Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling

scientific article

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1031128276
P356DOI10.1038/NATURE09707
P932PMC publication ID3166217
P698PubMed publication ID21326202
P5875ResearchGate publication ID49840833

P50authorMichael KarinQ1458081
P2093author name stringJin Q Cheng
Wei Tan
Robert M Hoffman
Sergei Grivennikov
Weizhou Zhang
Amy Strasner
P2860cites workRANK is essential for osteoclast and lymph node developmentQ24598872
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerQ24605866
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligandQ24653311
Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptorQ24680555
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Immunity, Inflammation, and CancerQ27861048
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing MaspinQ28294196
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisQ28294501
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentQ28508430
Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic diseaseQ28570541
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerQ29547699
Mesenchymal stem cells within tumour stroma promote breast cancer metastasisQ29614303
Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer modelQ33517133
HER-2/neu amplification and overexpression in primary human breast cancer is associated with early metastasisQ34242741
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophagesQ34995099
B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal diseaseQ35222008
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cellsQ36023768
Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune responseQ36402967
Regulation of cancer cell migration and bone metastasis by RANKL.Q40298349
Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic targetQ46344166
Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome.Q51798642
Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates.Q51803777
Possible involvement of regulatory T cells in tumor onset and progression in primary breast cancer.Q53814302
Quantification of Regulatory T Cells Enables the Identification of High-Risk Breast Cancer Patients and Those at Risk of Late RelapseQ58211903
Elevated expression of the CC chemokine regulated on activation, normal T cell expressed and secreted (RANTES) in advanced breast carcinomaQ73010328
Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposureQ84346511
P433issue7335
P407language of work or nameEnglishQ1860
P921main subjectcancer metastasisQ120912394
P304page(s)548-553
P577publication date2011-02-16
P1433published inNatureQ180445
P1476titleTumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling
P478volume470

Reverse relations

cites work (P2860)
Q41218466A "vicious cycle" of NK-cell immune evasion in acute myeloid leukemia mediated by RANKL?
Q36482032A CXCL1 paracrine network links cancer chemoresistance and metastasis
Q24338768A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1
Q28306743A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4
Q47643448A nonimmune function of T cells in promoting lung tumor progression
Q58700691A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than wild-type IL-2
Q35626799A seven-gene CpG-island methylation panel predicts breast cancer progression
Q41564767A signal-based method for finding driver modules of breast cancer metastasis to the lung.
Q35659971Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors
Q37706111Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer
Q53070583Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.
Q37356654Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines
Q91754904Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression
Q37685867Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
Q38097243An inflammatory vicious cycle: Fibroblasts and immune cell recruitment in cancer
Q38075495Animal model for mammary tumor growth in the bone microenvironment
Q26796542Antibody-based immunotherapy of solid cancers: progress and possibilities
Q36922033Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity
Q36854682Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis
Q38045603Basic principles of tumor-associated regulatory T cell biology
Q28265584Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab
Q34366449Biology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond
Q36537204Blood Genome-Wide Transcriptional Profiles of HER2 Negative Breast Cancers Patients
Q92253913Bone Metastasis: Current State of Play
Q27022883Bone specific immunity and its impact on metastasis
Q28087676Bone-targeted therapy in metastatic breast cancer - all well-established knowledge?
Q36653524Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade
Q37973821Breast-cancer stem cells-beyond semantics
Q34657809C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation
Q37295330CCL20 mediates RANK/RANKL-induced epithelial-mesenchymal transition in endometrial cancer cells
Q35214342CD105 expression on CD34-negative spindle-shaped stromal cells of primary tumor is an unfavorable prognostic marker in early breast cancer patients
Q35968894CXCL13 activation of c-Myc induces RANK ligand expression in stromal/preosteoblast cells in the oral squamous cell carcinoma tumor-bone microenvironment
Q58781616Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu
Q35598951Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation
Q91691166Cancer-associated fibroblasts in gastrointestinal cancer
Q92963134Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy
Q84744532Cancer-derived matrix metalloproteinase-9 contributes to tumor tolerance
Q37061749Carcinoma-associated fibroblasts are a promising therapeutic target.
