Abstract is: Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) or tumour necrosis factor receptor superfamily member 11B (TNFRSF11B), is a cytokine receptor of the tumour necrosis factor (TNF) receptor superfamily encoded by the TNFRSF11B gene. OPG was first discovered as a novel secreted TNFR related protein that played a role in the regulation of bone density and later for its role as a decoy receptor for receptor activator of nuclear factor kappa-B ligand (RANKL). OPG also binds to TNF-related apoptosis-inducing ligand (TRAIL) and inhibits TRAIL induced apoptosis of specific cells, including tumour cells. Other OPG ligands include syndecan-1, glycosaminoglycans, von Willebrand factor, and factor VIII-von Willebrand factor complex. OPG has been identified as having a role in tumour growth and metastasis, heart disease, immune system development and signalling, mental health, diabetes, and the prevention of pre-eclampsia and osteoporosis during pregnancy.
Abstract is: Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 gene. RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. RANKL is expressed in several tissues and organs including: skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. Variation in concentration levels of RANKL throughout several organs reconfirms the importance of RANKL in tissue growth (particularly bone growth) and immune functions within the body.
protein | Q8054 |
P705 | Ensembl protein ID | ENSP00000239849 |
ENSP00000351347 | ||
ENSP00000381775 | ||
ENSP00000384042 | ||
ENSP00000444913 | ||
P2888 | exact match | http://purl.uniprot.org/uniprot/O14788 |
P646 | Freebase ID | /m/0g4r43 |
P486 | MeSH descriptor ID | D053245 |
P672 | MeSH tree code | D12.644.276.374.750.562 |
D12.776.467.374.750.562 | ||
D23.529.374.750.562 | ||
P6366 | Microsoft Academic ID | 2779428903 |
2910053612 | ||
2910283315 | ||
P10283 | OpenAlex ID | C2779428903 |
C2909639871 | ||
P638 | PDB structure ID | 3URF |
5BNQ | ||
P637 | RefSeq protein ID | NP_003692 |
NP_143026 | ||
XP_011533582 | ||
XP_016876291 | ||
XP_016876292 | ||
P2892 | UMLS CUI | C0666364 |
P352 | UniProt protein ID | O14788 |
P682 | biological process | cell differentiation | Q210861 |
ossification | Q1121544 | ||
immune response | Q1612119 | ||
bone resorption | Q4941581 | ||
calcium ion homeostasis | Q14599743 | ||
positive regulation of gene expression | Q14633893 | ||
multicellular organism development | Q14645705 | ||
positive regulation of NF-kappaB transcription factor activity | Q14761969 | ||
positive regulation of protein kinase B signaling | Q14761970 | ||
positive regulation of intracellular signal transduction | Q21097262 | ||
positive regulation of osteoclast development | Q21118908 | ||
cellular response to leukemia inhibitory factor | Q21482848 | ||
regulation of actin binding | Q22299757 | ||
positive regulation of transcription by RNA polymerase II | Q14818068 | ||
ERK1 and ERK2 cascade | Q14820681 | ||
monocyte chemotaxis | Q14860501 | ||
osteoclast differentiation | Q14860557 | ||
positive regulation of phosphorylation | Q14860559 | ||
positive regulation of bone resorption | Q14860560 | ||
protein homooligomerization | Q14860815 | ||
cytokine-mediated signaling pathway | Q14863107 | ||
animal organ morphogenesis | Q14863363 | ||
positive regulation of I-kappaB kinase/NF-kappaB signaling | Q14864035 | ||
tumor necrosis factor-mediated signaling pathway | Q14864211 | ||
positive regulation of DNA-binding transcription factor activity | Q14864461 | ||
positive regulation of MAP kinase activity | Q14864686 | ||
mammary gland alveolus development | Q14864690 | ||
positive regulation of T cell activation | Q14864794 | ||
positive regulation of JNK cascade | Q14864950 | ||
calcium-mediated signaling | Q14865170 | ||
regulation of signaling receptor activity | Q14865464 | ||
paracrine signaling | Q14873666 | ||
bone development | Q14877686 | ||
positive regulation of corticotropin-releasing hormone secretion | Q14878210 | ||
regulation of osteoclast differentiation | Q14883343 | ||
positive regulation of fever generation by positive regulation of prostaglandin secretion | Q14897631 | ||
TNFSF11-mediated signaling pathway | Q14897632 | ||
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling | Q14897633 | ||
osteoclast proliferation | Q14904215 | ||
positive regulation of osteoclast differentiation | Q14904250 | ||
mammary gland epithelial cell proliferation | Q14905565 | ||
positive regulation of homotypic cell-cell adhesion | Q14905566 | ||
tooth eruption | Q15178060 | ||
osteoclast development | Q15319426 | ||
P681 | cell component | plasma membrane | Q29548 |
cytoplasm | Q79899 | ||
extracellular space | Q1385443 | ||
integral component of membrane | Q14327652 | ||
membrane | Q14349455 | ||
extracellular region | Q14645596 | ||
integral component of plasma membrane | Q14859540 | ||
P702 | encoded by | TNFSF11 | Q14905567 |
P703 | found in taxon | Homo sapiens | Q15978631 |
P527 | has part(s) | Tumour necrosis factor domain | Q24724854 |
P680 | molecular function | protein binding | Q167149 |
cytokine activity | Q14862699 | ||
tumor necrosis factor receptor binding | Q14866094 | ||
tumor necrosis factor receptor superfamily binding | Q14877604 | ||
P361 | part of | Tumour necrosis factor ligand 10/11 | Q24722917 |
Tumour necrosis factor-like domain superfamily | Q24783304 | ||
Tumour necrosis factor domain, protein family | Q83135284 |
FileName: PBB GE TNFSF11 210643 at fs.png
Description: Gene expression pattern of the TNFSF11 gene.
Artist: AndrewGNF at en.wikipedia
Work is copyrighted.
License: CC BY-SA 3.0
Attribution is required.
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Q408283 | denosumab | physically interacts with | P129 |
Q14905567 | TNFSF11 | encodes | P688 |
az | RANK-L | wikipedia |
cy | TNFSF11 | wikipedia |
RANK-Ligand | wikipedia | |
RANKL | wikipedia | |
RANKL | wikipedia | |
RANKL | wikipedia | |
gl | RANKL | wikipedia |
RANKL | wikipedia | |
RANKL | wikipedia | |
Serbo-Croatian (sh / Q9301) | RANKL | wikipedia |
RANKL | wikipedia | |
Tatar language (tt / Q25285) | TNFSF11 | wikipedia |
TNFSF11 | wikipedia | |
RANKL | wikipedia |
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