Understanding the focused CD4 T cell response to antigen and pathogenic organisms

scientific article published on 07 February 2009

Understanding the focused CD4 T cell response to antigen and pathogenic organisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12026-009-8095-8
P698PubMed publication ID19198764

P2093author name stringAndrea J Sant
Jason M Weaver
P2860cites workCleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infectionQ24537437
Antiviral CD4+ memory T cells are IL-15 dependentQ24676283
The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNAQ27640425
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motifQ27640503
Structures of an MHC class II molecule with covalently bound single peptidesQ27732720
Functional association between viral and cellular transcription during influenza virus infectionQ27863933
Nuclear traffic of influenza virus proteins and ribonucleoprotein complexesQ27864127
Nuclear import and export of influenza virus nucleoproteinQ27867703
Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of actionQ28138259
Occurrence of an HIV-1 gp160 endoproteolytic activity in low-density vesicles and evidence for a distinct density distribution from endogenously expressed furin and PC7/LPC convertasesQ28142392
The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II moleculesQ28142443
Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsQ28146072
Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodesQ28202515
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phasesQ28237805
Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionQ28273723
The Impact of H2-DM on Humoral Immune ResponsesQ28506169
Clustering of Th Cell Epitopes on Exposed Regions of HIV Envelope Despite Defects in Antibody ActivityQ79125450
Functional specialization of memory Th cells revealed by expression of integrin CD49bQ79834615
The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominanceQ80416551
Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical modelsQ80444901
Endoproteolysis in health and diseases--implications of proprotein convertases (PCs)Q81190073
Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activationQ81469542
Modulation of peptide-dependent allospecific epitopes on HLA-DR4 molecules by HLA-DM.Q41052024
Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicityQ41116405
Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifsQ41154435
The endogenous pathway of MHC class II antigen presentation.Q41168212
Mediation by HLA-DM of dissociation of peptides from HLA-DRQ41333614
How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?Q41370585
Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assaysQ41450491
How HLA-DM Affects the Peptide Repertoire Bound to HLA-DR MoleculesQ41594025
Selection of the MHC Class II-associated peptide repertoire by HLA-DMQ41649540
Interference with the binding of a naturally processed peptide to class II alters the immunodominance of T cell epitopes in vivoQ41662292
Antigen-presenting cells and the selection of immunodominant epitopesQ41674613
MHC class II-restricted presentation of intracellular antigenQ41694984
Protein sorting within the mhc class II antigen-processing pathwayQ41710771
The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitorsQ42472217
The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residuesQ42679630
Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine designQ42925957
Primary and memory T cell responses induced by hepatitis C virus multiepitope long peptidesQ42998313
Immunization with a synthetic multiepitope antigen induces humoral and cellular immune responses to hepatitis C virus in miceQ43037078
Heterogeneity of the T cell response to immunodominant determinants within hen eggwhite lysozyme of individual syngeneic hybrid F1 mice: implications for autoimmunity and infection.Q43464025
Kinetics of precursor cleavage at the dibasic sites. Involvement of peptide dynamicsQ43962943
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cellsQ44479232
Structural basis for helper T-cell and antibody epitope immunodominance in bacteriophage T4 Hsp10. Role of disordered loopsQ44619152
Antigen processing and T cell repertoires as crucial aleatory features in induction of autoimmunityQ44750798
Impairment of immunological memory in the absence of MHC despite survival of memory T cellsQ45072920
Imaging of plasmacytoid dendritic cell interactions with T cellsQ45817701
A Bayesian regression approach to the prediction of MHC-II binding affinityQ45828576
Efficient synthesis of influenza virus hemagglutinin in mammalian cells with an extrachromosomal Epstein-Barr virus vector.Q45845331
Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivoQ46150935
From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensisQ46315736
Lymphoid reservoirs of antigen-specific memory T helper cellsQ46609740
Measurement of peptide dissociation from MHC class II moleculesQ46629980
Insertion of the dibasic motif in the flanking region of a cryptic self-determinant leads to activation of the epitope-specific T cellsQ46635947
The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM functionQ46916435
Modulation of the immunogenicity of antigenic determinants by their flanking residuesQ48013126
Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behaviorQ51807705
Static energy analysis of MHC class I and class II peptide-binding affinityQ51887363
