The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.

scientific article published on 29 August 2013

The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.461848
P8608Fatcat IDrelease_cwiczlzbnfgehpmnq4fhkvqmcy
P932PMC publication ID3829441
P698PubMed publication ID23990468
P5875ResearchGate publication ID256290877

P50authorPaul H AndersonQ56233362
Gerald J AtkinsQ56233363
P2093author name stringTsuyoshi Sato
Masafumi Tsujimoto
Peter C Gray
Yasushi Okazaki
Masahito Matsumoto
Naoki Kato
Aya Fukuda
Koji Hisatake
David M Findlay
Shigehiro Katayama
Tatsuo Suda
Masakazu Kogawa
Tetsuya Yoda
Yukiko Kanesaki-Yatsuka
Seiki Wada
Yuichiro Enoki
P2860cites workBirth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1Q22306225
Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1Q24300916
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I)Q24322489
Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho familyQ24594237
RANK is essential for osteoclast and lymph node developmentQ24598872
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcificationQ24603266
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand familiesQ28137631
The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclastsQ28140929
Bone resorption by osteoclastsQ28145169
RANK-L and RANK: T cells, bone loss, and mammalian evolutionQ28203468
Getting your Pax straight: Pax proteins in development and diseaseQ28212326
PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defectsQ28240060
Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant miceQ28278850
Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling systemQ28283972
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosisQ28295246
Pax2 contributes to inner ear patterning and optic nerve trajectoryQ28511597
Pax3 functions at a nodal point in melanocyte stem cell differentiationQ28587774
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiationQ28590799
Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp(2H))/Pax3 mouse mutantQ28594842
Mouse small eye results from mutations in a paired-like homeobox-containing geneQ29617930
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.Q32024327
The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Q33637181
Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP.Q34026199
The role of Pax-1 in axial skeleton development.Q34329886
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium developmentQ34335517
Pax genes and organogenesis.Q34439185
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitroQ34459310
Reaching a genetic and molecular understanding of skeletal developmentQ34611297
Requirement for NF-kappaB in osteoclast and B-cell developmentQ35199657
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiationQ35848573
PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.Q36105975
Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE.Q36409971
Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changesQ38310017
Activation of the transcription factor ISGF3 by interferon-gammaQ38322204
Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in miceQ38340348
The Groucho/TLE/Grg family of transcriptional co-repressorsQ38610837
The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.Q39460862
IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaBQ39946703
Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylationQ39962419
Corecruitment of the Grg4 repressor by PU.1 is critical for Pax5-mediated repression of B-cell-specific genesQ40099900
Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitorsQ40489394
Regulation of receptor activator of NF-kappaB ligand-induced tartrate-resistant acid phosphatase gene expression by PU.1-interacting protein/interferon regulatory factor-4. Synergism with microphthalmia transcription factorQ40796459
Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factorQ40838540
Osteopetrosis in mice lacking haematopoietic transcription factor PU.1.Q41121255
Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.Q42826784
Complex regulatory element within the gammaE- and gammaF-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid.Q43954150
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet developmentQ44055107
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper proteinQ44500763
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) functionQ47073232
Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebratesQ47899785
Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila.Q48354415
Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.Q50943562
IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKLQ51027178
Darier disease, multiple bone cysts, and aniridia due to double de novo heterozygous mutations in ATP2A2 and PAX6.Q51930227
Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.Q52192178
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-βQ57675150
Bone and haematopoietic defects in mice lacking c-fosQ58326969
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γQ59064307
Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreasQ59070691
Pleiotropic effects of a null mutation in the c-fos proto-oncogeneQ62555352
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)Q73907464
P433issue43
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)31299-31312
P577publication date2013-08-29
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation
P478volume288

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cites work (P2860)
Q58728809A Metabolomics Study on the Bone Protective Effects of a Lignan-Rich Fraction From Sambucus Williamsii Ramulus in Aged Rats
Q37671291Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo.
Q37082335Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase
Q47595585Gα12 regulates osteoclastogenesis by modulating NFATc1 expression
Q47140180Kaempferide Prevents Titanium Particle Induced Osteolysis by Suppressing JNK Activation during Osteoclast Formation
Q49907069Paeoniflorin ameliorates collagen-induced arthritis via suppressing NF-κB signaling pathway in osteoclast differentiation.
Q33890247Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

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