Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

scientific article

Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/IJMM.2014.1812
P932PMC publication ID4094585
P698PubMed publication ID24939714
P5875ResearchGate publication ID263207756

P2093author name stringBin Li
Yisong Wang
Bo Meng
P2860cites workUnderstanding pRb: toward the necessary development of targeted treatments for retinoblastomaQ27011911
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The human PAX6 gene is mutated in two patients with aniridiaQ28207886
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Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain developmentQ28505893
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
Pax-6, a murine paired box gene, is expressed in the developing CNSQ29616329
Quantitation of PAX6 and PAX6(5a) transcript levels in adult human lens, cornea, and monkey retinaQ33700593
cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cellsQ33721835
Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes.Q33779430
The transcription factor, Pax6, is required for cell proliferation and differentiation in the developing cerebral cortexQ33875072
Regulation of the G2/M transition by p53.Q33943437
Pax6 is a human neuroectoderm cell fate determinantQ33996031
P27 in cell cycle control and cancer.Q34024231
Vertebrate neural cell-fate determination: lessons from the retinaQ34185937
Pax-6 is essential for lens-specific expression of zeta-crystallinQ34358084
Apoptosis: a link between cancer genetics and chemotherapyQ34520432
The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreasQ34552224
BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype.Q34581850
Hepatitis B virus induces G1 phase arrest by regulating cell cycle genes in HepG2.2.15 cellsQ35016383
Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lensQ35959737
Long-range downstream enhancers are essential for Pax6 expressionQ36661860
Tumor resistance to apoptosisQ37323744
Dynamic Pax6 expression during the neurogenic cell cycle influences proliferation and cell fate choices of retinal progenitorsQ37341223
Pax6: a multi-level regulator of ocular developmentQ38007801
The role of Pax-6 in eye and nasal developmentQ38295745
The oncogenic potential of Pax genesQ38318897
Effect of VEGF-targeted antisense gene therapy on retinoblastoma cell line SO-RB50 in vitro and in vivoQ39287718
Expression profile of genes regulated by curcumin in Y79 retinoblastoma cellsQ39366939
Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines.Q39688506
Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and deathQ39751952
Pax6 overexpression suppresses cell proliferation and retards the cell cycle in corneal epithelial cellsQ40275696
Pax6 is required for the multipotent state of retinal progenitor cellsQ40813005
Pax6 controls radial glia differentiation in the cerebral cortexQ42465397
Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signalingQ42613006
The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced osteoclast differentiation.Q42905527
Pax6 is essential for lens fiber cell differentiationQ43096272
Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosisQ48257854
Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalitiesQ48964218
Pax6 controls the proliferation rate of neuroepithelial progenitors from the mouse optic vesicle.Q51999703
Diabetes and pancreatic tumours in transgenic mice expressing Pa x 6.Q52169150
Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors.Q52545088
Characteristics of an established cell line of retinoblastoma.Q53438363
Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells.Q54346608
Pax6 regulates proliferation and apoptosis of human retinoblastoma cells.Q54396510
Pax6 dosage requirements in iris and ciliary body differentiationQ57985896
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cellsQ74190453
Effects of matrine on proliferation and apoptosis of cultured retinoblastoma cellsQ84820613
P433issue2
P921main subjectretinoblastomaQ500695
P304page(s)399-408
P577publication date2014-06-17
P1433published inInternational Journal of Molecular MedicineQ6051492
P1476titleSuppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells
P478volume34

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cites work (P2860)
Q42378296Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells
Q50123973Construction of a lentiviral vector carrying short?hairpin RNA targeting PAX6 and its effect on proliferation of glioma U251 cells in vitro
Q91677737Differential response of pineal microglia to surgical versus pharmacological stimuli
Q36375151Effects of PPARγ agonistrosiglitazone on human retinoblastoma cell in vitro and in vivo
Q52715022Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress.
Q89495625LINC00858 promotes retinoblastoma cell proliferation, migration and invasion by inhibiting miR-3182
Q97524093LINC01619 promotes non-small cell lung cancer development via regulating PAX6 by suppressing microRNA-129-5p
Q41113404MicroRNA-375 targets PAX6 and inhibits the viability, migration and invasion of human breast cancer MCF-7 cells
Q52641733Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer.

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