Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis

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Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2010PNAS..10713028S
P356DOI10.1073/PNAS.1000546107
P932PMC publication ID2919936
P698PubMed publication ID20615964
P5875ResearchGate publication ID45113506

P50authorUlf Müller-LadnerQ47261506
P2093author name stringEdgar G Engleman
Emily Stein
William H Robinson
Ingo H Tarner
Paula Colmenero
Kalle Söderström
Cristina Teixeira de Matos
Ulrich Purath
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKLQ24338171
CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activationQ80967934
Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 primingQ80975562
Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 productionQ81899298
Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytesQ83022902
The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destructionQ83880460
RANK is essential for osteoclast and lymph node developmentQ24598872
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell originQ24817058
Bone resorption by osteoclastsQ28145169
Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoireQ28189785
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
NK cell recognitionQ29615107
Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46Q33278681
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cellsQ33803260
Effects of denosumab on bone mineral density and bone turnover in postmenopausal womenQ34656025
Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritisQ34967810
Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritisQ35789185
Natural killer cells trigger differentiation of monocytes into dendritic cellsQ36007747
Rheumatic diseases: the effects of inflammation on boneQ36324975
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptorQ36363861
Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivoQ37379361
Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathologyQ41038908
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destructionQ41927546
Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factorQ42139985
IL-15 is chemotactic for natural killer cells and stimulates their adhesion to vascular endotheliumQ42800241
NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma.Q43562662
Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subsetQ43600819
A randomized, double-blind study comparing twenty-four-week treatment with recombinant interferon-gamma versus placebo in the treatment of rheumatoid arthritisQ49174472
Activated T lymphocytes suppress osteoclastogenesis by diverting early monocyte/macrophage progenitor lineage commitment towards dendritic cell differentiation through down-regulation of receptor activator of nuclear factor-kappaB and c-Fos.Q50925640
Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells.Q51583908
The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritisQ57232112
Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trialQ57752107
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γQ59064307
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor geneQ59092154
In vitro spontaneous osteoclastogenesis of human peripheral blood mononuclear cells is not crucially dependent on T lymphocytes.Q64892036
Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factorQ70358362
The role of NK cells during in vivo antigen-specific antibody responsesQ70994039
Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissueQ72871576
Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patientsQ73880310
A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2Q74595874
Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune responseQ77320555
Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibodyQ79826358
Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretionQ80374068
Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironmentQ80445625
P433issue29
P407language of work or nameEnglishQ1860
P304page(s)13028-13033
P577publication date2010-07-06
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleNatural killer cells trigger osteoclastogenesis and bone destruction in arthritis
P478volume107

Reverse relations

cites work (P2860)
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