NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor

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NF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1005250112
P356DOI10.1186/AR2298
P8608Fatcat IDrelease_sfeuc2lydndnrpnq2jvyrsjpny
P932PMC publication ID2212584
P698PubMed publication ID17892600
P5875ResearchGate publication ID5951288

P2093author name stringKazuhiro Aoki
Nobuyuki Miyasaka
Toshihiro Nanki
Kazuo Umezawa
Tetsuo Kubota
Keiichi Ohya
Yukiko Komano
Machiko Hoshino
P2860cites workEffect of a small molecule inhibitor of nuclear factor-kappaB nuclear translocation in a murine model of arthritis and cultured human synovial cellsQ24812982
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Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study GroupQ29616063
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclastsQ29618116
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A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone lossQ34567407
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Mechanistic insight into osteoclast differentiation in osteoimmunologyQ36073894
Cytokines regulating osteoclast formation and functionQ36501069
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Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligandQ38515705
Autoamplification of NFATc1 expression determines its essential role in bone homeostasisQ42972503
TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesisQ43641805
Inhibition of tumor necrosis factor-alpha -induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicinQ43976225
NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesisQ44049672
Novel nuclear factor kappa B activation inhibitor prevents inflammatory injury in unilateral ureteral obstructionQ44357448
NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclastsQ45856471
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1.Q46375837
Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivoQ47446256
Osteoprotegerin deficiency and juvenile Paget's diseaseQ48292818
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.Q50779374
Rapid preparation of fresh frozen tissue-engineered bone sections for histological, histomorphological and histochemical analyses.Q51101797
Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritisQ74844694
A selective NFkappaB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient miceQ79456479
15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factorsQ79984740
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with early rheumatoid arthritisQ80038515
Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trialQ82690898
The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destructionQ83880460
P433issue5
P921main subjectmacrophageQ184204
P304page(s)R97
P577publication date2007-01-01
P1433published inArthritis Research and TherapyQ15757229
P1476titleNF-kappaB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor
P478volume9

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