Requirement for NF-kappaB in osteoclast and B-cell development

scientific article

Requirement for NF-kappaB in osteoclast and B-cell development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.11.24.3482
P932PMC publication ID316809
P698PubMed publication ID9407039
P5875ResearchGate publication ID247610036

P2093author name stringU Siebenlist
L Xing
T Tran
B F Boyce
G Franzoso
K D Brown
A Leonardi
E W Shores
L Carlson
L Poljak
P2860cites workPerinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase SykQ24303475
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibitionQ28155838
Markers of mouse macrophage development detected by monoclonal antibodiesQ28247978
The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimersQ28260566
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimersQ28267241
Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast functionQ28274181
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responsesQ28505819
Immunological defects in mice with a targeted disruption in Bcl-3Q28506495
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κBQ28508403
Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactionsQ28509551
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Function and activation of NF-kappa B in the immune systemQ29547790
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
An essential role for NF-kappaB in preventing TNF-alpha-induced cell deathQ29614707
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociationQ29615580
Germinal centersQ29616234
Suppression of TNF-alpha-induced apoptosis by NF-kappaBQ29618717
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
Structure, regulation and function of NF-kappa BQ29620225
Positive selection of thymocytesQ33366862
The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.Q34061332
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Qualitative changes in the subunit composition of kappa B-binding complexes during murine B-cell differentiationQ35361444
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized miceQ35824596
The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populationsQ35917603
Two subsets of epithelial cells in the thymic medullaQ36231612
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.Q36301037
B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switchingQ36367374
Mutant mice without B lymphocyte folliclesQ36367422
Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.Q36377290
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitectureQ36400143
IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in miceQ36559410
Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cellsQ37531252
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factorQ37654865
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient miceQ38289217
How many women have osteoporosis now?Q40528035
Selective events in T cell developmentQ40661180
Cytokines and estrogen in bone: anti-osteoporotic effectsQ40900427
The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal developmentQ40957485
Clonal selection and learning in the antibody systemQ41002744
Cellular interactions in thymocyte development.Q41039662
Inhibition of NF-kappaB/Rel induces apoptosis of murine B cellsQ41077008
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.Q41121255
In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activationQ41130580
A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locusQ41182422
Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouseQ41205540
A conserved signaling pathway: the Drosophila toll-dorsal pathwayQ41275284
Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cellsQ41373053
B-cell development and differentiationQ41448847
Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiationQ41450875
The Carl Prausnitz Memorial Lecture. The development of lymphocytesQ41454884
p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout miceQ41954424
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responsesQ42488424
Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclatureQ44660713
Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ.Q50335866
Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta.Q51005281
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.Q52192552
Corepression of RelA and c-rel inhibits immunoglobulin kappa gene transcription and rearrangement in precursor B lymphocytes.Q52198668
Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organsQ52214145
Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.Q52519188
Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent.Q52522051
c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodelingQ58326943
Bone and haematopoietic defects in mice lacking c-fosQ58326969
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortexQ59071991
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expressionQ62817899
Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytesQ67540351
Increased osteoclast development after estrogen loss: mediation by interleukin-6Q68188964
Dendritic cells of the mouse recognized by two monoclonal antibodiesQ69444823
Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cellsQ69834637
Deficiency of osteoclasts in osteopetrotic mice is due to a defect in the local microenvironment provided by osteoblastic cellsQ70118663
B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switchingQ70994054
Role of TCR zeta chain in T cell development and selectionQ71658710
Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy periodQ72332068
Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cellsQ72678853
Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient miceQ73128606
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cellsQ73479969
NF-kappaB inhibitors stimulate apoptosis of rabbit mature osteoclasts and inhibit bone resorption by these cellsQ73545409
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)3482-3496
P577publication date1997-12-01
P1433published inGenes & DevelopmentQ1524533
P1476titleRequirement for NF-kappaB in osteoclast and B-cell development
P478volume11

Reverse relations

cites work (P2860)
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Q36238400Myocardial NF-κB activation is essential for zebrafish heart regeneration.
Q62806043NEMO/IKK gamma: linking NF-kappa B to human disease.
