Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms

scientific article published on January 2008

Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/138920208785133253
P932PMC publication ID2685644
P698PubMed publication ID19471607
P5875ResearchGate publication ID26243029

P2093author name stringPeng Gao
Yan Jiao
Cong-Yi Wang
Weikuan Gu
Qing Xiong
Ivan Gerling
P2860cites workStimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cellsQ24296669
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other lociQ24306903
Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cellQ24307724
The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMOQ24336822
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB betaQ24669877
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in SwedenQ24671765
HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusionQ24683388
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetesQ24797435
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.Q27863762
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levelsQ28186484
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune diseaseQ28201947
Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cellsQ28241044
Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencingQ28241093
The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patientsQ28263324
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene familyQ28279615
Effects of diabetes and insulin on the expression of galanin-like peptide in the hypothalamus of the ratQ28565208
TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant ratQ28571409
Hedgehog signaling regulation of insulin production by pancreatic beta-cellsQ28571445
Glucotoxicity in the INS-1 rat insulinoma cell line is mediated by the orphan nuclear receptor small heterodimer partnerQ28571879
ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ cultureQ28595049
Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregatesQ30478349
Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set.Q30987903
High-resolution SNP scan of chromosome 6p21 in pooled samples from patients with complex diseasesQ31139643
An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).Q32036980
Prolactin regulation of the expression of TNF-alpha, IFN-gamma and IL-10 by splenocytes in murine multiple low dose streptozotocin diabetesQ33220660
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseasesQ33235613
HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patientsQ33275239
Increased islet neogenesis without increased islet mass precedes autoimmune attack in diabetes-prone rats.Q33300946
Variants in the FFAR1 gene are associated with beta cell functionQ33305200
Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channelsQ33873543
Genetic contribution of the BAT2 gene microsatellite polymorphism to the age-at-onset of insulin-dependent diabetes mellitusQ33917878
Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytesQ33968499
TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetesQ34001477
Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes.Q34008199
G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathyQ34025902
A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetesQ34114132
Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice.Q34329403
Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell lineQ34474467
Identification of the transcription factor ARNTL2 as a candidate gene for the type 1 diabetes locus Idd6.Q34555029
Screening for insulitis in adult autoantibody-positive organ donorsQ34580251
Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetesQ34623221
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell functionQ34680127
Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populationsQ34685525
Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetesQ35024550
Modeling CTLA4-linked autoimmunity with RNA interference in miceQ35133842
CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetesQ35580417
The Fas pathway is involved in pancreatic beta cell secretory functionQ35669781
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alphaQ35720840
Wnt signaling regulates pancreatic beta cell proliferationQ35741102
Deletion of decay-accelerating factor (CD55) exacerbates autoimmune disease development in MRL/lpr miceQ35789124
CD69 downregulates autoimmune reactivity through active transforming growth factor-beta production in collagen-induced arthritis.Q35919881
Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulationQ35942736
CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetesQ35978587
Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2Q36369080
Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic miceQ36380617
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesionQ36399063
Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitusQ36513158
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasisQ36549465
Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility regionQ36554041
The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the JapaneseQ36666052
Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretionQ36676305
The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell lossQ36689966
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis.Q36711611
Insights in congenital hyperinsulinismQ36994981
Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14.Q38296273
Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitusQ38312840
Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitusQ38345343
A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic miceQ38346388
Mutation scan of a type 1 diabetes candidate gene: the human interleukin-18 binding protein geneQ38346769
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.Q40051110
Detection of amplifiable mRNA extracellular to insulin-producing cells: potential for predicting beta cell mass and functionQ40089893
SOX6 suppresses cyclin D1 promoter activity by interacting with beta-catenin and histone deacetylase 1, and its down-regulation induces pancreatic beta-cell proliferationQ40148736
Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathwayQ40228505
Reg (regenerating) gene overexpression in islets from non-obese diabetic mice with accelerated diabetes: role of IFNbeta.Q40245065
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.Q40250584
The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47.Q40258118
PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).Q40329862
Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetesQ40401659
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.Q40501687
A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD miceQ40754533
Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cellsQ40877238
Constitutive and regulated expression of the class IB molecule Qa-1 in pancreatic beta cells.Q41015671
Proprotein-processing endoprotease furin controls growth of pancreatic beta-cellsQ41098342
Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1.Q41351136
Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes.Q41504683
The Idd6.2 diabetes susceptibility region controls defective expression of the Lrmp gene in nonobese diabetic (NOD) miceQ42166847
A case of acquired deficiency of pituitary GH, PRL and TSH, associated with type 1 diabetes mellitusQ42464738
Decreased expression of t-SNARE, syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets: restoration of decreased t-SNARE proteins improves impaired insulin secretionQ42480566
Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucoseQ43935399
No association between lck gene polymorphisms and protein level in type 1 diabetes.Q44195294
Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetesQ44278004
Steroids in adult men with type 1 diabetes: a tendency to hypogonadismQ44453217
Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetesQ44459456
Linkage of the human inducible nitric oxide synthase gene to type 1 diabetesQ44593642
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetesQ44625248
Abnormalities within CD4 and CD8 T lymphocyte subsets in type 1 (insulin-dependent) diabetesQ44743179
Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic miceQ44752917
Elevated SNAP-25 is associated with fatty acid-induced impairment of mouse islet functionQ44829676
Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutationsQ44865625
Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overviewQ45032366
Association analysis of the lymphocyte-specific protein tyrosine kinase (LCK) gene in type 1 diabetesQ45032420
Immunoglobulin allotypes and virus antibodies in Finnish type 1 diabetic patientsQ45077917
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupusQ45180946
Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigreesQ45231011
Relationship between 12/15-lipoxygenase and COX-2 in mesangial cells: potential role in diabetic nephropathyQ46160227
The complement component C4 in black Americans with type 1 (insulin-dependent) diabetes mellitusQ46180179
No evidence for association of the TATA-box binding protein glutamine repeat sequence or the flanking chromosome 6q27 region with type 1 diabetesQ46454811
In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.Q46583266
Galanin-like peptide rescues reproductive function in the diabetic rat.Q46620688
Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidneyQ46681131
Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onsetQ46877730
Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic miceQ46956195
Stromal cell-derived factor-1/CXCL12 stimulates chemorepulsion of NOD/LtJ T-cell adhesion to islet microvascular endothelium.Q46972089
The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitisQ47310086
Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouseQ47316028
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patientsQ47670854
A functional variant of IRS1 is associated with type 1 diabetes in families from the US and UK.Q47835919
Promoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in JapaneseQ48025145
IKBL promoter polymorphism is strongly associated with resistance to type 1 diabetes in JapaneseQ48025158
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetesQ48028283
The hypothalamic-pituitary-thyroid axis in type 1 diabetes: influence of diabetic metabolic controlQ48677239
No evidence for linkage in the promoter region of the inducible nitric oxide synthase gene (NOS2) in a Danish type 1 diabetes population.Q50568213
Immunoreactive gastric inhibitory polypeptide response to a meal during the first eighteen months after diagnosis of type 1 (insulin dependent) diabetes mellitus.Q51640134
Continuous stimulation of human glucagon-like peptide-1 (7-36) amide in a mouse model (NOD) delays onset of autoimmune type 1 diabetes.Q51746108
Heightened interferon-alpha/beta response causes myeloid cell dysfunction and promotes T1D pathogenesis in NOD mice.Q51775394
Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.Q51930232
Plexin-A4 negatively regulates T lymphocyte responses.Q51966689
The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect.Q52085896
Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility.Q53626789
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.Q53630908
Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes.Q53643072
Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.Q53859877
Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis.Q54030011
Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.Q54139892
Predisposing genetic factors for diabetic polyneuropathy in patients with type 1 diabetes: a population-based case-control study.Q54735438
Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6.Q54748529
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetesQ56902091
Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1Q56902378
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese populationQ56905015
Gene Expression in Peripheral Blood Mononuclear Cells from Children with DiabetesQ57063478
Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone miceQ57089497
A key role for ICAM-1 in generating effector cells mediating inflammatory responsesQ57227924
Multiple Variants in Vascular Endothelial Growth Factor (VEGFA) Are Risk Factors for Time to Severe Retinopathy in Type 1 DiabetesQ57591578
A Haplotype-Based Analysis of the PTPN22 Locus in Type 1 DiabetesQ58006357
Characterization of a nuclear-factor-kappa B (NFκB) genetic marker in type 1 diabetes (T1DM) familiesQ58201234
Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?Q58423201
Sex Hormone Binding Globulin Levels in Adolescent Subjects with Diabetes MellitusQ58811278
BMP4-BMPR1A Signaling in β Cells Is Required for and Augments Glucose-Stimulated Insulin SecretionQ59600039
Study of T-cell activation in Type I diabetic patients and pre-Type I diabetic subjects by cytometric analysis: Antigen expression defectin vitroQ63256817
Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene.Q64891039
Association studies between Type 1 (insulin-dependent) diabetes and 27 genetic markers: lack of association between Type 1 diabetes and Kidd blood groupQ70455368
Detection of anti-myeloperoxidase antibodies in the serum of patients with type 1 diabetes mellitusQ71685771
Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistantQ72787291
Prolactin protects against diabetes induced by multiple low doses of streptozotocin in miceQ73170321
von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetesQ73225929
Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 miceQ73943065
HLA associations in type 1 diabetes: merging genetics and immunologyQ74432165
C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritisQ74500092
NFkappaB polymorphisms and susceptibility to type 1 diabetesQ74633719
Transmission of G-protein beta3 subunit C825T alleles to offspring affected with end-stage renal diseaseQ77089089
MTHFR gene polymorphism and diabetic nephropathy in type 1 diabetesQ77345813
Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetesQ77426294
No abnormalities of reg1 alpha and reg1 beta gene associated with diabetes mellitusQ77503855
Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signalsQ77704341
Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamateQ77712805
Characterization of monocyte-derived dendritic cells in recent-onset diabetes mellitus type 1Q78668290
Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiationQ78680071
CD14 triggers autoimmune Type 1 diabetes in the NOD mouseQ79290916
RegII is a beta-cell protein and autoantigen in diabetes of NOD miceQ79456060
Modulating protective and pathogenic CD4+ subsets via CD137 in type 1 diabetesQ79456112
CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responsesQ79843191
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes modelsQ80465675
Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetesQ80813712
Idd1 and Idd3 are necessary but not sufficient for development of type 1 diabetes in NOD mouseQ81057803
Molecular pathways altered by insulin b9-23 immunizationQ81378726
Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunityQ81391315
Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes: evidence for involvement of CCR8 and CCL1Q81464236
Altered chemokine levels in individuals at risk of Type 1 diabetes mellitusQ82357734
Molecular genetic analysis of MODY candidate genes in Japanese patients with non-obese juvenile onset diabetes mellitusQ82960027
P433issue5
P304page(s)324-337
P577publication date2008-01-01
P1433published inCurrent GenomicsQ5195047
P1476titleGenetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms
P478volume9

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cites work (P2860)
Q50554021Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets.
Q33889236GLUT1-mediated selective tumor targeting with fluorine containing platinum(II) glycoconjugates
Q37725553Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling
Q33729528Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes
Q34447630Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes
Q35188468Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22

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