The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes

scientific article

The CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2012/320495
P8608Fatcat IDrelease_ftfxusnqsfhy5hoohd7ropk2oy
P932PMC publication ID3480695
P698PubMed publication ID23118504
P5875ResearchGate publication ID232766300

P2093author name stringJennifer L. McRae
Joanne S. J. Chia
Karen M. Dwyer
Peter J. Cowan
P2860cites workCrucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxiaQ24817161
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologiesQ28196175
The transgenic expression of human CD39 on murine islets inhibits clotting of human blood.Q64895051
The role of thymic immunity and insulitis in the development of streptozocin-induced diabetes in miceQ72822590
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Upregulation of CD39/NTPDases and P2 receptors in human pancreatic diseaseQ80141838
A1 receptor deficiency causes increased insulin and glucagon secretion in miceQ81297403
Improved blood glucose disposal and altered insulin secretion patterns in adenosine A(1) receptor knockout miceQ84052940
Adenosine signaling promotes regeneration of pancreatic β cells in vivoQ42197940
Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injuryQ42199760
Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker ratsQ42847859
Reversal of dietary-induced insulin resistance in muscle of the rat by adenosine deaminase and an adenosine-receptor antagonistQ42848477
Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretionQ43242952
Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistanceQ43795785
NTPDase and 5'-nucleotidase activities in rats with alloxan-induced diabetesQ44910861
The impact of purinergic signaling on renal ischemia-reperfusion injuryQ46185587
Inhibition of Ca2+ signaling and glucagon secretion in mouse pancreatic alpha-cells by extracellular ATP and purinergic receptorsQ46694898
Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injuryQ46962262
Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia.Q50849047
Expression and function of P2X(7) receptor and CD39/Entpd1 in patients with type 2 diabetes and their association with biochemical parameters.Q51374940
The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy.Q53556059
Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injuryQ57708452
CD73/Ecto-5′-Nucleotidase Protects Against Vascular Inflammation and Neointima FormationQ61612314
Multiple immuno-regulatory defects in type-1 diabetesQ28344695
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replicationQ28568760
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionQ29615344
Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humansQ30428503
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gammaQ30439604
ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cellQ33778734
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantationQ33784839
Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocinQ34082851
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosineQ34578972
Multiple low-dose streptozotocin-induced diabetes in the mouse. Evidence for stimulation of a cytotoxic cellular immune response against an insulin-producing beta cell lineQ34613096
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.Q34621389
The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significanceQ34769236
Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8.Q34769242
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epitheliaQ34797847
Activation of ecto-5'-nucleotidase by protein kinase C and its role in ischaemic tolerance in the canine heartQ35025385
Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA ActivityQ35067242
Impaired glucose tolerance in the absence of adenosine A1 receptor signalingQ35227208
Introduction to adenosine receptors as therapeutic targetsQ36153376
The P2Y(1) receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in miceQ36173756
Adenosine receptor activation ameliorates type 1 diabetes.Q36427003
Physiological roles for ecto-5'-nucleotidase (CD73).Q36478279
Deletion of cd39/entpd1 results in hepatic insulin resistanceQ36842553
Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic isletsQ36973397
Central role of Sp1-regulated CD39 in hypoxia/ischemia protectionQ37039131
Purinergic receptors in the endocrine and exocrine pancreas.Q37119875
Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal diseaseQ37141784
A2B adenosine receptor dampens hypoxia-induced vascular leakQ37336475
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolismQ38337539
Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion.Q39671882
CD73-generated adenosine restricts lymphocyte migration into draining lymph nodesQ39990373
Dexamethasone inhibits proliferation and stimulates ecto-5'-nucleotidase/CD73 activity in C6 rat glioma cell lineQ40142178
The impact of adenosine and A(2B) receptors on glucose homoeostasisQ40164891
Metabolic coupling factors in pancreatic beta-cell signal transductionQ40422075
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophagesQ40488434
Effect of purinergic agonists and antagonists on insulin secretion from INS-1 cells (insulinoma cell line) and rat pancreatic isletsQ40718427
CD39 and control of cellular immune responsesQ40730152
Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype.Q41985015
Evidence for an A2-subtype adenosine receptor on pancreatic glucagon secreting cellsQ42109553
Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets.Q42182907
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecttype-1 diabetesQ124407
heterocyclic compoundQ193430
pathogenesisQ372016
signal transductionQ828130
enzymeQ8047
type 2 diabetesQ3025883
apyrase familyQ24770179
CD antigensQ66660268
P304page(s)320495
P577publication date2012-01-01
2012-10-14
P1433published inJournal of Biomedicine and BiotechnologyQ15752146
P1476titleThe CD39-adenosinergic axis in the pathogenesis of immune and nonimmune diabetes
P478volume2012

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cites work (P2860)
Q38358000Adenosine signalling in diabetes mellitus--pathophysiology and therapeutic considerations
Q91654961Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease
Q34703746Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states
Q42372999Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina
Q31170140Integrating genomic data from high-throughput studies with computational modeling reveals differences in the molecular basis of hyposalivation between type 1 and type 2 diabetes
Q35436829Loss of survival factors and activation of inflammatory cascades in brain sympathetic centers in type 1 diabetic mice
Q55261560The Role of Extracellular Adenosine Generation in the Development of Autoimmune Diseases.

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