Q90278559Caveolin‑1 enhances RANKL‑induced gastric cancer cell migration
Q39014552Cell lineage determinants as regulators of breast cancer metastasis
Q37078475Chemokines and chemokine receptors as promoters of prostate cancer growth and progression
Q90401357Chemokines in Physiological and Pathological Bone Remodeling
Q38682103Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort
Q53732017Clinical predictors of survival in patients with castration-resistant prostate cancer receiving sipuleucel-T cellular immunotherapy.
Q39036670Clinical significance of CYLD downregulation in breast cancer
Q91651961Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas
Q36075768Comprehensive prognostic analysis in breast cancer integrating clinical, tumoral, micro-environmental and immunohistochemical criteria
Q34201118Constitutive expression of TNF-related activation-induced cytokine (TRANCE)/receptor activating NF-κB ligand (RANK)-L by rat plasmacytoid dendritic cells
Q35624809Continuous requirement of ErbB2 kinase activity for loss of cell polarity and lumen formation in a novel ErbB2/Neu-driven murine cell line model of metastatic breast cancer.
Q42571627Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer
Q37986124Denosumab for treatment of breast cancer bone metastases and beyond
Q37974570Denosumab in patients with cancer-a surgical strike against the osteoclast
Q36450727Denosumab: Delay of bone metastasis in men with nonmetastatic castrate-resistant prostate cancer
Q58762354Distribution and prognostic value of tumor‑infiltrating T cells in breast cancer
Q38955517Drugs in early clinical development for the treatment of osteosarcoma
Q48193895Dynamics of regulatory T cells (Tregs ) in patients with oral squamous cell carcinoma.
Q36698273Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells.
Q37441693Effects of RANKL-Targeted Therapy in Immunity and Cancer
Q55077356Emerging Functions of Regulatory T Cells in Tissue Homeostasis.
Q35686250Emerging candidates in breast cancer stem cell maintenance, therapy resistance and relapse.
Q38264092Emerging roles of regulatory T cells in tumour progression and metastasis
Q38008496Emerging roles of the tumor-associated stroma in promoting tumor metastasis.
Q36854062Emerging therapeutic targets in metastatic progression: A focus on breast cancer
Q38341899Endocrine hormones and local signals during the development of the mouse mammary gland.
Q89164779Engineering the pre-metastatic niche
Q57154016Evaluation of two inflammation-based prognostic scores in patients with resectable gallbladder carcinoma
Q35014814Expression of pim-1 in tumors, tumor stroma and tumor-adjacent mucosa co-determines the prognosis of colon cancer patients
Q91310928Fibroblasts Fuel Immune Escape in the Tumor Microenvironment
Q39984572Flesh-eating Streptococcus pyogenes triggers the expression of receptor activator of nuclear factor-κB ligand
Q59799443Frequent activating STAT3 mutations and novel recurrent genomic abnormalities detected in breast implant-associated anaplastic large cell lymphoma
Q38045235From sentinel cells to inflammatory culprits: cancer-associated fibroblasts in tumour-related inflammation
Q35659426From the ranks of mammary progesterone mediators, RANKL takes the spotlight
Q38202990Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans.
Q36076453Future perspectives of prostate cancer therapy
Q33652169GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer
Q26825120Galectin-1 research in T cell immunity: past, present and future
Q24568374Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression
Q38735527HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone.
Q37476039Harnessing the immune system for the treatment of breast cancer
Q90442956Harnessing the versatile role of OPG in bone oncology: counterbalancing RANKL and TRAIL signaling and beyond
Q33558230Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis
Q34598936Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells
Q38226179Hormonal regulation of the immune microenvironment in the mammary gland
Q53236646IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells.
Q36924500Identification of novel human receptor activator of nuclear factor-kB isoforms generated through alternative splicing: implications in breast cancer cell survival and migration
Q37719488Immune Regulation of the Metastatic Process: Implications for Therapy
Q26991724Immune cell promotion of metastasis
Q35642044Immune microenvironments in solid tumors: new targets for therapy
Q36204083Immune modulation of CD4(+)CD25(+) regulatory T cells by zoledronic acid
Q27005871Immune regulation of bone metastasis
Q57791068Immune regulation of metastasis: mechanistic insights and therapeutic opportunities
Q38122647Immune system: a double-edged sword in cancer
Q36106053Immunity, inflammation, and cancer: an eternal fight between good and evil
Q38608340Immunological hallmarks of stromal cells in the tumour microenvironment
Q84066899Immunology: Pro-metastatic T(Reg)cells get RANKed
Q28083450Immunosuppression associated with chronic inflammation in the tumor microenvironment
Q38154151Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines.
