Protein sorting within the MHC class II antigen-processing pathway

scientific article published on January 1998

Protein sorting within the MHC class II antigen-processing pathway is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1049400488
P356DOI10.1007/BF02786439
P698PubMed publication ID9479576

P2093author name stringMarks MS
P2860cites workAllelic differences affecting invariant chain dependency of MHC class II subunit assemblyQ72112282
MHC class II molecules: transport pathways for antigen presentationQ80818128
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3Q24303524
AP-3: an adaptor-like protein complex with ubiquitous expressionQ24315945
Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexesQ24319982
Adaptor self-aggregation, adaptor-receptor recognition and binding of alpha-adaptin subunits to the plasma membrane contribute to recruitment of adaptor (AP2) components of clathrin-coated pitsQ24564624
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furinQ24568252
HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cellsQ24675139
B lymphocytes secrete antigen-presenting vesiclesQ24678522
Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigensQ24678747
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chainsQ27913878
Mechanisms of intracellular protein transportQ28131681
A new human HLA class II-related locus, DMQ28235428
Interaction of tyrosine-based sorting signals with clathrin-associated proteinsQ28290076
Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi networkQ28290088
Mice lacking the MHC class II-associated invariant chainQ28507606
Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expressionQ28585705
The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motifQ28585954
Reconstitution of an operational MHC class II compartment in nonantigen-presenting cellsQ28588469
Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction.Q42594655
Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB.Q42636390
Invariant chain influences post-translational processing of HLA-DR moleculesQ42827453
Different domains of the AP-1 adaptor complex are required for Golgi membrane binding and clathrin recruitmentQ42829381
Involvement of dileucine motifs in the internalization and degradation of the insulin receptor.Q42833117
HLA-D region antigen-associated invariant polypeptides as revealed by two-dimensional gel analysis. Glycosylation and structural inter-relationshipsQ44194497
Intracellular transport of class II MHC molecules directed by invariant chain.Q45941447
Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathwaysQ46424023
Protein sorting by tyrosine-based signals: adapting to the Ys and whereforesQ47895888
Transient aggregation of major histocompatibility complex class II chains during assembly in normal spleen cells.Q49164800
Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemmaQ50195579
The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses.Q52043164
Effect of transmembrane and cytoplasmic domains of IgE on the IgE response.Q52043166
Saturation of the endocytic pathway for the transferrin receptor does not affect the endocytosis of the epidermal growth factor receptor.Q52196657
Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cellsQ58323390
Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied moleculesQ59096640
Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytesQ59098594
A peptide sequence confers retention and rapid degradation in the endoplasmic reticulumQ68691399
Analysis of the oligosaccharides on the HLA-DR and DC1 B cell antigensQ70981513
Structural determinants of interaction of tyrosine-based sorting signals with the adaptor medium chainsQ71763363
Receptor-mediated endocytosis of antigens overcomes the requirement for HLA-DM in class II-restricted antigen presentationQ71929769
Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cellsQ71961178
Invariant chain-independent antigen presentation depends primarily upon the pool of newly synthesized MHC class II moleculesQ71961180
Biosynthesis and maturation of HLA-DR antigens in vivoQ72093191
Invariant chain prevents the HLA-DR-restricted presentation of a cytosolic peptideQ72095816
MHC class II-associated invariant chain contains a sorting signal for endosomal compartmentsQ28612553
A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic PathwayQ28612864
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DMQ28613111
Expression of major histocompatibility complex class II molecules in HeLa cells promotes the recruitment of AP-1 Golgi-specific assembly proteins on Golgi membranesQ28613132
Editing of the HLA-DR-peptide repertoire by HLA-DMQ28613148
HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pHQ28613162
Signal-dependent membrane protein trafficking in the endocytic pathwayQ29622948
The dynamins: redundant or distinct functions for an expanding family of related GTPases?Q30176654
Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigensQ33714644
Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.Q33938149
Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigensQ34274593
Assembly, transport, and function of MHC class II moleculesQ34328789
Isolation and characterization of the intracellular MHC class II compartment.Q34340778
Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase geneQ35789284
Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulumQ35843755
In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sortingQ35851542
The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesiclesQ35909761
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequenceQ36233082
Assembly and targeting of adaptin chimeras in transfected cellsQ36233323