Class II-independent generation of CD4 memory T cells from effectorsQ52031200
T cell recognition of myoglobin. Localization of the sites stimulating T cell proliferative responses by synthetic overlapping peptides encompassing the entire moleculeQ52209814
Control of Leishmania major by a monoclonal alpha beta T cell repertoireQ52530262
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chainQ52552855
Proliferating CD4+ T cells undergo immediate growth arrest upon cessation of TCR signaling in vivoQ53509518
Antigen three-dimensional structure guides the processing and presentation of helper T-cell epitopesQ54458197
Induction of T cell responses by chimeric bacterial proteins expressing several copies of a viral T cell epitope.Q54648972
Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigenQ56922571
Intercellular Adhesion Molecule-1-Dependent Stable Interactions between T Cells and Dendritic Cells Determine CD8+ T Cell MemoryQ58862007
Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunityQ58862024
In vivo competition between self peptides and foreign antigens in T-cell activationQ59065328
Helper T-cell Epitope Immunodominance Associated with Structurally Stable Segments of Hen Egg Lysozyme and HIV gp120Q59600025
Expression of heterologous peptides at two permissive sites of the MalE protein: antigenicity and immunogenicity of foreign B-cell and T-cell epitopesQ67541840
Mechanisms of T cell epitope immunodominance analyzed in murine listeriosisQ71829469
Immunodominance: a single amino acid substitution within an antigenic site alters intramolecular selection of T cell determinantsQ72090150
Role of amino acid sequences flanking dibasic cleavage sites in precursor proteolytic processing. The importance of the first residue C-terminal of the cleavage siteQ72572370
Identification of distinct predominant epitopes recognized by myoglobin-specific T cells under the control of different Ir genes and characterization of representative T cell clonesQ72722984
Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registersQ73277342
Immunodominance is independent of structural constraints: each region within hen eggwhite lysozyme is potentially available upon processing of native antigenQ73705562
T Cell Receptor Recognition of MHC Class II–Bound Peptide Flanking Residues Enhances Immunogenicity and Results in Altered TCR V Region UsageQ73767636
Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processingQ73827781
Cutting edge: introduction of an endopeptidase cleavage motif into a determinant flanking region of hen egg lysozyme results in enhanced T cell determinant displayQ73910685
Dynamic imaging of T cell-dendritic cell interactions in lymph nodesQ74253957
The proprotein convertasesQ28609903
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DMQ28613111
Editing of the HLA-DR-peptide repertoire by HLA-DMQ28613148
Accelerated migration of respiratory dendritic cells to the regional lymph nodes is limited to the early phase of pulmonary infectionQ30310545
Multiple anti-interferon actions of the influenza A virus NS1 proteinQ30361157
Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutininQ30361736
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic miceQ30498716
Identification of destabilizing residues in HLA class II-selected bacteriophage display libraries edited by HLA-DM.Q30652859
Integrating epitope data into the emerging web of biomedical knowledge resourcesQ31111568
Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivoQ33236315
Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infectionQ33296558
Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infectionQ33302672
Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpanQ33349439
Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responsesQ33652450
Reversal of immunodominance among autoantigenic T-cell epitopesQ33753125
Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchangeQ33815440
HLA-DM and the MHC class II antigen presentation pathwayQ33878174
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexesQ33930509
HLA-DM, HLA-DO and tapasin: functional similarities and differencesQ34492989
Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cellsQ34512471
Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivoQ34558048
Endosomal trafficking and proprotein convertase cleavage of cis Golgi protein GP73 produces marker for hepatocellular carcinomaQ34657401
Epitope identification and vaccine design for cancer immunotherapyQ34675496
The convergent roles of tapasin and HLA-DM in antigen presentation.Q34784992
Optimizing vaccine design for cellular processing, MHC binding and TCR recognitionQ35005969
Epitope-based vaccines: an update on epitope identification, vaccine design and deliveryQ35192612
T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph nodeQ35731136
Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected miceQ35848499
MODPROPEP: a program for knowledge-based modeling of protein-peptide complexesQ35914254
In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DMQ36158655
CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cellsQ36228572
T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypesQ36229970
The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stabilityQ36238108
The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexesQ36266503