Q33840418NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
Q46831922NF-kB induces lung maturation during mouse lung morphogenesis
Q24803655NF-kB inhibitor blocks B cell development at two checkpoints
Q73291757NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development
Q28271031NF-kappaB and the immune response
Q33840493NF-kappaB and the innate immune response
Q33959017NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.
Q34720640NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.
Q36401969NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor
Q37363042NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
Q37231783NF-kappaB pathways in the immune system: control of the germinal center reaction
Q28205043NF-kappaB regulation in the immune system
Q34264609NF-kappaB signaling and human disease
Q34013841NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival
Q28290224NF-kappaB-related genetic diseases
Q33930920NF-kappaB/rel/IkappaB: implications in gastrointestinal diseases
Q42009786NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis
Q35740901NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells
Q29617726NF-kappaB: a key role in inflammatory diseases
Q37653034NF-κB RelB negatively regulates osteoblast differentiation and bone formation
Q92012828NF-κB Signaling Regulates Physiological and Pathological Chondrogenesis
Q104795129NF-κB activity during pancreas development regulates adult β-cell mass by modulating neonatal β-cell proliferation and apoptosis
Q39142554NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases
Q35348282NF-κB in immunobiology.
Q57675122NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1
Q38178074NF-κB pathways in hematological malignancies
Q37449635NF-κB signaling and bone resorption
Q38533864NF-κB signaling in B-1 cell development
Q38025541NF-κB signaling pathways: role in nervous system physiology and pathology
Q35260971NF-κB-Mediated Regulation of Osteoclastogenesis
Q33768994NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis
Q40632338NMDA glutamate receptors are expressed by osteoclast precursors and involved in the regulation of osteoclastogenesis
Q33961022NOD mice are defective in proteasome production and activation of NF-kappaB
Q33808220NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.
Q39491637Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation
Q36324551Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation.
Q23923136New insights into the role of nuclear factor-KB, a ubiquitous transcription factor in the initiation of diseases
Q33785173New insights into the roles of ReL/NF-kappa B transcription factors in immune function, hemopoiesis and human disease
Q37987556New regulation mechanisms of osteoclast differentiation
Q49793888Niche signals and transcription factors involved in tissue-resident macrophage development
Q52317346Niches for Hematopoietic Stem Cells and Their Progeny.
Q27024640Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures
Q36635311Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
Q34530518Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin
Q43224836Noncanonical NF-κB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions.
Q38305549Novel NF-κB inhibitors: a patent review (2011 - 2014).
Q34806538Novel functions for NFκB: inhibition of bone formation
Q36830310Novel osteoclast signaling mechanisms.
Q35107411Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2
Q36283770Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium
Q28566184Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis
Q35791198Nuclear factor-kappaB: its role in health and disease
Q35008666Nuclear transcription factors in the hippocampus.
Q28817299OCLI-023, a Novel Pyrimidine Compound, Suppresses Osteoclastogenesis In Vitro and Alveolar Bone Resorption In Vivo
Q28589430OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Q35787723Onset and dynamics of osteosclerosis in mice induced by Reilly-Finkel-Biskis (RFB) murine leukemia virus. Increase in bone mass precedes lymphomagenesis
Q36040583Osteoblast-induced osteoclast apoptosis by fas ligand/FAS pathway is required for maintenance of bone mass
Q35348955Osteoclast activity modulates B-cell development in the bone marrow
Q29547556Osteoclast differentiation and activation
Q28593804Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha
Q36568536Osteoclast fusion and regulation by RANKL-dependent and independent factors
Q37489600Osteoclasts and the immune system
Q24683898Osteoclasts: what do they do and how do they do it?
Q34896003Osteoclasts; culprits in inflammatory osteolysis
Q36514172Osteocyte control of osteoclastogenesis
Q88248494Osteoimmunology
Q47944184Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems.
Q36942525Osteoimmunology: a view from the bone
Q37544448Osteoimmunology: crosstalk between the immune and bone systems
Q38960189Osteoimmunology: memorandum for rheumatologists.
Q28294477Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Q54588690Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss.
Q41753607Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
Q33611312Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development.
