OPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer

scientific article published on 15 April 2014

OPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer is …
instance of (P31):
meta-analysisQ815382
scholarly articleQ13442814

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P356DOI10.1016/J.MOLONC.2014.04.003
P932PMC publication ID5528573
P698PubMed publication ID24785095

P50authorKarl Eugen RuckhäberleQ100415175
Karin Milde-LangoschQ38297224
Thomas KarnQ40714980
P2093author name stringTanja Fehm
Volkmar Müller
Sven Becker
Achim Rody
Giampaolo Bianchini
Nicole Sänger
Uwe Holtrich
Erich Franz Solomayer
Tomas Heinrich
P2860cites workProgestin effects on cell proliferation pathways in the postmenopausal mammary glandQ21092903
Bioconductor: open software development for computational biology and bioinformaticsQ21194861
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerQ24605866
Comprehensive molecular portraits of human breast tumoursQ24630844
Measuring inconsistency in meta-analysesQ27860655
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentQ28142247
Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: a combined analysis of 3 pivotal, randomised, phase 3 trialsQ28275006
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisQ28294501
affy--analysis of Affymetrix GeneChip data at the probe levelQ29547353
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancerQ29615523
The causes and consequences of genetic heterogeneity in cancer evolutionQ29615848
Tackling the widespread and critical impact of batch effects in high-throughput dataQ30004214
Molecular pathways: osteoclast-dependent and osteoclast-independent roles of the RANKL/RANK/OPG pathway in tumorigenesis and metastasisQ44486779
Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastasesQ45814967
Hormone receptor status and survival in a population-based cohort of patients with breast carcinomaQ46448642
Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trialQ46786144
A meta-analysis of gene expression-based biomarkers predicting outcome after tamoxifen treatment in breast cancerQ46799300
Progesterone/RANKL is a major regulatory axis in the human breast.Q51042996
Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling.Q54535173
Reporting recommendations for tumor marker prognostic studiesQ81236405
The humoral immune system has a key prognostic impact in node-negative breast cancerQ81561686
Cancer. Heterogeneity and tumor historyQ83937521
Data-driven derivation of cutoffs from a pool of 3,030 Affymetrix arrays to stratify distinct clinical types of breast cancerQ33448620
The bimodality index: a criterion for discovering and ranking bimodal signatures from cancer gene expression profiling dataQ33498527
Use of ER/PR/HER2 subtypes in conjunction with the 2007 St Gallen Consensus Statement for early breast cancerQ33584322
Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes.Q33586734
A comparison of methods for data-driven cancer outlier discovery, and an application scheme to semisupervised predictive biomarker discoveryQ33902424
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survivalQ33939753
RecurrenceOnline: an online analysis tool to determine breast cancer recurrence and hormone receptor status using microarray dataQ33966102
Sequence analysis of mutations and translocations across breast cancer subtypesQ34032470
Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signaturesQ34119025
Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data from 1287 patientsQ34141028
Use of archived specimens in evaluation of prognostic and predictive biomarkersQ35007222
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trialsQ35186747
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signallingQ35194008
A clinically relevant gene signature in triple negative and basal-like breast cancerQ35683578
Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patientsQ35749359
Lung metastasis genes couple breast tumor size and metastatic spread.Q35800363
Prognostic significance of progesterone receptor-positive tumor cells within immunohistochemically defined luminal A breast cancerQ36494250
Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reportingQ36709828
Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98.Q36902695
Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial.Q37155629
Osteoimmunology: crosstalk between the immune and bone systemsQ37544448
RANKL inhibition: a promising novel strategy for breast cancer treatment.Q37865171
Gene expression profiling in breast cancer: classification, prognostication, and predictionQ37958156
Effects of bone-targeted agents on cancer progression and mortality.Q38023206
Progesterone signalling in breast cancer: a neglected hormone coming into the limelightQ38109029
RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasisQ39365550
Bimodal gene expression and biomarker discoveryQ39479059
Melanoma antigen family A identified by the bimodality index defines a subset of triple negative breast cancers as candidates for immune response augmentationQ42491260
Prognostic evaluation of the B cell/IL-8 metagene in different intrinsic breast cancer subtypesQ42517986
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind studyQ42829926
The effect of a single dose of osteoprotegerin in postmenopausal womenQ43520860
A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastasesQ44291815
P433issue7
P304page(s)1196-1207
P577publication date2014-04-15
P1433published inMolecular OncologyQ2190736
P1476titleOPG and PgR show similar cohort specific effects as prognostic factors in ER positive breast cancer
P478volume8

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cites work (P2860)
Q41135883Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer.
Q30240711Deciphering the divergent roles of progestogens in breast cancer
Q38699879Evaluation of the Prognostic Value of RANK, OPG, and RANKL mRNA Expression in Early Breast Cancer Patients Treated with Anthracycline-Based Adjuvant Chemotherapy
Q90781774Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer
Q47250561Key Factors in Breast Cancer Dissemination and Establishment at the Bone: Past, Present and Future Perspectives.
Q36252676Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers
Q36273402Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort
Q28081803Osteoprotegerin in breast cancer: beyond bone remodeling
Q92134531Osteoprotegerin: Relationship to Breast Cancer Risk and Prognosis
Q36750660RANK/OPG ratio of expression in primary clear-cell renal cell carcinoma is associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs
Q57801311Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort
Q36356112The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis.
Q40714796The prognostic impact of age in different molecular subtypes of breast cancer

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