Q55257180Immunotherapeutic interventions of Triple Negative Breast Cancer.
Q28732675In vivo expansion of naïve CD4+ CD25(high) FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration
Q34974617In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique
Q84515527Increased number of regulatory T cells (T-regs) in the peripheral blood of patients with Her-2/neu-positive early breast cancer
Q38769921Infiltrating T Cells Promote Bladder Cancer Progression via Increasing IL1→Androgen Receptor→HIF1α→VEGFa Signals
Q38964798Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling
Q28396089Inflammation and skeletal metastasis
Q29620242Inflammation meets cancer, with NF-κB as the matchmaker
Q64099539Inhibition of NK Reactivity Against Solid Tumors by Platelet-Derived RANKL
Q34295493Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer
Q42578523Integrated Analysis Reveals hsa-miR-142 as a Representative of a Lymphocyte-Specific Gene Expression and Methylation Signature
Q36848283Interaction among cells of bone, immune system, and solid tumors leads to bone metastases
Q55313422Interplay of Viral Infection, Host Cell Factors and Tumor Microenvironment in the Pathogenesis of Nasopharyngeal Carcinoma.
Q36503942Intraosseous inoculation of tumor cells into bone marrow promotes distant metastatic tumor development: A novel tool for mechanistic and therapeutic studies
Q38019416Intratumoral stages of metastatic cells: a synthesis of ontogeny, Rho/Rac GTPases, epithelial-mesenchymal transitions, and more
Q54200830LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.
Q37317234LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway
Q52714204LW106, A Novel Inhibitor of IDO1, Suppresses Tumor Progression by Limiting Stroma-Immune Crosstalk and Cancer Stem Cell Enrichment in the Tumor Microenvironment.
Q36845822Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade
Q37987842Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity
Q34308847Lymphotoxin, NF-ĸB, and cancer: the dark side of cytokines
Q42182045MMP1, MMP9, and COX2 expressions in promonocytes are induced by breast cancer cells and correlate with collagen degradation, transformation-like morphological changes in MCF-10A acini, and tumor aggressiveness.
Q37078995Maraviroc decreases CCL8-mediated migration of CCR5(+) regulatory T cells and reduces metastatic tumor growth in the lungs
Q38439266Mechanisms of aromatase inhibitor resistance.
Q35673417Mechanisms of cancer cell metastasis to the bone: a multistep process
Q44577463Mechanisms of tumor immune escape in triple-negative breast cancers (TNBC) with and without mutated BRCA 1.
Q58724203Merkel cell polyomavirus and Langerhans cell neoplasm
Q38059338Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance?
Q88693147Metabolic Regulation of Tregs in Cancer: Opportunities for Immunotherapy
Q92243276MiR-195 restrains lung adenocarcinoma by regulating CD4+ T cell activation via the CCDC88C/Wnt signaling pathway: a study based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and bioinformatic analysis
Q35157020MicroRNAs in Human Diseases: From Cancer to Cardiovascular Disease
Q87573906Molecular response of the axillary lymph node microenvironment to metastatic colonization
Q35063276Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region
Q38155200Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis
Q38359190NF-κB in cancer therapy.
Q26801253New and emerging factors in tumorigenesis: an overview
Q38052462New developments in osteoimmunology
Q97419539Novel Melatonin, Estrogen, and Progesterone Hormone Therapy Demonstrates Anti-Cancer Actions in MCF-7 and MDA-MB-231 Breast Cancer Cells
Q41135180OPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer
Q37180457OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.
Q37330542Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
Q63565679Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Q92052373Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice
Q36413217Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas
Q36480992Oral squamous carcinoma cells secrete RANKL directly supporting osteolytic bone loss
Q97423686Osteoclast Signal Transduction During Bone Metastasis Formation
Q47712068Osteoclast inhibitors to prevent bone metastases in men with high-risk, non-metastatic prostate cancer: A systematic review and meta-analysis.
Q47944184Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
Q92668034Osteoimmunology: evolving concepts in bone-immune interactions in health and disease
Q47861377Ovarian cancer stem cells promote tumour immune privilege and invasion via CCL5 and regulatory T cells.
