Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells

scientific article published on 5 February 2016

Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1501120
P932PMC publication ID4779691
P698PubMed publication ID26851215

P50authorGovind BhagatQ38546986
P2093author name stringKathryn Silva
Nilushi S De Silva
Ulf Klein
Michael M Anderson
P2860cites workIkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIKQ24321797
Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathwayQ24324346
Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple JuncturesQ27024640
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2Q27639845
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BAFF-R, a newly identified TNF receptor that specifically interacts with BAFFQ28213294
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathwayQ28214369
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1Q28302936
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral responseQ28590125
IkappaB kinase signaling is essential for maintenance of mature B cellsQ28594778
CD40 regulates the processing of NF-kappaB2 p100 to p52Q28610678
Signaling to NF-kappaBQ29547844
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The noncanonical NF-κB pathwayQ34031207
The NF-κB genomic landscape in lymphoblastoid B cellsQ34175522
Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunitsQ34230576
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathwaysQ34331911
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Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell developmentQ35149531
Requirement for NF-kappaB in osteoclast and B-cell developmentQ35199657
Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signalsQ35748742
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Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organsQ36072414
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complexQ36123185
Control of lymphocyte development by nuclear factor-kappaB.Q36133144
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organsQ36156167
BAFF controls B cell metabolic fitness through a PKC beta- and Akt-dependent mechanismQ36228028
Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestationsQ36375661
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitectureQ36400143
Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responsesQ36400158
The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.Q36768345
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cellsQ36858600
A pathway switch directs BAFF signaling to distinct NFκB transcription factors in maturing and proliferating B cells.Q36957946
IRF4 controls the positioning of mature B cells in the lymphoid microenvironments by regulating NOTCH2 expression and activity.Q37397830
Context-specific BAFF-R signaling by the NF-κB and PI3K pathwaysQ37460813
Cracking the BAFF code.Q37517172
The follicular versus marginal zone B lymphocyte cell fate decisionQ37621246
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B cell localization: regulation by EBI2 and its oxysterol ligandQ38088546
The BAFF/APRIL system in SLE pathogenesis.Q38194895
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.Q38293065
B lymphocyte-specific, Cre-mediated mutagenesis in miceQ39719513
An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway.Q40472871
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinaseQ40504374
PI3 kinase signals BCR-dependent mature B cell survivalQ41886641
IkappaB kinase alpha is essential for mature B cell development and functionQ42175977
BAFF mediates survival of peripheral immature B lymphocytesQ42944182
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center responseQ44233229
B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centersQ45140656
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like diseaseQ46495884
Integrin-mediated long-term B cell retention in the splenic marginal zone.Q46500117
Cutting edge: BAFF regulates CD21/35 and CD23 expression independent of its B cell survival functionQ47283207
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimerQ47372605
Constitutive alternative NF-kappaB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen.Q50688564
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.Q51981842
CD9 is a unique marker for marginal zone B cells, B1 cells, and plasma cells in mice.Q52119704
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.Q52192552
Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma.Q52615711
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.Q52621343
BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.Q53664665
Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation.Q54262805
B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.Q54707196
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.Q54707207
Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon ActivationQ57198219
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent PathwayQ57230082
NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cellsQ64140399
IKKβ Is Required for Peripheral B Cell Survival and ProliferationQ73299772
Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-kappa B-inducing kinaseQ73948741
Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokinesQ74321402
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLySQ74419758
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFFQ75439201
TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cellsQ80991122
CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cellsQ81097968
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)2591-2601
P577publication date2016-02-05
P1433published inJournal of ImmunologyQ3521441
P1476titleImpairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells
P478volume196

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cites work (P2860)
Q92283518Biological characteristics of transcription factor RelB in different immune cell types: implications for the treatment of multiple sclerosis
Q33569314Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Q41927622Development, Diversity, and Function of Dendritic Cells in Mouse and Human
Q37714249Differential requirements for the canonical NF-κB transcription factors c-REL and RELA during the generation and activation of mature B cells
Q57459224Immature lung TNFR2 conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
Q28080198Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host
Q49912101Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia
Q90440475RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells
Q49832796The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function.
Q39350735The non-canonical NF-κB pathway in immunity and inflammation
Q37181833Transcription factors of the alternative NF-κB pathway are required for germinal center B-cell development
Q42369425Zoon Vulvitis Treated Successfully With Platelet-Rich Plasma: First Case Reported

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