RANKL/RANK: from bone loss to the prevention of breast cancer

scientific article

RANKL/RANK: from bone loss to the prevention of breast cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1098/RSOB.160230
P932PMC publication ID5133443
P698PubMed publication ID27881737

P50authorJosef PenningerQ1674391
Verena SiglQ96091465
Laundette P JonesQ125251393
P2860cites workOsteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Central control of fever and female body temperature by RANKL/RANKQ24321735
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionQ24336057
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptorQ24555775
RANK is essential for osteoclast and lymph node developmentQ24598872
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerQ24605866
Mammary stem cells and the differentiation hierarchy: current status and perspectivesQ27003345
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trialQ27860743
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
RANK-L and RANK: T cells, bone loss, and mammalian evolutionQ28203468
Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2Q28212276
Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumabQ28265584
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisQ28294501
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland developmentQ28508430
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Triple-Negative Breast CancerQ29391607
Generation of a functional mammary gland from a single stem cellQ29616496
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesQ29617680
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandQ29619331
Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological dataQ33239350
The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cellsQ33652431
Osteoclasts: more than 'bone eaters'.Q33993757
The mechanisms of estrogen regulation of bone resorptionQ34086515
International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriersQ34116505
Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutationQ34129784
The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblastsQ34183259
Breast cancer and hormone-replacement therapy in the Million Women StudyQ34223870
Lessons learned from the Women's Health Initiative trials of menopausal hormone therapy.Q34319242
Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.Q34334383
Signaling pathways in mammary gland development.Q34434909
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unitQ34750367
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signallingQ35194008
From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancerQ35348210
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.Q53370119
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.Q54200830
A role for Brca1 in chromosome end maintenanceQ57790639
Abnormal bone remodeling process is due to an imbalance in the receptor activator of nuclear factor–κB ligand (RANKL)/osteoprotegerin (OPG) axis in patients with solid tumors metastatic to the skeletonQ57904787
Pregnancy and risk of early breast cancer in carriers of BRCA1 and BRCA2Q59238517
BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected CellsQ60568779
Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosisQ83392350
Bone loss in relation to serum levels of osteoprotegerin and nuclear factor-kappaB ligand: the Tromsø StudyQ84453968
Clinical implications of genetic testing for BRCA1 and BRCA2 mutations in AustriaQ86959921
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancerQ35957703
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cellsQ36023768
Repression of mammary stem/progenitor cells by p53 is mediated by Notch and separable from apoptotic activityQ36113210
RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.Q36200979
Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation CarriersQ36252676
Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studiesQ36368636
BRCA1 regulates human mammary stem/progenitor cell fateQ36446479
The role of BRCA1 in transcriptional regulation and cell cycle controlQ36602565
Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospectsQ36602578
BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancerQ36732507
BRCA1, hormone, and tissue-specific tumor suppressionQ37020551
BRCA1 and BRCA2: different roles in a common pathway of genome protectionQ37149848
Genetic predisposition to breast cancer: past, present, and futureQ37187786
Linking the cellular functions of BRCA genes to cancer pathogenesis and treatmentQ37309421
RANKL/RANK control Brca1 mutation-driven mammary tumorsQ37457304
Osteoimmunology: crosstalk between the immune and bone systemsQ37544448
Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2.Q37602035
Clinical practice. Breast-cancer screeningQ37931934
How pregnancy at early age protects against breast cancerQ38172737
The mammary stem cell hierarchy.Q38179662
The Role of Risk-Reducing Surgery in Hereditary Breast and Ovarian CancerQ38721385
Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.Q38764888
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.Q39670403
Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonistQ40202330
Soluble RANKL and risk of nontraumatic fractureQ40527958
Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trialQ40872467
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Progesterone induces adult mammary stem cell expansionQ42471079
Control of mammary stem cell function by steroid hormone signalling.Q43103606
Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutationsQ43520691
Pharmacological properties of mifepristone: toxicology and safety in animal and human studiesQ44707949
The sex hormone system in carriers of BRCA1/2 mutations: a case-control study.Q45802281
"The race" to clone BRCA1.Q48081790
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectosteoporosisQ165328
breast neoplasmQ23929670
TNF superfamily member 11Q418934
TNF receptor superfamily member 11aQ906651
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2016-11-01
P1433published inOpen BiologyQ7095958
P1476titleRANKL/RANK: from bone loss to the prevention of breast cancer
P478volume6

Reverse relations

cites work (P2860)
Q50033721Breast cancer in young women: do BRCA1 or BRCA2 mutations matter?
Q38682103Circulating RANKL and RANKL/OPG and Breast Cancer Risk by ER and PR Subtype: Results from the EPIC Cohort
Q92636699Clinical Impact of RANK Signalling in Ovarian Cancer
Q64939796RANK-RANKL Signaling in Cancer of the Uterine Cervix: A Review.
Q90547034RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women
Q64903679RANKL/RANK Pathway and Its Inhibitor RANK-Fc in Uterine Leiomyoma Growth.
Q60917149RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Q89186597Receptor Activator of Nuclear Factor Kappa B (RANK) and Clinicopathological Variables in Endometrial Cancer: A Study at Protein and Gene Level
Q97643643Soluble RANKL is physiologically dispensable but accelerates tumour metastasis to bone
Q57790452The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases
Q64102143The RANKL-RANK Axis: A Bone to Thymus Round Trip
Q91662693Therapeutic potentials and modulatory mechanisms of fatty acids in bone
Q59335358Update Breast Cancer 2018 (Part 3) – Genomics, Individualized Medicine and Immune Therapies – in the Middle of a New Era: Prevention and Treatment Strategies for Early Breast Cancer

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