Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells

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Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.181.3.1798
P8608Fatcat IDrelease_mwkzrscpe5byzhd5ncrc2ilhwq
P932PMC publication ID3025323
P698PubMed publication ID18641317
P5875ResearchGate publication ID51415413

P2093author name stringElana Godebu
Bas J G Baaten
Linda M Bradley
Melissa M Lin
Daphne Summers-Torres
P2860cites workTGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetesQ47667692
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.Q51103369
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.Q53859655
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell functionQ73062421
Origin of regulatory T cells with known specificity for antigenQ74381747
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-betaQ80427911
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10Q80785928
Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivoQ83059341
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
The inhibitory cytokine IL-35 contributes to regulatory T-cell functionQ28258462
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Q28591451
Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancerQ29014531
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanismQ29614266
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidQ29615586
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic miceQ30644510
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing TregsQ34546789
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitisQ34719541
Enteroviruses and type 1 diabetes mellitus.Q35598941
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cellsQ35669757
Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune diseaseQ35703559
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatmentQ35748567
The NOD mouse: a model of immune dysregulationQ36072434
Mechanisms of suppression by suppressor T cellsQ36078047
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD miceQ36228938
Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivoQ36370731
Interleukin 7 regulates the survival and generation of memory CD4 cellsQ36371578
Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunityQ36394540
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetesQ36399048
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.Q36399104
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralizationQ36402763
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.Q36891917
The Foxp3+ regulatory T cell: a jack of all trades, master of regulationQ37088900
Turnover of naive- and memory-phenotype T cellsQ41475935
Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies.Q44729936
Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicryQ45754853
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cellsQ45858705
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttype-1 diabetesQ124407
P304page(s)1798-1805
P577publication date2008-08-01
P1433published inJournal of ImmunologyQ3521441
P1476titlePolyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells
P478volume181

Reverse relations

cites work (P2860)
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Q37889181CD8(+) Tregs in autoimmunity: learning "self"-control from experience
Q33778359Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid
Q37912653Clinical perspectives for regulatory T cells in transplantation tolerance
Q36186226Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes.
Q35116303Current state of type 1 diabetes immunotherapy: incremental advances, huge leaps, or more of the same?
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Q42554128Functional islet-specific Treg can be generated from CD4+CD25- T cells of healthy and type 1 diabetic subjects
Q35716720Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes
Q36200557IL-7 uniquely maintains FoxP3(+) adaptive Treg cells that reverse diabetes in NOD mice via integrin-β7-dependent localization
Q33815506Immunotherapy of type 1 diabetes: where are we and where should we be going?
Q35223997In vitro induced regulatory T cells are unique from endogenous regulatory T cells and effective at suppressing late stages of ongoing autoimmunity
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Q33583241Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis
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Q35070048Targeting CD44 augments the efficacy of Tregs in autoimmune diabetes
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Q34875345Tolerogenic vaccination reduced effector memory CD4 T cells and induced effector memory Treg cells for type I diabetes treatment
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Q37386987Understanding the focused CD4 T cell response to antigen and pathogenic organisms