Q54586775Overexpression of Bcl-3 inhibits the development of marginal zone B cells.
Q33916614Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis.
Q40966176Overexpression of RelA causes G1 arrest and apoptosis in a pro-B cell line
Q45275681P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts
Q38744013PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.
Q58699564PRMT1 mediates RANKL-induced osteoclastogenesis and contributes to bone loss in ovariectomized mice
Q40686068PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility
Q40773247PU.1/Spi-B regulation of c-rel is essential for mature B cell survival
Q36029217Paget disease of bone
Q42197999Parthenolide inhibits osteoclast differentiation and bone resorbing activity by down-regulation of NFATc1 induction and c-Fos stability, during RANKL-mediated osteoclastogenesis
Q92798193Pentamidine Inhibits Titanium Particle-Induced Osteolysis In Vivo and Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation In Vitro
Q36944827Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis
Q91941325Piceatannol attenuates RANKL-induced osteoclast differentiation and bone resorption by suppressing MAPK, NF-κB and AKT signalling pathways and promotes Caspase3-mediated apoptosis of mature osteoclasts
Q51395263Platycodin D Inhibits Osteoclastogenesis by Repressing the NFATc1 and MAPK Signaling Pathway.
Q35751362Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling
Q35617594Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
Q41008741Possible stage-specific function of NF-kappaB during pre-B cell differentiation
Q40596266Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas
Q35085082Proepithelin stimulates growth plate chondrogenesis via nuclear factor-kappaB-p65-dependent mechanisms
Q73150091Progressive increase in bone mass and development of odontomas in aging osteopetrotic c-src-deficient mice
Q33391408Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kappaB p50/p65.
Q38943284Protein kinase C inhibitor, GF109203X attenuates osteoclastogenesis, bone resorption and RANKL-induced NF-κB and NFAT activity.
Q92099986Protocatechuic acid attenuates anterior cruciate ligament transection-induced osteoarthritis by suppressing osteoclastogenesis
Q38691526RANK as a therapeutic target in cancer.
Q24598872RANK is essential for osteoclast and lymph node development
Q37108966RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
Q41107411RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.
Q40326890RANKing the importance of measles virus in Paget's disease
Q24629421RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro
Q58776864Rab GTPases in Osteoclastic Endomembrane Systems
Q34611297Reaching a genetic and molecular understanding of skeletal development
Q50215136Recent advances in osteoclast biology.
Q40633180Receptor Activator of NF-κB Ligand Stimulates Recruitment of SHP-1 to the Complex Containing TNFR-Associated Factor 6 That Regulates Osteoclastogenesis
Q42918767Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts
Q43855536Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass
Q35014068Regulation of B-cell fate by antigen-receptor signals
Q38324140Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cells
Q27021109Regulation of NFATc1 in Osteoclast Differentiation
Q24657260Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
Q38774316Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
Q40796459Regulation of receptor activator of NF-kappaB ligand-induced tartrate-resistant acid phosphatase gene expression by PU.1-interacting protein/interferon regulatory factor-4. Synergism with microphthalmia transcription factor
Q35216951Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
Q38132390Regulations of gene expression in medullary thymic epithelial cells required for preventing the onset of autoimmune diseases
Q34728971Regulatory mechanisms of osteoblast and osteoclast differentiation
Q36638965RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
Q36499078RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation
Q35292814RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function.
Q37635761RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.
Q78049289Required and nonessential functions of nuclear factor-kappa B in bone cells
Q35174052Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption
Q39607279Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand (RANKL) activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells
Q34078699Retracted: Intermittent Hypoxia Effect on Osteoclastogenesis Stimulated by Neuroblastoma Cells
Q73226560Role of B lymphocytes in new bone formation
Q39221657Role of FK506 binding protein 5 (FKBP5) in osteoclast differentiation
Q35347883Role of NF-κB in the skeleton
Q34963016Role of RANKL and RANK in bone loss and arthritis.