Separation of subcellular compartments containing distinct functional forms of MHC class IIQ36233913
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable componentsQ36237576
Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunityQ36241838
Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complexQ36250635
The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.Q36364225
Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.Q36364390
Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopesQ36366680
The Mycobacterium tuberculosis phagosome interacts with early endosomes and is accessible to exogenously administered transferrinQ36367495
Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II moleculesQ36367514
Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single proteinQ36376527
HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR moleculesQ36377428
Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75Q36382701
A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.Q36382769
Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartmentQ36382892
Biochemical dissection of AP-1 recruitment onto Golgi membranes.Q36383269
100-kD proteins of Golgi- and trans-Golgi network-associated coated vesicles have related but distinct membrane binding propertiesQ36531520
Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell linesQ36534895
Invariant chain can function as a chaperone protein for class II major histocompatibility complex moleculesQ36892768
Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartmentQ37438792
Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virusQ37545426
T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.Q37603731
An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surfaceQ37623766
Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.Q37628980
New class II-like genes in the murine MHC.Q38332928
Protein transport to the yeast vacuoleQ40380603
HLA-DM: an in vivo facilitator of MHC class II peptide loadingQ40410057
The biochemistry and cell biology of antigen presentation by MHC class I and class II molecules. Implications for development of combination vaccines.Q40454287
The role of clathrin, adaptors and dynamin in endocytosisQ40647427
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tailQ40790070
Phosphoinositides as regulators in membrane trafficQ40968891
Receptor-mediated protein sorting to the vacuole in yeast: roles for a protein kinase, a lipid kinase and GTP-binding proteinsQ41020937
How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathwayQ41020969
Characterization of transport of newly assembled, T cell-stimulatory MHC class II-peptide complexes from MHC class II compartments to the cell surfaceQ41099576
Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the Ig(alpha)/Ig(beta) dimerQ41101974
Endosomal targeting by the cytoplasmic tail of membrane immunoglobulinQ41115369
A membrane-associated protein complex with selective binding to the clathrin coat adaptor AP1.Q41147004
Processing and presentation of endocytically acquired protein antigens by MHC class II and class I moleculesQ41168208
Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICsQ41183877
Regulation of receptor-mediated endocytosis by Rho and Rac.Q41185352
A novel adaptor-related protein complexQ41202077
Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.Q41269334
Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DRQ41270789
Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentationQ41306022
Mediation by HLA-DM of dissociation of peptides from HLA-DRQ41333614
Antigen presentation mediated by recycling of surface HLA-DR molecules.Q41335304
Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteinsQ41383287
Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes.Q41410373
Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartmentsQ41412265
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cellsQ41440525
Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structuresQ41450247
Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigenQ41467922
Targeting and mistargeting of plasma membrane adaptors in vitroQ41511613
The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tailQ41515589
Intracellular distribution of the MHC class II molecules and the associated invariant chain (Ii) in different cell linesQ41535102
A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting functionQ41607768
Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: effects of brefeldin A and G protein activatorsQ41629883
Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chainQ41653246
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartmentsQ41695026
Invariant chain association with HLA-DR molecules inhibits immunogenic peptide bindingQ41731115
Invariant chain influences the immunological recognition of MHC class II moleculesQ41734417
A DR17-restricted T cell epitope from a secreted Mycobacterium tuberculosis antigen only binds to DR17 molecules at neutral pH.Q41928732
P433issue1-2
P407language of work or nameEnglishQ1860
P304page(s)141-154
P577publication date1998-01-01
P1433published inImmunologic ResearchQ15754981
P1476titleProtein sorting within the MHC class II antigen-processing pathway
P478volume17

Reverse relations

cites work (P2860)
Q33664142Immunological self/nonself discrimination: integration of self vs nonself during cognate T cell interactions with antigen-presenting cells.
Q74751980Synaptotagmin II negatively regulates MHC class II presentation by mast cells
Q37386987Understanding the focused CD4 T cell response to antigen and pathogenic organisms
Q38264088mRNA transcript therapy

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