Q36080689POSITIVE study: physical exercise program in non-operable lung cancer patients undergoing palliative treatment
Q64244173PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185 Tumor Immunotherapy
Q35612391Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells
Q26777205Paving the Road to Tumor Development and Spreading: Myeloid-Derived Suppressor Cells are Ruling the Fate
Q52804185Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC 6H 4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitinatio
Q38857539Precancer Atlas to Drive Precision Prevention Trials.
Q38109029Progesterone signalling in breast cancer: a neglected hormone coming into the limelight
Q51042996Progesterone/RANKL is a major regulatory axis in the human breast.
Q27318199Prospects for therapeutic tolerance in humans
Q43142242Prospects of adjuvant RANKL inhibition in breast cancer?
Q36729107Protumor activities of the immune response: insights in the mechanisms of immunological shift, oncotraining, and oncopromotion.
Q26830075Pushing tumor cells towards a malignant phenotype: stimuli from the microenvironment, intercellular communications and alternative roads
Q36134061Quantitation of the Rank-Rankl Axis in Primary Biliary Cholangitis
Q38691526RANK as a therapeutic target in cancer.
Q52877576RANK expression as a prognostic and predictive marker in breast cancer.
Q47106594RANK expression in EBV positive nasopharyngeal carcinoma metastasis: a ready-to-treat target?
Q39055979RANK expression on breast cancer cells promotes skeletal metastasis
Q33895612RANK rs1805034 T>C polymorphism is associated with susceptibility of esophageal cancer in a Chinese population
Q37648868RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization
Q26747442RANK-RANKL signalling in cancer
Q88911025RANK-c attenuates aggressive properties of ER-negative breast cancer by inhibiting NF-κB activation and EGFR signaling
Q35218182RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy
Q40030944RANK/RANKL expression in prostate cancer
Q36491425RANK/RANKL pathway in cancer: Biological activity beyond bone?
Q37865171RANKL inhibition: a promising novel strategy for breast cancer treatment.
Q36253034RANKL/OPG in Breast Cancer - Extending Its Territory to BRCA Mutation Carriers
Q37582762RANKL/RANK pathway abrogates cetuximab sensitivity in gastric cancer cells via activation of EGFR and c-Src
Q92612736RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR
Q60917149RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Q28075004RANKL/RANK: from bone loss to the prevention of breast cancer
Q49371326Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
Q91253715Receptor activator of NF-κB (RANK)-mediated induction of metastatic spread and association with poor prognosis in renal cell carcinoma
Q38747404Receptor activator of nuclear factor kappa B (RANK) expression in primary breast cancer correlates with recurrence-free survival and development of bone metastases in I-SPY1 (CALGB 150007/150012; ACRIN 6657).
Q36180432Regulation of IL-20 Expression by Estradiol through KMT2B-Mediated Epigenetic Modification
Q26742012Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting
Q36018275Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners
Q26991447Regulatory T cell: a protection for tumour cells
Q33784969Regulatory T cells in multiple sclerosis and myasthenia gravis.
Q38139203Regulatory T cells in nonlymphoid tissues
Q57471979Regulatory T cells in the treatment of disease
Q36085081Regulatory T cells turn pathogenic
Q38202988Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation
Q34473935Relationship between the inflammatory molecular profile of breast carcinomas and distant metastasis development
Q36342182Reproductive history and breast cancer risk.
Q35799094Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells.
Q37679393Roadblocks to translational advances on metastasis research
Q37241255Role of RANKL/RANK in primary and secondary breast cancer
Q30455154Role of denosumab in prostate cancer
Q39914415Role of the nervous system in cancer metastasis.
Q38830072Roles of regulatory T cells in cancer immunity
Q60489259Roles of the RANKL–RANK axis in antitumour immunity — implications for therapy
Q34413441Roles of tumor suppressors in regulating tumor-associated inflammation
Q34100910SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination
Q64951290Sclerotic Bone Metastasis in Pulmonary Adenocarcinoma.
Q39090351Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study
Q38581768Skeletal metastases from breast cancer: pathogenesis of bone tropism and treatment strategy.
Q37238831Specific recruitment of γδ regulatory T cells in human breast cancer.
Q38172858Stimuli-induced organ-specific injury enhancement of organotropic metastasis in a spatiotemporal regulation.
Q35130819Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
Q38017601Stromal biomarkers in breast cancer development and progression
Q35609967Stromal cells in tumor microenvironment and breast cancer
Q50994600Systematic analysis of breast cancer morphology uncovers stromal features associated with survival.