Influences of antigen processing on the expression of the T cell repertoire. Evidence for MHC-specific hindering structures on the products of processingQ36355124
Mechanisms influencing the immunodominance of T cell determinantsQ36355734
Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathwaysQ36361976
Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II moleculesQ36367514
DM determines the cryptic and immunodominant fate of T cell epitopesQ36368876
Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) virusesQ36370707
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.Q36404572
Immunopathogenesis of hepatitis C virus infection: multifaceted strategies subverting innate and adaptive immunityQ36423743
Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell-based cancer vaccinesQ36543806
Time Course of Synthesis and Assembly of Influenza Virus ProteinsQ36565531
Confronting complexity: real-world immunodominance in antiviral CD8+ T cell responsesQ36626160
Novel features of the respiratory tract T-cell response to influenza virus infection: lung T cells increase expression of gamma interferon mRNA in vivo and maintain high levels of mRNA expression for interleukin-5 (IL-5) and IL-10.Q36637398
Immune epitope mapping in the post-genomic era: lessons for vaccine developmentQ36656929
Direct class I HLA antigen discovery to distinguish virus-infected and cancerous cellsQ36689109
The function of local lymphoid tissues in pulmonary immune responsesQ36693484
Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cellsQ36742276
Harnessing bioinformatics to discover new vaccinesQ36805723
Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine designQ36837134
Three dimensional structure directs T-cell epitope dominance associated with allergyQ36908976
The influenza virus NS1 protein: inhibitor of innate and adaptive immunityQ37066762
SAP-controlled T-B cell interactions underlie germinal centre formationQ37119530
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activationQ37233655
Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.Q37361625
Antigen structure influences helper T-cell epitope dominance in the human immune response to HIV envelope glycoprotein gp120.Q37373708
Synthesis and function of influenza A virus glycoproteinsQ37419117
Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoproteinQ37742876
Modulating the immunological properties of a linear B-cell epitope by insertion into permissive sites of the MalE protein.Q38350738
Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequentialQ39549098
Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteersQ39566146
Specific antitumor immune response induced by a novel DNA vaccine composed of multiple CTL and T helper cell epitopes of prostate cancer associated antigensQ40422465
Endogenous antigen presentation by MHC class II molecules.Q40447881
Dominance and crypticity of T cell antigenic determinantsQ40486347
Sorting of furin in polarized epithelial and endothelial cells: expression beyond the Golgi apparatusQ40564413
Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM.Q40676502
The involvement of antigen processing in determinant selection by class II MHC and its relationship to immunodominanceQ40780290
Several protein regions contribute to determine the nuclear and cytoplasmic localization of the influenza A virus nucleoproteinQ40905176
Role of APC in the selection of immunodominant T cell epitopes.Q40913991
Assessment of the role of determinant selection in genetic control of the immune response to insulin in H-2b miceQ40933813
The Distinctive Features of Influenza Virus Infection of Dendritic CellsQ41048210
P433issue2-3
P304page(s)123-143
P577publication date2009-02-07
P13046publication type of scholarly workreview articleQ7318358
P1433published inImmunologic ResearchQ15754981
P1476titleUnderstanding the focused CD4 T cell response to antigen and pathogenic organisms
P478volume45

Reverse relations

cites work (P2860)
Q42149041CD4 T-cell memory responses to viral infections of humans show pronounced immunodominance independent of duration or viral persistence.
Q30363065Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.
Q34460478Flanking Residues Are Central to DO11.10 T Cell Hybridoma Stimulation by Ovalbumin 323–339
Q42754778Immune System as a Sensory System
Q41961320Immunology at the university of Rochester
Q64248501Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus
Q84498369Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host
Q91868521Myalgic Encephalomyelitis/Chronic Fatigue Syndrome as a Hyper-Regulated Immune System Driven by an Interplay Between Regulatory T Cells and Chronic Human Herpesvirus Infections
Q41534356Population mechanics: A mathematical framework to study T cell homeostasis
Q30371474Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads
Q28384290Spectrum of HLA associations: the case of medically refractory pediatric acute lymphoblastic leukemia
Q37453545T cell immunodominance is dictated by the positively selecting self-peptide
Q37249406The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings
Q27335659The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance
Q37208000Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal
Q50089598βarrestin-2-dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T Helper Type 2 Cells

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