Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery

scientific article published on 10 February 2018

Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JAUT.2018.01.005
P932PMC publication ID5949247
P698PubMed publication ID29439835

P2093author name stringYi Liu
Yongge Zhao
Kristin V Tarbell
Chie Hotta-Iwamura
William D Coley
Juan A Quiel
Charles Benck
P2860cites workA novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
Chromogranin A is an autoantigen in type 1 diabetesQ24605199
Central role of defective interleukin-2 production in the triggering of islet autoimmune destructionQ24650734
Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 DiabetesQ26770386
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targetsQ28140238
Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic miceQ30644510
FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availabilityQ33580878
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjectsQ33604570
CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cellsQ33623556
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunityQ33918375
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cellsQ34096577
Interleukin 2 signaling is required for CD4(+) regulatory T cell functionQ34527240
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.Q34553677
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.Q34636874
An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cellsQ34682216
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasisQ35159540
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouseQ35288506
The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune DiseasesQ35739662
STAT5 is a potent negative regulator of TFH cell differentiationQ35761809
The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell developmentQ35832534
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.Q36043724
DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit DiabetesQ36104619
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD miceQ36228938
Transcription factor Foxp3 and its protein partners form a complex regulatory networkQ36250037
On the role of dendritic cells in peripheral T cell tolerance and modulation of autoimmunityQ36370816
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.Q36399104
Specialized role of migratory dendritic cells in peripheral tolerance inductionQ36580331
Antigen-specific effector CD4 T lymphocytes school lamina propria dendritic cells to transfer innate toleranceQ36920276
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host diseaseQ36940174
Interleukin-2 and regulatory T cells in graft-versus-host diseaseQ37055805
Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host diseaseQ37076418
Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.Q37098079
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivoQ37312884
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.Q37418499
Regulatory T cell memoryQ37420611
CD8+ dendritic cell-mediated tolerance of autoreactive CD4+ T cells is deficient in NOD mice and can be corrected by blocking CD40L.Q37496758
Etiology of type 1 diabetesQ37735981
Antigen-specific immunotherapy of autoimmune and allergic diseasesQ37790023
Antigen presentation events in autoimmune diabetes.Q37969489
IL-2 therapy in type 1 diabetes: "Trials" and tribulationsQ38090144
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseasesQ38424758
Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areataQ38429515
The Importance of Dendritic Cells in Maintaining Immune Tolerance.Q39164401
Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.Q40110921
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cellsQ41872700
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactionsQ41911767
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic developmentQ42006714
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trialQ42232023
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patientsQ42472173
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitisQ43048001
Murine pancreatic islet isolationQ43189242
Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes.Q50759104
Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus.Q50940528
Selective stimulation of T cell subsets with antibody-cytokine immune complexes.Q51984700
Lymph node T-cells do not optimally transfer diabetes in NOD miceQ72616540
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetesQ81690799
ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic miceQ83194001
A protocol for islet isolation from mouse pancreasQ84817750
P577publication date2018-02-10
P1433published inJournal of AutoimmunityQ15716783
P1476titleLow CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery