Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis

scientific article published on 28 July 2011

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1012668241
P356DOI10.1186/AR3380
P932PMC publication ID3239343
P698PubMed publication ID21861862
P5875ResearchGate publication ID51590495

P2093author name stringJochen Zwerina
Tobias Braun
P2860cites workIL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesQ24294720
Discovery of a cytokine and its receptor by functional screening of the extracellular proteomeQ24310846
The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal modelsQ24519770
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesisQ24563235
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritisQ24564656
RANK is essential for osteoclast and lymph node developmentQ24598872
Control of RANKL gene expressionQ24619669
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokinesQ24678115
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Fibroblast biology. Effector signals released by the synovial fibroblast in arthritisQ24792451
IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathwaysQ24793443
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
LDL-receptor-related protein 6 is a receptor for Dickkopf proteinsQ28116567
Bone resorption by osteoclastsQ28145169
The interleukin-1 family: 10 years of discoveryQ28243296
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130Q28279735
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systemsQ28294477
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationQ28505419
Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defectsQ28505493
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingQ28513445
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFalpha or anti-IL-1 therapiesQ28570898
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritisQ77742326
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient miceQ78124718
High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck studyQ79422602
Dickkopf-1 is a master regulator of joint remodelingQ79610564
Risk of fracture in ulcerative colitis: a population-based study from Olmsted County, MinnesotaQ79770437
Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironmentQ80445625
Interleukin-6 directly inhibits osteoclast differentiation by suppressing receptor activator of NF-kappaB signaling pathwaysQ80763818
Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritisQ83398961
Denosumab-mediated increase in hand bone mineral density associated with decreased progression of bone erosion in rheumatoid arthritis patientsQ84062765
IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17Q84511967
Osteoporosis in Ankylosing SpondylitisQ84641713
Radiographic study on the pattern of wrist joint destruction in rheumatoid arthritisQ85059586
Annotating genes with potential roles in the immune system: six new members of the IL-1 familyQ28679180
Genetic regulation of osteoclast development and functionQ29617421
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Interleukin-1 is essential for systemic inflammatory bone lossQ33406072
Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouseQ33646429
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interactionQ33886695
Transcriptional regulation of bone and joint remodeling by NFATQ33998768
Natural killer cells trigger osteoclastogenesis and bone destruction in arthritisQ34059280
Interleukin-1 (IL-1) pathwayQ34093681
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugsQ34110066
M-CSF mediates TNF-induced inflammatory osteolysisQ34133595
Strength of TRAF6 signalling determines osteoclastogenesisQ34166675
IgG1 plasmacytosis in interleukin 6 transgenic miceQ34308376
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis.Q34360402
The IL-33/ST2 pathway: therapeutic target and novel biomarkerQ34776884
Risk of vertebral fracture in women with rheumatoid arthritisQ35187252
Requirement for NF-kappaB in osteoclast and B-cell developmentQ35199657
IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivoQ35575987
Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathologyQ35592741
Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathwaysQ35632149
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritisQ35788463
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivoQ35804512
Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitorsQ35824058
TNF-induced structural joint damage is mediated by IL-1.Q35880188
Cytokine patterns and pathogenicity in autoimmune diseases.Q35939237
Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytesQ36101730
Macrophage- and neutrophil-dominant arthritis in human IL-1 alpha transgenic miceQ36166760
Interleukin 6 plays a key role in the development of antigen-induced arthritisQ36172826
Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritisQ36371110
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritisQ36371158
The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesisQ36371653
Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient miceQ36375776
Interleukin 6 is required for the development of collagen-induced arthritisQ36400353
Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathwaysQ42494588
Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B.Q42811250
Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesisQ43146568
Tumor necrosis factor-alpha supports the survival of osteoclasts through the activation of Akt and ERK.Q43775920
Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defectsQ43833399
Tumor necrosis factor alpha-mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerinQ43937881
Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destructionQ43945860
IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariaeQ44129538
Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL.Q46030946
Mast cells express IL-17A in rheumatoid arthritis synoviumQ46151437
Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivoQ46265274
Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal systemQ46280827
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.Q46711436
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasisQ47761859
Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survivalQ47982674
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.Q48083226
TRAF2 is essential for TNF-alpha-induced osteoclastogenesis.Q50335956
Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptorQ51049420
Treatment with TNF-α inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis.Q51548531
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice.Q54420652
Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitisQ57232104
Interleukin-6 modulates production of T lymphocyte–derived cytokines in antigen-induced arthritis and drives inflammation-induced osteoclastogenesisQ57265520
Multiple roles of M-CSF in human osteoclastogenesisQ57533490
NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1Q57675122
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trialQ57752107
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanismsQ58326878
Bone and haematopoietic defects in mice lacking c-fosQ58326969
T Cell Activation Induces Human Osteoclast Formation via Receptor Activator of Nuclear Factor κB Ligand-Dependent and -Independent MechanismsQ60524745
Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokinesQ60524890
The -Isoform of p38 MAPK Specifically Regulates Arthritic Bone LossQ61900817
Pleiotropic effects of a null mutation in the c-fos proto-oncogeneQ62555352
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritidesQ68094829
Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin productionQ68435194
Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridizationQ68632086
Generalised bone loss in patients with early rheumatoid arthritisQ72682386
Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synoviumQ73343798
The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritisQ73414195
Tumor necrosis factor-alpha induces differentiation of and bone resorption by osteoclastsQ73441763
High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanismQ73458527
Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluidQ73601079
Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokinesQ74269794
IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophagesQ74412124
Tumor necrosis factor alpha-induced osteoclastogenesis requires tumor necrosis factor receptor-associated factor 6Q74488822
Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cellsQ74520565
A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2Q74595874
Membrane-associated IL-1 contributes to chronic synovitis and cartilage destruction in human IL-1 alpha transgenic miceQ75197457
Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synoviumQ77738643
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone lossQ36402985
Mechanisms of pathologic new bone formation.Q36594210
The molecular understanding of osteoclast differentiationQ36650749
IL-33 exacerbates antigen-induced arthritis by activating mast cellsQ36800502
The IL-6/sIL-6R complex as a novel target for therapeutic approachesQ36804420
TNF-mediated inflammatory disease.Q37045764
Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritisQ37253521
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiationQ37286240
Evidence that cytokines play a role in rheumatoid arthritisQ37316594
M-CSF elevates c-Fos and phospho-C/EBPalpha(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specificationQ37348266
Colony-stimulating factor-1 (CSF-1) directly inhibits receptor activator of nuclear factor-{kappa}B ligand (RANKL) expression by osteoblastsQ37418258
A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent mannerQ37438928
Osteoimmunology: crosstalk between the immune and bone systemsQ37544448
Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletionQ37629702
The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinaseQ37647341
TNF and boneQ37696082
Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritisQ37742906
Development of TNF inhibitor therapies for the treatment of rheumatoid arthritisQ37767493
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.Q38594831
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.Q38744013
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerinQ39116155
Macrophage-derived cytokine and nuclear factor kappaB p65 expression in synovial membrane and skin of patients with psoriatic arthritisQ39539886
Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cellsQ39645392
Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.Q39993181
Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseasesQ40184342
Murine dendritic cell transdifferentiation into osteoclasts is differentially regulated by innate and adaptive cytokinesQ40241909
Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosionQ40590532
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritisQ40646100
TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesisQ40666297
Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursorsQ40727130
Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation.Q40876856
IL-1 mediates TNF-induced osteoclastogenesisQ40909592
Macrophage colony-stimulating factor and interleukin-1 alpha maintain the survival of osteoclast-like cellsQ41373053
Interleukin-6 localisation in the synovial membrane in rheumatoid arthritisQ41702676
Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout miceQ41873647
Regulation by PGE2 of the production of interleukin-6, macrophage colony stimulating factor, and vascular endothelial growth factor in human synovial fibroblastsQ41910302
A novel T cell cytokine stimulates interleukin-6 in human osteoblastic cellsQ42474660
P433issue4
P921main subjectpeptideQ172847
rheumatoid arthritisQ187255
cytokineQ212354
osteoclastQ828410
bone resorptionQ4941581
P304page(s)235
P577publication date2011-07-28
P1433published inArthritis Research and TherapyQ15757229
P1476titlePositive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis
P478volume13

Reverse relations

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