Q27311542T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer
Q47852200T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.
Q39399239Taming the immune system through transfusion in oncology patients
Q59329292Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors
Q26849690Targeting RANKL in metastasis
Q91565659Targeting Tumor Microenvironment by Small-Molecule Inhibitors
Q98166041Targeting regulatory T cells for improving cancer therapy: Challenges and prospects
Q27022348Targeting regulatory T cells in cancer
Q38703565Targeting regulatory T cells in tumors
Q98771227Targeting the RANKL/RANK/OPG Axis for Cancer Therapy
Q91688036Tertiary Lymphoid Organs in Cancer Immunology: Mechanisms and the New Strategy for Immunotherapy
Q64105357The Contribution of the Immune System in Bone Metastasis Pathogenesis
Q36356112The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis.
Q93216958The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice
Q88723986The Immunobiology of Receptor Activator for Nuclear Factor Kappa B Ligand and Myeloid-Derived Suppressor Cell Activation in Immunoglobulin G4-Related Sclerosing Cholangitis
Q38524842The Impact of Immune System in Regulating Bone Metastasis Formation by Osteotropic Tumors
Q57166654The Interplay between Circulating Tumor Cells and the Immune System: From Immune Escape to Cancer Immunotherapy
Q34066731The IκB kinase complex is required for plexin-B-mediated activation of RhoA
Q41200607The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy.
Q64120685The Uncovered Role of Immune Cells and NK Cells in the Regulation of Bone Metastasis
Q53807792The association between RANKL and Osteoprotegerin gene polymorphisms with breast cancer.
Q38029394The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction
Q37976939The diverse and complex roles of NF-κB subunits in cancer
Q37474735The diverse roles of the TNF axis in cancer progression and metastasis
Q64934031The effects of epidural anaesthesia and analgesia on T lymphocytes differentiation markers and cytokines in patients after gastric cancer resection.
Q37033451The immune system and inflammation in breast cancer
Q26851314The microenvironment in breast cancer progression: biology and implications for treatment
Q35931795The pro-metastatic role of bone marrow-derived cells: a focus on MSCs and regulatory T cells
Q37520235The prognostic role of RANK SNP rs34945627 in breast cancer patients with bone metastases.
Q49163652The relative change in regulatory T cells / T helper lymphocytes ratio as parameter for prediction of therapy efficacy in metastatic colorectal cancer patients
Q35531372The role of the cell-cell interactions in cancer progression
Q38922999The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas.
Q38039112The split nature of tumor-infiltrating leukocytes: Implications for cancer surveillance and immunotherapy
Q35538728The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies
Q35034370The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment
Q55117611Therapeutic and Preventive Effects of Osteoclastogenesis Inhibitory Factor on Osteolysis, Proliferation of Mammary Tumor Cell and Induction of Cancer Stem Cells in the Bone Microenvironment.
Q38157750Therapeutic gene delivery using bioreducible polymers
Q26798116Therapeutic potential of chemokine signal inhibition for metastatic breast cancer
Q33745632Top Notch cancer stem cells by paracrine NF-κB signaling in breast cancer
Q37246484Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy
Q38160740Tumor metastasis: moving new biological insights into the clinic
Q50073017Tumor microenvironment heterogeneity: challenges and opportunities
Q37728585Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis
Q39198945Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis
Q37950602Tumor promotion via injury- and death-induced inflammation
Q37028767Tumor-infiltrating regulatory T cells: phenotype, role, mechanism of expansion in situ and clinical significance
Q84067389Tumour immunology: Pro-metastatic T(Reg) cells get RANKed
Q26766468Tumour progression and metastasis
Q34281252Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Q36759374Understanding and targeting osteoclastic activity in prostate cancer bone metastases
Q38988078Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy.
Q38673589When Good Turns Bad: Regulation of Invasion and Metastasis by ErbB2 Receptor Tyrosine Kinase
Q54975654miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers.
Q37452957microRNA-mediated regulation of the tumor microenvironment
Q55118190α-Tocopheryl Succinate Inhibits Osteolytic Bone Metastasis of Breast Cancer by Suppressing Migration of Cancer Cells and Receptor Activator of Nuclear Factor-κB Ligand Expression of Osteoblasts.
Q64279107<Editors' Choice> Meddling with meddlers: curbing regulatory T cells and augmenting antitumor immunity