Q37118770Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss
Q36177501Roles for NF-kappaB and c-Fos in osteoclasts
Q33800318Roles of the NF-kappaB pathway in lymphocyte development and function
Q39817003Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts
Q39714931Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
Q47446256Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
Q33752186Selectivity of the NF-{kappa}B response
Q34116362Series introduction: the transcription factor NF-kappaB and human disease
Q26766637Signaling Pathways in Osteoclast Differentiation
Q36082866Signaling networks that control the lineage commitment and differentiation of bone cells
Q35553533Signalling in osteoclasts and the role of Fos/AP1 proteins
Q34582666Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program
Q39020213Small non-coding RNAs-based bone regulation and targeting therapeutic strategies.
Q36320978Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells
Q33299652Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation
Q34182834Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data
Q24301850Stimulation by toll-like receptors inhibits osteoclast differentiation
Q39957832Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK.
Q41954511Stimulatory effects of insulin-like growth factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65
Q28586492Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP
Q34166675Strength of TRAF6 signalling determines osteoclastogenesis
Q58079146Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors
Q91711303Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB
Q38972321Suppression of NF-κB activation by gentian violet promotes osteoblastogenesis and suppresses osteoclastogenesis
Q36185717Synergistic Effect of Sorafenib and Radiation on Human Oral Carcinoma in vivo.
Q43641805TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesis
Q35750113TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression
Q38042619TNF receptor family signaling in the development and functions of medullary thymic epithelial cells
Q34471711TRAF family member-associated NF-κB activator (TANK) induced by RANKL negatively regulates osteoclasts survival and function
Q36217430TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation
Q24300996TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor
Q38733018TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid.
Q28513445TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Q46592953Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production.
Q41684447The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption
Q41062466The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling
Q36371653The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis
Q28512132The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
Q41161836The Nuclear Protein IκBζ Forms a Transcriptionally Active Complex with Nuclear Factor-κB (NF-κB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs
Q92050583The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition "Killing Two Birds with One Stone"?
Q33187279The TNF family members BAFF and APRIL: the growing complexity
Q34682769The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression
Q28508398The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis
Q51040187The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.
Q38940135The botanical molecule p-hydroxycinnamic acid as a new osteogenic agent: insight into the treatment of cancer bone metastases
Q36796472The central role of wear debris in periprosthetic osteolysis
Q33657947The chosen few? Positive selection and the generation of naive B lymphocytes
Q34048761The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
Q35716042The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
Q35128219The complexities of skeletal biology
Q37700164The complicated role of NF-kappaB in T-cell selection.
Q38669228The effects of tumour necrosis factor-α on bone cells involved in periodontal alveolar bone loss; osteoclasts, osteoblasts and osteocytes.
Q28274046The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor
Q30481368The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis
Q35216957The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity
Q28577304The intracellular domain of CD44 promotes the fusion of macrophages
Q38654344The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state
Q42905527The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.
Q34827459The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts
Q52532301The protein tyrosine kinase p60c-Src is not implicated in the pathogenesis of the human autosomal recessive form of osteopetrosis: a study of 13 children.
Q47933661The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation
Q35561576The role of Rel/NF-kappaB transcription factors in B lymphocyte survival
Q24805207The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption.
Q36731651The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.
Q44681011The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity
Q38997808Therapeutic Effect of Cistanoside A on Bone Metabolism of Ovariectomized Mice
Q36147288Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug.
Q37696067Transcriptional control of the TNF gene
Q36146925Transcriptional networks in developing and mature B cells
Q38290706Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B.
Q46346390Transcriptional regulation of B-cell differentiation
Q39340507Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences
Q41004339Transforming growth factor-beta stimulates the production of osteoprotegerin/osteoclastogenesis inhibitory factor by bone marrow stromal cells
Q35155960Transitional B cells: step by step towards immune competence
Q38260633Translational biology of osteosarcoma
Q37185295Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling
Q24653311Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
Q73853199Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture
Q35592741Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology
Q42197175Tusc2/Fus1 regulates osteoclast differentiation through NF-κB and NFATc1.
Q42139802Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2.
Q36838785Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins
Q36637897Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.
Q35877574When developmental biology meets human pathology
Q28204249X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling
Q36413357ZIP4 silencing improves bone loss in pancreatic cancer
Q51842272Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice.
Q40591694p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.

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