatin receptorQ31164490
Cloning of the mouse SSTR5 geneQ32042474
Somatostatin receptors in the haematopoietic systemQ33181416
Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibodyQ33542704
Environmental factors in the pathogenesis of type 1 diabetes mellitus.Q33752334
The role of CD4 and CD8 T cells in the development of autoimmune diabetesQ33767929
The role of CD4 vs. CD8 T cells in IDDM.Q33767934
Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activityQ33897208
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicityQ33947102
The somatostatin immunoregulatory circuit present at sites of chronic inflammationQ34078378
Somatostatin receptor subtypes in human immune cellsQ34078382
Physiological and pathophysiological role of somatostatin receptors in the human thymusQ34078386
Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cellsQ34112278
Peptides as regulators of the immune system: emphasis on somatostatinQ34126245
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.Q34178157
Type I diabetes mellitus. A chronic autoimmune diseaseQ34181699
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth HormoneQ34216319
Human islet transplantation: update.Q34245824
Type 1 diabetes: new perspectives on disease pathogenesis and treatmentQ34321603
Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation.Q34355810
Diabetes mellitus and genetically programmed defects in beta-cell functionQ34462316
Neuroendocrine aspects of immunolymphoproliferative diseasesQ34474185
In-vitro differentiation of pancreatic beta-cellsQ34484370
A choice of death--the signal-transduction of immune-mediated beta-cell apoptosisQ34495385
Chemokine receptors: multifaceted therapeutic targetsQ34575325
Immunoreactive somatostatin is present in discrete cells of the endocrine pancreasQ35075503
Selective binding of somatostatin-14 and somatostatin-28 to islet cells revealed by quantitative electron microscopic autoradiographyQ35582075
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoireQ35602289
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.Q36366075
Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.Q36370525
Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD miceQ36370868
The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) miceQ36401103
Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotypeQ36526442
Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumorsQ37374477
Islet somatostatin--microvascular, paracrine, and pulsatile regulationQ37599144
CD154-dependent priming of diabetogenic CD4(+) T cells dissociated from activation of antigen-presenting cellsQ38288576
Late potentials: are they related to cardiovascular complications in children with type 1 diabetes?Q39608627
The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United KingdomQ39736694
Fatal attraction: chemokines and type 1 diabetesQ39740128
The order of islet microvascular cellular perfusion is B----A----D in the perfused rat pancreasQ40377665
The adhesion cascade and anti-adhesion therapy: an overviewQ40419219
The family of G‐protein‐coupled receptorsQ40439041
The somatostatin receptor family.Q40482710
Targeted gene replacement.Q40728488
Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitizationQ40744546
Optimized autoantibody-based risk assessment in family members. Implications for future intervention trialsQ40791302
A pancreatic beta -cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta ), HNF-1alpha, and SPs transcription factorsQ40817135
Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY).Q40934999
Early infant diets and insulin-dependent diabetesQ41012417
Cellular interactions in thymocyte development.Q41039662
Binding properties of somatostatin receptor subtypesQ41081376
Endocrine Pancreas: Three-Dimensional Reconstruction Shows Two Types of Islets of LangerhansQ41138694
Sexual dimorphism and testosterone-dependent regulation of somatostatin gene expression in the periventricular nucleus of the rat brainQ41276473
Aspartic acid residue 124 in the third transmembrane domain of the somatostatin receptor subtype 3 is essential for somatostatin-14 bindingQ41278828
The beta cell transcription factors and development of the pancreasQ41496269
Regulation of Islet Somatostatin Secretion and Gene Expression: Selective Effects of Adenosine 3′,5′- Monophosphate and Phorbol Esters in Normal Islets of Langerhans and in a Somatostatin-Producing Rat Islet Clonal Cell Line 1027 B2*Q41690348
Viruses and other perinatal exposures as initiating events for beta-cell destructionQ41695561
Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytesQ41789085
Preferential location of somatostatin receptors in germinal centers of human gut lymphoid tissueQ41913209
Prolonged somatostatin pretreatment desensitizes somatostatin's inhibition of receptor-mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclaseQ42446849
Somatostatin Inhibits B-Cell Secretion via a Subtype-2 Somatostatin Receptor in the Isolated Perfused Human PancreasQ42481202
Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophsQ42481826
Use of the Fab fragment for immunoneutralization of somatostatin in the isolated perfused human pancreasQ42491019
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetesQ42507820
Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreasQ42511056
Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cellsQ43585447
Artificial endocrine pancreasQ43731603
Dominant role of intercellular adhesion molecule-1 in the pathogenesis of autoimmune diabetes in non-obese diabetic miceQ43759565
Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate sublociQ43786589
Sulfonylurea receptor knockout causes glucose intolerance in mice that is not alleviated by concomitant somatostatin subtype receptor 5 knockout.Q44009398
Comparison of serum concentrations of soluble adhesion molecules in diabetic microangiopathy and macroangiopathyQ44163405
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasisQ44269095
Pancreatic somatostatin inhibits insulin secretion via SSTR-5 in the isolated perfused mouse pancreas modelQ44376890
Insulitis in type 1 (insulin-dependent) diabetes mellitus in man--macrophages, lymphocytes, and interferon-gamma containing cellsQ44937498
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic modelQ45783598
An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitusQ47785242
High basal gastric acid secretion in somatostatin receptor subtype 2 knockout miceQ48019605
Cloning and expression of a novel mouse somatostatin receptor (SSTR2B).Q48152351
Somatostatin is expressed in the murine thymus and enhances thymocyte developmentQ48550414
Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neuronsQ48608364
Identification of Human Mononuclear Leukocytes Bearing Receptors for Somatostatin and GlucagonQ72456636
Reversal of Increased Gastric Somatostatin in Streptozotocin-diabetic Rats by Whole Pancreas TransplantationQ72486921
Antisomatostatin Gamma Globulin Augments Secretion of Both Insulin and Glucagon In Vitro: Evidence for a Physiologic Role for Endogenous Somatostatin in the Regulation of Pancreatic A- and B-Cell FunctionQ72622348
Potent inhibitory effects of a type four receptor-selective somatostatin analog on rat insulin releaseQ72661363
Regulatory role of intraislet somatostatin on insulin secretion in the isolated perfused human pancreasQ72678492
Specific inhibition of rat pancreatic insulin or glucagon release by receptor-selective somatostatin analogsQ72903541
Age-related decrease of somatostatin receptor number in the normal human thymusQ72992111
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitusQ73153922
Effects of cholinergic blockade by pirenzepine on insulin and glucose response to oral and intravenous glucose and to arginine load in obesityQ73165677
Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetesQ73224777
A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetesQ73306925
Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout miceQ73310120
Serological markers of recurrent beta cell destruction in diabetic patients undergoing pancreatic transplantationQ73398704
Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 lociQ73403570
Development of low-dose streptozotocin-induced diabetes in ICAM-1-deficient miceQ73433829
Somatostatin receptor subtypes in human thymoma and inhibition of cell proliferation by octreotide in vitroQ73687582
Intraislet regulation of pancreatic polypeptide secretion in the isolated perfused rat pancreasQ73854070
Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological evidence of cellular autoimmunityQ73932422
Update on islet-cell transplantation for type 1 diabetesQ74387510
Pancreatic hormone expression in the murine thymus: localization in dendritic cells and macrophagesQ74493415
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB StudyQ74607777
The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7Q74650540
Dissecting the genetics of type 1 diabetes: relevance for familial clustering and differences in incidenceQ74812215
A comparative immunohistochemical study of pancreatic islets in laboratory animals (rats, dogs, minipigs, nonhuman primates)Q74816782
Insulin secretion is inhibited by subtype five somatostatin receptor in the mouseQ77098085
Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody WorkshopQ77628562
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigensQ77658430
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
sst2 somatostatin receptor mediates cell cycle arrest and induction of p27(Kip1). Evidence for the role of SHP-1Q77754899
Autoantibodies to GAD, IA-2 and insulin in ICA-positive first-degree relatives of children with type 1 diabetes: a comparison between parents and siblingsQ77841503
Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulatorsQ77845928
Stimulatory transducing systems in pancreatic islet cellsQ77934841
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetesQ78014697
sst5 somatostatin receptor mRNA induction by mitogenic activation of human T-lymphocytesQ78125284
Growth inhibitory effects of somatostatin on human leukemia cell lines mediated by somatostatin receptor subtype 1Q78125289
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)15-30
P577publication date2005-01-01
P1433published inDiabetes - Metabolism: Research and ReviewsQ15750056
P1476titleSomatostatin receptors and autoimmune-mediated diabetes
P478volume21

Reverse relations

cites work (P2860)
Q46167278Microarray analysis of somatostatin receptor 5-regulated gene expression profiles in murine pancreas.
Q41553609Thymic Structures Containing Somatostatin

Search more.