Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial

scientific article published on 8 October 2013

Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S2213-8587(13)70113-X
P698PubMed publication ID24622415

P50authorMichelle RosenzwajgQ42238594
Olivier BourronQ42412294
David KlatzmannQ22248690
P2093author name stringGilbert Bensimon
Agnès Hartemann
Claude Bernard
Sophie Jacqueminet
Nathalie Nicolas
Michèle Fonfrede
Christine A Payan
P2860cites workThe multiple origins of Type 1 diabetesQ38062580
Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitisQ43048001
Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo.Q50510804
Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Effect of age, gender and HLA typeQ73567429
Toxicity management in patients receiving low-dose aldesleukin therapyQ77757437
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetesQ79843146
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
Central role of defective interleukin-2 production in the triggering of islet autoimmune destructionQ24650734
Concise review: pancreas regeneration: recent advances and perspectivesQ27013646
Regulatory T cells exert checks and balances on self tolerance and autoimmunityQ28267935
Clinical toxicity of interleukin-2.Q33355316
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cellsQ34096577
The role of interleukin-2 during homeostasis and activation of the immune systemQ34255232
Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trialsQ34318993
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseasesQ34615216
Immune intervention in type 1 diabetes.Q35226251
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trialQ35321191
Central role for interleukin-2 in type 1 diabetesQ35612414
Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivityQ35966086
Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in childrenQ36181380
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell functionQ36182476
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
Interleukin-2 and regulatory T cells in graft-versus-host diseaseQ37055805
Expansion of human regulatory T-cells from patients with type 1 diabetesQ37105331
Limitations of IL-2 and rapamycin in immunotherapy of type 1 diabetesQ37110531
Rapamycin prevents and breaks the anti-CD3-induced tolerance in NOD miceQ37141795
Human regulatory T cells: role in autoimmune disease and therapeutic opportunitiesQ37211296
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trialsQ37307777
IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity.Q37484957
B cell-directed therapies in type 1 diabetesQ37870572
P433issue4
P921main subjecttype-1 diabetesQ124407
interleukinsQ194908
placeboQ269829
phase I clinical trialQ5452194
phase II clinical trialQ42824440
P304page(s)295-305
P577publication date2013-10-08
P1433published inThe Lancet: Diabetes & EndocrinologyQ27725107
P1476titleLow-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
P478volume1

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